*  KAKEN - Research Projects | THE ESTABLISHING OF THE IMMUNE SYSTEM OF THE scid MOUSE BY THE TRANSPLANTATION OF THE XENOGENEIC...
Therefore, when transplanting the bone-barrow cells of nude (rnu/rnu) rat to the scid mouse (rat BMT scid mouse), the ... Then, this mouse falls into GVHD after several months of the rat thymus graft and dies. At the rat BMT scid mouse, neither GVHD ... scid/scid) mouse. However the thymus is equipped with the normal organization. ... The rat BMT scid mouse is the model which is extremely useful to study education effects to the T cell of the thymus. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670247/
*  Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced...
Through the use of xenograft transplantation models, such as nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice ... However, because of the low frequency and/or homing efficiency of SCID repopulating cells (SRC) in bone marrow (BM), studies ... Mice, Mice, Inbred NOD, Mice, SCID, NAD+ Nucleosidase, Retroviridae, Time Factors, Transduction, Genetic ... Through the use of xenograft transplantation models, such as nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice ...
  https://www.rdm.ox.ac.uk/publications/573052
*  "Growth and metastasis of human melanoma in SCID mice: the effect of hu" by Laurie Lynn Hill
Hill, Laurie Lynn, "Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor ... Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor growth in vivo ...
  http://jdc.jefferson.edu/theses/379/
*  Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.
... antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthri ... These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an ... The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the ...
  http://www.prohealth.com/library/showarticle.cfm?libid=25871
*  Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T C...: Ingenta Connect
... mouse recipients of congenic splenocytes. The H. pylori-infected and uninfected C57BL/6J and recipient SCID mice were evaluated ... Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T Cells in Apoptosis and Epithelial Proliferation Associated with ... Recipient mice differed, however, according to the source of the transferred CD4+ cells. The CD4+ cell scores for recipients of ... In all H. pylori-infected mice, gastric CD4+ cell scores were increased, compared with scores for uninfected controls. ...
  http://www.ingentaconnect.com/content/aalas/cm/2003/00000053/00000005/art00006
*  Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 | Science
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ...
  http://science.sciencemag.org/content/283/5403/845
*  Center for Humanized SCID Mouse Models | Microbiology and Immunology | SUNY Upstate Medical University
SUNY Upstate Medical University currently maintains a severe combined immunodeficiency (SCID) mouse facility which has been ...
  http://upstate.edu/microb/research/scidcenter/
*  Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane
... Ming- ... "Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane," ...
  https://www.hindawi.com/journals/ecam/2012/415231/cta/
*  Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice |...
Human T-cell engraftment in Hu-NOD/SCID mice.. Human CD45+ PBMC engraftment in NOD/SCID mice recipients of allogeneic islet ... ILT3-Fc treatment prevents islet allograft rejection in hu-NOD/SCID mice. Diabetic NOD/SCID mice were transplanted under the ... hu-NOD/SCID mice).. RESEARCH DESIGN AND METHODS. NOD/SCID female mice purchased from Charles River Laboratories were used at 6- ... Ts cell assays in ILT3-Fc-treated (▵) and human IgG-treated (▪) hu-NOD/SCID mice recipients of allogeneic islet cells. Mice ...
  http://diabetes.diabetesjournals.org/content/57/7/1878
*  Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice | Molecular Cancer Therapeutics
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Lubing Gu, Hailong Zhang, Tao ... When given for a period of 2 weeks (20 mg/kg/day, 3×/week), AQ-101 inhibited development of ALL in nude or SCID mice with a ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ...
  http://mct.aacrjournals.org/content/17/2/497
*  Construction of Human‐SCID Chimeric Mice - Current Protocols
Until recently, testing of new therapeutic agents has relied extensively upon the use of mice and nonhuman primates for in vivo ... C.B‐17 scid/scid (SCID) or C.B‐17 scid/scid bg/bg (SCID.BG) mice, preferably male, 6 to 8 weeks old (Taconic Farms) ... SCID‐hu mice). The describes the surgical implantation of human fetal thymus and liver under the kidney capsules of SCID mice ( ... SCID‐hu Thy/Liv model). Subcutaneous transplantation of human fetal bone marrow and thymus (SCID‐hu Bm/Thy mice) is described ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0408.html?quicktabs_cp=materials
*  siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice | Springer for Research &...
P-gp over-expressing MDA435/LCC6 MDR1 cells were used to establish xenografts in NOD-SCID mouse. Cationic polymers ... siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice. ...
  https://rd.springer.com/article/10.1007/s11095-011-0480-z
*  Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute...
Methods: : Acute ischemia-reperfusion injury was induced in the right eye of adult NOD-SCID mice (n = 20) by elevating the ... Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute ... Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute ... grade human bone marrow-derived CD34+ cells in NOD-SCID mice with acute retinal ischemia-reperfusion injury in order to ...
  https://iovs.arvojournals.org/article.aspx?articleid=2353918
*  Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. | JEM
Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.. B A Vandekerckhove, R Baccala, D Jones, D H ... Implantation of pieces of human fetal liver and thymus into SCID mice results in the development of a human thymus-like organ, ... Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. ... Thymic selection in SCID-hu thymus induces changes in V beta usage by the single-positive CD4+ or CD8+ T cells comparable with ...
  http://jem.rupress.org/content/176/6/1619
*  SCID mouse reprogramming platform
... SCID mouse differentiation and maturation platform: A unique solution to solve the issue of ... Univercell-Biosolutions SCID mouse differentiation and mataration platform is composed by two unique elements: ... 1- A "Maturation Bioreactor": use of a SCID mouse as a "bioreactor" for immature cell fate maturation, ... Univercell-Biosolutions proposes the SCID mouse as differentiation and maturation bioreactor in partnership for developing new ...
  http://www.univercell-biosolutions.com/human-heart-cells-and-stem-cells-production/our-technology/scid-mouse-reprogramming-platform
*  Human tumor models in the severe combined immune deficient (scid) mouse - Semantic Scholar
Therefore, the scid mouse models may be useful for testing new chemotherapeutic agents against various human cancer types. ... CPA and doxorubicin improved survival in the HL60 leukemia model (P = 0.0018). Conclusions: These scid mouse human tumor models ... for growth in the scid mouse and the tumors' response to conventional chemotherapeutic drugs. Methods: Established melanoma ( ... to reflect the clinical situation in that clinically active chemotherapeutic drugs are similarly active in the scid mouse ...
  https://www.semanticscholar.org/paper/Human-tumor-models-in-the-severe-combined-immune-Paine-Murrieta-Taylor/cdf242f8ccf399a24f3bc7b8d0dc4e95c8c9360e
*  Gene therapy of destructive arthritis in SCID mice | Arthritis Research & Therapy | Full Text
Cells (500,000) were injected directly into the knee joinst of mice with severe combined immunodeficiency (SCID). Mice were ... Induction of cartilage destruction by intraarticular application of fibroblast like cells into SCID mice can be modulated by ... cell line which induces a rapid destruction of articular cartilage following intraarticular instillation in SCID mice and in ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar706
*  Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells. - The Kennedy...
... was localized to the lamina propria of mildly affected mice but became transmural in severely affected mice. ... Some mice also had scattered multinucleated giant cells. Mucin depletion and epithelial hyperplasia resulting in glandular ... The changes in the large intestine of these mice are similar to those seen in patients with idiopathic inflammatory bowel ... Chronic inflammation developed spontaneously in the large intestine of C.B-17 scid mice restored with the CD45RBhigh subset of ...
  https://www.kennedy.ox.ac.uk/publications/17526
*  Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with...
... and transferred into immunodeficient SCID mice. Germ-free (GF) SCID mice or SCID mice monoassociated with Enterococcus faecalis ... SCID mice were colonized by a defined cocktail of specific pathogen-free (SPF) bacteria. Mice were evaluated 8-12 weeks after ... SCID) mice restored with the CD45 RB(high) subset of CD4+T cells isolated from the spleen of normal BALB/c mice. METHODS: A CD4 ... T-cell subpopulation to SCID mice severe colitis was present in conventional animals and in mice colonized with a cocktail of ...
  https://www.kennedy.ox.ac.uk/publications/27864
*  CD3+ T cells in severe combined immunodeficiency (scid) mice. II. Transplantation of dm2 lymphoid cells into semi-allogeneic...
... mice. II. Transplantation of dm2 lymphoid cells into semi-allogeneic scid mice , Angelika Rudolphi; Sibylle Spiess; Peter ... mice. II. Transplantation of dm2 lymphoid cells into semi-allogeneic scid mice. Angelika Rudolphi; Sibylle Spiess; Peter ... mice. II. Transplantation of dm2 lymphoid cells into semi-allogeneic scid mice. ... CD3+ T cells in severe combined immunodeficiency (scid) ... CD3+ T cells in severe combined immunodeficiency (scid) ...
  http://booksc.org/book/1230605/73a168/?_ir=1
*  Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. | JEM
We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige ... Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.. D E Mosier ... The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T ... Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. ...
  http://jem.rupress.org/content/177/1/191?ijkey=f9d9033f94a8e1b880907ad7d88d9cfc5935a538&keytype2=tf_ipsecsha
*  Transformation of spleen cells prepared from dengue virus-2 immunized hu-TLC-SCID mice -- Vol. 11, No 02, 1996 -- Virologica...
... that the Hu-TLC-SCID mouse spleen cell has been successfully trans-foimed by EBV.The EBV-transformed Hu-TLC-SCID mouse spleen ... TLC-SCID)immunized with dengue virus 2 type(DV_2)in vitro and in vivo were trans-formed by Epstein-Barr virus(EBV).Specific ... The spleen cells isolated from SCID mice transplanted with human tonsillar lymphocytes(Hu- ... The spleen cells isolated from SCID mice transplanted with human tonsillar lymphocytes(Hu- TLC-SCID)immunized with dengue virus ...
  http://www.virosin.org/Paper/1996/11/02/VS19961102.0132
*  High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA...
C.B-17 mice. The incidences of colon tumors, either adenomas or adenocarcinomas, in Scid and C.B-17 mice after administration ... The multiplicity of colon tumors in Scid mice was also significantly higher than in C.B-17 mice, being 2.2 ± 1.5 and 0.9 ± 1.2 ... Severe combined immunodeficiency (Scid) mice have defects in V(D)J recombination and DNA double-strand breaks repair caused by ... Severe combined immunodeficiency (Scid) mice have defects in V(D)J recombination and DNA double-strand breaks repair caused by ...
  http://oxfordindex.oup.com/view/10.1093/carcin/22.9.1551
*  ASMscience | Lyme Borreliosis
The plethora of inbred mouse strains, including genetically modified animals, and the depth of knowledge of the murine immune ... system have made studies of the mouse particularly valuable. The chapter presents the diagnosis, treatment, and prevention of ... To gain a better understanding of pathogenetic mechanisms, animal models of Lyme disease have been developed in mice, hamsters ... Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice. Infect. Immun. 65:4334-4336.. ...
  http://www.asmscience.org/content/book/10.1128/9781555816490.chap11
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Experimental compounds that demonstrate activity in cell culture assays are evaluated in vivo using NOD-SCID-gamma (NSG) mice ... 4T1 mouse mammary tumor cells can be implanted sub-cutaneously in nu/nu mice to form palpable tumors in 15 to 20 days. This ... mouse, embryonic, organ culture, coronary plexus, ex vivo, cell culture, transgenic mice, animal model ... Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of ...
  https://www.jove.com/visualize/abstract/23300962/long-term-in-vivo-imaging-of-multiple-organs-at-the-single-cell-level