'mice mutant strains' Protocols and Video...
Mice, Mutant Strains: Mice bearing mutant genes which are phenotypically expressed in the animals. ...https://www.jove.com/keyword/mice+mutant+strains
Inhibition of the Plasma SCUBE1, a Novel Platelet Adhesive Protein, Protects Mice Against ThrombosisSignificance |...
Generation of a New Genetic Mutant Mouse Strain With Deficiency in Producing Plasma SCUBE1. Based on the in vitro deletion data ... mice were generated by crossing male protamine (Prm)-Cre; Scube1Flox/+ mice to wild-type female mice. Mice homozygous for the ... mice and 14.5±2.2% for Δ/Δ mice (47% lower than +/+; P,0.01). Similarly, the thrombus volume obtained from Δ/Δ mice was 56% ... mice; Figure 5D). Thus, thrombus formation in Δ/Δ mice did not develop as rapidly or as extensively as in +/+ mice. Indeed, ...http://atvb.ahajournals.org/content/34/7/1390
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the...
Recombination efficiency is similar for the two mutant mouse strains. Representative blot for n = 3 mice of each genotype, ... TSLPR−/− mice were indistinguishable from wild type mice and therefore only the results of TSLPR−/− mice are shown. (A) ... mice (* p,0.01; ** p,0.001) showing relative increased expression of a wide panel of cytokines in mutant mice. TSLP shows the ... mice revealing a 400 fold increase of this cytokine in mutant mice. The experiment was performed in triplicates. (C-D) Control ...https://www.ncbi.nlm.nih.gov/pubmed/20174635?access_num=20174635&link_type=MED&dopt=Abstract
A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration.
Mice. Mice, Mutant Strains. Pyridinium Compounds / metabolism. Receptors, Chemokine / genetics. Retinal Pigment Epithelium / ... 0/A2E compound; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Cx3cr1 protein, mouse; 0/Fatty Acids, Omega-3; 0/Interleukin-6; 0/ ... Some mice that were given high levels of n-3 fatty acids had lesion reversion. We found a shunted arachidonic acid metabolism ... Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared ...http://www.biomedsearch.com/nih/high-omega-3-fatty-acid/19608872.html
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.
Mice. Mice, Mutant Strains. Mutation, Missense*. Neoplasm Proteins / genetics, metabolism*. Period Circadian Proteins / ... mice and their littermates were derived from PER2S662 mutants and ClockΔ19 mutants33 by crossing with p53R175H/+ mice. All ... we mated PER2S662 mutant mice with p53R172H knock-in mice. These knock-in mice have a mutation that corresponds to the p53R175H ... compound mutant mice. These mice all had the same genetic background of C57BL/6. We monitored these mice for tumor development ...http://www.biomedsearch.com/nih/circadian-mutation-PER2S662G-linked-to/21818120.html
Category:B6CBACa Aw-J/A-Kcnj6wv/J mouse
Type: JAX GEMM Strain - Mutant Strain Ty … Type: JAX GEMM Strain - Mutant Strain Type: JAX GEMM Strain - Spontaneous Mutation ... Type: JAX GEMM Strain - Mutant Strain Ty … Type: JAX GEMM Strain - Mutant Strain Type: JAX GEMM Strain - Spontaneous Mutation ... Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in ... Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in ...http://neurolex.org/wiki/Special:Browse/Category:B6CBACa-20Aw-2DJ-2FA-2DKcnj6wv-2FJ-20mouse
JCI - Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat. Genet. 1998. 18:374-377. View this article via: ... C57BL/6J mice were infused with DHA/BSA or OA/BSA for 6 hours. The mice were then injected via the jugular vein with [35S]-Met/ ... Automated measurement of mouse apolipoprotein B: convenient screening tool for mouse models of atherosclerosis. Clin. Chem. ... This line of reasoning provides an attractive explanation for the pathophysiology of a spontaneously mutant mouse proposed to ...https://www.jci.org/articles/view/19197
000259 - JE/LeJ
... show behavior typical of the circling mutants - head-tossing, circling, and hyperactivity. Homozygous mutant mice are deaf from ... JE/Le mice are also homozygous for the nonagouti (,i,a,/i,) and ruby-eye (,i,Hps6,sup,ru,/sup,,/i,) mutations. ... Heterozygous jerker mice undergo a similar type of degeneration, but the onset is delayed. Auditory brainstem response is ... totally absent in homozygotes while heterozygous mice undergo a progressive impairment with age.,br,,br,Flexed tail homozygotes ...https://www.jax.org/strain/000259
Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator | Development
Mouse. INTRODUCTION. Lurcher (Lc) is a neurological mutant mouse strain. Homozygous Lurcher (Lc/Lc) mice die within a few hours ... Mice. Lurcher mice (B6CBACaAW-J/A-Grid2Lc) were purchased from the Jackson Laboratory, and mated with tPA-/- (Plat-/- - Mouse ... We generated Lc heterozygous mice on a tPA-deficient background by first mating Lc/+ mice to tPA-/- mice, and then crossing the ... we set out to examine the impact of its ablation on the exaggerated-apoptosis-prone mutant mouse strain, Lurcher. As tPA ...http://dev.biologists.org/content/129/8/2043
High oxygen prevents fetal lethality due to lack of catecholamines.
When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble ... Mice. Mice, Inbred Strains. Mice, Mutant Strains. Norepinephrine / blood*, deficiency. Oxygen / pharmacology*. Oxygen ... When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble ... supporting the notion that mutants experience lower oxygen tension or have an enhanced response to hypoxia. Hypoxia induces a ...http://www.biomedsearch.com/nih/High-oxygen-prevents-fetal-lethality/18635452.html
This mutant mouse strain may be useful in studies of Alzheimer's disease. ... These transgenic mice exhibit increasing expression of human amyloid beta precursor protein in the cortex, hippocampus, brain ... "MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or ... This mutant mouse strain may be useful in studies of Alzheimer's disease and cerebral amyloid angiopathy. ...https://www.jax.org/strain/007027
005439 - B6.129S-Mecp2|tm1Hzo|/J
This mutant mouse strain may be useful in studies of Rett Syndrome. ... male mutant mice of this strain begin to exhibit tremors, progressive motor dysfunction, oily disheveled fur, hypoactivity, ... "MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or ... Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available ...https://www.jax.org/strain/005439
Malfunction of Gene Causes Schizophrenia, Depression ( An international team of researchers ha...)
... theory was that different mutant variations of DI...To test this theory they screened a large population of mouse mut..., ... The researchers said their findings in mice offer a possible anima...In their experiments the researchers sought to explore the ... Additionally, these symptoms could be alleviated in the mice by anti-psychotic drugs. Similarly, the other mutant mouse strain ... They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the ...http://www.bio-medicine.org/medicine-news/Malfunction-of-Gene-Causes-Schizophrenia--Depression-20451-1/
MPD: Data set: Paigen3
Mice: obesity mutants 8 strains ♀♂ age 15-19wks 1 cohort Select table page: 5. 10. 25. 100. all. ... Inbred strains see Paigen1 • Obesity mutant strains (this project) Paigen3 Acknowledgements. Funding provided by NIH DK51568, ... and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains (2000) Bouchard G, Johnson D, Carver T, Paigen B, ... of Strains. Sex. Age. Sample Size (Avg). Paigen3 2805 body weight high-fat diet body weight [g] start after 8wks on diet ...https://phenome.jax.org/projects/Paigen3
Lipid Metabolism sub-cluster 5
Observations in humans and, more recently, in several induced mutant mouse strains have provided ... ... and permanent J774 mouse macrophages were fractionated into lipid ... ...http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-5-p10.html
The authors thank Anton Berns for Trp53 and Ink4a/Arf conditional mutant mouse strains; Kirsten A. Hubbard and Jennifer Morton ... Mouse lines. Albumin-tv-a and albumin-cre transgenic mice, and Trp53 and Ink4a/Arf conditional mutant mice have been previously ... Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004; 119: 847-60. ... We therefore crossed albumin-tv-a transgenic mice to animals bearing conditional mutant alleles (floxed alleles) of the Trp53 ...http://cancerres.aacrjournals.org/content/67/16/7589
The generation of the truncated dystroglycan mutant mouse strain was previously described (Satz et al., 2009). The genotypes of ... although migration defects are present in both mouse strains. Differences in the phenotypes of the two mouse strains might be ... mice. Homozygous floxed-dystroglycan (Dag1 lox/lox) mice were bred to mice hemizygous for Cre. Mice heterozygous for the floxed ... Nestin-Cre/DG-null mice were born according to Mendelian ratio. To confirm the loss of dystroglycan in the mutant mice, brains ...http://www.jneurosci.org/content/30/43/14560
Laura Attardi | Stanford Medicine Profiles
... several mouse strains expressing mutant p53 proteins corresponding to human-tumor-derived mutants have demonstrated that mutant ... To address this issue, our laboratory generated a p53 mutant knock-in mouse strain in which residues 25 and 26, previously ... This p53QS mutant mouse strain represents a powerful means to dissect p53 function in vivo. ... A number of different variables affect the incidence and spectrum of tumors in p53 mutant mice. These include strain background ...https://med.stanford.edu/profiles/laura-attardi
Learn what is in the name of genetically engineered and mutant mouse strains. ... Nomenclature for Mouse Strains JAX provides you comprehensive resources to understand appropriate nomenclature for mouse ... Quick Guide to Mouse Nomenclature Learn the highlights of mouse strain nomenclature with this poster. ... Handbook: Genetically Standardized Mice The definitive resource for anyone working with laboratory mice, this is the 6th ...https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/
JCI - Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-β2 signaling
Mice. The mutant mouse strains used in this study have all been reported previously (6, 22, 39, 62). To produce mutant mice ... Ext1flox mice) were bred to transgenic mice with Cre recombinase driven by the Wnt1 promoter (Wnt1-Cre mice). The mutant ... Genotyping of the mice was performed by PCR-based methods that used DNA prepared from tail biopsies. All of the mice strains ... For analysis of the iridocorneal angle of the Tgfb2 and Ext1 double-mutant mice, 6-week-old mice were sacrificed and used to ...https://www.jci.org/articles/view/38519
Protocols and Video Articles Authored by Tsuyoshi Miyakawa (Translated to Swedish)
... of all known mouse genes have been investigated by creating mutant mice. Some of these mutant mouse strains were found to ... generated mutant mouse strain (Grin1(Rgsc174)/Grin1+) that has a non-synonymous mutation in Grin1. These mutant mice showed ... caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice; thus, ... Some mutant mouse strains were found to exhibit behavioral abnormalities reminiscent of human psychiatric disorders. Here we ...https://www.jove.com/author/Tsuyoshi_Miyakawa?language=Swedish
Protocols and Video Articles Authored by Keizo Takao (Translated to Hindi)
... of all known mouse genes have been investigated by creating mutant mice. Some of these mutant mouse strains were found to ... generated mutant mouse strain (Grin1(Rgsc174)/Grin1+) that has a non-synonymous mutation in Grin1. These mutant mice showed ... Some mutant mouse strains were found to exhibit behavioral abnormalities reminiscent of human psychiatric disorders. Here we ... Some mutant mouse strains were found to exhibit behavioral abnormalities reminiscent of human psychiatric disorders. Here we ...https://www.jove.com/author/Keizo_Takao?language=Hindi
Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor | Cancer Research
Targeted disruption of the Cxcr6 locus and the establishment of a mutant mouse strain. A, top, wild-type allele of the Cxcr6 ... Generation of Cxcr6 mutant mice. Mutant mice were generated by Lexicon Genetics, Inc. (The Woodlands, TX). A targeting vector, ... To evaluate the effect of HhAntag on medulloblastomas derived from Cxcr6 mutant mice, cohorts of mice bearing tumor allografts ... Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor. Ken Sasai, Justyna T. Romer, ...http://cancerres.aacrjournals.org/content/67/8/3871
Behavioural phenotyping of mutant mouse strains. Neuroscientists. Monitoring of circadian behaviour in mice. Behavioural ... Design your experiment to include manually scored behaviours (e.g. feeding) and independent variables (e.g. animal code, strain ... if a mouse approaches the shelter too closely, a sound stimulus can be generated. ...http://www.tracksys.co.uk/products/phenolab
004321 - B6.129S2-Mapk9|tm1Flv|/J
This mutant mouse strain represents a model that may be useful in studies related to signal transduction. ... Primary murine embryonic fibroblasts prepared from mutant embryos have decreased viability and increased genomic DNA ... Th1 cell differentiation is impaired in these mice. ... This mutant mouse strain represents a model that may be useful ... "MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or ...https://www.jax.org/strain/004321