*  Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and...
These results show that in TN-C knockout mice OP cells appear sooner in the optic nerve than in wild-type animals and are then ... We now report such an analysis for TN-C knockout mice. To examine precursor cell behaviour we focused on the OP cells that give ... At all stages in both wild-type and knockout mice, no PDGFαR mRNA-positive cells entered the part of the optic nerve ... Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and ...
  http://dev.biologists.org/content/128/13/2485
*  Biology-Online • View topic - Knockout mice
If one parent is a wild-type mouse and the other is a homozygous knockout mouse, their offspring will be heterozygous at the ... Knockout mice. by cassieconte » Tue Feb 05, 2013 4:54 pm Can someone please explain how it is possible to have a heterozygous ... knock out mouse? If a gene is 'knocked-out,' how can the mouse be heterozygous for the gene? Will the mouse still produce ... If there is some of the protein made, the mouse is a knock-down and not a knock-out. Watch out for the other meaning of ...
  http://www.biology-online.org/biology-forum/post-149536.html
*  "Phenotypic Characterization of the Pancreatic-Derived Factor (PANDER) " by Shari Moak
Here we present the first phenotypic characterization of our global PANDER knockout mouse on a C57BL/6J background (PANKO-C57) ... Overall, the PANKO-C57 mice exhibited increased body weights with enhanced glucose tolerance and lower fasting glycemia, ... mouse. However, PANDER's overall role in glycemic regulation and glucose homeostasis has yet to be studied in a purebred C57BL/ ... and most recently our mixed genetic C57/129J PANDER knockout (PANKO) ...
  http://scholarcommons.usf.edu/etd/4830/
*  Knockout Mouse Catalog | Drug Development | genOway
Ready-to-use Knockout mouse models for target discovery and confirmation, in vivo compound specificity, MOA and clinical ... Custom Mouse Models. Custom Rat Models. Custom Cell Models. Catalog Models. *Off-the-Shelf Knockouts *Overview ... We offer you ready-to-use Knockout mouse models that perfectly fit into any tight schedule. ... I started this project with no personal experience in creating knockout mice. My early discussions with your scientists and ...
  https://www.genoway.com/services/catalog/knockout-mouse.htm?
*  Hyperplastic Gastric Tumors with Spasmolytic Polypeptide-Expressing Metaplasia Caused by Tumor Necrosis Factor-α-Dependent...
... we introduced a knockout mutation of Rag2 gene into the K19-C2mE mice to generate Rag2 (−/−) K19-C2mE mice that lack T and B ... The K19-C2mE mice were crossed with respective knockout mouse strains to generate Tnf (−/−) K19-C2mE, Il1r1 (−/−) K19-C2mE, and ... Suppression of gastric tumorigenesis by Tnf knockout mutation. In the glandular stomach of K19-C2mE mice, expression is ... Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 2000 ...
  http://cancerres.aacrjournals.org/content/65/20/9147
*  Knockout Mice | Conditional and Constitutive | Taconic Biosciences
Design your own conditional and constitutive knockout mice or use existing strains. ... Accelerate your research with custom-engineered knockout mouse models. ... Knockout Mice. , , Knockout Mice. Use custom-engineered knockout mouse models to accelerate your research with insights into ... Design your own conditional and constitutive knockout mice or search Taconic's knockout repository. Constitutive Knockout Mice ...
  http://kodatabase.taconic.com/genetically-engineered-animal-models/knockout-mice/
*  Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task - pdf descargar
Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task. . Biblioteca virtual ... In this study, we conducted a series of behavioral analyses on Capsr3-knockout KO mice and equivalent wild-type WT mice to ... In the late phase, the performance of the Caspr3-KO mice caught up to the level of WT mice, suggesting that the deletion of ... Correction: Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of ...
  http://libros.duhnnae.com/2017/jun9/149853141056-Caspr3-Deficient-Mice-Exhibit-Low-Motor-Learning-during-the-Early-Phase-of-the-Accelerated-Rotarod-Task.php
*  Research Resource
Studies in M1R knockout mice show that M1 receptors may be involved in cortical memory functions that require interactions ... M1R knockout mice are viable and fertile, and have no major morphological abnormalities. ... is virtually abolished in primary cortical cultures or CA1 hippocampal pyramidal neurons in M1R knockout mice. ... Acronym: Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1) NIDDK Contact: tao@niddk.nih.gov Principal Investigator(s): ...
  https://www.niddk.nih.gov/pages/RRSplash.aspx?ID=286
*  F2R knockout cell line
Fast delivery of F2R knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes ... How are Hap1 knockout cell lines generated?. HAP1 knockouts are engineered using the CRISPR-Cas9 system to introduce frameshift ... How are HAP1 knockouts validated?. All HAP1 knockout cell lines are validated by PCR amplification and Sanger Sequencing to ... F2R HAP1 knockout Cell Culture. Biosafety Level. 1 Media Type. IMDM, 10% FCS Freeze Medium. IMDM, 20% FCS, 10% DMSO Revival. ...
  https://www.horizondiscovery.com/human-f2r-knockout-cell-line-hzghc2149
*  Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis | Blood Journal
E) Viability of the cdc42 knockout primary mice and the bone marrow transplant recipient mice is depicted by the Kaplan-Meier ... Primary MxTgcdc42f/f (f/f) mice, n = 16; WT mice with f/f bone marrow reconstitution, n = 6; mice with WT bone marrow ... Mice. Mx1-Cre;cdc42flox/flox mice were generated as previously described and maintained on a 129/C57BL/6 mixed background in ... In previous studies using a Cdc42GAP knockout, Cdc42 gain-of-activity mouse model, we have shown that constitutively increased ...
  http://www.bloodjournal.org/content/110/12/3853?sso-checked=true
*  Van Remmen, Holly
Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in ... The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse ... Using a mouse model of sarcopenia, we're looking specifically at the role of oxidative stress, or free radicals, in the long- ... Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Nov 5;455:103-14. PMCID: ...
  https://omrf.org/research-faculty/scientists/van-remmen-holly/
*  Caspase-7 was regarded as redundant with caspase-3 because these related cystein - How NF-B is activated: the role of the IB...
For instance eye lenses of caspase-7 knockout mice are grossly normal whereas those of caspase-3 deficient mice display marked ... Finally caspase-7 lacking mice are resistant to endotoxemia whereas caspase-3 knockout mice are vulnerable. These findings ... Oddly enough C57BL/6 mice deficient for both caspase-3 and -7 perish shortly after delivery while mice missing only caspase-3 ... Caspase-7?/? MEFs are more resistant to FasL- and UV-induced apoptosis than caspase 3?/? MEFs although double knockout MEFs are ...
  http://cancercurehere.com/?p=2125
*  Hear This: Knockout Mice Show Genes Linked to Deafness - Egghead
One response to "Hear This: Knockout Mice Show Genes Linked to Deafness" * Pingback: Survey of knockout mice reveals genes ... The consortium tested 3,006 strains of knockout mice for signs of hearing loss. Knockout mice have one gene from their genome ... The knockout mice tested so far in this study represented only about 15 percent of mouse genes, so the researchers estimate ... Kent Lloyd, director of the UC Davis Mouse Biology Program, in the lab. Gene-edited and "knockout" mice have become a vital ...
  http://blogs.ucdavis.edu/egghead/2017/10/12/hear-knockout-mice-show-genes-linked-deafness/
*  Knockout mouse | medical research | Britannica.com
Knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or ... Knockout mouse models also give a better understanding of the role of similar genes involved in human diseases. Knockout mouse ... Generation of knockout mice. Technologies used to generate knockout mice include homologous recombination (or gene targeting) ... In order to generate a pair of true knockout mice (homologous knockouts), the mice must be bred over several generations. ...
  https://www.britannica.com/topic/knockout-mouse
*  Safe Knockout Mouse | Knockout Engineering | genOway
Safe Knockout to generate both conventional and tissue-specific Knockout mice from a single project, and substantially save ... Safe Knockout Mice. Generating both conventional (constitutive) and tissue-specific Knockout mouse models with the same gene ... technology that allows us to generate both conventional and tissue-specific KO mice from a single project. This innovative ...
  https://www.genoway.com/services/customized-mouse/knockout-models/safe-ko.htm
*  Estrogen Receptor-α Knock-Out Mouse Model at Charles Drew University of Medicine and Science
Estrogen Receptor-α Knock-Out Mouse Model is an eagle-i resource of type Mus musculus at Charles Drew University of Medicine ... Estrogen Receptor-α Knock-Out Mouse Model. eagle-i ID. http://cdrewu.eagle-i.net/i/00000135-e500-8525-1a88-e81c80000000 ...
  http://cdrewu.eagle-i.net/i/00000135-e500-8525-1a88-e81c80000000
*  Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. - PubMed - NCBI
Mice generated from double-targeted ES cells were mated to a germ-line Cre to create homozygous Adh-del knockout mice lacking ... Deletion of entire mouse ADH gene family. The Adh-del strain was made possible by the fact that all six ADH genes in the mouse ... Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.. Kumar S1, Sandell LL, Trainor PA, ... Alcohol and Aldehyde Dehydrogenases: Retinoid Metabolic Effects in Mouse Knockout Models. Biochim Biophys Acta. ;1821(1):198- ...
  https://www.ncbi.nlm.nih.gov/pubmed/21515404
*  Knockout Mice Help Researchers Find Ways To Knockout Incontinence - Redorbit
When the researchers tested the bladders of the integrin knockout mice, they found the bladders were constantly squeezing and ... They also found that the mice overfilled their bladders and took much longer to urinate than the normal mice. ... while the second group of mice was normal. Both groups of mice had normal appearing bladders, but the group without the ... The research team tested two groups of mice. One group were genetically modified to be missing an important member of the ...
  http://www.redorbit.com/news/health/1112780817/bladder-incontinence-study-of-the-epithelium-and-integrins-020913/
*  Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice
... Hiroshi Nagahisa,1 Kazuma Okabe,1 Yoshihito Iuchi,2 Junichi ... "Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice," Oxidative Medicine and Cellular Longevity, vol. 2016, Article ...
  https://www.hindawi.com/journals/omcl/2016/9345970/cta/
*  Human Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan
... Shuji Mizumoto,1 Shuhei Yamada,1 and Kazuyuki ... phosphosulfate formation in brachymorphic mice," Proceedings of the National Academy of Sciences of the United States of ... D. H. Lum, J. Tan, S. D. Rosen, and Z. Werb, "Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2 ... C. L. R. Merry, S. L. Bullock, D. C. Swan et al., "The Molecular Phenotype of Heparan Sulfate in the Hs2st-/- Mutant Mouse," ...
  https://www.hindawi.com/journals/bmri/2014/495764/ref/
*  Medical Xpress - knockout mice
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
  https://medicalxpress.com/tags/knockout+mice/sort/popular/1d/
*  Frontiers | Urea Transporter Physiology Studied in Knockout Mice | Physiology
Over the past few years, multiple UT knockout mouse models have been generated enabling us to explore the physiological roles ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... This review summarizes the new insights of urea transporter functions in different organs from UT knockout mice. Finally, we ... Since UT-B has a wide distribution, multiple phenotypic abnormalities were found in UT-B null mice, such as defective urine ...
  https://www.frontiersin.org/articles/10.3389/fphys.2012.00217/full
*  Enhanced Blood Pressure Variability in eNOS Knockout Mice | Hypertension
... blood pressure variance was significantly larger in eNOS knockout mice than in controls, and only 2 out of 10 knockout mice had ... During resting conditions, blood pressure variability was markedly enhanced in knockout mice compared with wild-type mice (10.5 ... Statistical comparisons between eNOS knockout mice and wild-type mice were performed by unpaired t tests. ... amount of sequences in the eNOS knockout mice would suggest that the larger blood pressure variability in eNOS knockout mice is ...
  http://hyper.ahajournals.org/content/33/6/1359
*  Knockout Mouse Phenotyping | NIH Common Fund
NIH…Turning Discovery Into Health®. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892. U.S. Department of Health and Human Services. ...
  https://commonfund.nih.gov/multimedia/videos/knockout-mouse-phenotyping
*  JCI - Welcome
Pdx1 restores β cell function in Irs2 knockout mice. Jake A. Kushner ... Marc R. Montminy, Morris F. White Jake A. Kushner ... ... mice. Before the onset of diabetes, Pdx1 was reduced in islets from Irs2-/- mice, whereas it was expressed normally in islets ... mice. By contrast, transgenic expression of Pdx1 restored β cell mass and function in Irs2-/- mice and promoted glucose ... Here we show that expression of IGF-I in β cells of transgenic mice (in both C57BL/6-SJL and CD-1 genetic backgrounds) ...
  https://www.jci.org/tags/20?content=articles&page=17