METHYL METHANESULFONATE MUTAGENESIS IN BACTERIOPHAGE T4 | Genetics
MMS induces diverse rII mutations from a wild-type background in bacteriophage T4. About 56% are base pair substitutions, about 30% are frameshift mutations, and the remainder is a miscellaneous set of rapidly reverting or leaky mutants of unknown composition; but deletions were not detected. MMS-induced forward mutation is sharply reduced by the mutations px and y, which also reduce ultraviolet, photodynamic and γ-ray mutagenesis and increase killing by all of these agents. Thus, many of the mutations arise via the T4 WXY system. The induction of G:C → A:T transitions was detected even in a px or y background using sensitive reversion tests, and the few forward rII mutations that were induced from this background also behaved like transition mutations. Thus, some MMS-induced mutations arise independently of the WXY system, perhaps as a result of the (rather weak) ability of MMS to alkylate the O6 position of guanine.. ...http://www.genetics.org/content/102/4/639
Methyl methanesulfonate - Wikipedia
Methyl Methanesulfonate Scorecard.org Accessed 14 Feb 08 Medical.Webends.com: Methyl Methanesulfonate Archived 2008-02-15 at ... Methyl methanesulfonate (MMS), also known as methyl mesylate, is an alkylating agent and a carcinogen. It is also a suspected ... "Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks". Nucleic ...https://en.wikipedia.org/wiki/Methyl_methanesulfonate
Inactivation of Ultraviolet Repair in Normal and Xeroderma Pigmentosum Cells by Methyl Methanesulfonate | Cancer Research
Inactivation of Ultraviolet Repair in Normal and Xeroderma Pigmentosum Cells by Methyl Methanesulfonate. J. E. Cleaver ... The inactivation could be represented by a semilog relationship between the amount of repair and methyl methanesulfonate ... No consistent, large difference in sensitivity to methyl methanesulfonate was found in any xeroderma pigmentosum ... Inactivation of Ultraviolet Repair in Normal and Xeroderma Pigmentosum Cells by Methyl Methanesulfonate ...http://cancerres.aacrjournals.org/content/42/3/860
Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone...
The present study assessed the role of Brahmarasayana (BR) on Ethyl methanesulfonate (EMS)-and Methyl methanesulfonate (MMS)- ... Ethyl methanesulfonate (EMS) (CAS No. 62-50-0) and Methyl methanesulfonate (MMS) (CAS No. 66-27-3) served as standard ... The present study assessed the role of Brahmarasayana (BR) on Ethyl methanesulfonate (EMS)-and Methyl methanesulfonate (MMS)- ... Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-113
Methyl Methanesulfonate - Phenotypes | CTD
Methyl Methanesulfonate DNA repair Methyl Methanesulfonate affects DNA repair. 1: Homo sapiens. Spleen , Leukocytes , Cell Line ... Methyl Methanesulfonate cell growth Methyl Methanesulfonate results in decreased cell growth. 1: Danio rerio. Embryo, ... Methyl Methanesulfonate mitotic cell cycle arrest Methyl Methanesulfonate results in increased mitotic cell cycle arrest. 1: ... Methyl Methanesulfonate cell death Methyl Methanesulfonate results in increased cell death. 1: Rattus norvegicus. Hepatocytes ...http://ctdbase.org/detail.go?type=chem&acc=D008741&view=phenotype
Synergistic effect of Gentiana lutea L. on methyl methanesulfonate genotoxicity in the Drosophila wing spot test
... 2013. ... and its antigenotoxicity against methyl methanesulfonate (MMS). Materials and methods: The water infusion of the underground ...http://ibiss-r.rcub.bg.ac.rs/handle/123456789/1033?locale-attribute=sr
Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans | Genetics
Methyl methanesulfonate. L4 hermaphrodites were incubated in 0, 0.0025, 0.005, and 0.01% MMS (50-9480886, Fisher Healthcare) ... Yeast with Shu complex disruptions exhibit sensitivity to the alkylating agent methylmethane sulfonate (MMS), increased ...http://www.genetics.org/content/203/1/133
Human toxicity of various oximes. 2-Pyridine aldoxime methyl chloride, its methane sulfonate salt, and 1,1'-trimethylenebis-(4...
2-Pyridine aldoxime methyl chloride, its methane sulfonate salt, and 1,1'-trimethylenebis-(4-formylpyridinium chloride).' by B ... 2-Pyridine aldoxime methyl chloride, its methane sulfonate salt, and 1,1'-trimethylenebis-(4-formylpyridinium chloride).. @ ... 2-Pyridine aldoxime methyl chloride, its methane sulfonate salt, and 1,1'-trimethylenebis-(4-formylpyridinium chloride).}, ...https://www.semanticscholar.org/paper/Human-toxicity-of-various-oximes.-2-Pyridine-methyl-Calesnick-Christensen/fa62760cdd744b4e1026079cfa8660596c6266d0
Global response of Saccharomyces cerevisiae to an alkylating agent | PNAS
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the ... By using chips bearing oligonucleotide arrays, we show that, after exposure to the alkylating agent methyl methanesulfonate, ≈ ... Mismatch Repair-Dependent Transcriptome Changes In Human Cells Treated with the Methylating Agent N-Methyl-N'-Nitro-N- ...http://www.pnas.org/content/96/4/1486.short
ATSDR-PHA-HC-Isla de Vieques Bombing Range, Vieques, Puerto Rico
The Navy reported very low levels of cyclotrimethylene trinitramine (RDX) and methyl-2,4,6-trinitrophenylnitramine (tetryl) in ... Methyl methanesulfonate. Naphthalene. Nitrobenzene. n-Nitrosodiethylamine. n-Nitrosodimethylamine. n-Nitrosodi-n-butylamine. ...https://www.atsdr.cdc.gov/HAC/pha/reports/isladevieques_10162001pr/appendices.html
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool...
Methyl methanesulphonate. MNvit. In vitro micronucleus test. MNviv. In vivo micronucleus test ... Miller K (1991) Clastogenic effects of bleomycin, cyclophosphamide, and ethyl methanesulfonate on resting and proliferating ...https://link.springer.com/article/10.1007/s00204-018-2172-5
Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop | Genetics
ED, β-estradiol; gal, galactose; glu, glucose; MI, binucleate; MII, tetranucleate; MMS, methyl methanesulfonate; Spo, ...http://www.genetics.org/content/206/1/497.figures-only
Identification of Pathways Controlling DNA Damage Induced Mutation In Saccharomyces cerevisiae
methyl methanesulfonate. EMS. ethyl methanesulfonate. HU. hydroxyurea.. Footnotes. Publisher's Disclaimer: This is a PDF file ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2441895/?lang=en-ca
Subtle Alterations in PCNA-Partner Interactions Severely Impair DNA Replication and Repair
methyl methanesulfonate. PCNA. proliferating cell nuclear antigen. PIP. PCNA-interacting protein. SPR. surface plasmon ... or methyl methanesulfonate (MMS), drugs that cause global replication stress and DNA alkylation, respectively (Figure 5B). ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2953525/
AROMATIC SULFONATION .91. THE SULFONATION OF ANISOLE, PHENOL, PHENYL METHANESULFONATE, POTASSIUM PHENYL SULFATE, AND A SERIES...
THE SULFONATION OF ANISOLE, PHENOL, PHENYL METHANESULFONATE, POTASSIUM PHENYL SULFATE, AND A SERIES OF METHYL-SUBSTITUTED, ... THE SULFONATION OF ANISOLE, PHENOL, PHENYL METHANESULFONATE, POTASSIUM PHENYL SULFATE, AND A SERIES OF METHYL-SUBSTITUTED, ... THE SULFONATION OF ANISOLE, PHENOL, PHENYL METHANESULFONATE, POTASSIUM PHENYL SULFATE, AND A SERIES OF METHYL-SUBSTITUTED, ...http://discovery.ucl.ac.uk/76055/
Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity | G3: Genes | Genomes | Genetics
... the emerging idea that DNA replication stress causes CIN by examining the effect of hydroxyurea and methyl methanesulfonate by ...http://www.g3journal.org/content/5/6/1043.full
GCN2, an old dog with new tricks | Biochemical Society Transactions
... methyl methanesulfonate; MRS, methionyl-tRNA synthetase; iNOS, inducible NO synthase; PERK, PKR (double-stranded-RNA-dependent ...http://www.biochemsoctrans.org/content/41/6/1687
NSMCE2 Gene - GeneCards | NSE2 Protein | NSE2 Antibody
Methyl Methanesulfonate Sensitivity Gene 21 3 * Chromosome 8 Open Reading Frame 36 2 ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=NSMCE2
SFA1 - S-(hydroxymethyl)glutathione dehydrogenase - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) -...
By formaldehyde, ethanol and methyl methanesulphonate.. ,p>This section provides information on the quaternary structure of a ...http://www.uniprot.org/uniprot/P32771
Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases...
MMS indicates methyl methanesulfonate; H2O2, hydrogen peroxide; 5-FU, 5-fluorouracil; HU, hydroxyurea; Dox, doxorubicin; Rap, ... As shown in Figure 5, Blm10 loss reduced resistance to low concentrations of methyl methanesulfonate and strikingly compromised ... methyl methanesulfonate, ultraviolet irradiation, and camptothecin (Iwanczyk et al. 2006). In the same study these strains also ... methyl methanesulfonate, and calcofluor. Fluorescently tagged Blm10 localized in nuclei, with enhanced fluorescence after DNA ...http://www.g3journal.org/content/2/8/943
DNA Repair and Mutagen Interaction in Saccharomyces: Theoretical Considerations | SpringerLink
Saccharomyces Cerevisiae Repair Pathway Repair System Detoxification System Methyl Methanesulfonate These keywords were added ...https://link.springer.com/chapter/10.1007/978-1-4684-3842-0_10
MMS22L Gene - GeneCards | MMS22 Protein | MMS22 Antibody
Methyl Methanesulfonate-Sensitivity Protein 22-Like 4 * Chromosome 6 Open Reading Frame 167 2 ...http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=253714
355. Acephate (Pesticide residues in food: 1976 evaluations)
A positive control (MMS, methyl methanesulfonate) was also used. The females were sacrificed 1 week after removal from the ... Under alkaline conditions it forms S-methyl phosphorothioate. Demethylacephate (S-methyl acetylphosphoramidothioate) is also ... azinphos-methyl, carbaryl, malathion, parathionmethyl and oxydemeton-methyl) on male rats. The LD50 values for equitoxic ... Using S-methyl-14C-acephate for soil treatment, it has been shown that 14CO2 is released as the acephate decreases. Further, ...http://inchem.org/documents/jmpr/jmpmono/v076pr02.htm
DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks |...
A) Induction of SSBs by methyl methanesulfonate (MMS). Ten day old seedlings of Arabidopsis Col0 were treated with for 1 hour. ...https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-9-79
Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma
Cell viability assay after treatment with 5-fluorouracil (5-FU) and Methyl methanesulfonate (MMS). ATAD5 knock down and control ... for 24h and Methyl methanesulfonate (MMS) for 1h. Cells were washed thrice with 1X PBS at the end of treatment and cultured in ... Methyl methanesulfonate (MMS). Cell viability was quantified using WST1 reagent as described in methods. Data was presented as ... Methyl methanesulfonate) (Fig. 6B) indicating ATAD5 protected cells from apoptosis induced by different stresses and thus ATAD5 ...http://www.ijbs.com/v12p0030.htm