Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array - Lab on a Chip (RSC...
... a disintegrin and metalloproteinases), participate in diverse pathological processes. To simultaneously measure multiple ... from families of enzymes such as matrix metalloproteinases (MMPs) and ADAMs ( ... from families of enzymes such as matrix metalloproteinases (MMPs) and ADAMs (a disintegrin and metalloproteinases), participate ... a series of parallel enzyme reactions combined with a series of inhibitor analyses for proteolytic activity matrix analysis ( ...http://pubs.rsc.org/en/content/articlelanding/2015/lc/c4lc01162g
Abstract 12438: Effects of Pressure-Overload Induced Left Ventricular Remodeling on Membrane Type-1 Matrix Metalloproteinase...
While the regulation of matrix metalloproteinases (MMPs) likely plays a role in this process, the induction and mechanistic ... Abstract 12438: Effects of Pressure-Overload Induced Left Ventricular Remodeling on Membrane Type-1 Matrix Metalloproteinase ... Abstract 12438: Effects of Pressure-Overload Induced Left Ventricular Remodeling on Membrane Type-1 Matrix Metalloproteinase ... Abstract 12438: Effects of Pressure-Overload Induced Left Ventricular Remodeling on Membrane Type-1 Matrix Metalloproteinase ...http://circ.ahajournals.org/content/122/Suppl_21/A12438
Adhesion and Integrins - Barts Cancer Institute
We have been the first to show that αvβ6 promoted invasion, in part, by regulating matrix-metalloproteinases (MMPs). Strong ... Cell adhesion to the extracellular matrix and to other cells, via specialised receptors such as integrins (cell-matrix and cell ...https://www.bci.qmul.ac.uk/en/our-research/adhesion-integrins
Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma | Clinical Cancer Research
Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. Am J Obstet Gynecol 2004;190:899-909. ...http://clincancerres.aacrjournals.org/content/14/21/6839.long
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. | Sigma-Aldrich
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.. [Eyal Zcharia, ... The lack of major abnormalities is attributed to a marked elevation in the expression of matrix metalloproteinases, for example ... specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix. ...https://www.sigmaaldrich.com/catalog/papers/19360105
Localizing matrix metalloproteinase activities in the pericellular environment. - Nuffield Department of Orthopaedics,...
They are secreted from cells or bound to the plasma membrane and hydrolyze extracellular matrix (ECM) and cell surface-bound ... Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes containing a zinc ion in the active ... Localizing matrix metalloproteinase activities in the pericellular environment. Share Share Share Share ... Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes containing a zinc ion in the active ...https://www.ndorms.ox.ac.uk/publications/227452
Sagescript Institute: Five Enzymes Found in Skin
2. Matrix Metalloproteinases (MMP) - are responsible for breaking down proteins. They are found throughout the body but in skin ... Typically, this is a bad thing because it weakns the matrix and leads to wrinkles; however, this is a good thing if the enzymes ... their role is to breakdown and recycle the skin matrix of the dermis, specifically collagen and elastin. ...http://sagescript.blogspot.com/2015/02/five-enzymes-found-in-skin.html
Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
"The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases ... Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update. Shane O'Sullivan, John F. Gilmer, and Carlos Medina ... Akinori Tokito, and Michihisa Jougasaki, "Matrix Metalloproteinases in Non-Neoplastic Disorders," International Journal of ... Abdul Amin, Achintya Saha, and Tarun Jha, "Exploring in house glutamate inhibitors of matrix metalloproteinase-2 through ...https://www.hindawi.com/journals/mi/2015/964131/citations/
1BQO: Discovery Of Potent, Achiral Matrix Metalloproteinase Inhibitors
STROMELYSIN-11,3-Bis-(4-Methoxy-Benzenesulfonyl)-5,5-Dimethyl-Hexahydro-Pyrimidine-2-Carboxylic Acid HydroxyamideCalcium IonZinc Ionhttps://www.ncbi.nlm.nih.gov/Structure/pdb/1BQO
Varicose Veins: Venous Wall Changes, Inflammation, and Matrix Metalloproteinases | SpringerLink
Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol. 2008;6:158-72.PubMed ... Kowalewski R, Sobolewski K, Wolanska M, Gacko M. Matrix metalloproteinases in the vein wall. Int Angiol. 2004;23:164-9.PubMed ... Matrix metalloproteinase-2 induced venous dilation via hyperpolarization and activation of K + channels. Relevance to varicose ... Raffetto J.D. (2013) Varicose Veins: Venous Wall Changes, Inflammation, and Matrix Metalloproteinases. In: Gabriel E., Gabriel ...https://link.springer.com/chapter/10.1007/978-1-4471-4429-8_22
Evaluation of 11 Scoring Functions Performance on Matrix Metalloproteinases
V. Vargová, M. Pytliak, and V. Mechírová, "Matrix metalloproteinases.," EXS, vol. 103, pp. 1-33, 2012. View at Publisher · View ... Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a central role in various physiological processes ... J. Hu, P. E. van den Steen, Q.-X. A. Sang, and G. Opdenakker, "Matrix metalloproteinase inhibitors as therapy for inflammatory ... Matrix metalloproteinases (MMPs) have distinctive roles in various physiological and pathological processes such as ...https://www.hindawi.com/journals/ijmc/2014/162150/
Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
... Vivek Mehta, Jonathan Russin, ... "Early matrix metalloproteinase-9 concentration in the first 48 h after aneurysmal subarachnoid haemorrhage predicts delayed ...https://www.hindawi.com/journals/nri/2013/943761/citations/
Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
"Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central ... "Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged ... "Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem ... "Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic ...https://www.hindawi.com/journals/bri/2012/789083/
Matrix Metalloproteinases and Minocycline: Therapeutic Avenues for Fragile X Syndrome
... Saul S. Siller1,2 and Kendal Broadie1 ... A. Page-McCaw, A. J. Ewald, and Z. Werb, "Matrix metalloproteinases and the regulation of tissue remodelling," Nature Reviews ... A. Page-McCaw, J. Serano, J. M. Santë, and G. M. Rubin, "Drosophila matrix metalloproteinases are required for tissue ... A. Page-McCaw, "Remodeling the model organism: matrix metalloproteinase functions in invertebrates," Seminars in Cell and ...https://www.hindawi.com/journals/np/2012/124548/
DBGET Search Result: KEGG Matrix metalloproteinase
... matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 ... K08001 matrix metalloproteinase-23 (CA-MMP) [EC:3.4.24.-] , (RefSeq) MMP23B, MIFR, MIFR-1, MMP22, MMP23A; matrix ... K07994 matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-] , (RefSeq) MMP13, CLG3, MANDP1, MDST, MMP-13; matrix ... K08004 matrix metalloproteinase-26 (matrilysin-2, endometase) [EC:3.4.24.-] , (RefSeq) MMP26; matrix metallopeptidase 26 ...http://www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&dbkey=kegg&keywords=Matrix+metalloproteinase
Role of matrix metalloproteinases in coronary artery disease.
Matrix metalloproteinases (MMPs) contribute both in the formation as well as in the destabilization of atherosclerotic plaque. ... AIM: Matrix metalloproteinases (MMPs) contribute both in the formation as well as in the destabilization of atherosclerotic ...http://www.biomedsearch.com/nih/Role-matrix-metalloproteinases-in-coronary/19729688.html
Putative targeting of matrix metalloproteinase-8 in atherosclerosis.
There is compelling evidence indicating that some members of the matrix metalloproteinase (MMP) family play important roles in ... There is compelling evidence indicating that some members of the matrix metalloproteinase (MMP) family play important roles in ...http://www.biomedsearch.com/nih/Putative-targeting-matrix-metalloproteinase-8/25448039.html
The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
"Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 ... R. Visse and H. Nagase, "Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and ... "Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix ... "Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix," Glia ...https://www.hindawi.com/journals/jir/2013/914104/ref/
MMP17 - Matrix metalloproteinase - Homo sapiens (Human) - MMP17 gene & protein
Matrix metalloproteinaseUniRule annotation. ,p>Information which has been generated by the UniProtKB automatic annotation ... tr,F5GWR3,F5GWR3_HUMAN Matrix metalloproteinase (Fragment) OS=Homo sapiens GN=MMP17 PE=3 SV=1 ...http://www.uniprot.org/uniprot/F5GWR3
Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis.
The present study was performed to evaluate the role of matrix metalloproteinases (MMP) in the pathogenesis of the inflammatory ... Matrix Metalloproteinase 9 / cerebrospinal fluid. Matrix Metalloproteinases / antagonists & inhibitors, genetics, physiology*. ... 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; EC 3.4.24.-/Matrix Metalloproteinases; EC 184.108.40.206/Matrix Metalloproteinase 9 ... The present study was performed to evaluate the role of matrix metalloproteinases (MMP) in the pathogenesis of the inflammatory ...http://www.biomedsearch.com/nih/Matrix-metalloproteinases-contribute-to-brain/10639424.html
Matrix Metalloproteinase 16 Summary Report | CureHunter
... enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE ... Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition it can ... A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the ... Matrix Metalloproteinases: 8496*Membrane-Associated Matrix Metalloproteinases: 57*Matrix Metalloproteinase 16: 31*human MMP16 ...http://www.curehunter.com/public/keywordSummaryD053513.do
Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
C. X. Zhou, Y. Gao, N. W. Johnson, and J. Gao, "Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 ... E. M. Schnaeker, R. Ossig, T. Ludwig et al., "Microtubule-dependent matrix metalloproteinase-2/matrix metalloproteinase-9 ... "Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9," Journal of ... "Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell ...https://www.hindawi.com/journals/tswj/2013/920595/
Role of matrix metalloproteinases in tumour invasion: immunohistochemistry of peritoneum from peritoneal carcinomatosis |...
Presence of matrix metalloproteinases. MMP-1. Matrix metalloproteinase 1 (MMP-1) expression in tumour-invaded peritoneum was ... Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and ... Matrix metalloproteinases (MMPs) play an essential role in cancer cell invasion and dissemination. The aim of this study was to ... Matrix metalloproteinase-2 (MMP-2) expression in the tumour-invaded areas was only seen in the proximity of inflammatory cells ...https://link.springer.com/article/10.1007/s12032-018-1122-7
Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction
... John W. ... The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of ... Tissue inhibitors of metalloproteinases (TIMPs) are designed to deactivate MMPs permitting the reestablishment of CAMs, thus ... designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia. ...https://www.hindawi.com/journals/np/2009/579382/abs/
Photorefractive keratectomy: measuring the matrix metalloproteinase ac | OPTH
We measured matrix metalloproteinase-9 (MMP-9) activity and chondroitin 4 sulfate and chondroitin 6 sulfate concentrations in ... matrix metalloproteinase, chondroitin sulfate, human tear fluid, photorefractive keratectomy, corneal wound healing ... measuring the matrix metalloproteinase activity and chondroitin sulfate concentration in tear fluid Tetsuya Mutoh, Masaya ... Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in ...https://www.dovepress.com/photorefractive-keratectomy-measuring-the-matrix-metalloproteinase-act-peer-reviewed-article-OPTH