Matrix metalloproteinase 27 | definition of matrix metalloproteinase 27 by Medical dictionary
Looking for online definition of matrix metalloproteinase 27 in the Medical Dictionary? matrix metalloproteinase 27 explanation free. What is matrix metalloproteinase 27? Meaning of matrix metalloproteinase 27 medical term. What does matrix metalloproteinase 27 mean?http://medical-dictionary.thefreedictionary.com/matrix+metalloproteinase+27
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory...
Using a competitive PCR technique we have established a system for rapid and simultaneous measurement of multiple genes involved in the metabolism of the ECM within a single colonic biopsy. To gain further insight into their biological function in inflammatory bowel disease we analysed relative mRNA expression of collagen type III, matrix metalloproteinases MMP-1 and MMP-2, their respective major activators MMP-3 and MMP-14, as well as their physiological inhibitors TIMP-1 and TIMP-2 in endoscopic biopsies from inflamed and non-inflamed colon of IBD patients.. We observed that mRNA expression of all MMPs was significantly increased in inflamed compared with non-inflamed colonic mucosa of these patients. This increase was most pronounced in ulcerated colonic mucosa. By performing westerns blots, increased expression of MMP-1, MMP-2, and MMP-3 was also demonstrated at the protein level, which supports previous in vitro studies showing a close correlation between mRNA and ...http://gut.bmj.com/content/47/1/63
Patent US5022750 - Active matrix reflective projection system - Google Patents
An active matrix reflective projection system utilizing a conventional wafer includes a reflective image plane module. The reflective image plane module includes light directing and reflecting structures and a wafer based active matrix mated thereto. A source of light is directed to the reflective image plane module wherein the wafer based active matrix imparts information onto a light beam reflected therefrom. The reflective image plane module projects the reflected beam for viewing, such as through one or more lens. The active matrix reflective projection system can be a monochrome projector including a single reflective image plane module or can be a full color system including three reflective image plane modules. Each color reflective image plane module operates on a single color component, red, green or blue, which then are combined on a screen or before projecting on the screen to form the full color projection image. The wafer based ...http://www.google.com/patents/US5022750?dq=4740761
Expression and Complex Formation of MMP9, MMP2, NGAL, and TIMP1 in Porcine Myocardium but Not in Skeletal Muscles in Male Pigs...
MMP9: matrix metalloproteinase type 9; MMP2: matrix metalloproteinase type 2; NGAL: neutrophil gelatinase-associated lipocalin; TIMP1: tissue inhibitor of metalloproteinases type 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase ...https://www.hindawi.com/journals/bmri/2013/283856/tab1/
Prediction on the Inhibition Ratio of Pyrrolidine Derivatives on Matrix Metalloproteinase Based on Gene Expression Programming ...
Prediction on the Inhibition Ratio of Pyrrolidine Derivatives on Matrix Metalloproteinase Based on Gene Expression Programming. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.http://libros.duhnnae.com/2017/jun8/149836239082-Prediction-on-the-Inhibition-Ratio-of-Pyrrolidine-Derivatives-on-Matrix-Metalloproteinase-Based-on-Gene-Expression-Programming.php
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase...
The hydrolysis of collagen (collagenolysis) is one of the committed steps in extracellular matrix turnover. Within the matrix metalloproteinase (MMP) family distinct preferences for collagen types are seen. The substrate determinants that may guide these specificities are unknown. In this study, we have utilized 12 triple-helical substrates in combination with 10 MMPs to better define the contributions of substrate sequence and thermal stability toward triple helicase activity and collagen specificity. In general, MMP-13 was found to be distinct from MMP-8 and MT1-MMP(Delta279-523), in that enhanced substrate thermal stability has only a modest effect on activity, regardless of sequence. This result correlates to the unique collagen specificity of MMP-13 compared with MMP-8 and MT1-MMP, in that MMP-13 hydrolyzes type II collagen efficiently, whereas MMP-8 and MT1-MMP are similar in their preference for type I collagen. In turn, MMP-1 was the least efficient ...https://www.kennedy.ox.ac.uk/publications/227294
Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma | Clinical Cancer Research
The key findings of this study are that stress-related biobehavioral factors were associated with both stromal and tumor expression of factors supporting angiogenesis and invasion in the tumor microenvironment of ovarian cancer patients. Specifically, depressed patients and patients reporting higher levels of chronic stress, current stress, and negative affect showed higher MMP-9 expression in TAMs. In contrast, patients with higher levels of social support had lower levels of VEGF and MMP-9 expression in tumor cells. MMP-2 expression by macrophages or tumor cells was not significantly associated with any of the biobehavioral factors examined. To the best of our knowledge, this is the first clinical study to show significant associations between biobehavioral factors and stromal macrophage production of MMPs.. These findings extend previous experiments showing that chronic stress and social isolation increase expression of VEGF and MMP-9 by human ovarian tumors implanted orthotopically in mice ...http://clincancerres.aacrjournals.org/content/14/21/6839.long
Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405...
Matrix metalloproteinases (MMPs) can degrade a number of proteins that constitute the extracellular matrix. Previous studies have shown that atherosclerotic plaques contain substantial amounts of fibrin(ogen)-related antigen, and more recently, MMPs have been identified in such lesions. The hypothesis that MMPs play a role in the degradation of fibrinogen (Fg) and cross-linked fibrin (XL-Fb) was investigated. Fibrinogen became thrombin-unclottable when treated with matrix metalloproteinase 3 (MMP-3, stromelysin 1) but not with matrix metalloproteinase 2 (MMP-2, gelatinase A). Incubation of XL-Fb clots (made with 125I-Fg) with MMP-3 resulted in complete lysis after 24 h. A D monomer-like fragment was generated by MMP-3 degradation of fibrinogen, XL-Fb, and fragment DD. Immunoreactivity with monoclonal antibody (MoAb)/4-2 (anti-gamma 392-406) but not with MoAb/4A5 (anti-gamma 397-411) ...https://www.ndorms.ox.ac.uk/publications/411400
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14...
Membrane type 1 matrix metalloproteinase (MT1-MMP) is a potent modulator of the pericellular environment and promotes tumor cell invasion and proliferation in many types of tumor. The activation of proMMP-2 and processing of collagen I by MT1-MMP have been thought to be important for its tumor-promoting function. These activities can be inhibited by mutant forms of MT1-MMP lacking the catalytic domain. However, the effect of such dominant-negative mutants has never been evaluated in vivo. Various mutants lacking the catalytic domain (dCAT) were prepared and confirmed to inhibit MT1-MMP activity in human fibrosarcoma HT1080 cells, and tumor cells expressing these mutants were implanted s.c. into nude mice to monitor tumor formation. Only the membrane-anchored form of a dCAT construct through the transmembrane domain [dCAT(1)] showed potent antitumor activity not only in HT1080 cells but also in gastric carcinoma MKN28 and MKN45 cells expressing MT1-MMP. A soluble form of dCAT ...https://oacentre.kennedy.ox.ac.uk/publications/224438
Matrix Metalloproteinase-9 and Airway Remodeling in Asthma | BenthamScience
Title: Matrix Metalloproteinase-9 and Airway Remodeling in Asthma. VOLUME: 4 ISSUE: 2. Author(s):Hiroyuki Ohbayashi and Kaoru Shimokata. Affiliation:Department of Internal Medicine, Tohno-Kousei Hospital, 76-1, Toki-cho, Mizunami City, Gifu Pref. 509-6101, Japan.. Keywords:matrix metalloproteinase, asthma, the extracellular matrix, tissue inhibitor of metalloproteinase. Abstract: Airway remodeling is a major change responsible for irreversible asthmatic airflow restriction. The Th-2 cytokines-dominant eosinophilic inflammatory mechanism cannot fully explain the progressive subepithelial fibrosis and structural changes in the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are the key enzymes responsible for ECM degradation. MMPs are normally produced and secreted under the tight regulation of, at least, 3 different levels: the gene ...http://www.eurekaselect.com/90337/article
Localizing matrix metalloproteinase activities in the pericellular environment. - Nuffield Department of Orthopaedics,...
Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes containing a zinc ion in the active site. They are secreted from cells or bound to the plasma membrane and hydrolyze extracellular matrix (ECM) and cell surface-bound molecules. They therefore play key roles in morphogenesis, wound healing, tissue repair and remodeling in diseases such as cancer and arthritis. Although the cell anchored membrane-type MMPs (MT-MMPs) function pericellularly, the secreted MMPs have been considered to act within the ECM, away from the cells from which they are synthesized. However, recent studies have shown that secreted MMPs bind to specific cell surface receptors, membrane-anchored proteins or cell-associated ECM molecules and function pericellularly at focussed locations. This minireview describes examples of cell surface and pericellular partners of MMPs, as well as how they alter enzyme function and cellular behaviour.https://www.ndorms.ox.ac.uk/publications/227452
Patent US5648685 - Active matrix assembly with lines of equal resistance - Google Patents
An active matrix panel including a matrix of driving electrodes couples through thin film transistor switches to a corresponding source line and gate line and at least one of a driver circuit including complementary thin film transistors for driving the source and/or gate lines of the picture elements on the substrate. The thin film transistors of the active matrix have the same cross-sectional structure as the P-type or the N-type thin film transistors forming the driver circuit and are formed during same patterning process.http://www.google.com/patents/US5648685?dq=6668407
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016 ...https://pharos.nih.gov/idg/targets/Q9NRE1
Abstract P601: Matrix Metalloproteinase 2 Plays An Important Role In Angiotensin Ii-induced Vascular Injury Mediated In Part...
Background: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced blood pressure (BP) rise and vascular injury.. Methods: Ten to 12-week-old male Mmp2 knockout (Mmp2-/-) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic BP was measured by telemetry, mesenteric arteries (MA) endothelial function and vascular remodeling by pressurized myography. In aortic wall or perivascular fat (PVAT), reactive oxygen species (ROS) generation was determined using dihydroethidium staining, and vascular cell adhesion protein 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) expression and monocyte/macrophage infiltration by immunofluorescence. Spleen T cells and monocyte profile were assessed by flow cytometry. Vascular smooth muscle cells (VSMCs) were isolated from MA of WT and Mmp2 ...http://hyper.ahajournals.org/content/66/Suppl_1/AP601
Expression of matrix metalloproteinase 13 (MMP-13) in h | Open-i
Expression of matrix metalloproteinase 13 (MMP-13) in human rheumatoid arthritis (RA) (A) synovial tissue (magnification ×200) and (B) the isotype control (maghttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2925150_ard-69-05-0898-fig1&req=4
Matrix Metalloproteinase 2 - Gelatinase A Summary Report | CureHunter
Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.http://www.curehunter.com/public/keywordSummaryD020778-Matrix-Metalloproteinase-2-Gelatinase-A.do
Cellular-Fibronectin and Matrix Metalloproteinase-9 in Patients With Stroke | Stroke
To the Editor:. The article by Castellanos et al on the plasma cellular-fibronectin (c-Fn) and matrix metalloproteinase-9 (MMP-9) concentrations in patients with acute ischemic stroke needs some clarification.1. In the Materials and Methods section it is stated that plasma MMP-9 levels were measured by a commercially available ELISA assay. The Amersham Biosciences, from which the assay was purchased, provides different types of assay for determination of MMP-9. One of them is for human MMP-9 and measures both free pro-MMP-9 and pro-MMP-9 complexed to TIMP-1. The other method, called MMP-9 activity assay, is used for determination of the active form of the compound.. It is not clear which form of MMP-9 was determined in the study. The MMP-9 human assay's range of detection in plasma is 4 to 128 ng/mL, whereas the median values obtained in the study were within the range of 54 to 225 ng/mL. We therefore guess that the authors did not measure the active form of the enzyme ...http://stroke.ahajournals.org/content/36/1/3
AID 108320 - Inhibition of collagen IV degradation by matrix metalloprotease-9 at 10 uM (no data) - PubChem
BioAssay record AID 108320 submitted by ChEMBL: Inhibition of collagen IV degradation by matrix metalloprotease-9 at 10 uM (no data).https://pubchem.ncbi.nlm.nih.gov/bioassay/108320
Immunolocalisation of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with...
Immunolocalisation of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritishttp://www.readabstracts.com/Health/Immunolocalisation-of-matrix-metalloproteinase-3-stromelysin-in-rheumatoid-synovioblasts-B-cells-cor.html
MMP11 (matrix metalloproteinase 11 (stromelysin 3))
... , Authors: Paul Basset, Marie-Christine Rio. Published in: Atlas Genet Cytogenet Oncol Haematol.http://atlasgeneticsoncology.org/Genes/ST3ID200.html
Analyses of MT1-MMP activity in cells. - The Kennedy Institute of Rheumatology
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane protein which exhibits biological activities on the cell surface. One of the characteristic functions of this enzyme is activation of proMMP-2 on the cell surface (1). This process can be monitored using gelatin zymography to detect the pro- and active forms of MMP-2. Cellular MT1-MMP activity can also be directly detected by in situ degradation of layers of either gelatin or collagen. By combining inhibitors, western blotting, and immunohistochemistry, one can detect and conclude the presence of MT1-MMP activity in the cells.https://www.kennedy.ox.ac.uk/publications/224640
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013 ...https://pharos.nih.gov/idg/targets/Q8N119
DigitalCommons@PCOM - Research Day: Roles of Zinc-binding Protein-89 and NF-kB in Regulation of Matrix Metalloproteinase-3...
May 13th, 1:00 PM Roles of Zinc-binding Protein-89 and NF-kB in Regulation of Matrix Metalloproteinase-3 Expression in Response to Cytokines. Philadelphia. ...http://digitalcommons.pcom.edu/research_day/research_day_PA_2015/researchPA2015/34/
Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway...
Sigma-Aldrich offers abstracts and full-text articles by [Eleni Papakonstantinou, George Karakiulakis, Spyros Batzios, Spasenija Savic, Michael Roth, Michael Tamm, Daiana Stolz].http://www.sigmaaldrich.com/catalog/papers/26126526
Effect of interleukin (IL)-17A and IL-17E on the produc | Open-i
Effect of interleukin (IL)-17A and IL-17E on the production of matrix metalloproteinase (MMP)-3, MMP-12, and tissue inhibitor of metalloproteinase (TIMP)-1 by ihttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3733737_1755-1536-6-13-5&req=4