*  Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback...
Rapid and potent macrophage activation is driven by cytokine-mediated feedforward loops, while excessive activation is ... Macrophage activation needs to be tightly regulated to rapidly mount responses to infectious challenges but to avoid toxicity ... Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback ... Regulation of macrophage polarization and plasticity by complex activation signals, Integr. Biol., 2016, 8, 9, 946. CrossRef ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2008.00707.x/abstract
*  "Macrophage activation by interferon: dissociation between tumoricidal " by D Boraschi, D Soldateschi et al.
Boraschi, D; Soldateschi, D; and Tagliabue, A, "Macrophage activation by interferon: dissociation between tumoricidal capacity ...
  https://mouseion.jax.org/ssbb1982/2304/
*  ZC3H12B - NBP1-77141 | acris-antibodies.com
ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation ... ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation ... It is highly expressed in brain, thymus, and testis, but unlike ZC3H12A and ZC3H12C, not expressed in macrophages after ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/zc3h12b-nbp1-77141.htm
*  Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice | The...
miR-146a modulates macrophage activation in WT and Akt2−/− macrophages. mRNA levels of iNOS (A), C/EBPβ (B), Arg-1 (C), and ... Alveolar macrophages participate in the pathogenesis of ARDS. To investigate the role of macrophage activation in aseptic lung ... M1 activation of macrophages was observed in WT mice; alveolar macrophages overexpressed iNOS (Fig. 3A, 3C, 3D, 3F) and IL-12β ... macrophage activation in acid-induced lung injury was reduced in Akt2−/− mice. iNOS and IL-12β, markers of M1 activation, were ...
  http://www.jimmunol.org/content/192/1/394
*  Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs - Jianqing Fan
Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs Fan, Jianqing Princeton University, Princeton, ... Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs. Fan, Jianqing / Princeton University. ... Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs. Fan, Jianqing / Princeton University. $351,442 ... Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs. Fan, Jianqing / Princeton University. $362,499 ...
  http://grantome.com/grant/NIH/R01-GM100474-02
*  Model‐driven multi‐omic data analysis elucidates metabolic immunomodulators of macrophage activation | Molecular Systems Biology
de Souza LF, Jardim FR, Sauter IP, de Souza MM, Bernard EA (2008) High glucose increases RAW 264.7 macrophages activation by ... While macrophage activation functions at the front line of host defense, improper control of its activation has also been ... Macrophage activation states are also modulated by parasitic organisms, which hijack host macrophage cells to promote their ... aspartate shuttle may be an effective mechanism for modulating macrophage metabolic activation as the LPS‐stimulated macrophage ...
  http://msb.embopress.org/content/8/1/558
*  Macrophage Activation Syndrome: Background, Pathophysiology, Epidemiology
Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency,... ... Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease that, for unknown reasons, occurs ... encoded search term (Macrophage%20Activation%20Syndrome) and Macrophage Activation Syndrome What to Read Next on Medscape. ... Macrophage activation syndrome in rheumatic diseases in children]. Rev Rhum Ed Fr. 1994 Jun. 61(6):447-51. [Medline]. ...
  https://emedicine.medscape.com/article/1380671-overview
*  Frontiers | Metabolism Supports Macrophage Activation | Immunology
An important conceptual advance in the field of macrophage biology, emerging from recent studies, is that macrophage activation ... An important conceptual advance in the field of macrophage biology, emerging from recent studies, is that macrophage activation ... Metabolic shifts fuel multiple aspects of macrophage activation, and preventing these shifts impairs appropriate activation. ... Metabolic shifts fuel multiple aspects of macrophage activation, and preventing these shifts impairs appropriate activation. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00061/full
*  Macrophage Activation: Enhanced Oxidative and Antiprotozoal Activity | SpringerLink
Although only one of the array of secretory properties displayed by activated macrophages, the capacity to generate increased ... Macrophage Activation: Enhanced Oxidative and Antiprotozoal Activity. In: Adams D.O., Hanna M.G. (eds) Macrophage Activation. ... Enhanced oxidative metabolism as an expression of macrophage activation, J. Exp. Med. 152: 1596-1609.PubMedCrossRefGoogle ... Nathan, C. F., Nogueira, N., Juangbhanich, C., Ellis,J., and Cohn, Z. A., 1979, Activation of macrophages in vivo and in vitro ...
  https://link.springer.com/chapter/10.1007/978-1-4757-1445-6_5
*  Proteomic analysis of microtubule-associated proteins during macrophage activation. - PubMed - NCBI
Proteomic analysis of microtubule-associated proteins during macrophage activation.. Patel PC1, Fisher KH, Yang EC, Deane CM, ... Classical activation of macrophages induces a wide range of signaling and vesicle trafficking events to produce a more ... Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation. Mol Cell Proteomics. 2009 Nov;8(11):2500- ... Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation. Mol Cell Proteomics. 2009 Nov;8(11):2500- ...
  https://www.ncbi.nlm.nih.gov/pubmed/19651621
*  Using macrophage activation to augment immunotherapy of established tumours. - PubMed - NCBI
Macrophage depletion reduced the effect of combining immunotherapy with macrophage activation, supporting the importance of ... Using macrophage activation to augment immunotherapy of established tumours.. Fridlender ZG1, Jassar A, Mishalian I, Wang LC, ... In several different murine models of immunotherapy for lung cancer, DMXAA-induced macrophage activation significantly ... The numbers in each quadrant are the percentages of M1 (F4/80+/CD206−) and M2 (F4/80+/CD206+) macrophages. (D) The calculated ' ...
  https://www.ncbi.nlm.nih.gov/pubmed/23481183?dopt=Abstract
*  Treatment of Macrophage Activation Syndrome (MAS) With Anakinra - Full Text View - ClinicalTrials.gov
Treatment of Macrophage Activation Syndrome (MAS) With Anakinra (MAS). The safety and scientific validity of this study is the ... Macrophage activation syndrome (MAS) is a disorder whereby the immune system generates very high levels of substances ( ... Macrophage Activation Syndrome. Disease. Pathologic Processes. Lymphoproliferative Disorders. Immunoproliferative Disorders. ... for macrophage activation syndrome with either:. two or more Laboratory criteria: 1. Decreased platelet count (≤262 ×10 9/L) 2 ...
  https://clinicaltrials.gov/ct2/show/NCT02780583
*  Macrophage activation by lipopolysaccharide, interferon-γ and interleukin-4: effect of fatty acid metabolism
... H. Darmani,1 J. L ... H. Darmani, J. L. Harwood, J. Parton, and S. K. Jackson, "Macrophage activation by lipopolysaccharide, interferon-γ and ...
  https://www.hindawi.com/journals/mi/1995/970754/cta/
*  FDA Grants Soligenix Orphan Drug Designation for Dusquetide for Treatment of Macrophage Activation Syndrome
... and the treatment of macrophage activation syndrome (MAS). SGX942 information includes news, clinical trial results and side ... About Macrophage Activation Syndrome. Macrophage activation syndrome (MAS) is characterized by a highly stimulated but ... FDA Grants Soligenix Orphan Drug Designation for Dusquetide for Treatment of Macrophage Activation Syndrome. Print this page ... has granted orphan drug designation to the active ingredient dusquetide for treatment of macrophage activation syndrome (MAS). ...
  https://www.drugs.com/nda/sgx942_160818.html
*  Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation
In this study, we explored the effects of cathelicidins on DNA-induced activation of chicken macrophages and elucidated the ... Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation. Journal. The journal of ... 2 strongly enhances DNA-induced activation of both chicken and mammalian macrophages because of enhanced endocytosis of DNA- ... is known about their influence on DNA-induced macrophage activation. ...
  http://dare.uva.nl/search?metis.record.id=512781
*  PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
In primary macrophages, PARP9 and PARP14 have opposing roles in macrophage activation. PARP14 silencing induces pro- ... Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show ... "PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation." Nature Communications 7 (1): 12849. doi: ... These findings suggest that PARP9 and PARP14 cross-regulate macrophage activation. Other Sources http://www.ncbi.nlm.nih.gov/ ...
  https://dash.harvard.edu/handle/1/29626127
*  Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization | The Journal of Immunology
PI3K activation has been reported as an essential step toward M2 activation of macrophages in response to surfactant protein A ... 1). Activation or overexpression of PI3K or Akt kinases resulted in reduced macrophage activation by LPS, whereas nonspecific ... Activation of macrophages is mediated by signaling cascades downstream of TLR and cytokine receptors. Upon activation, ... between the STAT6 and PI3K activation is required for IL-4-induced M2 macrophage activation in SHIP-deficient macrophages (22 ...
  http://www.jimmunol.org/content/198/3/1006
*  Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization | The Journal of Immunology
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. Eleni Vergadi, Eleftheria Ieronymaki, Konstantina Lyroni ... Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. Eleni Vergadi, Eleftheria Ieronymaki, Konstantina Lyroni ... Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization Message Subject (Your Name) has forwarded a page to you ... Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. Eleni Vergadi, Eleftheria Ieronymaki, Konstantina Lyroni ...
  http://www.jimmunol.org/content/198/3/1006/tab-article-info
*  Astrocyte elevated gene-1 (AEG-1) regulates macrophage activation in hepatocellular carcinogenesis | Cancer Research
These results unravel a central role of AEG-1 in regulating macrophage activation and indicate that AEG-1 is required in both ... Astrocyte elevated gene-1 (AEG-1) regulates macrophage activation in hepatocellular carcinogenesis. Chadia L Robertson, Rachel ... Astrocyte elevated gene-1 (AEG-1) regulates macrophage activation in hepatocellular carcinogenesis ... Astrocyte elevated gene-1 (AEG-1) regulates macrophage activation in hepatocellular carcinogenesis ...
  http://cancerres.aacrjournals.org/content/early/2018/09/01/0008-5472.CAN-18-0659
*  Impaired lung function is associated with systemic inflammation and macrophage activation | European Respiratory Society
Impaired lung function is associated with systemic inflammation and macrophage activation. Katherine J. Baines, Vibeke Backer, ... Impaired lung function is associated with systemic inflammation and macrophage activation. Katherine J. Baines, Vibeke Backer, ... Impaired lung function is associated with systemic inflammation and macrophage activation. Katherine J. Baines, Vibeke Backer, ... In addition to the known adverse effects of CRP on lung function, we found that elevated levels of the macrophage activation ...
  http://erj.ersjournals.com/content/45/2/557
*  An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation | JEM
An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation. Carol Ho Yan Fong, Magali Bebien ... An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation ...
  http://jem.rupress.org/content/early/2008/05/19/jem.20080124
*  Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation
To investigate the activation and role of macrophages in chronic HCV-induced liver fibrosis, we utilized a recently developed ... We showed that M2 macrophage activation was associated with liver fibrosis during chronic HCV infection in the livers of both ... "Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation." Scientific Reports 6 (1 ... Importantly, HCV-activated monocytes/macrophages promoted hepatic stellate cell activation. These results suggest a critical ...
  https://dash.harvard.edu/handle/1/29738991
*  Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness
... ... "Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness," ...
  https://www.hindawi.com/journals/jir/2014/613136/cta/
*  Macrophage activation syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
... information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Macrophage activation ...
  https://rarediseases.info.nih.gov/diseases/12124/macrophage-activation-syndrome