*  Total synthesis of altohyrtin A (spongistatin 1): an alternative synthesis of the CD-spiroacetal subunit.
C16-C28 subunit I, as used in the total synthesis of the potent cytotoxic macrolide altohyrtin A (spongistatin 1), was prepd. ...
  https://research-repository.griffith.edu.au/handle/10072/22614
*  Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics - UCL Discovery
Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics. PURE AND APPLIED CHEMISTRY ... Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics ... Synthetic studies on the A83586C and bryostatin antitumor macrolides and the monamycin antibiotics. ...
  http://discovery.ucl.ac.uk/184373/
*  Notes from Dr. RW: Macrolides and mortality in critically ill patients with community acquired pneumonia
These results suggest that macrolides be considered first-line combination treatment in critically ill patients with community- ... Conclusions:In observational studies of almost 10,000 critically ill patients with community-acquired pneumonia, macrolide use ...
  http://doctorrw.blogspot.com/2014/08/macrolides-and-mortality-in-critically.html
*  Macrolide 2'-kinase: Definition with Macrolide 2'-kinase Pictures and Photos
Definition of Macrolide 2'-kinase with photos and pictures, translations, sample usage, and additional links for more ... macrolide. macrolide 2'-kinase. macrolide glycosyltransferase. macrolides. macrolike. macrolinguistic. macrology. macromanage. ... Medical Definition of Macrolide 2'-kinase. 1. Inducible intracellular enzyme which inactivates 14-member ring macrolides at the ... macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase I, mph(2')i (26 Jun 1999) ...
  http://www.lexic.us/definition-of/macrolide_2
*  Overview: Macrolides possess diverse natural activities and an capability to modulate - How NF-B is activated: the role of the...
183 325 In this review macrolide antibiotics are called "macrolides." The nonantimicrobial properties of macrolides were ... Erythromycin A a 14-membered macrolide was isolated more than 50 years ago from cultures of and was the first macrolide ... low-dose macrolide therapy) are effective; (iii) the effect is seen even when patients are infected with macrolide-resistant ... Overview: Macrolides possess diverse natural activities and an capability to modulate. April 24, 2017. By cancercurehere with ...
  http://cancercurehere.com/?p=2115
*  Macrolide Antibiotics - Health tips, Health care, Diseases treatment, Cancer, Blood Pressure
The Topic in which i am going to write today is a Topic on which you would have listen and read almost thousand of times because it is a ver ...
  http://health38.blogspot.com/2012/08/macrolide-antibiotics.html
*  Dirithromycin (Oral route)
Macrolide Uses of This Medicine:. Dirithromycin is used to treat bacterial infections in many different parts of the body. It ...
  https://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/600559.htm
*  Improving Glycosyltransferase by RACHITT Gene Shuffling | SBIR.gov
... macrolides. Moreover, we expect to generate a recombinant DesVII that has a higher enzymatic activity toward the 14-membered ... biosynthesis of novel macrolide anti-infective agents. In this proposal, a new gene shuffling technology, RACHITT, is applied ...
  https://www.sbir.gov/sbirsearch/detail/69495
*  Macrolides
... can differ in their macrocyclic ring (modified to create clarithromycin (Biaxin©) and azithromycin (Zithromax©) with ... Most of macrolides are antibiotics inhibiting protein synthesis by blocking microbial ribosome. Ketolides are especially ... nhibiting proteiniAntibiotic macrolides*Azithromycin - unique; does not inhibit CYP3A4; approved by FDA ... are also macrolides. They have similar activity to ciclosporin. ...
  http://www.aurametrix.com/topics/macrolides
*  Macrolide - Wikipedia
Some macrolides are also known to cause cholestasis. Macrolides should not be taken with colchicine as it may lead to ... Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are ... Macrolides are protein synthesis inhibitors. The mechanism of action of macrolides is inhibition of bacterial protein ... Cruentaren is another example of an antifungal macrolide. A variety of toxic macrolides produced by bacteria have been isolated ...
  https://en.wikipedia.org/wiki/Macrolide
*  Macrolides - MP Biomedicals
Erythromycin is a macrolide antibiotic that bind to the 50S ribosomal subunit and inhibit protein synthesis. This is an ... Erythromycin is a macrolide antibiotic that bind to the 50S ribosomal subunit and inhibit protein synthesis. This is an ... Kitasamycin is a macrolide antibiotic produced by Streptomyces kitasatoensis. The drug has antimicrobial activity against a ...
  http://www.mpbio.com/index.php?cPath=1_6_30_206&country=223
*  Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance | Hypertension
Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. A Proof-of-Concept Study in KCNJ5 Mutated Adenoma Cells Ex ... Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, ... Macrolides Blunt Aldosterone BiosynthesisNovelty and Significance. Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, ... Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which ...
  http://hyper.ahajournals.org/content/70/6/1238
*  Macrolide 2'-kinase - Wikipedia
In enzymology, a macrolide 2'-kinase (EC 2.7.1.136) is an enzyme that catalyzes the chemical reaction ATP + oleandomycin ⇌ {\ ... The systematic name of this enzyme class is ATP:macrolide 2'-O-phosphotransferase. O'Hara K, Kanda T, Kono M (June 1988). " ...
  https://en.wikipedia.org/wiki/Macrolide_2'-kinase
*  Erythromycin and related macrolides for gastroparesis | Cochrane
Erythromycin and related macrolides for gastroparesis. To assess the effects of erythromycin (including derivatives) for ... To compare erythromycin (or other macrolide or its derivatives) versus control (no treatment, placebo, prokinetic, antiemetic ... Erythromycin and related macrolides for gastroparesis. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: ... Treatment with macrolide antibiotics for people with cystic fibrosis and chronic chest infection ...
  http://www.cochrane.org/CD012154/UPPERGI_erythromycin-and-related-macrolides-gastroparesis
*  Eosinophilic Gastroenteritis Medication: Corticosteroids, Mast cell stabilizers, Leukotriene receptor antagonists, Macrolides
Semisynthetic macrolide antibiotic that reversibly binds to P site of 50S ribosomal subunit of susceptible organisms and may ... Successful treatment with other anti-inflammatory medications, such as leukotriene modifiers (eg, montelukast), macrolides, and ...
  https://emedicine.medscape.com/article/174100-medication
*  Macrolide antibiotics allosterically predispose the ribosome for translation arrest | PNAS
Macrolides, from the prototype erythromycin (ERY) to the newest macrolide derivatives-ketolides, e.g., solithromycin (SOL)-bind ... Expression of macrolide resistance genes is triggered by drug-induced ribosome stalling at a defined codon of the uORF (3⇓-5). ... 1975) The macrolide antibiotics. Antibiotics III. Mechanism of Action of Antimicrobial and Antitumor Agents, eds Corcoran JW, ... Macrolide antibiotics allosterically predispose the ribosome for translation arrest Message Subject (Your Name) has sent you a ...
  http://www.pnas.org/content/111/27/9804.long
*  Study raises concerns over macrolides in CHD patients | News Article | Pulse Today
It follows research first reported by Pulse in September last year finding macrolides were associated with an increased risk of ... We need to exercise some care on prescribing macrolides.'. The Medicines and Healthcare Products Regulatory Agency said: 'These ... A new study raises concerns over use of macrolide antibiotics in patients with coronary heart disease - after finding ... It does create a question-mark over our use of macrolides in patients with CVD. ...
  http://www.pulsetoday.co.uk/study-raises-concerns-over-macrolides-in-chd-patients/10921830.article
*  Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
to a range of macrolides and macrolide-like agents resulted in significant attenuation of the production of pneumolysin, while ... This includes a number of in vitro studies which have demonstrated the inhibitory effects of macrolides and macrolide-like ... M. J. Schultz, "Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and crystic ... Y. Fukuda, K. Yanagihara, Y. Higashiyama et al., "Effects of macrolides on pneumolysin of macrolide-resistant Streptococcus ...
  https://www.hindawi.com/journals/mi/2012/584262/
*  JCI - Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Macrolides are potent inhibitors of KCNJ5MUT, but not KCNJ5WT. Macrolides feature a many-membered lactone ring with one or more ... Eight macrolides or macrolide derivatives tested had no significant effect on KCNJ5WT channels; several of these, including ... Further exploration of macrolides showed that KCNJ5MUT was similarly selectively inhibited by idremcinal, a macrolide motilin ... Synthesis of macrolide derivatives without antibiotic or motilide activity. The use of macrolide antibiotics is associated with ...
  https://www.jci.org/articles/view/91733
*  Macrolide antibiotics | definition of Macrolide antibiotics by Medical dictionary
What is Macrolide antibiotics? Meaning of Macrolide antibiotics medical term. What does Macrolide antibiotics mean? ... Looking for online definition of Macrolide antibiotics in the Medical Dictionary? Macrolide antibiotics explanation free. ... macrolide. (redirected from Macrolide antibiotics). Also found in: Dictionary, Encyclopedia. macrolide. [mak´ro-līd] 1. a ... macrolide. (măk′rō-līd). n.. A class of antibiotics that are produced by certain actinomycetes of the genus Streptomyces, are ...
  http://medical-dictionary.thefreedictionary.com/Macrolide+antibiotics
*  Sketchy - Macrolides Flashcards by Languages 247365 | Brainscape
Use what macrolide for atypical (walking) pneumonia as caused by Mycoplasma, Chlamydia and Legionella? ...
  https://www.brainscape.com/flashcards/sketchy-macrolides-5291501/packs/7868247
*  Statin-macrolide combination 'doubles risk of kidney injury' | News Article | Pulse Today
GPs should avoid prescribing macrolide antibiotics with statins 'where possible' as the combination doubles the risk of acute ... The risk of all-cause mortality was also one and a half times higher in the statin/macrolide patients, compard with those ... The Canadian researchers found the risk of all-cause mortality was one and a half times higher in patients taking macrolides ... They also found a greater risk of acute kidney injury, with 0.46% of patients taking statins and macrolides diagnosed with the ...
  http://www.pulsetoday.co.uk/clinical/prescribing/statin-macrolide-combination-doubles-risk-of-kidney-injury/20003333.article