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*  Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2 |...
The transcription factor myocyte enhancer factor 2 (MEF2) plays a critical role in neuronal survival. Cyclin-dependent kinase 5 ... MEF2, isoforms A-D, belongs to a family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors ... Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (1993) A fourth human MEF2 transcription factor, hMEF2D ... Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2. Xiaoli ...
  http://www.jneurosci.org/content/25/19/4823.long
*  MEF2C - Myocyte-specific enhancer factor 2C - Sus scrofa (Pig) - MEF2C gene & protein
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific ... Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific ... transcription factor activity, sequence-specific DNA binding Source: UniProtKB. *transcription regulatory region DNA binding ... RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: UniProtKB ...
  http://www.uniprot.org/uniprot/A4UTP7
*  Most recent papers in the shared collection Parkinsons Disease & NIR | Read by QxMD
... induced neurotoxicity in PC12 cells was achieved through the activation of transcription factor myocyte enhancer factor 2D ( ... MEF2D), as evidenced by the fact that SU4312 stimulated myocyte enhancer factor 2 (MEF2) transcriptional activity and prevented ... The study aimed to uncover which factor between rigidity and bradykinesia is more associated with the reduction of arm and leg ... it remains uncertain which factor is more responsible for the decrease of arm and leg swings. ...
  https://www.readbyqxmd.com/shared-collection/7702
*  Functional and genomic analysis of MEF2 transcription factors in neural development
The MEF2 family of transcription factors (TFs) plays many essential roles in neural development; however, the mechanisms of ... Functional and genomic analysis of MEF2 transcription factors in neural development. Doctoral dissertation, Harvard University. ... We find that one MEF2 family member in particular, MEF2D, is an essential regulator of the development and function of retinal ... CRX recruits MEF2D away from canonical MEF2 binding sites by promoting MEF2D binding to retina-specific enhancers that lack a ...
  https://dash.harvard.edu/handle/1/13070059
*  Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist | Science
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites ... Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist ... Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist ... Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist ...
  http://science.sciencemag.org/content/272/5267/1476?ijkey=4dd848fc5c5655346415c4cc13acce47f5576231&keytype2=tf_ipsecsha
*  The transcription factor Mef2 is required for normal circadian behavior in Drosophila. - Semantic Scholar
We found that Mef2 is normally produced in all adult clock neurons and that Mef2 overexpression in clock neurons leads to long ... Knocking down Mef2 expression via RNAi or expressing a repressor form of Mef2 caused flies to lose circadian behavioral rhythms ... while Mef2 knockdown strongly dampens molecular rhythms. Thus, a normal level of Mef2 activity is required in clock neurons to ... Here, we describe a role for Mef2 in the Drosophila pacemaker neurons that regulate circadian behavioral rhythms. ...
  https://www.semanticscholar.org/paper/The-transcription-factor-Mef2-is-required-for-in-Blanchard-Collins/62e78e3e108a78af29578298a301bbfd10f36476
*  Myocyte Enhancer Factor 2C as a Neurogenic and Antiapoptotic Transcription Factor in Murine Embryonic Stem Cells | Journal of...
MCM1-agamous-deficiens-serum response factor) family of transcription factors (Yu et al., 1992; Naya and Olson, 1999). MEF2 ... MEF2 is clearly not the only important transcription factor in neuronal differentiation, but it may represent a branch point in ... 1993) MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci ... 1997) A dominant-negative form of transcription factor MEF2 inhibits myogenesis. J Biol Chem 272:33271-33278. ...
  http://www.jneurosci.org/content/28/26/6557.long
*  Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons...
2006) Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311:1008-1012. ... This novel cis-acting element contains binding sites for 3 major activity-dependent transcription factors, CREB, MEF2, and SRF ... Contribution of 3 Activity-Regulated Transcription Factors, CREB, MEF2, and SRF, in SARE Activation.. SARE contained 4 ... Participation of 3 Major Activity-Regulated Transcription Factors CREB, SRF, and MEF2 in Arc/Arg-3.1 Transcriptional Response. ...
  http://www.pnas.org/content/106/1/316
*  Patent US7747389 - Scoring system for the prediction of cancer recurrence - Google Patents
... reverse transcription polymerase-chain reaction (hereinafter referred to as RT-PCR) to examine the expression of at least 2 or ... MADS/MEF2-family transcription factor (MEF2C), HUMLUCA19 Human cosmid clone LUCA19 from 3p21.3, DEAD-box protein p72, vimentin ... MADS/MEF2-family transcription factor (MEF2C), HUMLUCA19 Human cosmid clone LUCA19 from 3p21.3, DEAD-box protein p72, vimentin ... Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma, ...
  http://www.google.com/patents/US7747389?dq=6,064,942
*  Activity-dependent regulation of inhibitory synapse development by Npas4 - Semantic Scholar
Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses ... Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.. *Steven W. Flavell, ... Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF ... The transcription factor Npas4 contributes to adolescent development of prefrontal inhibitory circuits, and to cognitive and ...
  https://www.semanticscholar.org/paper/Activity-dependent-regulation-of-inhibitory-synapse-Lin-Bloodgood/992aeff798e47c8165502bc72edac8d1e72b5e47
*  MAPK14 - Wikipedia, la enciclopedia libre
de 1999). «Regulation of the MEF2 family of transcription factors by p38». Mol. Cell. Biol. (UNITED STATES) 19 (1): 21-30. ISSN ... de 1999). «Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors». Mol. Cell. Biol. (UNITED STATES) ... de 2001). «Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated ...
  https://es.wikipedia.org/wiki/MAPK14
*  The Molecular Bases of Training Adaptation | SpringerLink
Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 1999; 19 (1): 21-30PubMedGoogle Scholar ... Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) ... Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; ... Mitochondrial transcription factor A and respiratory complex IV increase in response to exercise training in humans. Pflugers ...
  https://link.springer.com/article/10.2165%2F00007256-200737090-00001
*  Frontiers | The Transcriptional Regulation of Germinal Center Formation | Immunology
This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles ... This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles ... MEF2 transcription factors: developmental regulators and emerging cancer genes. Oncotarget (2016) 7:2297-312. doi: 10.18632/ ... Transcription factors that are downstream of the BCR, such as the transcription coactivator OBF1 (a.k.a. OCA-B, or Bob1), a B ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.02026/full
*  MKK6 | SpringerLink
Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science. 1999;286(5440):785-90.CrossRefPubMed ... Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol. 1999;1:21-30.CrossRefGoogle Scholar ... Participation of the Mef2c transcription factor. J Biol Chem. 1999;274(8):5193-200.CrossRefPubMedGoogle Scholar ... Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_622
*  Plus it
2006) Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311:1008-1012. ... 2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function ... Recent studies have demonstrated that transcriptional regulators, such as the MEF2 (myocyte enhancer factor 2) family and NPAS4 ... suggesting that not only transcription factors but also epigenetic mechanisms play crucial roles in the development of synaptic ...
  http://www.jneurosci.org/content/29/25/8288
*  Plus it
The transcription factor MEF2 (myocyte enhancer factor 2), a negative regulator of synapse density (Flavell et al., 2006), is ... 2006) Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311:1008-1012, ... 2013) MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J ... However, MEF2 is not required for normal levels of MHCI to regulate synapse number, because inhibiting MEF2 does not increase ...
  http://www.jneurosci.org/content/34/35/11844
*  Plus it
1999) Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286:785-790. ... 2008) Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 1144:97-112. ... 2002a) Nerve growth factor-dependent activation of the small GTPase Rin. J Biol Chem 277:17605-17615. ... A similar reliance on trophic/growth factor support has not been described for the survival of immature neurons, perhaps making ...
  http://www.jneurosci.org/content/32/29/9887
*  Life Sciences Faculty - Suzanne Paradis
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.' Science 311: 1008-1012. ...
  http://www.bio.brandeis.edu/faculty/paradis.html
*  The AMEDEO Literature Guide
Essential control of early B-cell development by Mef2 transcription factors.. Blood. 2016;127:572-81.. PubMed Text format ... Runx transcription factors in the development and function of the definitive hematopoietic system.. Blood. 2017;129:2061-2069. ... The GATA factor revolution in hematology.. Blood. 2017;129:2092-2102.. PubMed Text format Abstract available. *PORCHER C, ... Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell ...
  http://amedeo.com/medicine/stc/blood.htm
*  Table of Contents - April 11, 2000, 97 (8) | PNAS
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases Jianrong Lu, Timothy A. ... Activation of gene expression by small molecule transcription factors Anna K. Mapp, Aseem Z. Ansari, Mark Ptashne, and Peter B ... Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides M. Faria, C. D. Wood, L. ... Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites Shunbin Xiong, ...
  http://www.pnas.org/content/97/8/
*  Assays for Acetylation and Other Acylations of Lysine Residues - Current Protocols
Histone deacetylase 3 interacts and deacetylates MEF2 transcription factors. Mol. Cell Biol. 27:1280‐1295. doi: 10.1128/MCB. ... Basic analysis of transcription factor binding to nucleosomes. Methods Mol. Genet. 6:108‐128. doi: 10.1016/S1067‐2389(06)80009‐ ... Assays for interaction of transcription factor with nucleosome. Methods Enzymol. 304:313‐332. doi: 10.1016/S0076‐6879(99)04019‐ ... Gcn5p, a transcription‐related histone acetyltransferase, acetylates nucleosomes and folded nucleosomal arrays in the absence ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ps1411.html
*  What's hot today: Current papers in developmental biology and gene function
... identifies MEF2 (see Drosophila Mef2) transcription factors as crucial regulators of sprouting angiogenesis directly downstream ... These different timing classes each associate with binding sites for two transcription factors, GAGA-factor and Zelda, ... MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev 30: 2297-2309. PubMed ID: 27898394 ... Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-december2016.htm
*  Frontiers | Modulation of TonEBP activity by SUMO modification in response to hypertonicity | Physiology
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol. 25 ... In many other transcription factors whose transactivation is inhibited by sumoylation, the underlying mechanism involves ... Recent studies have shown that phosphorylation is required for sumolyation in several transcription factors such as heat-shock ... Emerging new role of TonEBP/NFAT5 transcription factor in health and disease ...
  https://www.frontiersin.org/articles/10.3389/fphys.2014.00200/full
*  Staufen1 expression is modulated during skeletal muscle | Open-i
MEF2 Transcription Factors/biosynthesis. *Mice. *Muscles/metabolism. *MyoD Protein/biosynthesis. *Regeneration/genetics ... Note that in contrast to myotubes, adult muscles express low levels of myogenic regulatory factors, including myogenin, because ... Note that in contrast to myotubes, adult muscles express low levels of myogenic regulatory factors, including myogenin, because ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4230783_3765fig2&req=4