*  The Lysosomal-Mitochondrial Axis Theory of Apoptosis
In mixtures of rat liver lysosomes and mitochondria, selective rupture of the lysosomes by the lysosornotropic detergent 0- ... selectively lyses lysosomes, while PLA2 attacks lysosomes as well as mitochondria. Released lysosomal enzymes, and aclivated ... B-cell leukemia/lymphoma 2 (Bcl-2) blocks oxidant-induced apoptosis at least partly by stabilizing lysosomes. Here we report ... In mixed lysosome-mitochondria preparations, the lysosomotropic detergent, 0-methyl-serine dodecylamide hydrochloride (MSDH), ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:248642
*  Mouse models of PI(3,5)P2 deficiency with impaired lysosome function. - Semantic Scholar
Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.. *. Guy M. Lenk. , Miriam H . Meisler ... article{Lenk2014MouseMO, title={Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.}, author={Guy M. Lenk and ...
  https://www.semanticscholar.org/paper/Mouse-models-of-PI-3-5-P2-deficiency-with-impaired-Lenk-Meisler/dfbec594f0d3681b6fbebe9f5bd57f144eee97b8
*  Lysosome-endosome fusion and lysosome biogenesis | Journal of Cell Science
Lysosome-endosome fusion and lysosome biogenesis Message Subject (Your Name) has sent you a message from Journal of Cell ... We also review lysosome biosynthesis, showing how recent studies of lysosome-like organelles including the yeast vacuole, ... Lysosomes are then re-formed from hybrid organelles by a process involving condensation of contents. In this Commentary we ... This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the ...
  http://jcs.biologists.org/content/113/9/1515
*  Lysosome-dependent pathways as a unifying theme in Parkinson's disease. - Oxford Neuroscience
Based on these studies, it is proposed that a protein network involved in trafficking to, or degradation by, lysosomes could be ... VPS35 and LRRK2 may regulate trafficking within lysosome-dependent pathways, such as autophagy and endosomal vesicle recycling ... Pink1 and Parkin regulate the degradation of damaged mitochondria by the lysosome (mitophagy). Glucocerebrosidase and ATP13A2 ... Based on these studies, it is proposed that a protein network involved in trafficking to, or degradation by, lysosomes could be ...
  https://www.neuroscience.ox.ac.uk/publications/349891
*  Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guérin: Lysosome Exocytosis into Tumor Cells | Science
Lysosomes of activated macrophages are secreted directly into the cytoplasm of susceptible target cells, which subsequently ... This reaction can be inhibited by agents which prevent the exocytosis of macrophage lysosomes (hydrocortisone) or which ... Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guérin: Lysosome Exocytosis into Tumor Cells ... Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guérin: Lysosome Exocytosis into Tumor Cells ...
  http://science.sciencemag.org/content/184/4135/468
*  Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver. - Semantic Scholar
The Involvement of Lysosomes in Myocardial Aging and Disease *Alexei Terman, Tino Kurz, Bertil Gustafsson, Ulf T Brunk ... Lysosomes in iron metabolism, ageing and apoptosis. *Tino Kurz, Alexei Terman, Bertil Gustafsson, Ulf T. Brunk ...
  https://www.semanticscholar.org/paper/Histochemical-indications-for-lysosomal-localizati-Brun-Brunk/83b388434411590fa8aeb7bf4c645bf2898d68fa
*  Macrophage Uptake of Oxidized LDL Inhibits Lysosomal Sphingomyelinase, Thus Causing the Accumulation of Unesterified...
The lysosome-rich fraction was not contaminated by cytosolic or microsomal fractions, as markers of the lysosome (such as β- ... The CE moiety in Ox-LDL is hydrolyzed normally in lysosomes, but the resulting UC is trapped in the lysosomes secondary to the ... Accumulation of Ox-LDL-Derived SM in Macrophage Lysosomes. UC accumulates in macrophage lysosomes after cell incubation with Ox ... their lysosomes were separated. [3H]Choline-labeled SM and [3H]UC accumulations in the lysosome-rich fraction were determined ...
  http://atvb.ahajournals.org/content/15/9/1378
*  A cells digestive enzymes are enclosed in a membrane bound organelle. How can these molecules funtion in the cell? - Kgb Answers
What creates a lysosome? You'll have to visit the Golgi complex for that answer. To learn more about lysosomes, go to www.ncbi. ... You will find lysosomes in nearly every animal-like eukaryotic cell. Lysosomes hold enzymes that were created by the cell. ... Lysosomes function as the digestive system of the cell, serving both to degrade material taken up from outside the cell and to ... Lysosomes thus represent morphologically diverse organelles defined by the common function of degrading intracellular material ...
  http://www.kgbanswers.com/a-cells-digestive-enzymes-are-enclosed-in-a-membrane-bound-organelle-how-can-these-molecules-funtion-in-the-cell/4662304
*  ALZFORUM | NETWORKING FOR A CURE
These findings reinforce the emerging concept of the lysosome as a vital regulator of diverse cell functions and as a highly ... The Dehay study raises an intriguing set of additional questions as to whether the lysosomes in specific neuron subtypes- ... they reveal pathogenic mechanisms involving defects in lysosome function that are remarkably similar and mutually validating. ... component needed for acidification is prematurely degraded in the endoplasmic reticulum and fails to reach the lysosome in ...
  http://www.alzforum.org/papers/loss-p-type-atpase-atp13a2park9-function-induces-general-lysosomal-deficiency-and-leads
*  Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4-/- mice | IOVS | ARVO Journals
Purpose : Lysosomes are recognized as a major store of intracellular Ca2+, and lysosomal Ca2+ signaling is implicated in ... Conclusions : The release of Ca2+ from lysosomes in mouse RPE cells is substantial, and is mediated, at least in part, by the ... The lysosomes of RPE cells process the shed tips of photoreceptor outer segments and their own autophagic material, and ...
  http://iovs.arvojournals.org/article.aspx?articleid=2638917
*  Lecture 13 11 - /02/07 Golgi Structure/Function Lysosome Exocytosis Glycosylation Protects lysosome membrane proteins from...
Exocytosis Glycosylation Protects lysosome membrane proteins from autodegradation ... but releases it at lysosome o pH of Golgi = 6 o pH of lysosome = 5 o pH of cytosol/ER = neutral Golgi  Lysosome transport ... Lecture 13 11/02/07 Golgi Structure/Function, Lysosome, Exocytosis Glycosylation • Protects lysosome membrane proteins from ... Lysosome Function 13 Lysosomes Fig 15 35 14 Unique internal environment of ...
  https://www.coursehero.com/file/211139/Lecture-13-11/
*  HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers |...
Lysosomes are shown in red and transfected cells in green. Yellow color represents WT-RILP-GFP and lysosome colocalization. (G ... Lysosome distribution may control invasion by tumor cells. The results presented above suggest that the location of lysosomes ... 5), suggesting that NHE1 and NHE3 both play a role in HGF-induced lysosome trafficking. Moreover, since EIPA prevented lysosome ... Essentially, Rab7-KD cells have peripheral lysosomes and are more invasive, while RILP-overexpressing cells have lysosomes ...
  http://jcs.biologists.org/content/123/7/1151
*  A Gene Network Regulating Lysosomal Biogenesis and Function | Science
TFEB itself can be activated when the lysosome malfunctions and can regulate both the abundance of lysosomes found in the cell ... Now, Sardiello et al. (p. 473; published online 25 June) have discovered a gene network regulating the lysosome, the major ... Lysosomes are organelles central to degradation and recycling processes in animal cells. Whether lysosomal activity is ...
  http://science.sciencemag.org/content/325/5939/473?ijkey=d89b2a653ecedb2fb96ede3d9591bd6798f01b38&keytype2=tf_ipsecsha
*  Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as...
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012;31:1095-108.View ... Lysosomes as mediators of drug resistance in cancer. Drug Resist Updat. 2016;24:23-33.View ArticlePubMedGoogle Scholar. ... we speculate that the high tropism for lysosomes promotes high intracellular nintedanib levels. Accordingly, lysosomes have ... The lysosome exclusivity of the green nintedanib fluorescence likely arises from drug accumulation to such a high extent that ...
  https://jeccr.biomedcentral.com/articles/10.1186/s13046-017-0592-3
*  Lysosomal localization of GLUT8 in the testis - the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1-...
Jonas AJ, Conrad P & Jobe H (1990) Neutral-sugar transport by rat liver lysosomes. Biochem J 272, 323-326. *PubMed, ... Bonifacino JS & Traub LM (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 72, ... Janvier K & Bonifacino JS (2005) Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins. Mol ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2009.07089.x/references
*  Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream...
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012;31:1095-1108. ... However, the degree to which an increased quantity of nascent lysosomes or an increased efficiency of the current lysosome pool ... Atherosclerotic Macrophages Have Dysfunctional Lysosomes. Optimal lysosome function requires the ability to maintain an acidic ... Atherosclerotic Macrophages Have Morphologically Abnormal Lysosomes. The lysosome receives extracellular cargo (via endocytosis ...
  http://atvb.ahajournals.org/content/34/9/1942
*  The Role of Intraorganellar Ca2+In Late Endosome-Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid...
... a rise in cytosolic Ca2+ has been shown to be necessary for lysosome-lysosome fusion (Bakker et al. 1997), lysosome-phagosome ... 1993), lysosomes (Storrie and Desjardins 1996; Bakker et al. 1997; Ward et al. 1997), and between late endosomes and lysosomes ... Thus, late endosome-lysosome fusion and lysosome reformation may be coupled by the requirement for lumenal free Ca2+. However, ... The numbers of lysosomes in a hybrid-enriched fraction pellet or reformed lysosome pellet were calculated by calculating the ...
  http://jcb.rupress.org/content/149/5/1053.long
*  Radiation-induced cell death : Importance of lysosomal destabilization
Since the major pool of low-mass redox-active intracellular iron seems to reside within lysosomes, arising from the continuous ... Cytochemical staining revealed that most redox-active iron was within the lysosomes. The increase of intralysosomal iron was ... Apoptosis, Ionizing radiation, Iron chelator, Lysosome, Macrophage, Oxidative stress National Category Medical and Health ... stabilized lysosomes and largely prevented cell death. These observations may provide a biological rationale for fractionated ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:271345
*  TSRI - News & View, Team Finds a Widely Used Anti-Malarial Drug Prevents Cancer Development
... lysosomes, in blue. Note the massive accumulation of large, dysfunctional lysosomes that precedes cell death in chloroquine- ... Lysosomes are cellular recycling centers that degrade old and unwanted material in the cell and recycle building blocks that ... Our studies have established that chloroquine inhibits a late step in the autophagy pathway by inhibiting lysosome functions ...
  http://www.scripps.edu/newsandviews/e_20080114/cleveland.html
*  ballabio - TIGEM
The regulation of lysosome-mediated cellular clearance is a new concept in cell biology. Our laboratory is now focused on the ... In eukaryotes, most of the cellular clearing processes occur in a specialized organelle, the lysosome. Given that the ...
  http://www.tigem.it/Staff/ballabio
*  Lysosomes | Smore Newsletters
Lysosomes - By: Scott Jakobsze by Scott Jakobsze , This newsletter was created with Smore, an online tool for creating ...
  https://www.smore.com/16465
*  Medical Xpress - lysosomes
The size of lysosomes varies from 0.1-1.2 μm. At pH 4.8, the interior of the lysosomes is acidic compared to the slightly ... Lysosome. Lysosomes are cellular organelles that contain acid hydrolase enzymes to break down waste materials and cellular ... Lysosomes digest excess or worn-out organelles, food particles, and engulf viruses or bacteria. The membrane around a lysosome ... The name lysosome derives from the Greek words lysis, to separate, and soma, body. They are frequently nicknamed "suicide-bags ...
  https://medicalxpress.com/tags/lysosomes/sort/date/6h/
*  LYSOSOMES IN LYMPHOID TISSUE | JCB
The results confirm and extend the conclusion, derived from previous investigations on normal animals, that the lysosomes of ...
  http://jcb.rupress.org/content/32/2/349
*  What Is Inside a Lysosome? | Reference.com
Lysosomes are small vesicles that contain a variety of acidic hydrolase enzymes capable of disposing of biological material ... The enzymes contained within a lysosome are strong enough to kill the host cell if not contained within the lysosome's membrane ... A cell may contain hundreds of lysosomes. Lysosomes are only found within certain complex cells known as eukaryotes, which ... Lysosomes are located within a cell's cytoplasm, which is a liquid layer contained by the outer cell membrane. Many of a cell's ...
  https://www.reference.com/science/inside-lysosome-6791f3fb79660860