Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine | Nature Communications
... signaling responses. Structures of a light-oxygen-voltage paradigm at around 1 Å resolution revealed highly similar light- ... and their signalling process has been extensively characterized. Here the authors report that the light signal is still ... Signaling without glutamine appears intrinsic to light-oxygen-voltage receptors, which pertains to biotechnological ... Light-oxygen-voltage (LOV) photoreceptors perceive blue light to elicit spatio-temporally defined cellular responses, ...
Information Transfer in Calcium Signal Transduction - VideoLectures.NET
Using the information-theoretic measure Transfer Entropy (Schreiber 2000) we studied the properties of this signal transduction ... Using the information-theoretic measure Transfer Entropy (Schreiber 2000) we studied the properties of this signal transduction ... They transfer extracellular signals (e.g. from hormones) to targets within the cell, like Ca2+-dependent enzymes or ... frequency and waveform of the Ca-signal and decoded again, later on, by cellular targets. After stimulation, the calcium ...
TRPM8: The Cold and Menthol Receptor - TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades - NCBI...
... describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and ... The identification of TRPM8 and the subsequent studies characterizing its properties have shed light on the molecular ... TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.. Show details. Liedtke WB, Heller S, editors. ... TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; ...
Myosin-light-chain phosphatase - Wikipedia
Somlyo, Andrew P.; Somlyo, Avril V. (November 10, 1999). "Signal Transduction by G-Proteins, Rho-Kinase and Protein Phosphatase ... that dephosphorylates the regulatory light chain of myosin II: [myosin light-chain] phosphate + H2O = [myosin light-chain] + ... Gomperts, Bastein D. (August 19, 2009). Signal Transduction: 2nd Edition. London: Academic Press. ISBN 978-0123694416. Shi, ... Myosin light-chain phosphatase, also called myosin phosphatase (EC 3.1.3.53; systematic name [myosin-light-chain]-phosphate ...
Cyanobacteria in motion
Cyanobacteria are able to move directly towards or away from a light source, a process called phototaxis. Recent studies have ... of directional light sensing at the small scale of bacteria and discuss our current understanding of signal transduction in ... Cyanobacteria are able to move directly towards or away from a light source, a process called phototaxis. Recent studies have ... 3 Institute of Biology III, University of Freiburg, D79104 Freiburg, Germany; BIOSS Centre of Biological Signalling Studies, ...
Genetics and Molecular Biology (eBook)
Binding Interactions in the Bacterial Chemotaxis Signal Transduction Pathway
However my results also brought to light some of the limitations and difficulties of this approach. ... This dissertation focuses on understanding some of the biochemical events that take place in the chemotaxis signal transduction ... The investigation of signal transduction pathways is critical to the basic understanding of cellular processes as these ... The investigation of signal transduction pathways is critical to the basic understanding of cellular processes as these ...
CV Physiology | Vascular Signal Transduction Mechanisms
The Rho-kinase pathway (not shown in figure) inhibits myosin light chain phosphatase, which enhances contraction. ... G-Protein Coupled Signal Transduction. Like heart muscle, the Gs-protein coupled pathway in smooth muscle stimulates adenylyl ... cGMP-Coupled Signal Transduction. A third mechanism that is very important in regulating vascular smooth muscle tone is the ... There are several signal transduction mechanisms that modulate intracellular calcium concentration and therefore the state of ...
Ching-Ju Tsai | LBR | Paul Scherrer Institut (PSI)
They contribute to signal transduction across the cell membrane. GPCRs are activated by extracellular stimuli such as light, ... Backbone NMR reveals allosteric signal transduction networks in the beta1-adrenergic receptor Isogai S, Deupi X, Opitz C, ... Structural biology: Signalling under the microscopeTsai CJ, Standfuss J, Glaeser RM Nature, 546(7656), 36-37 (2017). ... Crystal structure of rhodopsin in complex with a mini-G o sheds light on the principles of G protein selectivity Tsai C, Pamula ...
Plant Growth Regulator (PGRs): Weed on Steroids? | High Times
... for a hormone or light molecule) and a signal transduction pathway, which concludes with a cellular response that is relevant ... Signal transduction pathways work in sequences of biochemical reactions. From this a cell generates a response to a stimulus. ... In response to the signal transduction pathway (initiated by the presence of plant hormones or PGRs), repressor proteins for ... Plants make extensive use of signal transduction pathways throughout their life. They are feedback mechanisms that allow plants ...
RCSB PDB - 1WIO: STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, TETRAGONAL CRYSTAL FORM
We suggest that such dimers mayhave relevance as mediators of signal transduction in T cells. ... Dynamic light scattering measurements and chemical crosslinking of sCD4 corroborate dimerization at high protein concentration ... and it contributes directly to signal transduction through its cytoplasmic association with the lymphocyte kinase Lck. CD4 also ... and it contributes directly to signal transduction through its cytoplasmic association with the lymphocyte kinase Lck ... ...
Plants | Free Full-Text | Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and...
Since ABA signaling is a complex signaling network that integrates with other signaling pathways, the dissection of its ... In the present review, we focus on two aspects of ABA signaling. First, we examine the perception of the stress signal (abiotic ... and ABA signaling component ubiquitination. Second, ABA signaling in plant development processes, such as lateral root growth ... and the response network of ABA signaling components that transduce the signal to the downstream pathway to respond to stress ...
Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation |...
... as homeostasis initiates elimination as soon as signal transduction gets completed. ... 3: Comparison of the aggregation propensity in light of the charge distribution of the APRs.. ... Recent studies shed light on their importance in signalization, as well as in fine-tuning protein functions5,6,7. Furthermore, ... In light of the above, it is not surprising that the lifetime of the secretin-like gastrointestinal peptides in circulation is ...
Homepage of Judith Klein-Seetharaman: Publications
2. Klein, J. (2000) Visual Signal Transduction: Studies of Light-Induced Conformational Changes in the Cytoplasmic Face of ... IEEE Signal Processing Magazine. 21(3), 78-87 [pdf]. 25. Klein-Seetharaman,J., Yanamala, N.V.K., Javeed, F., Reeves, P.J., ... eds.) Oxygenic Photosynthesis: The Light Reactions. 2. Klein, J., De Las Rivas, J. and Barber, J. (1995) Indirect Reduction of ... Altenbach, C., Klein-Seetharaman, J., Hwa, J., Khorana, H.G. and Hubbell, W.L. (1999) Structural Features and Light-Dependent ...
Effect of Sucrose on Steviol Glycoside Biosynthesis Pathway in Stevia rebaudiana
Sugar-induced signal transduction in plants. Ann. Rev. Plant Physiol. Plant Mol. Biol., 51: 49-81.. CrossRef ... These plates were placed under normal 16/8 hour light/dark tissue culture conditions. The number of germinated seeds was ... Sugar coordinately and differentially regulates growth- and stress-related gene expression via a complex signal transduction ... and anatomical variations as well as by regulating the expression of various genes via a variety of signal transduction ...
Frontiers | Vitamin D Actions on CD4+ T Cells in Autoimmune Disease
The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble ... The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble ... effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3+CD4+ T-regulatory cell and CD4+ T- ... effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3+CD4+ Treg cell and CD4+ Tr1 cell ...
Yulin Jia : USDA ARS
Elucidation of the molecular basis of the Ptr gene in Black Hull Awn (BHA) weedy rice mediated signaling transduction - ( ... Bacteria disinfection of rice seeds by ultraviolet light irradiation in a biosafe flow cabinet - (Peer Reviewed Journal) ... Signaling in the Rhizoctonia solani-rice pathosystem - (Proceedings) Jia, Y. 2008. Signaling in the Rhizoctonia solani-rice ... A user-friendly rice seed disinfection by ultraviolet light irradiation in a biosafe flow cabinet - (Abstract Only) ...
MPI for the Science of Light | Max-Planck-Gesellschaft
... these are just a few skills mastered or developed by the scientists of the Max Planck Institute for the Science of Light. ... White light sources being several orders of magnitudes brighter than light bulbs, the manipulation of single photons or the ... This type of physics promises a variety of applications, from highly sensitive measurements to signal transduction in quantum ... Max Planck Institute for the Science of Light White light sources being several orders of magnitudes brighter than light bulbs ...
Major Research Areas | College of Graduate Studies | SUNY Upstate
Apoptotic signal transduction and cancer biology.. *Brittany Simone, DO. Assistant Professor. Tumor metabolism and the use of ... Other areas of emphasis are the mechanism and consequences of calcium ion mobilization, signaling in neurons, light ... Apoptotic signal transduction and cancer biology.. *Brittany Simone, DO. Assistant Professor. Tumor metabolism and the use of ... The signal transduction events that regulate the functional organization of neurons in the brain, and the phenotypes caused by ...
The Role of Rhodopsin Glycosylation in Protein Folding, Trafficking, and Light-Sensitive Retinal Degeneration | Journal of...
... although reduced signal transduction attributable to lack of glycosylation may impact visual sensitivity, it is unlikely to be ... 3C,D). These results indicate that T4K- and T17M-induced RDs were associated with light exposure and protection from light- ... Fluorescent signals derived from antibody labeling were adjusted linearly, whereas signals derived from wheat germ agglutinin ... Fluorescent signals derived from antibody labeling were adjusted linearly, whereas signals derived from wheat germ agglutinin ...
Accelerated Orthodontics for the General Practitioner - Dentistry Today
Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004; ... Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced ... Light is delivered from an LED source extraorally to the site requiring treatment for extractions and implants. ... The principle behind the use of a vibratory method is to place light, alternating forces on the teeth via mechanical or ...
Effects of Herb-Partitioned Moxibustion on Autophagy and Immune Activity in the Colon Tissue of Rats with Crohn's Disease
... activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction ... and autophagy signaling molecules, such as PI3KC, AKT1, LKB1, and mTOR, were detected by RT-qPCR. ,i,Results,/i,. Herb- ... All the animals were housed in a clean grade room with controlled temperature (20 ± 2°C), a light/dark (12 h:12 h) cycle, and ... a variety of signal transduction pathways are involved in the regulation of autophagy. Many of these signal transduction ...
Publications | Max Planck Institute of Colloids and Interfaces
Molecular Biology: Latest Research & News - Free Science Information
Another area of focus within molecular biology is signal transduction mechanisms, which regulate cellular responses. Cells ... This understanding not only provides insights into normal cellular functions but also helps shed light on diseases caused by ... This discovery has shed light on how miRNAs contribute to normal development and disease progression, providing valuable ... Through meticulous research, scientists have unraveled the complex steps involved in these processes, shedding light on how ...
Molecular Biology | Princeton University
... signal transduction and intracellular trafficking play in the commitment, differentiation and assembly of cells into ... We will explore specific clinical case studies in light of the molecular events underlying different cancers. ... followed by a survey of the signal transduction pathways and checkpoints that regulate it. We will discuss oncogenes, tumor ... Lectures will give an overview at levels ranging from molecular signaling to cognitive science with a focus on the neuroscience ...
Viruses | Free Full-Text | African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-κB...
In contrast, activation of IRF3 and ISRE signaling upon stimulation with TRIFΔRIP, cGAS/STING or RIG-I-CARD remained unaltered ... ĸB signaling. Additionally, A549 stably transduced for UBCv1 showed a significant decrease in the levels of NF-ĸB dependent ... modulates innate immune and inflammatory signaling. Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 ... activates cellular signal transduction pathways to coordinate an effective response against viruses [1,2]. The transcription ...
iTRAQ-based comparative proteome analyses of different growth stages revealing the regulatory role of reactive oxygen species...
Neurospora crassa light signal transduction is affected by ROS.. Journal of Signal Transduction 2012(2):791963 ... Genetic analysis of signal transduction through light-induced protein phosphorylation in Neurospora crassa perithecia.. ... Histidine Phosphotransfer proteins in fungal two-component signal transduction pathways.. Eukaryotic Cell 12(8):1052-1060 ... the MAPK signaling pathway was activated and passed the signal from an area of high oxidative stress to a low area to initiate ...
Events - Stazione Zoologica Anton Dohrn
Signal transduction and promoter regulation systems in marine diatoms in response to carbon dioxide and light :: Seminari di ... Diatom responses to light: a tale of energy, rhythms and colors :: Seminari di Istituto ... Signal perception in diatoms: dissecting chemical communication with molecular approaches :: Seminari Interni ... Photoprotective and antioxidant responses to light spectrum and intensity variations in the coastal diatom Skeletonema marinoi ...
Myelodysplastic Syndrome - Myeloproliferative Neoplasm Overlap Syndromes: Overview, MDS/MPN with SF3B1 Mutation and...
In 25% of JMML patients, RAS protein is involved in intracellular signal transduction on ligand binding to several receptors, ... Study of these disorders has helped shed light on the pathogenesis of JMML. ... Hyper-signalling of the RAS pathway is fundamental to the development of JMML. This phenomenon is caused by somatic or germline ... By interfering with the signals that suppress red blood cell (RBC) production, the agent improves patients ability to ...
SMART: PAS domain annotation
N- and C-terminal helices of oat LOV2 (404-546) are involved in light- induced signal transduction (cryo-trapped light ... Molecular mechanism of signal transduction in bjFixL. 2w0n. Plasticity of PAS domain and potential role for signal transduction ... are involved in light-induced signal transduction (room temperature (293K) light structure of LOV2 (404-546)). ... n- and c-terminal helices of oat lov2 (404-546) are involved in light-induced signal transduction (cryo dark structure of lov2 ...