*  Repositorio da Producao Cientifica e Intelectual da Unicamp: Leukotrienes play a role in the control of parasite burden in...
It is clear that leukotrienes mediate inflammatory response; new aspects of leukotriene function have recently been described. ... However, levels of leukotriene C-4, PGE(2), TNF-alpha, IL-3, IL-4, IFN-gamma, and IL-10 were comparable between the treated and ... High leukotriene levels were detected in the lungs and small intestines of Swiss mice. In infected Swiss mice treated with ... In this study, we demonstrate that leukotrienes are key chemical mediators in the control of parasite burdens in mice infected ...
  http://repositorio.unicamp.br/jspui/handle/REPOSIP/80873
*  reagents-immunoassay-allergy-leukotriene
Entry Terms : "IVD Test Reagent/Kits, Immunoassay, Allergy, Leukotriene Stimulation" , "LT (Leukotriene) Determination Reagents ... leukotrienes) that cause bronchial and other smooth muscle contractions. Leukotrienes are identified by letters from A to E, ... Some leukotrienes (e.g., LTC4, LTD4, LTE4) are considered mediators of bronchial constriction and allergic reactions (e.g., ... IVD Test Reagent/Kits, Immunoassay, Allergy, Leukotriene. Definition : Immunoassay reagents intended to perform qualitative and ...
  http://productguide.optometricmanagement.com/term/5546/reagents-immunoassay-allergy-leukotriene
*  Reactome | Synthesis of Leukotrienes (LT) and Eoxins (EX)
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
  http://www.reactome.org/content/detail/R-TGU-2142691
*  Leukotriene - Wikipedia
Leukotriene antagonists are used to treat these disorders by inhibiting the production or activity of leukotrienes. The name ... Leukotrienes are involved in asthmatic and allergic reactions and act to sustain inflammatory reactions. Several leukotriene ... Leukotrienes also have a powerful effect in bronchoconstriction and increase vascular permeability. Leukotrienes contribute to ... In excess, the cysteinyl leukotrienes can induce anaphylactic shock. A chemical synthesis of Leukotriene A methyl ester Eoxins ...
  https://en.wikipedia.org/wiki/Leukotriene
*  Leukotriene E4 - Wikipedia
Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white ... Lee CW, Lewis RA, Corey EJ, Austen KF (1983). "Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from ... "Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 ... Sala A, Voelkel N, Maclouf J, Murphy RC (1990). "Leukotriene E4 elimination and metabolism in normal human subjects". J Biol ...
  https://en.wikipedia.org/wiki/Leukotriene_E4
*  Leukotriene D4 - Wikipedia
Leukotriene D4 (LTD4) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, ... Other leukotrienes that function in a similar manner are leukotrienes C4 and E4. Pharmacological agents that inhibit the ... function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for ...
  https://en.wikipedia.org/wiki/Leukotriene_D4
*  Leukotriene A4 - Wikipedia
Leukotriene A4 is a leukotriene. Leukotriene A4 hydrolase converts it to leukotriene B4. Leukotriene C4 synthase converts it to ...
  https://en.wikipedia.org/wiki/Leukotriene_A4
*  Leukotriene C4 - Wikipedia
Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of ... All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering ... Chapter Two - The Leukotrienes: Immune-Modulating Lipid Mediators of Disease. 116. Academic Press. pp. 51-92. doi:10.1016/b978- ... Dvash, Efrat; Har-Tal, Michal; Barak, Sara; Meir, Ofir; Rubinstein, Menachem (2015-12-11). "Leukotriene C4 is the major trigger ...
  https://en.wikipedia.org/wiki/Leukotriene_C4
*  leukotriene - Wiktionary
leukotriene (plural leukotrienes). *(biochemistry) Any of several physiologically active lipids, related to the prostaglandins ... From leuko- +‎ triene, coined by Swedish biochemist Bengt I. Samuelsson.. Pronunciation[edit]. *(US) IPA(key): /ˌlu.koʊˈtɹaɪ.in ... Retrieved from "https://en.wiktionary.org/w/index.php?title=leukotriene&oldid=46899190" ...
  https://en.wiktionary.org/wiki/leukotriene
*  Leukotriene B4 - Wikipedia
Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice ... Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory ... It is synthesized by leukotriene-A4 hydrolase from leukotriene A4. A study at the University of California, San Diego School of ... Medicine has shown that leukotriene B4 promotes insulin resistance in obese mice. Obesity is the major cause of type 2 diabetes ...
  https://en.wikipedia.org/wiki/Leukotriene_B4
*  Leukotriene receptor - Wikipedia
Leukotriene B4 receptor 1) - LTB4R BLT2 (Leukotriene B4 receptor 2) - LTB4R2 Cysteinyl leukotriene receptors (CysLTRs) - bind ... The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include ... IUPHAR GPCR Database - Leukotriene receptors Leukotriene Receptors at the US National Library of Medicine Medical Subject ... "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand ...
  https://en.wikipedia.org/wiki/Leukotriene_receptor
*  Leukotriene-C4 synthase - Wikipedia
... leukotriene A4 + glutathione Hence, this enzyme has one substrate, leukotriene C4, and two products, leukotriene A4 and ... In enzymology, a leukotriene-C4 synthase (EC 4.4.1.20) is an enzyme that catalyzes the chemical reaction leukotriene C4 ⇌ {\ ... The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common ... Lam BK, Austen KF (2002). "Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes". ...
  https://en.wikipedia.org/wiki/Leukotriene-C4_synthase
*  Leukotriene C4 hydrolase - Wikipedia
This enzyme catalyses the following chemical reaction leukotriene C4 + H2O ⇌ {\displaystyle \rightleftharpoons } leukotriene D4 ... Leukotriene-C4 hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Carter, B.Z.; Wiseman, A.L.; Orkiszewski, R.; Ballard, K.D.; Ou, C.N.; Lieberman, M.W. (1997). "Metabolism of leukotriene C4 in ... Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase, GGT5) is an enzyme. ...
  https://en.wikipedia.org/wiki/Leukotriene_C4_hydrolase
*  Leukotriene-A4 hydrolase - Wikipedia
The protein encoded by this gene is a bifunctional enzyme (EC 3.3.2.6) which converts leukotriene A4 to leukotriene B4 and acts ... Inactivation of the enzyme with leukotriene A4 isomers". J. Biol. Chem. 262 (21): 10200-5. PMID 3038871. leukotriene A4 ... Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T (1987). "Leukotriene A4 ... Shimizu T, Seyama Y, Suzuki K (1987). "Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary ...
  https://en.wikipedia.org/wiki/Leukotriene-A4_hydrolase
*  Cysteinyl leukotriene receptor - Wikipedia
The cysteinyl leukotriene receptors (CysLTRs) include the following two receptors: Cysteinyl leukotriene receptor 1 (CysLTR1) ... "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand ... Leukotriene receptor Eicosanoid receptor Kanaoka Y, Maekawa A, Austen KF (2013). " ... Cysteinyl leukotriene receptor 2 (CysLTR2) The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third ...
  https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor
*  Leukotriene C4 synthase - Wikipedia
... is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of ... Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene. The protein encoded by this gene, LTC4S (or ... A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a ... leukotriene-C4 synthase at the US National Library of Medicine Medical Subject Headings (MeSH) UMich Orientation of Proteins in ...
  https://en.wikipedia.org/wiki/Leukotriene_C4_synthase
*  Leukotriene B4 receptor - Wikipedia
The leukotriene B4 receptors (BLTRs) include the following two receptors: Leukotriene B4 receptor 1 (BLTR1) Leukotriene B4 ...
  https://en.wikipedia.org/wiki/Leukotriene_B4_receptor
*  Cysteinyl leukotriene receptor 1 - Wikipedia
Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes# ... "Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and ... "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand ... "Leukotriene Receptors: CysLT1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
  https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1
*  Cysteinyl leukotriene receptor 2 - Wikipedia
Cysteinyl leukotriene receptor 2, also termed CYSLTR2, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes# ... "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand ... 2004). "A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha". ... "Leukotriene Receptors: CysLT2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
  https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2
*  Leukotriene B4 receptor 2 - Wikipedia
Discovered several years after the leukotriene B4 receptor 1 (BLT1), BLT2 receptor binds leukotriene B4 (LTB4) with far lower ... Tager AM, Luster AD (2003). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins, Leukotrienes, and Essential Fatty ... Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins, Leukotrienes, and Essential Fatty ... "Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin ...
  https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2
*  Leukotriene B4 receptor 1 - Wikipedia
Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene. Eicosanoid receptor Etalocib, an antagonist ... "Entrez Gene: LTB4R leukotriene B4 receptor". Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine ... 2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp ... "Leukotriene Receptors: BLT1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
  https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1
*  Leukotriene-E4 20-monooxygenase - Wikipedia
In enzymology, a leukotriene-E4 20-monooxygenase (EC 1.14.13.34) is an enzyme that catalyzes the chemical reaction (7E,9E,11Z, ... Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4". ... Orning L (1987). "Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. ... This enzyme is also called leukotriene-E4 omega-hydroxylase. This enzyme participates in arachidonic acid metabolism. ...
  https://en.wikipedia.org/wiki/Leukotriene-E4_20-monooxygenase
*  Leukotriene-B4 20-monooxygenase - Wikipedia
In enzymology, a leukotriene-B4 20-monooxygenase (EC 1.14.13.30) is an enzyme that catalyzes the chemical reaction (6Z,8E,10E, ... Soberman RJ, Harper TW, Murphy RC, Austen KF (1985). "Identification and functional characterization of leukotriene B4 20- ... Shak S, Goldstein IM (1985). "Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and ... Other names in common use include leukotriene-B4 20-hydroxylase, leucotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, and ...
  https://en.wikipedia.org/wiki/Leukotriene-B4_20-monooxygenase
*  Leukotriene C4 synthase deficiency - Wikipedia
Leukotriene C4 synthase deficiency is an inborn error of metabolism. Deficiency of Leukotriene C4 synthase can lead to a ... Mayatepek E, Flock B (November 1998). "Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal ... Mayatepek E, Zelezny R, Lehmann WD, Hammond JW, Hoffmann GF (June 2000). "Defects in the synthesis of cysteinyl leukotrienes: a ...
  https://en.wikipedia.org/wiki/Leukotriene_C4_synthase_deficiency
*  Patent US4442099 - Leukotriene analogues - Google Patents
The first leukotriene formed in this biosynthetic sequence is leukotriene A4 (LTA4, formula 1): ##STR3## LTA4 is a relatively ... This substance serves as a precursor to leukotrienes B4 (LTB4) which are potent chemotactic agents, and to a number of "slow ... Chemical synthesis has already been achieved for most of the natural leukotrienes, and a number of their isomers (c.f. E. J. ... It is yet another object of the invention to provide a process for the synthesis of stable biologically active leukotriene ...
  http://www.google.com/patents/US4442099?dq=7,346,539