Leukodystrophy, MetachromaticLeukodystrophy, Globoid CellCerebroside-SulfataseGalactosylceramidasePsychosineHereditary Central Nervous System Demyelinating DiseasesSulfoglycosphingolipidsPelizaeus-Merzbacher DiseaseDiffuse Cerebral Sclerosis of SchilderCerebrosidesSaposinsSulfatasesSphingolipid Activator ProteinsSphingolipidosesCanavan DiseaseN-Acylsphingosine GalactosyltransferaseLeukoencephalopathiesArylsulfatasesMice, Neurologic MutantsAlexander DiseaseBrainMyelin Proteolipid ProteinRotarod Performance TestEnzyme Replacement TherapyGalactosidasesLamin Type BDemyelinating DiseasesMyelin SheathConsanguinityBrain DiseasesHeterozygote DetectionOligodendrogliaMagnetic Resonance ImagingGalactosylceramidesDisease Models, AnimalMuscle Rigidity