*  Leptin Indirectly Activates Human Neutrophils via Induction of TNF-α | The Journal of Immunology
Leptin restores the expression of CD11b on neutrophils from leptin-deficient mice (19). However, the direct effect of leptin on ... Leptin augments the response of PMN in whole blood to PMA and TNF-α. Whole blood was preincubated with leptin (250 ng/ml) for 1 ... The presence of leptin receptor in human PMN was determined both at mRNA and protein levels, and the effect of leptin on PMN ... No effect of leptin on CD11b was observed (data not shown). Preincubating isolated PMN with leptin (250 ng/ml) for 1 h did not ...
  http://www.jimmunol.org/content/172/3/1809.long
*  Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance - Full Text View - ClinicalTrials.gov
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance. This study is currently recruiting participants. See ... we have observed that recombinant leptin has improved metabolic abnormalities in subjects with lipoatrophy and leptin ... Circulating leptin levels , 12.0 ng/ml in females and , 8.0 ng/ml in males as measured by Linco assay from serum samples after ... Leptin is a hormone produced by the fat cells that researchers have shown to play a role in controlling appetite. Certain ...
  https://clinicaltrials.gov/ct2/show/NCT00085982?term=Metabolic+Syndrome+OR+insulin+resistance+syndrome+OR+metabolic+syndrome+X&recr=Open&fund=01&rank=6
*  Leptin and Cardiovascular Disease | Circulation
Leptin and Lipid Profile. Leptin stimulates lipoprotein lipase secretion in cultured human and murine macrophages.31 Leptin ... Atherogenic Effects of Leptin. Leptin and Endothelial Cells. Functional leptin receptors are present on endothelial cells. ... Leptin and Insulin. Insulin potentiates leptin-induced NO release by enhancing leptin-stimulated phosphorylation of Akt and ... Because of reduced fat tissue, leptin levels are low. Leptin treatment is beneficial in these cases.93 Leptin therapy is also ...
  http://circ.ahajournals.org/content/117/25/3238
*  Diet plan for leptin resistance - ilotok-kirov.ru
What is leptin and how does it work? Leptin is a hormone that plays a crucial role in appetite and weight control. It is ... This is termed "leptin resistance," because even though the body has more than enough leptin in it, it doesn't respond to it ... What is leptin resistance? Studies in mice have shown that giving animals leptin reduces overeating and obesity. However, many ... Why does leptin resistance happen? While the definitive cause of leptin resistance isn't known, there are two main hypotheses. ...
  http://ilotok-kirov.ru/diet-plan-for-leptin-resistance.php
*  The Carb-Sane Asylum: Triglycerides and Leptin Resistance
Been reading a lot about leptin and leptin resistance lately and the recent theory that triglycerides cause leptin resistance. ... The leptin resistance theory of obesity is that our brains don't receive the leptin signal so we keep eating and get fatter.. ... Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier. Abstract. Obesity is associated with leptin resistance as ... This is in contrast with leptin action, so it's not the leptin that is suppressing hunger in that scenario. This is interesting ...
  http://carbsanity.blogspot.com/2010/06/triglycerides-and-leptin-resistance.html
*  Six Foods That Diabetics Should Avoid | Healthy Debates
High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent ... In an ideal world when your body stores fat, leptin levels go up and you feel full. But for someone with leptin resistance, the ... Now, let's talk about leptin, another hormone….. Leptin is produced by the body's fat cells. Basically what this hormone does ... For folks who have leptin resistance, when the leptin levels are high, the brain somehow doesn't get the message that they're ...
  http://www.healthydebates.com/articles/six-foods-diabetics-avoid/
*  Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS | Biochemical...
Defective central leptin signalling and impaired leptin entry into the CNS (central nervous system) represent two important ... I.c.v. injection of human CRP abolished hypothalamic signalling by human leptin, and ameliorated the effects of leptin on the ... Peripheral infusion of human CRP together with co-infused human leptin was associated with significantly decreased leptin ... Furthermore, following peripheral infusion of human leptin, the CSF (cerebrospinal fluid) concentration of leptin in transgenic ...
  http://www.biochemj.org/content/473/9/1215
*  Serum Leptin Levels and Lipid Profiles in Patients with Allergic Rhinitis and Mild Asthma | Allergologia et Immunopathologia
Leptin acts directly on T cells where it enhances the production of Th1 cells promoting inflammation2,3. Leptin also plays a ... 400 mg/dL16 Serum leptin levels were measured by a commercially available kit (BIOSOURCE LEPTIN EASIA [BioSource Europe S.A., ... Although the allergenic sensitivity seems to be no effect on serum leptin concentrations (p , 0.05) (table VII), leptin level ... Leptin is an anorexic peptide that is primarily known for its role as a hypothalamic modulator of food intake, body weight and ...
  http://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-serum-leptin-levels-and-lipid-profiles-in-13112988
*  Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome - Full Text View -...
This syndrome is associated with a deficiency of leptin, a hormone produced by fat cells. Recent studies involving leptin ... Role of Leptin in Highly Active Antiretroviral Therapy (HAART)-Induced Lipodystrophy and Metabolic Syndrome in HAART-Treated ... Leptin administration to patients with HAART-induced lipoatrophy may also lead to significant improvements in the metabolic ... Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome. This study has ...
  https://clinicaltrials.gov/show/NCT00140244?order=118
*  ActoFactor™ Recombinant Mouse Leptin | Creative Bioarray
Leptin expression is restricted to adipose tissue. Leptin binds to a high affinity receptor (OB-R) with homology to gp130 and G ... Leptin was identified as a protein product of the obese gene. Mice with mutations in the obese gene that block the synthesis of ... To reconstitute lyophilized leptin, add 15 mM sterile HCl (0.5 mL/1 mg) to the vial. After the protein is completely dissolved ... Mouse leptin cDNA encodes a 167 amino acid protein containing a 21 amino acid signal peptide. The recombinant methionyl form of ...
  https://www.creative-bioarray.com/ActoFactor-Recombinant-Mouse-Leptin-CSC-CTK0022-item-4224.htm
*  Leptin in Human Energy and Neuroendocrine Homeostasis - Tabular View - ClinicalTrials.gov
Drug: Leptin Leptin will be given as twice daily subcutaneous injections in doses titrated to replicate 8AM circulating leptin ... the adipocyte-derived hormone leptin. Systemic leptin administration to leptin-deficient rodents and humans reverses the ... Leptin in Human Energy and Neuroendocrine Homeostasis. Official Title ICMJE Leptin in Human Energy and Neuroendocrine ... 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol. 2014 Oct;223(1):T83-96. doi: 10.1530/JOE-14- ...
  https://clinicaltrials.gov/ct2/show/record/NCT00265980
*  Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure - Fonfara - 2011 - Journal of Veterinary Internal...
Leptin Results. Blood Samples.. Comparing leptin in blood samples of dogs with CHF and dogs without CD revealed significantly ... Elevated serumlevels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Heart Fail ... The role of leptin in development and progression of canine CD and CHF is not known. Therefore, leptin expression was ... Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Endocrinology 1997;138:4234 ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.00782.x/full?globalMessage=0
*  Leptin to Treat Severe Insulin Resistance - Pilot Study - Full Text View - ClinicalTrials.gov
Therefore, a strategy to achieve physiological concentrations of leptin hormone using recombinant leptin (A100, recombinant ... Leptin is a hormone produced by fat cells. It influences appetite, affects levels of reproductive hormones, and possibly ... When the above tests are completed, leptin therapy will start. The drug is injected under the skin twice a day for 4 months. ... This will allow us to learn if leptin can overcome a receptor defect by activating some of the down-stream molecules in insulin ...
  https://clinicaltrials.gov/ct2/show/NCT00027456
*  MORE NEWS ON LEPTIN
Leptin levels in fatty (fa) mutant rats were 50 times greater than that of non-mutant litter mates. In normal mice, leptin ... However, the leptin level varied greatly from person to person. For example, the amount of leptin for some obese patients with ... Reduced sensitivity to leptin in some patients could explain why more leptin is found in obese people, the scientists note. " ... "If resistance to leptin is partial, rather than complete, more leptin may be required for action." In addition, obesity may ...
  http://www.accessexcellence.org/WN/SUA06/morefat.html
*  From Fat Fighter to Risk Factor | Arteriosclerosis, Thrombosis, and Vascular Biology
2 The majority of obese humans with high levels of plasma leptin show a leptin insensitivity on the leptin receptor level.5 ... The mobilization of leptin may be regulated by hypoxemia since leptin gene expression is accelerated in ischemic tissues.25,26 ... There is a strong correlation of plasma leptin concentrations in humans with total body fat mass and body mass index.3,4 Leptin ... Leptin receptors are expressed on cultured endothelial cells, and stimulation of endothelial cells with leptin results in an ...
  http://atvb.ahajournals.org/content/24/1/7
*  Leptin Signaling and Obesity | Circulation Research
Leptin Signaling. Leptin and Leptin Receptor. Leptin is primarily secreted by adipocytes and circulates at a level of 5 to 15 ... Leptin Antagonists. Leptin antagonists used in animal models have been shown to block central leptin effects and increase ... Hyperleptinemia, central leptin resistance, and leptin deficiency are all associated with impaired postreceptor leptin ... Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1995; 1: 1311 ...
  http://circres.ahajournals.org/content/101/6/545.full
*  Effects of chronic leptin administration on nitric oxide production and immune responsiveness of greenfinches
Increase of plasma leptin was also induced by administration of anti-leptin, which can be most likely explained by increased ... This immune-enhancing effect was observable despite the similar plasma leptin levels of leptin-treated and control birds at the ... Here we tested the effects of chronic leptin and anti-leptin treatments on the NO production and phytohaemagglutinin- (PHA) ... Contrary to previous findings in mammals, leptin administration reduced systemic NO production. Leptin increased cutaneous ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:411641
*  Erythropoietin, Thrombopoietin and Leptin Receptors | SpringerLink
... and leptin are hormones with distinct physiological properties. While the first two regulate survival, growth and ... 1999 The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274: 30059-65.PubMedCrossRefGoogle Scholar ... 1996 Functional STAT 1 and 3 signaling by the leptin receptor ( OB-R); reduced expression of the rat fatty leptin receptor in ... 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in ...
  https://link.springer.com/chapter/10.1007/978-1-4757-3600-7_8
*  leptin - Symptoms, Treatments and Resources for leptin
Treatments and Tools for leptin. Find leptin information, treatments for leptin and leptin symptoms. ... leptin - MedHelp's leptin Center for Information, Symptoms, Resources, ... Anyone with Lyme Disease out there low on leptin, and can Lyme Disease cause low leptin? ... Beckerman, How is leptin resistance diagnosed and treated and for those who are ove... ...
  http://www.medhelp.org/tags/show/81274/leptin
*  Anti-Leptin antibody (ab7208) | Abcam
Rabbit polyclonal Leptin antibody validated for WB, sELISA and tested in Human. Referenced in 1 publication. Immunogen ... to Leptin (ab20101) at 1/200 and Detector Antibody Rabbit polyclonal to Leptin (ab7208) at 0.5µg/ml. Concentration of Mouse ... Standard curve for Leptin (Analyte: ab51273); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [BDI170] ... monoclonal [BDI170] to Leptin (ab20101) may vary from lot to lot; please use this curve as guideline. ...
  http://www.abcam.com/Leptin-antibody-ab7208.html
*  Anti-Leptin antibody (ab3583) | Abcam
Rabbit polyclonal Leptin antibody validated for WB, IHC, ICC, Flow Cyt, Inhibition, ICC/IF and tested in Human, Mouse and Rat. ... ab3583 staining Leptin in 3T3-L1 cells by Flow Cytometry. The sample was incubated with the primary antibody (3ug/ml in 2.5% ... Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer.. Exp ... ab3583 staining Leptin in 3T3-L1 cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with 4% ...
  http://www.abcam.com/leptin-antibody-ab3583.html
*  Anti-Leptin antibody (Biotin) | Abcam
Anti-Leptin antibody conjugated to Biotin validated for WB, ELISA and tested in Rat. Immunogen corresponding to recombinant ... Notes: detects 1.5 - 3.0 ng/lane of recombinant leptin under either reducing or non-reducing conditions Not yet tested in other ... Note: detects 0.2 - 0.4 ng/well of recombinant leptin. WB: Use at a concentration of 0.1 - 0.2 µg/ml. Predicted molecular ...
  http://www.abcam.com/leptin-antibody-biotin-ab55985.html
*  Anti-Leptin antibody (Biotin) | Abcam
Anti-Leptin antibody conjugated to Biotin validated for WB, ELISA, sELISA and tested in Rat. Immunogen corresponding to ... allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat Leptin. WB: Use at a concentration of 0.1 - 0.2 µg/ml. ... Allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat Leptin. sELISA: Use at a concentration of 0.25 - 1 µg/ml ... The detection limit for recombinant Rat Leptin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. ...
  http://www.abcam.com/leptin-antibody-biotin-ab84017.html