The basic approach of Sidney Stricklands laboratory is to use mouse models of neurological disease to elucidate the molecular ...

In Drosophila, four to five neurons (brown staining) in each larval brain hemisphere produce autonomous circadian rhythms of period, timeless, Clock and vrille gene expression. These "clock cells" persist in the adult brain where they regulate behavioral rhythmicity. Molecular rhythms are blocked, or the pace of the rhythm is altered, in these cells and in the adult by mutations that affect production of the PER, TIM, DBT, CLK, CYC, SGG or VRI proteins.. ...

The Rockefeller University , 1230 York Avenue, New York, NY 10065 , 212-327- ...

Laboratory of Biochemistry and Molecular Biology. Robert G. Roeder. Arnold and Mabel Beckman Professor ...