"39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein". The ... LDL-receptor-related protein-associated protein has been shown to interact with LRP2. Lipid metabolizing proteins may elevate ... LDL-Receptor+Related+Protein-Associated+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This ... Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which ...

LRP12 LDL receptor related protein 12 [Homo sapiens] LRP12 LDL receptor related protein 12 [Homo sapiens]. Gene ID:29967 ... low-density lipoprotein receptor-related protein 12. Names. LDLR-related protein 12. suppressor of tumorigenicity 7 protein. ... LDL receptor related protein 12provided by HGNC. Primary source. HGNC:HGNC:31708 See related. Ensembl:ENSG00000147650 MIM: ... LRP12 LDL receptor related protein 12 [ Homo sapiens (human) ] Gene ID: 29967, updated on 23-Nov-2023 ...

LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530-535 (2000). ... Bone morphogenetic proteins and secreted frizzled related protein 2 maintain the quiescence of adult mammalian retinal stem ... while the R-spondin family of proteins act as Lgr receptor agonists10. In congruence, the expansion capacity of organoids is ... 5d) including Eph4A, RNF43, SMO and the frizzled receptors FZD2 and FZD7 (Supplementary Table 1), all of which are known to ...

A gene encoding a novel transmembrane protein was identified by DNA sequence analysis within the insulin-dependent diabetes ... LDL-Receptor Related Proteins * Low Density Lipoprotein Receptor-Related Protein-5 * Membrane Proteins / genetics ... The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains ... three LDL-receptor (LDLR) repeats, a single transmembrane spanning domain, and a cytoplasmic domain. The encoded protein has a ...

... caused by mutations of the genes encoding proteins ... 2001) and LRP (LDL receptor-related protein) (May et al. 2007) ... May P, Woldt E, Matz RL, Boucher P (2007) The LDL receptor-related protein (LRP) family: an old family of proteins with new ... IL-1 receptor-associated kinase), an accessory protein recruited by interleukin-1 receptor and interacting with TRAF6 (Cao et ... Table 1 Mutation of genes encoding proteins involved in TNFα-related signal transduction pathway. Full size table. ...

High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002 May 16. 346(20):1513-21. [QxMD ... Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone ... Selective estrogen receptor modulators. Selective estrogen receptor modulators (SERMs) are considered to provide the beneficial ... Zebic L, Patel V. Preventing medication-related osteonecrosis of the jaw. BMJ. 2019 May 8. 365:l1733. [QxMD MEDLINE Link]. ...

Endocytosis by macrophages: interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1 (982 Online Views) ... Genomics of therapy-related myeloid neoplasms (1506 Online Views) Teodora Kuzmanovic, Bhumika J. Patel, Srinivasa R. Sanikommu ... Thrombopoietin receptor agonists for the treatment of inherited thrombocytopenia (629 Online Views) Michael Makris ... Conditions associated with polyclonal hypergammaglobulinemia in the IgG4-related disease era: a retrospective study from a ...

Chylomicron remnants are taken up by the LDL receptor or the LDL receptor-related protein. [14] ... and several of these have been shown to have defective binding to the LDL receptor and LDL receptor-like protein. These ... the LDL receptor is more accurately designated the B/E receptor. Apo E also binds with high affinity to the LDL receptor- ... Increased hepatic LDL uptake due to lower LDL receptor affinity of apo E2 and consequent decreased competition with the apo ...

... authors describe a previously unknown SBD in four families caused by mutations in TMEM53 and demonstrate the role this protein ... inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins ... which encodes a nuclear envelope transmembrane protein. Tmem53-/- mice recapitulate the human skeletal phenotypes. Analyses of ... Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone ...

2000) Modulation of amyloid beta-protein clearance and Alzheimers disease susceptibility by the LDL receptor-related protein ... C , Protein identification by MS/MS of tryptic digests of gel-extracted proteins yielded 101 total proteins exceeding MASCOT ... 2000) Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein ... NEEP21 contains a proline-rich N-terminal region, and the human form of a related protein, calcyon, is reported to bind group ...

... peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest., 2000, 106(12), 1489-1499.. [ ... Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for ... Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimers disease ... Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience, ...

... macrophage scavenger receptors and LDL receptor-related protein. Annu Rev Biochem 1994. 63:601-637. View this article via: ... and the related protein S100B, with nanomolar affinity (9). These findings lead us to predict that RAGE is a receptor for many ... Cloning and expression of RAGE: a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992. ... Enhanced cellular oxidant stress by the interaction of AGEs with their receptors/binding proteins. J Biol Chem 1994. 269:9889- ...

An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 2000 ... Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor predominantly expressed in adipose tissues to induce ... Peroxisome proliferator-activated receptor γ. WNT10B activates the canonical WNT signaling pathway to inhibit adipogenesis (33 ... The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca2+ pathway to antagonize Wnt/β-catenin ...

The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers ... The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers ... In people with HIV, age advancement was related to changes in the CD4+ T cell compartment and more reflective of immune ... These data suggest that varying exposures to lifestyle and infection-related factors may be associated with specific changes in ...

These included (i) temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis and (ii) post- ... These included (i) temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis and (ii) post- ... LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl ... The role of low-density lipoprotein receptor-related protein 1 in lipid metabolism, glucose homeostasis and inflammation. Int J ...

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Beisiegel, U., Weber, W., Ihrke, G., Herz, J., ... The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. Papkoff, J., Nigg, E.A., Hunter, T. ... Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive ... Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Choi, K.Y., Satterberg, B ...

low-density lipoprotein (LDL) receptor-related protein associated protein 1. MICA. MHC class I polypeptide-related sequence A. ... The LDL receptor-related protein associated protein 1 (LRPAP1; OR = 1.73, 95% CI: 1.49-1.97) is involved as an escort protein ... LDL) receptor-related protein associated protein 1, MICA = MHC class I polypeptide-related sequence A, NCR3 = natural ... LDL) receptor-related protein associated protein 1, MICA = MHC class I polypeptide-related sequence A, NCR3 = natural ...

LDL receptor-related protein-1 is a sialic-acid-independent receptor for myel... 2013 J Cell Sci. Stiles T.L. et al. DOI: ... Toll-like receptor mediated activation is possibly involved in immunoregulati... 2017 PLoS One. Kiewiet M.B. et al. DOI: ... LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differen... 2012 J Biol Chem. Jepson S. et al. DOI: ...

LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. Journal of the ... Pioneering work from this lab led to the identification of PLA2R (phospholipase A2 receptor) as the major target antigen in ... M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. New England Journal of Medicine, 2009 ...

... and of LDL-cholesterol, (the "bad" cholesterol), and raising the level of HDL-cholesterol (the "good" cholesterol). ... The protein that interferes with low-density lipoprotein (LDL) receptors that clear bad ... ... RELATED STORIES. Protein That Blocks Bodys Ability to Clear Bad Cholesterol Identified ... The results indicate that GTF acts similarly to insulin in the rats, lowering the level of glucose, and of LDL-cholesterol, ( ...

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its ... May P, Woldt E, Matz RL, and Boucher P (2007) The LDL receptor-related protein (LRP) family: an old family of proteins with new ... low-density lipoprotein receptor-related protein; RAP, receptor-associated protein; APP, amyloid precursor protein; KPI, Kunitz ... 2000) Clearance of Alzheimers amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier ...

Where you can participate in cutting-edge research and graduate programs that span a wide range of cancer-related topics. ... 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2- ... Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer. Journal of ... Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. ...

... cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of ... The protein that interferes with low-density lipoprotein (LDL) receptors that clear bad ... ... LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels ... LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels ...

... also called α2-macroglobulin receptor or the LDL-related protein), as it has been demonstrated to bind directly to a number of ... CD91: a receptor for heat shock protein gp96. Nat. Immunol. 2000. 1:151-155. View this article via: PubMed CrossRef Google ... CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity. 2001. 14:303-313. View this ... The protein concentration of each sample was also assessed by use of the Bio-Rad protein assay reagent in accordance with the ...

... to yield chylomicron remnant particles which are cleared by LDL receptors (LDLR) and LDLR-related proteins to the liver. The ... "Rhein protects against obesity and related metabolic disorders through liver X receptor-mediated uncoupling protein 1 ... found that the herb water extract (50 and 100 mg/kg/day, 30 days) significantly reduced the levels of serum TC, LDL and ox-LDL ... IDL and LDL) and HDL2 in a process regulated by the cholesterol ester transfer protein (CETP). In addition to the cholesterol ...

... and LDL receptor-related proteins (LRP) 5/6 (Angers and Moon, 2009; Bhanot et al., 1996; McNeill and Woodgett, 2010; Pinson et ... Dictyostelium use a distinct signal, secreted cAMP, that targets a family of specific cell-surface receptors (CAR1, CAR2, CAR3 ... Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together ... In Dictyostelium, the interaction of secreted cAMP with specific cell surface receptors regulates the activation/de-activation ...

Mutation In EGFP Domain of LDL Receptor-Related Protein 6 Impairs Cellular LDL Clearance. Circulation Research 2008;103(11): ... Wnt coreceptor LDL receptor-related protein 6 (LRP6) gene was the very first monogenic cause of coronary artery disease (OMIM: ... Low density lipoprotein (ldl) receptor-related protein 6 (lrp6) regulates body fat and glucose homeostasis by modulating ... LRP6 Regulates LDL Receptor Internalization and LDL UptakeMani A, Go G, Ye Z, Singh R. Abstract 321: LRP6 Regulates LDL ...

... inhibiting LDL receptor related protein 6 expression and enhancing β-catenin signaling, or binding to splicing factor proline ... RUNX2, Runt-related transcription factor 2; miR, microRNA; ER, estrogen receptor; NRF2, nuclear factor erythroid 2-related ... 132). ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2. ... The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in ...

View our 6 Norrin products for your research including Norrin Primary Antibodies and Norrin Proteins and Enzymes. ... requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway. ... Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to ... Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein, mutations in which cause Norrie disease (X ...

LDL receptor related protein 6. The human orthologue of this gene is associated. with the following human disease:*{Coronary ... low-density lipoprotein receptor-related protein 6,LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6,low ... LDL receptor related protein 6. CGNC ID. 8784. also known as. ... density lipoprotein receptor-related protein 6. gene type. ...