Gu C, Jan YN, Jan LY (2003). "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels". Science ... human K+ channel I), RBK1 (rubidium potassium channel 1), MBK (mouse brain K+ channel), voltage gated potassium channel HBK1, ... Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel ... KCNA1 potassium voltage-gated channel". "KCNA1 - Potassium voltage-gated channel subfamily A member 1 - Homo sapiens (Human) - ...

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... Voltage-gated potassium channel autoimmunity mimicking Creutzfeldt-Jakob disease. Arch Neurol 2008;65:1341-6. ... Neurological manifestations related to level of voltage-gated potassium channel antibodies. J Neurol Neurosurg Psychiatry 2013; ... Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral ...

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... Kinesigenic dyskinesia in a case of voltage-gated potassium channel-complex protein antibody encephalitis. Arch Neurol 2011;68: ... voltage-gated potassium channel complex. Faciobrachial dystonic seizures (FBDS) are a recently recognized immunotherapy- ... Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping. JAMA Neurol 2013;70:229-234. ...

... in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein is truncated at amino acid 230 out of 495. ... Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph ... Interactions between MCEPH and other Kv1 subunits were studied in cell culture, Xenopus oocytes and the brain. MCEPH can form ... Gu C, Jan YN, Jan LY: A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science. 2003, ...

... on the steady-state inactivation of Kv1.3 channels expressed in human lymphocytes. The obtained data showed that lowering the ... 6), which was significantly higher (p < 0.05) than the shift caused by Zn2+ alone. The Zn2+-induced shift of the Vi at pH ... 6) towards positive membrane potentials. This shift was also statistically significant (p < 0.05). The total shift of the Vi ... extracellular pH from 7.35 to 6.8 shifted the inactivation midpoint (Vi) by 17.4 ± 1.12 mV (n = 6) towards positive membrane ...

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet ... a subunit of Kv4.2 potassium channels. Ann Neurol 2013; 73: 120-128. doi: 10.1002/ana.23756. PMID: 23225603. ... Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders. Front Genet ...

2015 Quantitative confocal microscopy analysis as a basis for search and study of potassium Kv1.x channel blockers ... 2016 Kalium: a database of potassium channel toxins from scorpion venom * Kuzmenkov Alexey I., Krylov Nikolay A., Chugunov ... 2013 Variability of potassium channel blokers in Mesobuthus eupeus scorpion * Авторы: Kuzmenkov A.I., Vassilevski A.A., ... 2014 Variability of potassium channel blockers in Mesobuthus eupeus scorpion * Kuzmenkov A.I., Vassilevski A.A., Kudryashova K. ...

The voltage-gated potassium channel Kv1.1, which is abundant in the CNS and peripheral nervous system, controls neuronal ... channels. AgTx2-GFP possesses subnanomolar affinities for hybrid KcsA-Kv1.x (x = 3, 6) channels and a low nanomolar affinity to ... The growing interest in potassium channels as pharmacological targets has stimulated the development of their fluorescent ... The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is a tumor-specific acid-sensing channel, and its targeting can be considered ...

The family of two-pore domain potassium (K2P) channels. Historical overview. Potassium (K+) channels constitute the largest ... et al. Key role of Kv1 channels in vasoregulation. Circ Res 2006; 99: 53-60. ... Regulation of pulmonary vascular tone by potassium and calcium channels. Channel proteins are indicated by yellow (K+ channels ... et al. Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc ...

Product code: N/A. Categories: Kv channels, Potassium channels. Tags: 221889-63-0, Kv4. ... by altering the gating properties of these channels. 3. Neither are the Shaker (Kv1), Shab (Kv2) & Shaw (Kv3) subfamilies of ... Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis ... 1999) Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac ...

... voltage-gated potassium channel (VGKC) complexes (Kv1 subunit, leucine-rich glioma inactivated (LGI1) and contactin associated ... Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet ... Liu Y, Ho RC, Mak A: Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R) ... Leonard BE: The concept of depression as a dysfunction of the immune system. Curr Immunol Rev 2010, 6:205-212. ...

voltage-gated potassium channel activity delayed rectifier potassium channel activity potassium channel activity protein ... channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1 ... Protein Aliases: brain potassium channel protein-1; IA; MBK1; megencephaly; MGC126782; MGC138385; MKI; potassium (K+) channel ... potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily ...

A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein ... channels relative to typical mammalian CNGs. Similar to BRUSH, Kv1-Kv4 channel gating and subunit interactions are mediated by ... 1990) Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB Science 250:568-571. ... channels rather than the classical animal CNGC channels.. There is still much that is unknown about CNGC channels in plants and ...

Several Kv1.3 channel blockers have been characterized from scorpion venom; however, extensive studies require amounts of toxin ... In this work, we developed an efficient system for the production of three potent Kv1.3 channel blockers from different ... The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. ... The Kv channel family includes 12 subfamilies (Kv1-Kv12). The Kv1 (Shaker) subfamily consists of eight voltage-gated potassium ...

KTX-Sp4 could have related function with blocking Kv1.three channels, however it is essential to investigate the biological ... Da.Modulation of KTXSp4 on endogenous voltagegated potassium channelsexamined no matter if KTX-Sp4 could block endogenous Kv1. ... To avoid activation on the SKCa2 channel, a pipette option containing nearly zero cytosolic Ca2+ was adopted. Kv1.3-mediated ... which can be related towards the scorpion classical K+-channel blockers. The KTX-Sp4 was discovered identical with HLKTx4 [14 ...

HCN and low voltage-activated potassium channels have been implicated as the currents responsible for producing resonance ( ... 2004) Kv1 currents mediate a gradient of principal neuron excitability across the tonotopic axis in the rat lateral superior ... 2011) Grid cells use HCN1 channels for spatial scaling. Cell 147:1159-1170. doi:10.1016/j.cell.2011.08.051 pmid:22100643. ... 2016) Serotonin modulates spike probability in the axon initial segment through HCN channels. Nat Neurosci 19:826-834. doi: ...

We find an important role of Kv1-type potassium channels and show in addition that these channels act as a gating mechanism to ... We find an important part of Kv1-type potassium channels and show in addition that these channels act as a gating mechanism to ... 0.05). (KATP) potassium stations play only a function, voltage-gated potassium stations from the Kv1 family members play a ... GIRK channels in regulating DA release raises the question as to whether such channels or other types of potassium channels are ...

Cytochrome P450 3A4/CYP3A4+Maxi Potassium channel alpha/SLO+Maxi Potassium channel beta/KCNMB1+CYP2C (2). ... Kv2.2/KCNB2+KCNA10+KCNA5/KV1-5+Kir7.1/KCNJ13+KCND1 (1). * MC1-R+MC4-R+MC3-R+MC-2 (1). ... GABA Transporter 1 / GAT 1+Estrogen Receptor+Maxi Potassium channel alpha/SLO+Maxi Potassium channel (1). ... COX2 / Cyclooxygenase 2+COX1 / Cyclooxygenase 1+Maxi Potassium channel alpha/SLO+Maxi Potassium chan (1). ...

... where Kv1 potassium channels are concentrated; and (4) the internode, which are covered by compact myelin (Fig. 1). In the ... resulting in the sequestering of Kv1 channels (blue) in the juxtaparanodal region (JXP) away from nodal sodium channels (red). ... resulting in the sequestering of Kv1 channels (blue) in the juxtaparanodal region (JXP) away from nodal sodium channels (red). ... despite the abnormal presence of Kv1 channels at the paranodes and nodes, and in contrast to all known mutants lacking the ...

Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ... We examined the effects of axotomy on mRNA levels for various Kv1 family subunits and voltage-gated K+ curre... ...

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... In adults with AE, most antibodies to the voltage-gated potassium channel complex (VGKCC) do not bind to the channel, but to ... Clinical relevance of voltage-gated potassium channel-complex antibodies in children. Neurology 2015;5:967-975. ... Cytokine-related and sodium channel polymorphism as candidate predisposing factors for childhood encephalopathy FIRES/AERRPS. J ...

TITLE gsquid.mod squid potassium channel : FORREST MD (2014) Two Compartment Model of the Cerebellar Purkinje Neuron COMMENT ... kv1.mod *. Other models using kv1.mod:. Alcohol action in a detailed Purkinje neuron model and an efficient simplified model ( ... This is the original Hodgkin-Huxley treatment for the set of sodium, potassium, and leakage channels found in the squid giant ... potassium activation system alpha = .01*vtrap(-(v+55),10) beta = .125*exp(-(v+65)/80) sum = alpha + beta ninf = alpha/sum nexp ...

Shaw Potassium Channels Medicine & Life Sciences 46% * Voltage-Gated Potassium Channels Medicine & Life Sciences 42% ... The Kv family (Kv1-Kv6 and Kv8-Kv9 subfamilies). Rudy, B., Maffie, J., Amarillo, Y., Clark, B., Jeong, H. Y., Kruglikov, I., ... Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. ... Kwon, E., Nadal, M. & Zagha, E., Mar 22 2012, Ion Channels: From Structure to Function. Oxford University Press. Research ...

Oxygen-sensitivity of Kv1 potassium channels , , Conforti L, Freeman T. Millhorn D 06-1999. Regulation of Shaker-type potassium ... Oxygen-sensitive potassium channels in T lymphocytes FASEB J, 16 , A60. Petrovic M, Conforti L, Burnham C, Petrovic S, Wang Z, ... Potassium channels of T lymphocytes take center stage in the fight against cancer. Journal for immunotherapy of cancer, 5 , 2 ... Molecular basis and functional role of oxygen sensitive potassium channels , , Li H, Petrovic S, Petrovic M, Conforti L, Barone ...

The first is a group of diseases with antibodies against ion channels (voltage-gated potassium channels [VGCK]). This group of ... whereas symptoms of neuromyotonia and Morvans syndrome are more closely related to antibodies to the Kv1.2 channel.5 ... Antibodies against potassium channels have been described4 and animal experiements have shown that the disease can by ... Indeed, the potassium channel antibodies have been demonstrated to target two secreted neuronal proteins that function as ...

None of the 27 Kv1-precipitating samples bound live hippocampal neurons or Kv1 extracellular domains, but 16 (59%) bound to ... IgG precipitation of 125I-αDTX and 125I-αDTX-labelled Kv1 subunits, and by cell-based assays which expressed Kv1 subunits, LGI1 ... These intracellular Kv1 antibodies mainly associated with non-immune disease aetiologies, poor longitudinal clinical- ... CONCLUSIONS: Double-negative VGKC complex antibodies are often directed against cytosolic epitopes of Kv1 subunits and ...

COMMENT km.mod Potassium channel, Hodgkin-Huxley style kinetics Based on I-M (muscarinic K channel) Slow, noninactivating ... Kv1.mod *. Other models using Kv1.mod:. Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted) ... The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model ... Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008). ...

INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autistic disorder (ortholog); developmental and epileptic ... ENCODES a protein that exhibits voltage-gated potassium channel activity (ortholog); ... K_chnl_volt-dep_Kv1. UniProtKB/TrEMBL. K_chnl_volt-dep_Kv_tetra. UniProtKB/TrEMBL. ... cyclic GMP gated potassium channel; potassium channel, voltage gated shaker related subfamily A, member 10; potassium voltage- ...