Krüppel-like factors, KLF, Obesity, PPAR, C/EBP, SREBP proteins, Transcription factor ... Krüppel-like family of transcription factors: an emerging new frontier in fat biology. Int J Biol Sci. 5(6):622-636. ... Krüppel-like family of transcription factors: an emerging new frontier in fat biology Christopher W. Brey1, Mark P. Nelder1, ... Brey CW, Nelder MP, Hailemariam T, Gaugler R, Hashmi S. Krüppel-like family of transcription factors: an emerging new frontier ...

The Krüppel protein is a transcription factor, and has been shown to act as a repressor. It functions in collaboration with ... Brey CW, Nelder MP, Hailemariam T, Gaugler R, Hashmi S (October 2009). "Krüppel-like family of transcription factors: an ... Human homologs of Krüppel are collectively named Krüppel-like factors, a set of proteins well characterized for their role in ... Krüppel has shown homology to the mammalian Krüppel-like factors, which play key biological roles in the pathogenesis of many ...

Kruppel-Like Transcription Factors * Lung / abnormalities * Lung / embryology* * Lung / metabolism * Membrane Proteins / ... In mice, three zinc-finger transcription factors, Gli1, Gli2 and Gli3, have been implicated in the transduction of Shh signal. ...

Kruppel-Like Transcription Factors * MYCN protein, human * N-Myc Proto-Oncogene Protein ...

Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. J. Immunol. 178, 5496-5504 (2007). ... The transcription factor FLI-1 was shown to induce CCL5 expression in endothelial cells by binding to the Ccl5 promoter43, and ... The Fli-1 transcription factor regulates the expression of CCL5/RANTES. J. Immunol. 193, 2661-2668 (2014). ... RUNX transcription factor family proteins hetero-dimerizing with CBFβ, an essential partner protein, play important roles in ...

N2 - Krüppel-like transcription factors (KLFs) have elicited significant attention because of their regulation of essential ... AB - Krüppel-like transcription factors (KLFs) have elicited significant attention because of their regulation of essential ... Krüppel-like transcription factors (KLFs) have elicited significant attention because of their regulation of essential ... Dive into the research topics of Disruption of a novel krüppel-like transcription factor p300-regulated pathway for insulin ...

Kaczynski, J.; Cook, T.; Urrutia, R. Sp1- and Kruppel-like transcription factors. Genome Biol. 2003, 4, 206. [Google Scholar] ... Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic ... A number of members of the Sp1-like/KLF family of transcription factors (SP1, SP5, KLF10, KLF11, KLF13, KLF15, KLF16, KLF3, ... The AT-hook transcription factors, of which AKNA is a member, repress or activate gene networks controlling inflammation, ...

... signaling in naive T cells induces expression of the transcription factor Foxp3, a master regulator of regulatory T cells (T( ... Forkhead Transcription Factors * KLF10 protein, human * Kruppel-Like Transcription Factors * Repressor Proteins ... Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a ... regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor ...

This process involved the inhibition of genes that encode the early adipogenic transcription factors, e.g., Krüppel-like factor ... Brey, C.W.; Nelder, M.P.; Hailemariam, T.; Gaugler, R.; Hashmi, S. Krüppel-like Family of Transcription Factors: An Emerging ... They found that another Wnt pathway effector molecule, transcription factor 7-like 2 (Tcf7l2), is the target of the microRNA ... Karagianni, P.; Talianidis, I. Transcription Factor Networks Regulating Hepatic Fatty Acid Metabolism. Biochim. Biophys. Acta ...

Krüppel-related Zinc Finger Proteins. Helix-Loop-Helix Transcription Factors. Ephrins and Ephrin Receptors. Epidermal Growth ... 5. Transcription and RNA Processing. RNA Metabolism. RNA Polymerase and General Transcription Factors. hnRNP. Small RNAs in RNA ... Additional Genes in Development (includes MAF family, doublesex-related proteins, AP-2 transcription factors, MEF family, tubby ... Fibroblast Growth Factors. TGF-β Family. Growth Hormone and Related Hormones. Cadherins and Related Proteins. Melanoma Antigen ...

Krüppel-like factors (KLFs) are zinc finger transcription factors that share homology in three C-terminal zinc finger domains. ...

Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem ... and Gene Transcription Regulation Database (GTRD) (40) suggested that KLF4 may be a transcription factor involved in the ... Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells. FEBS Open Bio. ... Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem. 2005;280(46):38247-38258.. View ...

Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of ... Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.. Sci Rep. 2017; 7(1):8119 [PubMed] ... The transcription factor V-Ets avian erythroblastosis virus E26 oncogene homolog 2 (ETS2) was elevated in smooth muscle actin- ... The homeodomain transcription factor MEIS1 triggers chemokine expression and is involved in CD8+ T-lymphocyte infiltration in ...

1. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and kruppel-like factor family of transcription factors in cell growth ... Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule ... 2. Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppel-like transcription factors. Genome Biol. 2003;4:206 ... Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [1, 2]. ...

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during ... Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes.﻽. Steiner LA ... The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors ... HEXIM1 is an Essential Transcription Regulator During Human Erythropoiesis.﻽. Lv X, Murphy K, Murphy Z, Getman MR, Rahman NF, ...

... a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in ... phosphorylated eukaryotic initiation factor 2,i,α,/i, (eIF2,i,α,/i,), phosphorylated protein endoplasmic-reticular- ... Kruppel-like factor 6 (KLF6), a tumor suppressor and transcription factor, binds to the ATF-3 gene promoter and induces ATF-3 ... Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress ...

1994The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repressionPNAS. 91:4514-4518 ... Mammalian TIF1 proteins are chromatin-associated factors that have been shown to play an essential role in transcription, cell ... SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting ... The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that ...

Class: transcription. Keywords: Transcription Factor TFIIH, Erythroid Kruppel-Like Factor EKLF, Activator, Protein Structure, ... Compound: RNA polymerase II transcription factor B subunit 1. Species: Saccharomyces cerevisiae S288c [TaxId:559292]. Gene: ... R-factor: N/A. AEROSPACI score: 0.02 (click here for full SPACI score report) Chains and heterogens:. *Chain A:. ... Compound: Krueppel-like factor 1. Species: Homo sapiens [TaxId:9606]. Gene: EKLF, KLF1. Database cross-references and ...

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein ...

RESULTS: The authors report that Kruppel-like factor 4 (KLF4), a transcription factor of the KLF family, is an important target ... Liu S, Zhang H, Zhu L, Zhao L and Dong Y. Kruppel-like factor 4 is a novel mediator of selenium in growth inhibition. Molecular ... The increase of KLF4 mRNA is accounted for primarily by enhanced transcription, although the contribution of a slight abatement ... BACKGROUND: NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by ...

The Kruppel-like transcription factor zinc finger protein (ZNF)217 (mouse homolog ZFP217) contributes to tumorigenesis by ... regulation of transcription, DNA-dependent - sequence-specific DNA binding transcription factor activity - transcription ... Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation ... which is a transcription factor and a component of a Hela-S-derived HDAC1 complex, as a novel MDM2-interacting protein. When co ...

Erythroid Kruppel Like Factor (EKLF/KLF1) is a transcription factor that is essential for the proper regulation of hemoglobin ...

Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S (2008) Krüppel-like transcription factors: A functional family. Int J ... or forcing the expression of pro-regenerative factors (20, 21). A transcription factor called KLF6 has emerged as a ... Blackmore MG, et al. (2012) Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the ... KLF6 is a pro-regenerative transcription factor that is expressed by corticospinal tract (CST) neurons during periods of axon ...

miR-10b-5p targets the transcription factor Kruppel-like factor 11 (KLF11), which negatively regulates KIT expression. The miR- ... The data suggest that ERalpha plays a predominant role in E2-mediated transcription in E(t)C.1 cells. Our data are discussed in ... Activation of microglia with pro-inflammatory factors, LPS and INFgamma did not affect the enzymatic properties of these ... E2-induced ERE-Luc transcription was not increased by overexpression of hERalpha. In contrast, hERbeta overexpression reduced ...

... such as Kruppel-Like Factor 5 (KLF5), Kruppel-Like Factor 4 (KLF4), and the potent transcriptional coactivator myocardin (MYOCD ... the miRNA-143/145 cluster coordinates the phenotypic modulation of VSMC through a cooperative network of transcription factors ... Demographic, anthropometric, and cardiovascular risk factors such as diabetes, hypertension, and dyslipidemia were recorded. ... from a contractile to a proliferative state under the induction of platelet-derived growth factor (PDGF), resulting in ...

Octamer-binding transcription factor 4 (OCT-4), sex-determining region Y-box 2 (SOX2), and Kruppel-like factor 4 (KLF-4) ( ... The authors of the present study previously demonstrated that ectopically induced transcription factors, ... Growth Factor, Hypoxia, Imaging, Induced Pluripotent Stem Cells, Inflammation, Interferon, Kinase, Lentivirus, OCT, ... Phosphorylation, Pluripotency, Ribonucleic Acid, RNA, Small Molecules, Somatic Cells, Stem Cells, Transcription, Transcription ...

Purpose: To determine the role and mechanisms of Krüppel-like transcription factor 8 (KLF8) in acute myeloid leukemia (AML).. ...

... local densities of binding sites for multiple transcription factors (Bico ... local densities of binding sites for multiple transcription factors (Bicoid, Caudal, Hunchback, Kruppel and Knirps) using ... describes a similar study using clusters of binding sites to identify novel targets genes for the Dorsal transcription factor ( ... local densities of binding sites for multiple transcription factors (Bico. Jonathan Weitzman([email protected]) ...

In co-cultivated supernatants, the concentration of inflammatory factors in the experimental group was significantly lower than ... In co-cultivated supernatants, the concentration of inflammatory factors in the experimental group was significantly lower than ... while that in immunosuppressive factors was not significantly different. ... while that in immunosuppressive factors was not significantly different. ...