*  Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo
... Kyoung Hoon Jeong,1,2 ... Q. Wang, S. Yu, A. Simonyi, G. Y. Sun, and A. Y. Sun, "Kainic acid-mediated excitotoxicity as a model for neurodegeneration," ... J. J. Shacka, J. Lu, Z.-L. Xie, Y. Uchiyama, K. A. Roth, and J. Zhang, "Kainic acid induces early and transient autophagic ... Y. Jin, C.-M. Lim, S.-W. Kim et al., "Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus," ...
  https://www.hindawi.com/journals/ecam/2015/354326/ref/
*  Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo
... Kyoung Hoon Jeong,1,2 ... Kainic acid (KA) is well known as a chemical compound to study epileptic seizures and neuronal excitotoxicity. KA-induced ...
  https://www.hindawi.com/journals/ecam/2015/354326/abs/
*  Kainic acid - Wikipedia
Kainic acid, or kainate, is an acid that naturally occurrs in some seaweed. Kainic acid is a potent neuroexcitatory amino acid ... Kainic acid is commonly injected into laboratory animal models to study the effects of experimental ablation. Kainic acid is a ... In addition to inducing seizures, kainic acid is excitotoxic and epileptogenic. Kainic acid induces seizures via activation of ... concentrated doses kainic acid can be considered a neurotoxin, and in small doses of dilute solution kainic acid will ...
  https://en.wikipedia.org/wiki/Kainic_acid
*  Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain? | SpringerLink
Systemic or intracerebral injection of the neurotoxin kainic acid (KA) in rats induces a limbic seizure and brain damage ... Berger, M.L., Charton, G., and Ben-Ari, Y., The effect of seizures induced by intra-amygdaloid kainic acid on kainic acid ... Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain?. ... Maturation of kainic acid seizure-brain damage syndrome. III. Postnatal development of kainic acid binding sites in the limbic ...
  https://link.springer.com/chapter/10.1007/978-1-4684-7971-3_15
*  Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death...
Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death ... Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death ...
  http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02826.x/references
*  Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.
Systemic injection of kainic acid (KA) in the rat produces an animal model of human temporal lobe epilepsy. We examined the ... Glutamic Acid / metabolism*. Humans. Kainic Acid. Male. Neurons / cytology, metabolism. Patch-Clamp Techniques. Rats. Rats, ... 0/Amino Acid Transport System X-AG; 0/Excitatory Amino Acid Agonists; 0/Excitatory Amino Acid Transporter 3; 0/Glutamate Plasma ... Systemic injection of kainic acid (KA) in the rat produces an animal model of human temporal lobe epilepsy. We examined the ...
  http://www.biomedsearch.com/nih/Translocation-glutamate-transporter-subtype-excitatory/12875997.html
*  Matrix Metalloproteinase-7 Regulates Cleavage of Pro-Nerve Growth Factor and Is Neuroprotective following Kainic Acid-Induced...
1a). Kainic acid treatment also induced p75NTR expression in the same areas, which colocalized with PI labeling (Fig. 1b). ... Animals and kainic acid-induced seizures.. Adult male Sprague Dawley rats (250-275 g) were injected with KA (10 mg/kg, i.p.) ... Kainic acid treatment induces p75NTR-mediated cell death in organotypic hippocampal slice cultures. To examine the regulation ... d, Cell death following kainic acid treatment is p75NTR dependent. Slice cultures treated with a blocking antibody to p75NTR at ...
  http://www.jneurosci.org/content/32/2/703.full
*  Intra-Amygdaloid Injection of Kainic Acid in Rats with Genetic Absence Epilepsy: The Relationship of Typical Absence Epilepsy...
8A,B). However, this increase was less pronounced in kainic acid-injected GAERS than in kainic acid-injected Wistar rats (p , ... This breakdown may depend on the greater severity of the insult with kainic acid. Kainic acid or kindling models in rats with ... 1986) Effects of seizure-induced by intra-amygdaloid kainic acid on kainic acid binding sites in rat hippocampus and amygdala. ... p , 0.001, less-pronounced increase in kainic acid-injected GAERS than in kainic acid-injected Wistar rats. ...
  http://www.jneurosci.org/content/28/31/7828
*  Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat | Springer...
Adenomatous polyposis coli Astrocytes Oligodendrocytes GSK-3beta Beta-catenin Kainic acid This is a preview of subscription ... Zhang X, Le Gal La Salle G, Ridoux V et al (1997) Prevention of kainic acid-induced limbic seizures and Fos expression by the ... Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat. ... Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J Comp Neurol 192:333-359CrossRef ...
  https://rd.springer.com/article/10.1007/s11064-009-0036-3
*  Long-Term Expression of Proenkephalin and Prodynorphin in the Rat Brain after Systemic Administration of Kainic Acid - an in...
Kainic acid (KA) is a glutamate analog that binds to and activates ionotropic glutamate receptors. Administration of KA causes ... Granule Cell Dentate Gyrus Mossy Fiber Opioid Peptide Kainic Acid These keywords were added by machine and not by the authors. ... Kainic acid (KA) is a glutamate analog that binds to and activates ionotropic glutamate receptors. Administration of KA causes ... J. S. Hong, L. Grimes, T. Kanamatsu, and J. F. McGinty, Kainic acid as a tool to study the regulation and function of opioid ...
  https://rd.springer.com/chapter/10.1007/978-1-4899-0209-2_2
*  JAIRO | Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment...
Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment(要約)Acute ... reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment(要約). 神経特異的RNA結 ...
  http://jairo.nii.ac.jp/0050/00052581/en
*  DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. -...
By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread ... Excitatory Amino Acid Agonists, Heterozygote, Hippocampus, Immunohistochemistry, In Situ Nick-End Labeling, Kainic Acid, ... DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. ... By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread ...
  https://www.psy.ox.ac.uk/publications/374484
*  "Kainic acid receptor sites in the cerebellum of nervous, purkinje cell" by C A. Griesser, M Cuenod et al.
Kainic acid receptor sites in the cerebellum of nervous, purkinje cell degeneration, reeler, staggerer and weaver mouse mutant ... Griesser, C A.; Cuenod, M; and Henke, H, "Kainic acid receptor sites in the cerebellum of nervous, purkinje cell degeneration, ...
  https://mouseion.jax.org/ssbb1982/4154/
*  Seizures in the intrahippocampal kainic acid epilepsy model : characterization using long-term video-EEG monitoring in the rat ...
Seizures in the intrahippocampal kainic acid epilepsy model : characterization using long-term video-EEG monitoring in the rat ...
  https://repository.uantwerpen.be/link/irua/92283
*  Marine Drugs | Free Full-Text | Domoic Acid Epileptic Disease | HTML
Here, we present the concept of domoic acid epileptic disease as a delayed manifestation of domoic acid poisoning and review ... and was characterized as a chronic epileptic syndrome in California sea lions through investigation of a series of domoic acid ... Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. ... Although kainic acid acts via specific endogenous kainic acid receptors to produce the neurological sequelae [23], this model ...
  http://www.mdpi.com/1660-3397/12/3/1185/htm
*  Metabotropic glutamate receptors (mGluR) - GPCR / G Protein
Kainic acid monohydrate Kainate receptor agonist Kainate class of ionotropic glutamate receptor agonist. Has been shown to ... Ibotenic Acid NMDA& mGlu receptor agonist Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita ...
  http://www.adooq.com/metabotropic-glutamate-receptors-mglur.html
*  EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced...
kainic acid;. AP-1,. activator protein-1;. EMSA,. electrophoretic mobility-shift assay;. ROS,. reactive oxygen species;. SBDP, ... stress and neuropathology produced in the rat limbic system as a result of seizure activity elicited by systemic kainic acid ( ... Abscisic Acid and LATERAL ROOT ORGAN DEFECTIVE/NUMEROUS INFECTIONS AND POLYPHENOLICS Modulate Root Elongation via Reactive ... proposed to account for the pathological manifestations observed after systemic administration of the excitotoxin kainic acid ( ...
  http://www.pnas.org/content/96/17/9897.full
*  IJMS | Free Full-Text | Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application | HTML
Kainic acid (KA) and pilocarpine [11,12] are two common chemoconvulsants used to induce post-status epilepticus model in ... brain-derived neurotrophic factor (BDNF); electrical stimulation; erythropoietin; GABAergic neuron; kainic acid; kindling; ... decrease of inhibitory gamma-aminobutyric acid positive (GABAergic) interneurons, formation of abnormal neuronal circuit and ...
  http://www.mdpi.com/1422-0067/14/12/23390/htm
*  June 5th, 2000 - Volume 11 - Issue 8 : NeuroReport
Increase of GAP-43 expression following kainic acid injection into whisker barrel cortex. Yamamoto, Takamichi; Nguyen, Tien T ... A new member of acid-sensing ion channels from pituitary gland. Gründer, Stefan; Geissler, Hyun-Soon; Bässler, Eva-Lotta; More ... Amino acids in spinal dorsal horn of patients during surgery for neuropathic pain or spasticity. Mertens, Patrick; Ghaemmaghami ... Excitatory amino acids modulate epileptogenesis in the brain stem. Elazar, Zeev; Berchanski, Alex ...
  http://journals.lww.com/neuroreport/toc/2000/06050
*  Plus it
Kainic acid (KA; Ascent or Sigma-Aldrich) was dissolved in 0.9% saline and administered (30 mg/kg; i.p.) in a volume of 10 ml/ ... Nucleic Acids Res 30:e36, doi:10.1093/nar/30.9.e36, pmid:11972351. ... acetic acid) and a house light (25 lx) turned on. After 3 min, a 20 s tone (80 dB, 9 kHz sine wave, 10 ms rising and falling ...
  http://www.jneurosci.org/content/33/25/10264
*  Plus it
Kainic acid-induced seizures.. Rats with the ALZET pump implants (see above) were injected with kainic acid (15 mg/kg, i.p.; ... 1996) Kainic acid-induced seizures enhance dentate gyrus inhibition by downregulation of GABAB receptors. J Neurosci 16:4250- ... Latency to onset of first kainic acid-induced clonic seizure is shown (mean ± SEM; estradiol vs oil, #p , 0.0001; estradiol vs ... 2000) Kainic acid induces distinct types of epileptiform discharge with differential involvement of hippocampus and neocortex. ...
  http://www.jneurosci.org/content/27/22/6054
*  Plus it
Intrahippocampal kainic acid (KA) injection. Eight-week-old C57bl/6 mice were anesthetized with 5% inhaled isoflurane and ...
  http://www.eneuro.org/content/4/6/ENEURO.0364-17.2017
*  Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo | Journal of...
GlutamateKainic AcidWild Type LittermateGlutamate Receptor SubunitGluR2 Receptor. Background. The complement system is an ... Kainic Acid (KA) mediated lesions. All procedures involving animals met the guidelines described in the NIH Guide for the Care ... Kainic acid (KA) is an agonist for a subtype of ionotropic glutamate receptor, and administration of KA has been shown to ... Kainic acid (KA) is a potent glutamate receptor agonist with selectivity towards non-NMDA type glutamate receptors. Both ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-5
*  Buy Biochemical
Kainic acid, Biochemical. (#MBS842979). • Kainic acid. Other Names: (2S,3S,4S)-Carboxy-4-(1-methylethen-yl)-3-pyrrolidineacetic ... 3-[[[4-[4-[[[1- (2-Chlorophenyl) ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid. ... Kdo2-Lipid A ((3-Deoxy-D-manno-octulosonic acid)2-Lipid A). ...
  https://www.mybiosource.com/product.php?name=biochemical&fc=K