Iodocyanopindolol - Wikipedia
Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor ... Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research. 53 (6): 752-758. doi:10.1161/01.res.53.6 ...https://en.wikipedia.org/wiki/Iodocyanopindolol
iodo-(±)-Cyanopindolol, [125I], 500µCi | PerkinElmer
iodo-(±)-Cyanopindolol, [125I], 500µCi Part Number : NEX174500UC *Overview. *Related Products & Services. *Tools ...https://www-punchout.perkinelmer.com/product/-cyanopindolol-125i-iodo-nex174500uc
ChemIDplus - 83498-72-0 - WGSPBWSPJOBKNT-UHFFFAOYSA-N - Iodocyanopindolol - Similar structures search, synonyms, formulas,...
Iodocyanopindolol - Similar structures search, synonyms, formulas, resource links, and other chemical information. ... Substance Name: Iodocyanopindolol. RN: 83498-72-0. InChIKey: WGSPBWSPJOBKNT-UHFFFAOYSA-N. Note. *. A highly selective and ...https://chem.nlm.nih.gov/chemidplus/rn/83498-72-0
Decrease in beta-adrenergic receptors of lymphocytes in spontaneously occurring acute asthma.
Iodocyanopindolol. Lymphocytes / metabolism*. Male. Middle Aged. Pindolol / analogs & derivatives, metabolism. Receptors, ...http://www.biomedsearch.com/nih/Decrease-in-beta-adrenergic-receptors/8393400.html
Atomoxetine - The Full Wiki
Iodocyanopindolol • Iprocrolol • Isoxaprolol • Isamoltane • Labetalol • Landiolol • Levobetaxolol • Levobunolol • ...http://www.thefullwiki.org/Atomoxetine
Iodocyanopindolol ([125I]CYP) was prepared using cyanopindolol acquired from Sandoz (East Hanover, NJ) and 125I from New ...http://molpharm.aspetjournals.org/content/58/2/421
Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac β-Adrenergic Signal...
The antagonist affinity of [125I]iodocyanopindolol, as judged on the basis of the KD values, did not differ between the studied ... The ligand [125I]iodocyanopindolol was from Amersham. Dithiothreitol was from Serva. Pertussis toxin was from List Biological ... iodocyanopindolol bound/mg of protein) (n=7 to 10) (B). ...http://hyper.ahajournals.org/content/31/3/747
Membrane Target Systems: Adrenergic beta 3 (human) membrane preparation, in CHO-K1 cells. 400 Units. | PerkinElmer
We submit every batch of receptor to stringent quality control testing that includes saturation radioligand binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPgS data is also provided for some of our Gi coupled receptors ...http://www.perkinelmer.com/product/adrenergic-beta-3-human-membrane-es-035-m400ua
Pathway and mechanism of drug binding to G-protein-coupled receptors | PNAS
Involvement of Tyr356(7.43) in (+/−)cyanopindolol but not (+/−)[125Iodo]cyanopindolol binding. Eur J Med Chem 39:625-631. ...https://www.pnas.org/content/108/32/13118
Characterization of a potentially reversible increase in beta-adrenergic receptors in isolated, neonatal rat cardiac myocytes...
Binding parameters were measured using [125I]iodocyanopindolol. After 4 hours incubation in potassium cyanide and 2- ... iodocyanopindolol.. *S. L. Petrović, John K. McDonald, Gary D. Snyder, S M Mccann ...https://www.semanticscholar.org/paper/Characterization-of-a-potentially-reversible-in-in-Buja-Muntz/30ad456422a57e9acecc669ab325b830fa694ae9
Uncoupling between beta-adrenoceptors and adenylate cyclase in dog ischemic myocardium | SpringerLink
... iodocyanopindolol binding, in the absence and presence of ±-isoprenaline and GTP, and 2. adenylate cyclase activity. The ...https://link.springer.com/article/10.1007%2FBF00498853
Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters | Journal of...
5-HT binding sites in the AH were labeled with a selective 5-HT1B ligand, [125I]-iodocyanopindolol ([125I]CYP) (Hoyer et al., ... 1985) Characterization of 5-HT1B recognition sites in rat brain: binding studies with (−)[125I]iodocyanopindolol. Eur J ... iodocyanopindolol (B), a selective 5-HT1B receptor ligand. The binding shown was performed on contiguous 20 μm coronal sections ...http://www.jneurosci.org/content/17/11/4331.long
The neurobiology of stress and gastrointestinal disease | Gut
Time-dependent effects of chronic psychosocial stress on [125I] iodocyanopindolol binding sites. Cell Mol Neurobiol 17:417-432. ...http://gut.bmj.com/content/47/6/861.full
Nebivolol - Wikipedia
A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies". Eur. J. Pharmacol. 460 (1): 19-26. doi:10.1016/ ...https://en.wikipedia.org/wiki/Nebivolol
Erythema nodosum - Renal and Urology News
Morin, D, Zini, R, Urien, S. "Labelling of rat brain beta-adrenoceptors: (3H)CGP-12177 or (125I) iodocyanopindolol?". J Recept ...http://www.renalandurologynews.com/pediatrics/erythema-nodosum/article/622872/
ValiScreen Adrenergic beta 3 (human) cell line | PerkinElmer
Stable recombinant cell line expressing the Adrenergic, B3 receptor. Human recombinant, in CHO-K1 host cell. We provide: Two vials of the recombinant cell line as frozen cells; Detailed product information including sequence, cell line properties, culture conditions, pharmacological properties of the recombinant receptor in binding and functional assays (cAMP). In addition, for total reassurance, we will provide up to two free replacements within in a 2 year period should you accidently lose your cell line ...http://www.perkinelmer.de/product/adrenergic-beta3-camp-frozen-cells-es-035-cf
Cyanopindolol - Wikipedia
Its radiolabelled derivative iodocyanopindolol has been widely used in mapping the distribution of beta adrenoreceptors in the ...https://en.wikipedia.org/wiki/Cyanopindolol
Methysergide - DrugBank
... iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release. J Pharmacol Exp Ther. 1992 Feb;260(2):614-26. [ ...https://www.drugbank.ca/drugs/DB00247
Frontiers | The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract | Immunology
125 Iodocyanopindolol. Life Sci (1981) 29(21):2189-98. doi:10.1016/0024-3205(81)90490-2 ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01452/full
Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat. | Circulation Research
125I]iodocyanopindolol binding to membranes prepared from nonmyocyte elements of rat ventricle occurs with a dissociation ... The beta-adrenergic antagonist ligand (+/-)-[125I] iodocyanopindolol binds to 2 X 10(5) receptors per purified adult rat ... Computer analysis of competition of [125I]iodocyanopindolol binding by betaxolol, practolol, and zinterol in nonmyocyte ... iodocyanopindolol-binding sites on intact myocytes in monophasic manners with dissociation constants of 46, 845, and 923 nM, ...http://circres.ahajournals.org/content/56/1/126
... iodocyanopindolol binding to washed particles. For both ligands the number of binding sites was about 4-fold higher in ...http://cancerres.aacrjournals.org/content/46/5/2285
F 11440, a Potent, Selective, High Efficacy 5-HT1AReceptor Agonist with Marked Anxiolytic and Antidepressant Potential |...
... iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. Eur J Pharmacol 118:13-23. ...http://jpet.aspetjournals.org/content/287/1/266.long
Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography. | Circulation Research
... iodocyanopindolol in the presence of the selective agents betaxolol (beta 1) and zinterol (beta 2). [125I]Iodocyanopindolol ... iodocyanopindolol labeling of the juxtaglomeruluar granule cells was abolished at lower concentrations (10(-8) M) of betaxolol ...http://circres.ahajournals.org/content/57/2/278
Age-Related ENOX Proteins (arNOX) | Springer for Research & Development
The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. Gene 273: ...https://rd.springer.com/chapter/10.1007/978-1-4614-3958-5_9
Ventricular Hypertrophy Plus Neurohumoral Activation Is Necessary to Alter the Cardiac β-Adrenoceptor System in Experimental...
The density of β-adrenoceptors in right and left ventricular crude membranes was determined by (−)-[125I]-iodocyanopindolol ( ... iodocyanopindolol (ICYP, specific activity 2200 Ci/mmol), and γ-[32P]-ATP were purchased from Perkin-Elmer Life Sciences (Köln ...http://circres.ahajournals.org/content/91/11/1056