Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II...
Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis ... Interleukin 6 in systemic sclerosis and potential implications for targeted therapy. J Rheumatol 2012;39:1120-4.doi:10.3899/ ... Interleukin 6 (IL-6) appears to play a role in SSc pathogenesis.7 8 Patients with SSc have increased IL-6 expression in ... interleukin-6. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial ( ...http://ard.bmj.com/content/early/2017/10/25/annrheumdis-2017-211682.long
Dose-effect Relationship of Low-dose IL-2 in Type 1 Diabetes - Full Text View - ClinicalTrials.gov
This is in part due to a deficit in production of, or response to, interleukin 2 (IL-2). This cytokine is essential to Treg ... Interleukin-2. Antineoplastic Agents. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents. Peripheral Nervous System ... Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet ... Cancer progressing or cured for less than 5 years except for primary basal cell carcinoma or carcinoma in situ of the uterine ...https://clinicaltrials.gov/ct2/show/study/NCT01353833?view=results
Most recent papers with the keyword Cartilage biology | Read by QxMD
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of ... Interferon regulatory factor 5 (IRF5) is a member of the interferon regulatory factor family of transcription factors. Little ... Interferon regulatory factor 5 (IRF5) regulates the expression of matrix metalloproteinase-3 (MMP-3) in human chondrocytes. ... https://www.readbyqxmd.com/read/29274624/interferon-regulatory-factor-5-irf5-regulates-the-expression-of-matrix- ...https://www.readbyqxmd.com/keyword/23439
IL18BP antibody | acris-antibodies.com
Purified recombinant protein of Human interleukin 18 binding protein (IL18BP), transcript variant A. ...https://www.acris-antibodies.com/target/il18bp-antibody.htm
Mouse Interleukin Array Q1 | ABIN625788
Find and order arrays and products like this Mouse Interleukin Array Q1 on www.antikoerper-online.de. Jetzt Produkt ABIN625788 ... Quantibody® Mouse Interleukin Array 1 Kit. Detects 20 Mouse Interleukins. Suitable for all liquid sample types. ... Mouse Interleukin Array Q1. Details zu Produkt Nr. ABIN625788, Anbieter: Anmelden zum Anzeigen ... Perform 5 more serial dilutions by adding 100 µl Std2 to tube Std3 and so on.. 5. Add 100 µl Sample Diluent to another tube ...http://www.antikoerper-online.de/array/625788/Mouse+Interleukin+Array+Q1/
Background and purpose: The inflammatory cytokine interleukin-1 (IL-1) has profound actions - Polo-Like Kinases and Aurora...
Background and purpose: The inflammatory cytokine interleukin-1 (IL-1) has profound actions. Background and purpose: The ... blood-brain barrier model transcytosis microtubule Intro Interleukin-1 (IL-1) is definitely a pro-inflammatory cytokine that ... inflammatory cytokine interleukin-1 (IL-1) has profound actions in the brain causing neuronal cell death and exacerbating mind ... C inside a humidified atmosphere of 5% CO2 Mouse monoclonal to BMPR2 in air flow. Astrocyte isolation Mixed glial cell ...http://technumber.com/2016/03/29/background-and-purpose-the-inflammatory-cytokine-interleukin-1-il-1-has-profound-actions/
Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma - Full Text View - ClinicalTrials.gov
Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Melanoma vaccine plus interleukin-2 may kill ... Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma. The safety and scientific validity of this study is the ... Interleukin-2. Immunologic Factors. Physiological Effects of Drugs. Antineoplastic Agents. Analgesics, Non-Narcotic. Analgesics ... Patients receive gp100:209-217(210M) emulsified in Montanide ISA-51 SC on day 1 and interleukin-2 SC on days 1-5 and 8-13. ...https://clinicaltrials.gov/ct2/show/NCT00005949
Gentaur Molecular :Meridian Life Science \ Mouse Interleukin 6, Recombinant \ A52161H
Mouse Interleukin 6, Recombinant \ A52161H for more molecular products just contact us ... WP1838: Interleukin-1 processing. WP1839: Interleukin-1 signaling. WP1840: Interleukin-3, 5 and GM-CSF signaling. WP2287: Male ... A52161H Mouse Interleukin 6, Recombinant Ask technical file .. Price. : Ask Price ! Product name : Mouse Interleukin 6, ... Index / Meridian Life Science / Mouse Interleukin 6, Recombinant / Product Detail : A52161H Mouse Interleukin 6, Recombinant. ...http://www.antibody-antibodies.com/product_det.php?id=1138051&supplier=search&name=Mouse%20Interleukin%206,%20Recombinant
Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease - Tabular View...
Drug: Interleukin-2 Interleukin-2: Starting the day of Treg-enriched cell infusion, each participant will receive daily ... Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease. The safety ... Interleukin-2: Starting the day of Treg-enriched cell infusion, each participant will receive daily subcutaneous IL-2 for self- ... A Phase I Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease. ...https://clinicaltrials.gov/ct2/show/record/NCT01937468
Annotation score: 5 out of 5
"SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.". Wald D., Qin J., Zhao Z., Qian Y., ... "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.". Wald D., Qin J., Zhao Z., Qian Y., ... "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.". Qin J., ... "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.". Qin J., ...http://www.uniprot.org/uniprot/Q6IA17
TIRAP - Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA a - Homo sapiens (Human) - TIRAP gene ...
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_aImported. ,p>Information which has been ... tr,A0A024R3M4,A0A024R3M4_HUMAN Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_a OS=Homo ... Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_a. ... Annotation score:1 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ...http://www.uniprot.org/uniprot/A0A024R3M4
Neumega - FDA prescribing information, side effects and uses
interleukins Proleukin, oprelvekin, aldesleukin. platelet-stimulating agents Promacta, eltrombopag, Nplate, romiplostim, ... Interleukin eleven (IL-11) is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem ... 1) Du, X. and Williams, D., Interleukin 11: review of molecular, cell biology and clinical use. Blood. 1997;89(11):3897-3908. ... Reconstitute the Neumega 5 mg vial using the 1.0 mL of Sterile Water for Injection, USP (without preservative) contained in the ...https://www.drugs.com/pro/neumega.html
Phase I/II Study Evaluating the Infusion of Tumor-Infiltrating Lymphocytes (TILs) and Low-Dose Interleukin-2 (IL-2) Therapy...
This study will see how safe and useful infusion of tumor infiltrating lymphocytes and interleukin-2 therapy following a ... Phase I/II Study Evaluating the Infusion of Tumor-Infiltrating Lymphocytes (TILs) and Low-Dose Interleukin-2 (IL-2) Therapy ... Phase I/II Study Evaluating the Infusion of Tumor-Infiltrating Lymphocytes (TILs) and Low-Dose Interleukin-2 (IL-2) Therapy ...http://adisinsight.springer.com/trials/700255825?error=cookies_not_supported&code=6d109e67-4ccd-4f78-8432-911af08bc6bb
Interleukin-5 downregulation | GreenMedInfo | Pharmacological Action
Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Interleukin-5 downregulation, ... Pharmacological Actions : Interleukin-10 upregulation, interleukin-13 down-regulation, Interleukin-4 downregulation, ... Pharmacological Actions : Anti-Allergic Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 ... Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 ...http://www.greenmedinfo.com/pharmacological-action/interleukin-5-downregulation
Interleukin 5 - Wikipedia
... is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin ... Interleukin-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by ... Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ...https://en.wikipedia.org/wiki/Interleukin_5
Interleukin-5 receptor - Wikipedia
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and ... Takaki S, Kanazawa H, Shiiba M, Takatsu K (November 1994). "A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor ... Receptors, Interleukin-5 at the US National Library of Medicine Medical Subject Headings (MeSH). ... Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. 3 (2): 87-102. doi:10.1016/S0955-2235( ...https://en.wikipedia.org/wiki/Interleukin-5_receptor
increased interleukin-5 secretion Mammalian Phenotype Term (MP:0008702)
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.http://www.informatics.jax.org/vocab/mp_ontology/MP:0008702
interleukin-5 receptor complex QuickView - Correlation Engine
The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte- ... A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. ...http://www.nextbio.com/b/search/ov/interleukin-5%20receptor%20complex?id=34086&type=biogroup
Interleukin 5 receptor alpha subunit - Wikipedia
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 ... Interleukin 5 receptor alpha subunit has been shown to interact with: Interleukin 5, Janus kinase 2, Protein unc-119 homolog, ... Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM (2003). "Biosensor analysis of dynamics of interleukin 5 ... The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is ...https://en.wikipedia.org/wiki/Interleukin_5_receptor_alpha_subunit
Interleukin-5 / IL5 antibody | acris-antibodies.com
Interleukin-5(IL-5)is a secreted glycoprotein that belongs to the .-helical group of cytokines . Unlike other family members, ... Interleukin-5 / IL5 antibody. Not available. Rat. IgG2a. JES1-5A10. Purified. Hu. E, E(capture), E(detection). 0.5 mg / €320.00 ... Background of Interleukin-5 / IL5 antibody. Interleukin-5(IL-5)is a secreted glycoprotein that belongs to the .-helical group ... Alternative names for Interleukin-5 / IL5 antibody. IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T ...https://www.acris-antibodies.com/target/interleukin-5-antibody-il5-antibody.htm
Reactome | Interleukin-5 receptor alpha subunit binds Interleukin-5
Signaling by Interleukins (Mus musculus) * Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus) * Interleukin-5 ...http://www.reactome.org/content/detail/R-MMU-913456
Reactome | Interleukin-5 is a homodimer
Signaling by Interleukins (Homo sapiens) * Interleukin-3, 5 and GM-CSF signaling (Homo sapiens) * Interleukin-5 is a homodimer ... A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 1993. ... Human IL-5 is a disulphide-linked homodimer with 115 amino-acid residues in each chain. ...http://www.reactome.org/content/detail/R-HSA-913446
Frontiers | Anti-Interleukin 5 (IL-5) and IL-5Ra Biological Drugs: Efficacy, Safety, and Future Perspectives in Severe...
A more detailed knowledge of the immunological mechanisms of the asthma pathogenesis has enabled identifying interleukin 5 (IL- ... IL-5, in fact, exerts selective action on eosinophils which, in turn, sustain airway inflammation and worsen asthma symptoms ... IL-5, in fact, exerts selective action on eosinophils which, in turn, sustain airway inflammation and worsen asthma symptoms ... The development of drugs targeting IL-5 or its receptor alpha subunit (IL-5Rα) has been shown, in clinical trials, a promising ...https://www.frontiersin.org/articles/10.3389/fmed.2017.00135/full
Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a...
Comparison of anti-interleukin-5 therapies in patients with severe asthma: global and indirect meta-analyses of randomized ... Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled ... Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that directly depletes eosinophils. Its ... Matching-adjusted indirect comparison of benralizumab versus interleukin-5 inhibitors for the treatment of severe asthma: a ...http://erj.ersjournals.com/content/52/5/1801393
Emerging Anti-Interleukin 5 (IL-5) and IL-5Ra Based Biological Therapies: Efficacy, Safety and Future Perspectives in Severe...
Emerging Anti-Interleukin 5 (IL-5) and IL-5Ra Based Biological Therapies: Efficacy, Safety and Future Perspectives in Severe ... Apply emerging anti-interleukin-5 and interleukin-5Rα based therapies in patients with severe eosinophilic asthma ... Additional Software: Adobe Flash Player and/or an HTML 5 capable browser maybe required for video or audio playback. PowerPoint ...https://www.empr.com/emerging-anti-interleukin-5-il-5-and-il-5ra-based-biological-therapies-efficacy-safety-and-future-perspectives-in-severe-eosinophilic-asthma/activity/5535/