Spondyloarthropathy: interleukin 23 and disease modification. - The Kennedy Institute of Rheumatology
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IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(...
Although very high levels of interleukin (IL)-1β are present in the intestines of patients suffering from inflammatory bowel ... and we describe synergistic interactions between IL-1β and IL-23 signals that sustain innate and adaptive inflammatory ... Interleukin-17, Interleukin-1beta, Interleukin-23, Lymphocytes, Mice, Mice, Inbred C57BL, Receptors, Interleukin-1, Receptors, ... Although very high levels of interleukin (IL)-1β are present in the intestines of patients suffering from inflammatory bowel ...
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. - The Kennedy Institute of...
Serum concentrations of interleukin-23 (IL-23) are elevated and polymorphisms in the IL-23 receptor are associated with ... We show here that IL-23 is essential in enthesitis and acts on previously unidentified IL-23 receptor (IL-23R)(+), RAR-related ... These cells allow entheses to respond to IL-23 in vitro-in the absence of further cellular recruitment--and to elaborate ... the in vivo expression of IL-23 is sufficient to phenocopy the human disease, with the specific and characteristic development ...
IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. - The...
The present findings demonstrate that IL-27, a close relative of IL-12 and IL-23, can promote the onset of colitis in mice. We ... Animals, Chronic Disease, Cytokines, Disease Models, Animal, Disease Progression, Inflammatory Bowel Diseases, Interleukin-10, ... Mice, Mice, Knockout, Receptors, Cytokine, Receptors, Interleukin, T-Box Domain Proteins, Th1 Cells, Th2 Cells, Transcription ... The present findings demonstrate that IL-27, a close relative of IL-12 and IL-23, can promote the onset of colitis in mice. We ...