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Although very high levels of interleukin (IL)-1β are present in the intestines of patients suffering from inflammatory bowel ... and we describe synergistic interactions between IL-1β and IL-23 signals that sustain innate and adaptive inflammatory ... Interleukin-17, Interleukin-1beta, Interleukin-23, Lymphocytes, Mice, Mice, Inbred C57BL, Receptors, Interleukin-1, Receptors, ... Although very high levels of interleukin (IL)-1β are present in the intestines of patients suffering from inflammatory bowel ...
Serum concentrations of interleukin-23 (IL-23) are elevated and polymorphisms in the IL-23 receptor are associated with ... We show here that IL-23 is essential in enthesitis and acts on previously unidentified IL-23 receptor (IL-23R)(+), RAR-related ... These cells allow entheses to respond to IL-23 in vitro-in the absence of further cellular recruitment--and to elaborate ... the in vivo expression of IL-23 is sufficient to phenocopy the human disease, with the specific and characteristic development ...
The present findings demonstrate that IL-27, a close relative of IL-12 and IL-23, can promote the onset of colitis in mice. We ... Animals, Chronic Disease, Cytokines, Disease Models, Animal, Disease Progression, Inflammatory Bowel Diseases, Interleukin-10, ... Mice, Mice, Knockout, Receptors, Cytokine, Receptors, Interleukin, T-Box Domain Proteins, Th1 Cells, Th2 Cells, Transcription ... The present findings demonstrate that IL-27, a close relative of IL-12 and IL-23, can promote the onset of colitis in mice. We ...