Frontiers | Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Interleukin-22. Interleukin-22 is a member of the IL-10 family of cytokines and binds to IL-22R which is complex of IL-22R1 and ... Interleukin-4 and interleukin-10 gene polymorphisms in patients with inflammatory bowel disease. Immunol Invest (2017) 46(7): ... Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of ... Interleukin-12 and STAT4 also appear to be linked to IBD in humans. There are a number of IBD-associated SNPs in the IL12B gene ...
Frontiers | Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex
2012). Interleukin-17A and interleukin-23 in morphea. Arch. Med. Sci. 8, 1089-1095. doi: 10.5114/aoms.2012.32421 ...
Frontiers | A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation...
Keywords: natural killer cells, radiotherapy, rhabdomyosarcoma, RH30 cells, RD cells, interleukin-15, interleukin-21 ... Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp ... Trinchieri G. Interleukin-12 and its role in the generation of TH1 cells. Immunol Today (1993) 14:335-8. doi:10.1016/0167-5699( ... Lin S-J, Wang L-Y, Huang Y-J, Kuo M-L. Effect of interleukin (IL)-12 and IL-15 on apoptosis and proliferation of umbilical cord ...
Frontiers | Immune-Endocrine Links to Gregariousness in Wild House Mice
Rothwell, N. J., and Luheshi, G. N. (2000). Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends ... Studies in mice have shown that social interactions alter proinflammatory cytokine gene expression (interleukin-1, IL-1, and ... 23-730-571) to attach the frozen brain to a specimen disc, positioned coronally relative to the blade, as similar as possible ...
Frontiers | Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of...
Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., and Levy, B. D. (2008). Resolvin E1 regulates interleukin 23, interferon- ... interleukin (IL)-8, 6, 1β (Balough et al., 1995; Bonfield et al., 1995; Noah et al., 1997; Muhlebach et al., 1999; Tirouvanziam ... Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and ...
Frontiers | Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal ... CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii ... 23. Naik SH, Sathe P, Park H-Y, Metcalf D, Proietto AI, Dakic A, et al. Development of plasmacytoid and conventional dendritic ... 23-28), with terminal differentiation into cDC1 and cDC2 subsets occurring in the periphery (29); cDC1 and cDC2s are then ...
Frontiers | Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities
Th17 cells are a subset of proinflammatory CD4+ T cells characterized by production of interleukin-17 (IL-17) (23). Tregs are ... which leads to the upregulation of proinflammatory cytokine including interleukin-12 (IL-12), IL-23, and type I interferons, ... 23. Wang Y, Yin Y, Chen X, Zhao Y, Wu Y, Li Y, et al. Induction of intestinal Th17 cells by flagellins from segmented ... Int J Rheum Dis (2020) 23(4):472-9. doi: 10.1111/1756-185x.13802 ... N Engl J Med (2011) 365(23):2205-19. doi: 10.1056/NEJMra1004965 ...
Frontiers | Significance of Interleukin-33 and Its Related Cytokines in Patients with Breast Cancers
... an important member of the interleukin-1 family. IL-33 binds to its receptor ST2 to induce type 2 cytokines and exert both pro- ... Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the IL-1 family. IL-33 binds to its receptor ... Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the interleukin-1 family. IL-33 binds to its ... Significance of interleukin-33 and its related cytokines in patients with breast cancers. Jing Liu1† Jia-Xin Shen1,2† Jia-Lin ...
Frontiers | Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects
YXT131 an endophytic actinobacterium modulated the immune response by reducing the proinflammatory cytokines interleukin (IL)- ... 12/IL-23 p40 in the serum of mice (Wei et al., 2018). The use of bioagents in immune modulation of some diseases is a current ...
Frontiers | The Role of Paracrine Regulation of Mesenchymal Stem Cells in the Crosstalk With Macrophages in Musculoskeletal...
Donnelly, R. P., Dickensheets, H., and Finbloom, D. S. (1999). The interleukin-10 signal transduction pathway and regulation of ... Stein, M., Keshav, S., Harris, N., and Gordon, S. (1992). Interleukin 4 potently enhances murine macrophage mannose receptor ... stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6. ... interleukin-4 (IL-4), IL-6, and IL-10 released from MSCs can induce the Mφ polarization toward M2 to accelerate tissue ...
Frontiers | BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention
Interleukin 12 (IL-12), and Interleukin 23 (IL-23) were over-expressed in ER-negative breast carcinoma and that the three major ... and 23 positive women (and men) (Stagnaro-Neri and Stagnaro, 1995; Stagnaro, 2004, 2009; Stagnaro and Stagnaro-Neri, 2004a,b; ...
Frontiers | Adverse Events in Patients With Rheumatoid Arthritis and Psoriatic Arthritis Receiving Long-Term Biological Agents...
... and inhibitors of interleukin (IL)-12 and IL-23 (ustekinumab) (Rosman et al., 2013). Indications for use vary between the ...
Frontiers | Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation
High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of ... High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of ... High-sensitive C-reactive protein (hsCRP) and high-sensitive interleukin 6 (hsIL-6) were measured in the serum as markers of ... Serum concentrations of hsCRP and high-sensitive interleukin 6 (hsIL-6) were determined by enzyme-linked immunosorbent assay ( ...
Frontiers | Caffeine Protects Against Retinal Inflammation
... such as interleukin-6 (IL-6), interleukin-1β (IL-1β), or tumor necrosis factor-alpha (TNF-α) (Holtkamp et al., 1998; Izumi- ... 2015). Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and ... 2020). An Allosteric Interleukin-1 Receptor Modulator Mitigates Inflammation and Photoreceptor Toxicity in a Model of Retinal ... 2007). Interleukin-6 Receptor-Mediated Activation of Signal Transducer and Activator of Transcription-3 (STAT3) Promotes ...
Frontiers | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
Yang, D., Chen, X., Wang, J., Lou, Q., Lou, Y., and Li, L. (2019). Dysregulated lung commensal bacteria drive Interleukin-17B ... Jog, N. R., Chakravarty, E. F., Guthridge, J. M., and James, J. A. (2018). Epstein barr virus interleukin 10 suppresses anti- ... Borilova Linhartova, P., Kastovsky, J., Lucanova, S., Bartova, J., Poskerova, H., and Vokurka, J. (2016). Interleukin-17A gene ... Sakakibara, S., and Tosato, G. (2011). Viral interleukin-6: role in Kaposis sarcoma-associated herpesvirus: associated ...
Frontiers | Non-Epithelial Stromal Cells in Thymus Development and Function
Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood (1999) 93(1):140-8. doi: 10.1182/blood. ... 23. Anderson G, Jenkinson EJ, Moore NC, Owen JJ. MHC class II-positive epithelium and mesenchyme cells are both required for T- ... Thus, mesenchyme-derived signals can either target developing thymocytes directly (22, 23), or indirectly by regulating TEC ... 23). For example, culture of CD4−CD8− (DN) T-cell precursors in the presence of TEC alone resulted in an absence of further T- ...
Frontiers | Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation
Interleukin-1β in Central Nervous System Injury and Repair. Eur J Neurodegener Dis (2012) 1:195-211. ... Interleukin-1β-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity. J ... 7. Luheshi NM, Kovács KJ, Lopez-Castejon G, Brough D, Denes A. Interleukin-1α expression precedes IL-1β after ischemic brain ... Aarreberg LD, Esser-Nobis K, Driscoll C, Shuvarikov A, Roby JA, Gale M. Interleukin-1β Induces mtDNA Release to Activate Innate ...
Frontiers | Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta ... 23. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in ... Proc Natl Acad Sci U S A (2002) 99(23):14740-5. doi:10.1073/pnas.192565799 ... Prog Neuropsychopharmacol Biol Psychiatry (2014) 53:23-34. doi:10.1016/j.pnpbp.2014.01.013 ...
Frontiers | IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models
Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness ... Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness ... Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T ... Keywords: breast cancer, interleukin-15/interleukin-15 receptor alpha complex, cancer immunotherapy, gene electrotransfer, ...
Frontiers | Oncolytic virus: A catalyst for the treatment of gastric cancer
Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to ... interleukin-6; ISGs, interferon-stimulated genes; IFN, interferon; IFNR, interferon receptor; JAK, Janus kinase; STAT, signal ... 23. Chow KT, Gale M Jr., Loo YM. Rig-I and other rna sensors in antiviral immunity. Annu Rev Immunol (2018) 36:667-94. doi: ... Biomacromolecules (2022) 23(4):1490-504. doi: 10.1021/acs.biomac.2c00065. PubMed Abstract , CrossRef Full Text , Google Scholar ...
Frontiers | A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection
Interleukin-6 gene alleles affect the risk of Alzheimers disease and levels of the cytokine in blood and brain. Neurobiol ... The interleukin-6−174 G,C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in ... Interleukin-6-174 G , C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 ... McGonagle D, Sharif K, ORegan A, Bridgewood C. The role of cytokines including Interleukin-6 in COVID-19 induced pneumonia and ...
Frontiers | Exploring Impact of Rare Variation in Systemic Lupus Erythematosus by a Genome Wide Imputation Approach
Interleukin-10 directly inhibits CD8+ T cell function by enhancing N-glycan branching to decrease antigen Sensitivity. Immunity ... acts as a transcriptional repressor inhibiting interleukin-2 (IL-2) gene expression. Note that IL-2 plays a critical role in ... 23. Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: challenges and strategies. Nat Rev ... Taking into account that pleiotropic effects on human complex traits was widespread (23), it would be expected that in a list ...
Frontiers | The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes,...
Kado S, Nagase T, Nagata N. Circulating levels of interleukin-6, its soluble receptor and interleukin-6/interleukin-6 receptor ... Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS ... Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab (1997) 82 ... Regulation of the human serotonin transporter by interleukin-1β. Biochem Biophys Res Commun (1995) 216(2):560-7. doi: 10.1006/ ...
Frontiers | Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis
Interleukin-6 and rheumatic diseases. Arthritis Res Ther (2006) 8 Suppl 2:S4. doi: 10.1186/ar1918 ... The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis Rheum (2003) 48:1177- ... 23. Peng L, Zhu N, Mao J, Huang L, Yang Y, Zhou Z, et al. Expression levels of CXCR4 and CXCL12 in patients with rheumatoid ... 23). Furthermore, the expression levels of CXCR4 and CXCL12 in the active RA group were found to be higher compared to the ...
Frontiers | Vitamin D Actions on CD4+ T Cells in Autoimmune Disease
Moore KW, de Waal Malefyt R, Coffman RL, OGarra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 19: ... Innate production of interleukin-10 and tumor necrosis factor affects the risk of multiple sclerosis. Ann Neurol (2000) 48:641- ... Interleukin-10 promoter polymorphisms in patients with multiple sclerosis. J Neurol Sci (2002) 202:93-7. doi:10.1016/S0022-510X ... Interleukin-10 promoter polymorphism in multiple sclerosis: association with disease progression. Eur Cytokine Netw (2002) 13: ...
Frontiers | CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer...
T cells redirected to interleukin-13Ralpha2 with interleukin-13 mutein-chimeric antigen receptors have anti-glioma activity but ... Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin Cancer Res. (1999) 5:985-90. ... Interleukin-13 receptor α 2 (IL-13Rα2) has first been described as a therapeutic target for GB two decades ago (89). It has ... Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme. Nat Commun. (2017) 8: ...
Frontiers | Human Antimicrobial RNases Inhibit Intracellular Bacterial Growth and Induce Autophagy in Mycobacteria-Infected...
Dhiman R, Venkatasubramanian S, Paidipally P, Barnes PF, Tvinnereim A, Vankayalapati R. Interleukin 22 inhibits intracellular ... 23. Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, et al. Ribonucleases 6 and 7 have antimicrobial ... On the other hand, RNase7 was reported to be abundantly expressed in epithelial cells (52) but poorly in macrophages (23). In ... Curr Opin Immunol. (2011) 23:448-55. doi: 10.1016/j.coi.2011.06.001 ...
Frontiers | Common and Rare Variants Genetic Association Analysis of Circulating Neutrophil Extracellular Traps
Interleukin-8 induces expression of foxc1 to promote transactivation of cxcr1 and ccl2 in hepatocellular carcinoma cell lines ... 23. Ward LD, Kellis M. Haploreg: A resource for exploring chromatin states, conservation, and regulatory motif alterations ... We used HaploReg v4.1 (http://www.broadinstitute.org/mammals/haploreg/haploreg.php; in the public domain) (23) to retrieve ...
Frontiers | Immunological Feature and Transcriptional Signaling of Ly6C Monocyte Subsets From Transcriptome Analysis in Control...
Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line. Blood ( ... Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am J Physiol Heart Circulatory Physiol (2006) 290: ... Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep ( ... interleukin)-1, IL-18, IL-15, and MCP (MC chemoattractant protein)-1 to contribute to systemic/tissue inflammation and T-cell ...
Frontiers | Sarcopenia and Androgens: A Link between Pathology and Treatment
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: ... 48) found that a sedentary lifestyle was associated with increased basal levels of markers of chronic inflammation (interleukin ... 23. Bean JF, Leveille SG, Kiely DK, Bandinelli S, Guralnik JM, Ferrucci L. A comparison of leg power and leg strength within ...