Anders Wallin | Göteborgs universitet
Ustekinumab - Wikipedia
It binds to the p-40 subunit of both IL-12 and IL-23 so that they subsequently cannot bind to their receptors. As of January ... The antibody targets a subunit of human interleukin 12 and interleukin 23, which are naturally occurring proteins that regulate ... Specifically, it blocks interleukin IL-12 and IL-23 which help activate certain T-cells. ... Koutruba N, Emer J, Lebwohl M (April 2010). "Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the ...
Ulcerative Colitis Pathology: Overview, Epidemiology, Etiology
IL-23 shares the p40 subunit with IL-12; both interleukin moieties affect the differentiation of naive T cells into effector T ... Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut. Gastroenterology. Jun 2009;136(7 ... A regulator of interleukin (IL)-23, IL-23R (found on chromosome 1), is also associated with Crohn disease and ulcerative ... The latter are thought to play a role in the pathogenesis of ulcerative colitis, and medications directed against p40 are being ...
IL-12 Products: R&D Systems
View our 66 IL-12 products for your research including IL-12 Primary Antibodies, Proteins and Enzymes, ELISAs, and Luminex ... is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 ... Interleukin-12) ... Both homodimeric p40, and IL-23 can bind to the IL-12 receptor ... Recombinant Human IL-12 (linked heterodimer) Protein, CF GS Linker, Defined heterodimer stoichiometry. ...
evidence investigator Archives - Randox Laboratories
IL-23 is a heterodimeric cytokine composed of disulphide linked p19 and p40 subunits. IL-23 plays a role in a signaling pathway ... Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15 - 18 kDa protein ... is a 75 kDa heterodimeric glycoprotein cytokine composed of disulphide linked p40 (40 kDa) and p35 (35 kDa) subunits that are ... an 80 kDa cognate receptor subunit (IL-6R) and a 130 kDa signal-transducing element (gp130). The gp130 subunit is expressed in ...
IL12B interleukin 12B [Homo sapiens (human)] - Gene - NCBI
IL12, subunit p40. NK cell stimulatory factor chain 2. cytotoxic lymphocyte maturation factor 40 kDa subunit. interleukin 12, ... p40. interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40). interleukin-12 ... This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of ... Association between interleukin 12B and interleukin 23R gene polymorphisms and systemic lupus erythematosus: a meta-analysis. ...
Fact file for Interleukin-12 (IL-12) p40 deficiency
European Crohn´s and Colitis Organisation - ECCO - P796 Effectiveness and safety of ustekinumab for patients with ulcerative...
APC Rat Anti-Mouse IL-12 (p40/p70)
p40 has also been described as a subunit of IL-23 and thus it is possible that the C15.6 antibody will crossreact with IL-23 ... p40 has also been described as a subunit of IL-23 and thus it is possible that the C15.6 antibody will crossreact with IL-23 ... forms of the p40 subunit of mouse interleukin-12 (IL-12). The immunogen used to generate the C15.6 hybridoma was recombinant ... forms of the p40 subunit of mouse interleukin-12 (IL-12). The immunogen used to generate the C15.6 hybridoma was recombinant ...
Comparative effectiveness of second-line biological therapies for ulcerative colitis and Crohn's disease in patients with prior...
Ustekinumab is a fully human monoclonal antibody targeting the common p40 subunit of interleukin (IL)-12 and IL-23 [10]. ... IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 2015;21(7): ... This can lead to treatment intensification or drug discontinuation in up to 20-50% of patients after 12 months of treatment [6 ... 12, 13]; however, there is insufficient real-world data. To date, the VARSITY study, which compared vedolizumab and adalimumab ...
New Biologic Stelara(R) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis | Antibodies | News...
... human monoclonal antibody with a novel mechanism of action that targets the p40 sub-unit of cytokines interleukin-12 (IL-12) ... First and Only Biologic Approved with Infrequent, Every Twelve-Week Maintenance Dosing ... Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results ... Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results ...
HBDB: Human Breathomics Database
interleukin-12 subunit p40. 653.85. 1. *Evaluation of leukotriene B4 in the canine exhaled breath: standardization of a ... The associated genes/proteins with Leukotriene B4 are CCL2 gene, LTB4R gene, interleukin-12 subunit p40, MAPK3 gene and TLR4 ... Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with ... 5,12-Hete. 71160-24-2. 5S,12R-diHETE. (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid. CHEMBL65061. 5S,12R ...
Human IL-12 Antibody AB-219-NA: R&D Systems
The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human ... subunit p35; IL12A; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic ... In Western blots, this antibody recognizes the p70 heterodimer as well as the p40 and p35 subunits. ... Arg23-Ser219 of p35; Ile23-Ser328 of p40. Accession # P29459 (p35) & P29460 (p40) ...
Frontiers | Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis
... a heterodimetric cytokine consisting of p35 and p40 subunits, is a key regulator of T helper 1 development (Th1), which ... Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. (2003) 14:155-74. doi: 10.1016/S1359-6101(03)00002-9 ... Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella ... Ding Y, Ai C, Mu Y, Ao J, Chen X. Molecular characterization and evolution analysis of five interleukin-17 receptor genes in ...
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the t...
Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation...
Cytokine expression by neutrophils of adult horses stimulated with virulent and avirulent Rhodococcus equi in vitro. - Texas A...
Interleukin-23 Subunit P19 * Interleukin-6 * Interleukin-8 * Neutrophils * RNA, Messenger * Rhodococcus Equi ...
IL-12 beta Protein, Human (HEK293) | MedChemExpress
... is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves ... IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, ... MedChemExpress offers high purity IL-12 beta Protein, Human (HEK293) with excellent lot-to-lot consistency, superior biological ... IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, ...
Genome bioinformatic analysis of nonsynonymous SNPs | BMC Bioinformatics | Full Text
... a protein homologous to the p40 subunit of interleukin 12 (IL-12). This is a cytokine that drives rapid clonal expansion of ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH: The interleukin-12/interleukin-12-receptor system: ... score and LS-SNP occurs in the interleukin 21 receptor (IL21R). IL-21R is a novel, T-cell specific type I cytokine receptor ... IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis [ ...
Maternal obesity is associated with phenotypic alterations in fetal immune cells by single-cell mass cytometry<...
Find Research outputs - University of Portsmouth
The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 ... subunit. Garnier, P., Mummery, R., Forster, M. J., Mulloy, B., Gibbs, R. V. & Rider, C. C., Oct 2018, In: Cytokine. 110, p. 159 ... Reck, A-K. & Montgomerie, M., 2011, In: Image & Narrative. 12, 2, p. 83-95 13 p.. Research output: Contribution to journal › ... 15-26 12 p. (WEBSIT).. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution ...
MMRRC:039366-MU
Pesquisa | Portal Regional da BVS
A lower abundance of select Lachnospiraceae species correlated to higher p40 subunit levels, while the detection of ... It enhanced the amount of interleukin-12 p40 subunit protein (IL12/23p40; P < 0.001) and interleukin-17a (IL-17A; P < 0.05) in ... Citrobacter rodentium , Vitamina B 12 , Humanos , Animais , Camundongos , Vitamina B 12/farmacologia , Interações entre ...
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease | Nature Reviews Gastroenterology & Hepatology
... p40; targeted by ustekinumab and briakinumab), or the IL-23-specific subunit (p19; targeted by risankizumab, guselkumab, ... and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and ... has led to the development of monoclonal antibodies that target a subunit common to IL-12 and IL-23 ( ... IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the ...
Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control...
In addition a novel allele was found for the interleukin 12B D5S2941 microsatellite. This study highlights the importance of ... A haplotype in interleukin 12B was nominally associated with tuberculosis (p = 0.02), but after permutation testing, done to ... namely interleukin 4 (IL4), interleukin 10 (IL10), interleukin 12B (IL12B), interleukin 12 receptor beta 1 (IL12RB1), ... Prabhu AS, Selvaraj P, Jawahar MS, Adhilakshmi AR, Narayanan PR: Interleukin-12B & interleukin-10 gene polymorphisms in ...
Recombinant Human Interleukin-12 (rHuIL-12) - Jiangsu Watson Bio Ltd
In humans, the p40 subunit can also associate with a p19 subunit to form IL-23. IL-12 signals through a receptor complex ... Natural killer cell stimulatory factor chain 2, NKSF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40 ... Natural killer cell stimulatory factor chain 2, NKSF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40 ... Recombinant Human Interleukin-12 (rHuIL-12) 2021年11月30日. /in Recombinant Proteins /by great_watson-int. Official Full Name. ...
exosomedx - Hoxyl beads
... is a heterodimeric molecule composed of p35 and p40 subunits. Analyses in vitro have outlined IL-12 as an necessary issue for ... Interleukin-12 (IL-12) ... quite a few research have concluded that IL-12… Continue ... Interleukina-23 zamiast interleukiny-12 jest cytokiną krytyczną dla autoimmunologicznego zapalenia mózgu. ...
Interleukin-12 Subunit p35 | Profiles RNS
A subunit of interleukin-12. It binds to the INTERLEUKIN-12 SUBUNIT P40 via a disulfide bond that results in the active ... "Interleukin-12 Subunit p35" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Interleukin-12 Subunit p35" by people in this website by year ... Below are the most recent publications written about "Interleukin-12 Subunit p35" by people in Profiles. ...
IL-12 p70 (Interleukin-12 p70), Human (mammalian cell expression) - Biofargo
Ulcerative Colitis Pathology: Overview, Epidemiology, Etiology
IL-23 shares the p40 subunit with IL-12; both interleukin moieties affect the differentiation of naive T cells into effector T ... Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut. Gastroenterology. Jun 2009;136(7 ... A regulator of interleukin (IL)-23, IL-23R (found on chromosome 1), is also associated with Crohn disease and ulcerative ... The latter are thought to play a role in the pathogenesis of ulcerative colitis, and medications directed against p40 are being ...