Interleukin-12 Subunit p35 | Profiles RNS
A subunit of interleukin-12. It binds to the INTERLEUKIN-12 SUBUNIT P40 via a disulfide bond that results in the active ... "Interleukin-12 Subunit p35" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Interleukin-12 Subunit p35" by people in this website by year ... Below are the most recent publications written about "Interleukin-12 Subunit p35" by people in Profiles. ...
Human IL-12 Antibody AB-219-NA: R&D Systems
... subunit p35; IL12A; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic ... CLMF p35; CLMF1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL12; IL-12; IL-12, ... In Western blots, this antibody recognizes the p70 heterodimer as well as the p40 and p35 subunits. ... Arg23-Ser219 of p35; Ile23-Ser328 of p40. Accession # P29459 (p35) & P29460 (p40) ...
EBI3 - Wikipedia
Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel ... EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and ... Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded ... IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12. GRCh38: ...
IL-12 Products: R&D Systems
View our 66 IL-12 products for your research including IL-12 Primary Antibodies, Proteins and Enzymes, ELISAs, and Luminex ... is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 ... Interleukin-12) ... Human/Mouse IL-12/IL-35 p35 Fluorescein-conjugated Antibody ... It signals through a receptor complex composed of IL-12 R beta 1 and IL-12 R beta 2. Both homodimeric p40, and IL-23 can bind ...
evidence investigator Archives - Randox Laboratories
... and p35 (35 kDa) subunits that are derived from separate genes1. p35 is expressed in a limiting and tightly regulated fashion ... Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15 - 18 kDa protein ... an 80 kDa cognate receptor subunit (IL-6R) and a 130 kDa signal-transducing element (gp130). The gp130 subunit is expressed in ... interleukin-2, interleukin-4, macrophage colony-stimulating factor, granulocyte macrophage colony-stimulating factor and growth ...
Thomas Moran - Publications & Research Outputs - Icahn School of Medicine at Mount Sinai
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23. Chen, L., Strohmeier, V., He, Z., Deshpande, M., ... 2021, In: mBio. 12, 1, p. 1-23 23 p., e02492-20.. Research output: Contribution to journal › Article › peer-review ... 12, p. 5647-5662 16 p.. Research output: Contribution to journal › Article › peer-review ... 12, p. 6428-6436 9 p.. Research output: Contribution to journal › Article › peer-review ...
IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-γ and macrophage and neutrophil populations in...
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the t...
Frontiers | Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis
... a heterodimetric cytokine consisting of p35 and p40 subunits, is a key regulator of T helper 1 development (Th1), which ... Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. (2003) 14:155-74. doi: 10.1016/S1359-6101(03)00002-9 ... Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella ... Ding Y, Ai C, Mu Y, Ao J, Chen X. Molecular characterization and evolution analysis of five interleukin-17 receptor genes in ...
exosomedx - Hoxyl beads
... is a heterodimeric molecule composed of p35 and p40 subunits. Analyses in vitro have outlined IL-12 as an necessary issue for ... Interleukin-12 (IL-12) ... quite a few research have concluded that IL-12… Continue ... Interleukina-23 zamiast interleukiny-12 jest cytokiną krytyczną dla autoimmunologicznego zapalenia mózgu. ...
IL-12 p70 (Interleukin-12 p70), Human (mammalian cell expression) - Biofargo
Active Recombinant Human EBI3/p28 protein, His-tagged EBI3-256H - Creative BioMart
EBI3; Epstein-Barr virus induced 3; interleukin-27 subunit beta; IL27 subunit; IL35 subunit; cytokine receptor; IL-27 subunit ... the 28 kDa glycoprotein that is related to the p35 chain of IL-12). The human EBI3 gene encodes a 229 amino acid (aa) precursor ... Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I ... It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and ...
Human IL-12 (p70) ELISA Kit (KOA0234) | Rockland
Get Rocklands Human IL-12(p70) AccuSignal ELISA Kit - KOA0234 for ELISA. Order online now! ... And the IL-12p70 is a heterodimer of p35 and p40 subunits; it is an important cytokine secreted by antigen-presenting cells in ... IL35 subunit, Interleukin 12 alpha chain, Interleukin 12 p35, Interleukin 12 p70, Interleukin-12 subunit alpha, Natural killer ... CLMF, CLMF p35, Cytotoxic lymphocyte maturation factor 1, Cytotoxic lymphocyte maturation factor 1 p35, Cytotoxic lymphocyte ...
Pesquisa | Prevenção e Controle de Câncer
... with a tumor targeting antibody respectively to TME and by bridging the two subunits into active heterodimeric form.Interleukin ... and demonstrated the formation of bioactive IL12p70 with TME targeting antibody toward both p35 and p40 to form as the active ... Doxorubicin treatment decreased interleukin-1ß (IL-1ß) expression in cultured myotubes and skeletal muscle, whereas transient ... Interleukin-1ß triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin- ...
Recombinant Human Interleukin-12 (rHuIL-12) - Jiangsu Watson Bio Ltd
In humans, the p40 subunit can also associate with a p19 subunit to form IL-23. IL-12 signals through a receptor complex ... Recombinant Human Interleukin-12 (rHuIL-12) 2021年11月30日. /in Recombinant Proteins /by great_watson-int. Official Full Name. ... You are here: Home1 / Recombinant Proteins2 / Recombinant Human Interleukin-12 (rHuIL-12) ... Recombinant Human Interleukin-12 (rHuIL-12). Synonyms. Natural killer cell stimulatory factor chain 2, NKSF2, Cytotoxic ...
Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated...
IL-35 shares the protein subunit p35, with IL-12p70. IL-12p70 is the most potent cytokine to induce Th1 responses during ... Interleukin-12 Grants and funding This work was supported by Cardiff University research funding and funding for XFZ from China ... which served as a mechanism for IL-12p70 suppression by competitive binding of the common protein subunit (p35) of IL-35 and IL ... cell line with biscistronic expression of IL-12p40 and p35 was constructed, followed by ectopic over-expression of EBI3. The ...
Introducing Dr. Jianguo Liu - Vasculitis Foundation
This is a significant finding since the p35 unit is only utilized by IL-12 while p40 is shared by both IL-23 and IL-12. ... My project was to figure out whether pro-inflammatory signals such as interleukin-12 (IL-12) and Nitric Oxide were affected by ... Xiaojing Ma, an expert on IL-12 gene regulation.. Since joining the laboratory of Dr. Ma as a postdoctoral fellow in 2000, my ... I first started out by studying the molecular mechanisms of IFN-g- and LPS-mediated IL-12 p35 gene expression. We were the ...
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts...
... a heterodimeric immunoregulatory cytokine composed of covalently linked p35 and p40 subunits, has antitumor activity in animal ... Ad.p35 plus Ad.p40, or Ad.IL-12, with or without Ad.CD, were administered (single-dose) intratumorally to Renca tumor-bearing ... The inhibition of tumor growth in mice treated with Ad.p35 plus Ad.p40 and Ad.CD, followed by injection of 5-FC, was ... Adenoviral vectors were constructed encoding one or both subunits of murine IL-12 (Ad.p35, Ad.p40 and Ad.IL-12) or cytosine ...
IL-12 beta Protein, Human (HEK293) | MedChemExpress
... is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves ... IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, ... MedChemExpress offers high purity IL-12 beta Protein, Human (HEK293) with excellent lot-to-lot consistency, superior biological ... IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, ...
APC anti-mouse IL-12/IL-23 p40 monomer, dimer, heterodimer Antibody anti-IL-12/IL-23 p40 - C15.6
APC anti-mouse IL-12/IL-23 p40 (monomer, dimer, heterodimer) Antibody - The C15.6 antibody reacts with mouse IL-12 p40 subunit ... of the IL-12 p70 and IL-23 p40 subunit of the IL-23 p19/p40, as well as p40 monomer and homodimer, or heterodimer. ... IL-12Rβ1 binds p40; dimeric with IL-12Rβ2 binds p35 Biology Area Immunology, Innate Immunity Molecular Family Cytokines/ ... Interleukin-12 p40, Interleukin-23 p40, Cytotoxic lymphocyte maturation factor (CLMF), Natural killer cell stimulatory factor ( ...
Recombinant IL-12 p40,Human,AF - Biofargo
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. - Immunology
CD40-induced colitis, but not wasting disease or serum proinflammatory cytokine production, depended on interleukin-23 p19 ... whereas interleukin-12 p35 secretion controlled wasting disease and serum cytokine production but not mucosal immunopathology. ... response that was functionally dependent on tumor necrosis factor-alpha and interferon-gamma as well as interleukin-12 p40 and ... Interleukin-23, Interleukin-23 Subunit p19, Interleukins, Mice, Mice, Knockout, Organ Specificity, Spleen, T-Lymphocytes, ...
HTRF Human IL12/Il23 p40 Detection kit | PerkinElmer
... p35 heterodimer), IL-23 (p40+p19 heterodimer), p40 (monomer), and p80 homodimer (p40+p40). Detection of the shared subunit p40 ... p40 is a common component of the p40 family of cytokines which encompasses IL-12 (p40+ ...
CD4+ Cell Development, Function & Dysregulation in Allergy and Autoimmune Diseases Essay - Free Summaries Examples
... composed of p35 and p40 subunits. IL-23 shares the p40 subunit, combined with p19, to make its structure. IFN-?-/- and p35-/- ... 2009) Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunological Signature of Subclinical Intestinal ... LEONARD, W.J. (2008) The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Current opinion in Immunology, Vol ... Alongside antigen presentation, interferon- ? (IFN-?) and interleukin-12 (IL-12) are required from the APC. IL-12R�2, on the ...
Human IL-12p70 Analyte Overview | Quansys Biosciences
... is a subunit of interleukin 12 (IL-12) a cytokine that has a broad range of biological activities in the immune system. The ... IL-12 inhibits the formation of new blood vessels and may play a role in autoimmune disorders. ... Also known as IL-12, Interleukin 12, Active Heterodimer of Interleukin-12. ... complete IL-12 unit aids in the differentiation of naïve T cells into Th1 cells and regulates the activity of natural killer ...
DeCS 2019 - June 12, 2019 version
IL1 Receptor Related Protein use Interleukin-18 Receptor alpha Subunit IL1 Receptor-Related Protein use Interleukin-18 Receptor ... IL 4 Receptors, Type II use Receptors, Interleukin-4, Type II IL 5 Receptor beta Subunit use Cytokine Receptor Common beta ... IFNAR1 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR1 Subunit, Interferon alpha-beta ... IFNAR2 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR2 Subunit, Interferon alpha-beta ...
DeCS 2018 - July 31, 2018 version
IL1 Receptor Related Protein use Interleukin-18 Receptor alpha Subunit IL1 Receptor-Related Protein use Interleukin-18 Receptor ... IL 4 Receptors, Type II use Receptors, Interleukin-4, Type II IL 5 Receptor beta Subunit use Cytokine Receptor Common beta ... IFNAR1 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR1 Subunit, Interferon alpha-beta ... IFNAR2 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR2 Subunit, Interferon alpha-beta ...
DeCS 2019 - June 12, 2019 version
IL1 Receptor Related Protein use Interleukin-18 Receptor alpha Subunit IL1 Receptor-Related Protein use Interleukin-18 Receptor ... IL 4 Receptors, Type II use Receptors, Interleukin-4, Type II IL 5 Receptor beta Subunit use Cytokine Receptor Common beta ... IFNAR1 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR1 Subunit, Interferon alpha-beta ... IFNAR2 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR2 Subunit, Interferon alpha-beta ...
DeCS 2017 - July 04, 2017 version
IL1 Receptor Related Protein use Interleukin-18 Receptor alpha Subunit IL1 Receptor-Related Protein use Interleukin-18 Receptor ... IL 4 Receptors, Type II use Receptors, Interleukin-4, Type II IL 5 Receptor beta Subunit use Cytokine Receptor Common beta ... IFNAR1 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR1 Subunit, Interferon alpha-beta ... IFNAR2 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR2 Subunit, Interferon alpha-beta ...
DeCS 2018 - July 31, 2018 version
IL1 Receptor Related Protein use Interleukin-18 Receptor alpha Subunit IL1 Receptor-Related Protein use Interleukin-18 Receptor ... IL 4 Receptors, Type II use Receptors, Interleukin-4, Type II IL 5 Receptor beta Subunit use Cytokine Receptor Common beta ... IFNAR1 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR1 Subunit, Interferon alpha-beta ... IFNAR2 Subunit, Interferon alpha beta Receptor use Receptor, Interferon alpha-beta IFNAR2 Subunit, Interferon alpha-beta ...