*  Reactome | VCAM1 binds Integrin alpha4beta1
Integrin cell surface interactions (Bos taurus) * VCAM1 binds Integrin alpha4beta1 (Bos taurus) ...
  http://www.reactome.org/content/detail/R-BTA-198941
*  Reactome | Integrin alpha4beta1 binds JAM2:JAM3
Integrin cell surface interactions (Gallus gallus) * Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus) ...
  http://www.reactome.org/content/detail/R-GGA-202706
*  Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. -...
Here we report on the identification of a high-affinity peptidomimetic ligand (LLP2A; IC50 = 2 pM) against alpha4beta1 integrin ... Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.. Peng ... We further demonstrate that LLP2A can be used to image alpha4beta1-expressing lymphomas with high sensitivity and specificity ... Thus, LLP2A provides an important tool for noninvasive monitoring of alpha4beta1 expression and activity during tumor ...
  https://www.ncbi.nlm.nih.gov/pubmed/16767086
*  Details and Download Full Text PDF: Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves...
Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function.. Authors:. ... The integrin alpha4beta1, expressed by these leukocytes, is a key to their activation and migration into/within tissue. ... The leukocyte integrin alpha4beta1 is crucial for their entry. The authors previously demonstrated that an anti-alpha4 ... Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy.. Authors: ...
  https://www.pubfacts.com/detail/19038604/Alpha4beta1-integrin-blockade-after-spinal-cord-injury-decreases-damage-and-improves-neurological-fu
*  Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine | IRIS Università degli Studi di Catania
... integrin by reducing infiltrated eosinophils. We propose that blockade of integrin-mediated cell adhesion might be a target of ... integrin by reducing infiltrated eosinophils. We propose that blockade of integrin-mediated cell adhesion might be a target of ... The adhesion molecule integrin alpha(4)beta(1) is expressed in eosinophils; it interacts with the vascular cell adhesion ... The adhesion molecule integrin alpha(4)beta(1) is expressed in eosinophils; it interacts with the vascular cell adhesion ...
  https://www.iris.unict.it/handle/20.500.11769/51349
*  Distribution of α4 on multiple K562-α4wt and K562 | Open-i
Previous studies have shown that integrin alpha chain tails make strong positive contributions to integrin-mediated cell ... Furthermore, alpha4 tail deletion also significantly decreased the membrane diffusivity of alpha4beta1, as determined by a ... Previous studies have shown that integrin alpha chain tails make strong positive contributions to integrin-mediated cell ... We now show here that integrin alpha4 tail deletion markedly impairs static cell adhesion by a mechanism that does not involve ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199079_JEM.962074f5&req=4
*  Immunohistochemical analysis of c-kit receptor express | Open-i
Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ... Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ... The SCF-stimulated adhesion occurred without concomitant changes in surface integrin expression, thereby indicating an avidity- ... The SCF-stimulated adhesion occurred without concomitant changes in surface integrin expression, thereby indicating an avidity- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198988_JEM.970564f2&req=4
*  NCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 Antibody
Integrin α4β1 inhibitor, Highly potent and selective inhibitor of integrin alpha4beta1. 0. ... Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAM1
*  CD169 mediates the capture of exosomes in spleen and lymph node | Blood Journal
Exosomes released during reticulocyte maturation bind to fibronectin via integrin alpha4beta1. Eur J Biochem. 2000;267(2):583- ... DC-derived exosomes abundantly express the ligand milk-fat globule lactadherin, a potential ligand for the αvβ3/β5 integrins.38 ... Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 2004;18(9):977-979. ...
  http://www.bloodjournal.org/content/123/2/208?sso-checked=true
*  Effect of rhSCF on the adhesion of human eosinophils t | Open-i
3). Treatment with rhSCF did not change the surface expression of integrin α4, α6, β1, α4β7, or c-kit receptor as evaluated by ... 3). Treatment with rhSCF did not change the surface expression of integrin α4, α6, β1, α4β7, or c-kit receptor as evaluated by ... Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ... Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198988_JEM.970564f3&req=4
*  LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Integrin-Mediated Cell Adhesion and Liver Metastasis |...
Integrin alpha4beta1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells ... For β1 integrin blockade, β1 integrin functional blocking antibody (2.0 μg/mL) or isotype control IgG1 (2.0 μg/mL) were ... Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at ... Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem 2007;282:22964-76. ...
  http://cancerres.aacrjournals.org/content/71/5/1989
*  Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis...
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development ... Proteomic analysis of alpha4beta1 integrin adhesion complexes reveals alpha-subunit-dependent protein recruitment. Proteomics. ... Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation ... Integrin-dependent signaling in erythroid cells. How are the phenotypic differences between α4- and α 5-integrins molecularly ...
  http://www.haematologica.org/content/98/11/1769
*  The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits. - Semantic...
... integrin), CD18 (beta(2) integrin) and the alpha sub-units of beta(2) integrin CD11a (LFA-1 integrin) and CD11b (Mac-1 integrin ... Treatment with the other anti-integrin mAbs had no effect on the acute bronchoconstriction after inhaled Ag challenge.Pre- ... treatment with the anti-integrin mAbs had differential effects in blocking the recruitment of inflammatory cells 24 h after ... The integrin adhesion molecules are involved in the recruitment and activation of inflammatory cells at sites of inflammation ...
  https://www.semanticscholar.org/paper/The-effect-of-anti-integrin-monoclonal-antibodies-Gascoigne-Holland/835de195266434990ac0574291b231f6938e9321
*  Table of Contents | Journal of Cell Science
Osteopontin is a ligand for the alpha4beta1 integrin K.J. Bayless, G.A. Meininger, J.M. Scholtz, G.E. Davis ... Vitronectin regulates smooth muscle contractility via alphav and beta1 integrin L.M. Dahm, C.W. Bowers ...
  http://jcs.biologists.org/content/111/9.most-read
*  IGSF8 - Wikipedia
2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013-9. doi:10.1182/blood-2003-07-2201. ... Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. ... 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. ...
  https://en.wikipedia.org/wiki/IGSF8
*  BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways | JCB
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation ... Integrin-linked kinase associated with integrin activation. Blood. 113:5304-5313. doi:10.1182/blood-2008-07-169136. ... which then activates integrin-linked kinase 1 (ILK-1) via α4-integrins. ILK-1 then induces the Wnt-PCP pathway by binding a ... We show that FN interacts with α4-integrins to activate integrin-linked kinase 1 (ILK-1). This leads to the formation of a ...
  http://jcb.rupress.org/content/192/1/171.full
*  Plus it
Combined blockade of integrin-alpha4beta1 plus cytokines SDF-1alpha or IL-1beta potently inhibits tumor inflammation and growth ... PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and ... Based on these findings, we surmised that PI3Kγ might activate a BTK-signaling pathway to promote integrin α4β1 activation on ... To characterize the interactions between PI3Kγ and BTK in myeloid cells, we first compared their roles in mediating integrin ...
  http://cancerdiscovery.aacrjournals.org/content/6/3/270
*  PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP | Journal of Cell Science
Reinhardt, P. H., Elliott, J. F. and Kubes, P. (1997). Neutrophils can adhere via alpha4beta1-integrin under flow conditions. ... Gao, X., Xu, N., Sekosan, M., Mehta, D., Ma, S. Y., Rahman, A. and Malik, A. B. (2001). Differential role of CD18 integrins in ... Heit, B., Colarusso, P. and Kubes, P. (2005). Fundamentally different roles for LFA-1, Mac-1 and {alpha}4-integrin in ... A second potential mechanism resulting in this delay is an alteration in the activation patterns of integrins (Reinhardt et al ...
  http://jcs.biologists.org/content/121/2/205
*  BCR activation induces integrin α4β1-mediated B cell | Open-i
BCR activation induces integrin α4β1-mediated B cell adhesion to VCAM-1 and FN. (A) Primary tonsillar B cells were not ... The control of integrin alpha4beta1-mediated B cell adhesion by the BCR involves cytoskeletal reorganization and integrin ... The control of integrin alpha4beta1-mediated B cell adhesion by the BCR involves cytoskeletal reorganization and integrin ... Here we show that the BCR controls integrin alpha4beta1 (VLA-4)-mediated adhesion of B cells to vascular cell adhesion molecule ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2194118_20011866f1&req=4
*  TR 14035 - AdisInsight
TR 14035 is an orally active dual α4β7/α4β1 integrin antagonist. It was originated by Tanabe Seiyaku and was being developed by ... Mechanism of Action Alpha4-beta7 integrin antagonists; Integrin alpha4beta1 antagonists * Orphan Drug Status Orphan designation ...
  http://adisinsight.springer.com/drugs/800012563?error=cookies_not_supported&code=940db574-f584-4dd3-8819-cf1d29e0a660
*  Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Transient alpha4beta1 integrin-mediated retention of immature B cells in bone marrow sinusoids during egress. ... The Role of Integrins in Leukocyte Migration and Motility. * Ronald N. Germain, NIAID, National Institutes of Health, USA ... Modularity of Signaling Networks Controlling Integrin Activation: The Rho-Module of LFA-1 Affinity Triggering. ... Transendothelial Migration and Bidirectional Signal Transmission in Integrins. Amanda E.I. Proudfoot Fichard, Merck Serono ...
  https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=938
*  CiNii 論文 - Raised Serum Chondroitin Sulfate Epitope Level in Ovarian Epithelial Cancer ...
A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion IIDA J. ...
  http://ci.nii.ac.jp/naid/10018841588
*  Experience of in vitro fertilization surrogacy in Finland.
Next Document: Expression of alpha(v)beta3 and alpha4beta1 integrins throughout the putative window of implantation.... ...
  http://www.biomedsearch.com/nih/Experience-in-vitro-fertilization-surrogacy/12174160.html