*  Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors | Biochemical Journal
P3-binding site of hepatocytes is likely to be the receptor that mediates Ca2+ mobilization, and that this receptor is at ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors. D L Nunn, C W Taylor ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ...
  http://www.biochemj.org/content/270/1/227
*  Two Functions for IP3 Receptor Partner | Science Signaling
Inositol 1,4,5-trisphosphate (IP3), a second messenger formed in response to stimulation of cell surface receptors, binds to ... IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol. Cell 22, 795 ... Phosphorylated IRBIT (IP3R-binding protein released with inositol 1,4,5-trisphosphate) binds to the IP3-binding region of the ... an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- ...
  http://stke.sciencemag.org/content/2006/341/tw211
*  Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor | Journal of...
Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor. Dmitry V. Sarkisov ... Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor ... Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor ... Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor ...
  http://www.jneurosci.org/content/28/1/133.long
*  Itpr2 - Inositol 1,4,5-trisphosphate receptor type 2 - Mus musculus (Mouse) - Itpr2 gene & protein
Inositol 1,4,5-trisphosphate receptor type 2Imported. ,p>Information which has been imported from another database using ... tr,B2KF89,B2KF89_MOUSE Inositol 1,4,5-trisphosphate receptor type 2 (Fragment) OS=Mus musculus GN=Itpr2 PE=1 SV=1 ... 1. Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/manual/ ... Annotation score:1 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ...
  http://www.uniprot.org/uniprot/B2KF89
*  Similar papers for Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5...
... which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists. ... The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective ... which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists. ... 5-trisphosphate.. *. Davide Bello. , Tashfeen Aslam. , +4 authors. Stuart J Conway. *. Published. 2007. in The Journal of ...
  https://www.semanticscholar.org/paper/Synthesis-and-biological-action-of-novel-4-positio-Bello-Aslam/9e0b5777f64c0afe2f201489301518fa59204e02?tab=relatedPapers
*  Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate. - Department...
... the ionization state of the phosphates of adenophostin A at near physiological pH is very similar to those of inositol 1,4,5- ... trisphosphate, indicating that differences in phosphate charge cannot account for the high potency of this molecule. The ... The logarithms of the first to the fourth stepwise protonation constants are, respectively, log K(1) = 8.48, log K(2) = 6.20, ... Adenophostin A is a glyconucleotide natural product with the highest known potency for the D-myo-inositol 1,4,5-trisphosphate ...
  https://pharm.ox.ac.uk/publications/678619
*  Ouabain, a steroid hormone that signals with slow calcium oscillations
Incubation of cells in Ca2+-free media, inhibition of voltage-gated calcium channels, inositol triphosphate receptor antagonism ... nf-kappa-b, cardiac myocytes, na+/k+-atpase, endogenous ouabain, gene-expression, inositol trisphosphate, transcription factor ... indicating that they were caused by a concerted action of inositol triphosphate receptors and capacitative calcium entry via ... The results demonstrate a new mechanism for steroid signaling via plasma membrane receptors and underline a novel role for the ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:339780
*  Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate. -...
However, they caused Ca2+ release from GH3 rat pituitary cells possessing predominantly subtype I receptors more potently; Ins( ... with special reference to the relation of potency to receptor subtype. Ins(1,4,6)P3 and Ins(1,3,6)P3 were weak agonists in rat ... of the subtype III receptor, potencies of 1/40 and approx. 1/200 for Ins(1, 4,6)P3 and Ins(1,3,6)P3 respectively were exhibited ... in spite of the dominant presence of subtype I receptors (71%), similar respective potencies to those seen with COS-1 cells ...
  https://pharm.ox.ac.uk/publications/640353
*  Inositol 1,4,5-trisphosphate receptor (IPR000493) | InterPro | EMBL-EBI
Inositol 1,4,5-trisphosphate receptor (IPR000493). Short name: InsP3_rcpt Family relationships *Ryanodine receptor-related ( ... Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.. J. Biol. Chem. 285 ... GO:0070679 inositol 1,4,5 trisphosphate binding GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel ... The inositol 1,4,5-trisphosphate (IP3)3 receptor (IP3R) are tetrameric intracellular Ca2+ release channels on the endoplasmic ...
  http://www.ebi.ac.uk/interpro/entry/IPR000493
*  Itpr2 - Inositol 1,4,5-trisphosphate receptor type 2 - Mus musculus (Mouse) - Itpr2 gene & protein
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Inositol 1,4,5-trisphosphate receptor type 2Add BLAST. 2701. Amino acid modifications. Feature key. Position(s). Description ... Inositol 1,4,5-trisphosphate bindingBy similarity. 5. ,p>This subsection of the 'Family and Domains' section describes a region ...
  http://www.uniprot.org/uniprot/Q9Z329
*  ITPR1 - Inositol 1,4,5-trisphosphate receptor type 1 - Bos taurus (Bovine) - ITPR1 gene & protein
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- ... trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 ... Inositol 1,4,5-trisphosphate receptor type 1Add BLAST. 2709. Amino acid modifications. Feature key. Position(s). Description ... Inositol 1,4,5-trisphosphate bindingBy similarity. 5. ,p>This subsection of the 'Family and Domains' section describes a region ...
  http://www.uniprot.org/uniprot/Q9TU34
*  Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones | Science
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R (IP3 ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ...
  http://science.sciencemag.org/content/282/5394/1705
*  Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. | JCB
Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.. L D Walensky, S H Snyder ... We have characterized inositol 1,4,5-trisphosphate (IP3)-gated calcium channels and upstream components of the phosphoinositide ... Western blotting using a polyclonal antibody directed against purified brain IP3 receptor (IP3R) identified a specific 260 kD ... Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. ...
  http://jcb.rupress.org/content/130/4/857
*  Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic...
In mouse eggs, these oscillations cease after a variable period of time and this is accompanied by a decrease in inositol 1,4,5 ... trisphosphate receptor (IP3R) responsiveness and down-regulation of the IP3R type 1 (IP3R-1). To investigate the signaling ... Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic ... Jellerette T1, He CL, Wu H, Parys JB, Fissore RA.. Author information. 1. Department of Veterinary and Animal Sciences, ...
  https://www.ncbi.nlm.nih.gov/pubmed/10882513?access_num=10882513&link_type=MED&dopt=Abstract
*  Inositol 1,4,5-trisphosphate receptor-interacting protein elisa and antibody
Recombinant Protein and Inositol 1,4,5-trisphosphate receptor-interacting protein Antibody at MyBioSource. Custom ELISA Kit, ... Shop Inositol 1,4,5-trisphosphate receptor-interacting protein ELISA Kit, ... Inositol 1,4,5-trisphosphate receptor-interacting protein. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 Antibody. Itpripl1 ELISA Kit. Itpripl1 Recombinant. Itpripl1 ...
  https://www.mybiosource.com/protein_family.php?root=inositol-1-4-5-trisphosphate-receptor-interacting-protein
*  Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2...
... functional IP3 receptors (IP3Rs) and the human homologue of the Drosophila transient receptor potential (Trp) channel, human ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ...
  http://www.biochemj.org/content/350/3/631
*  Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic...
... mobilizing inositol phosphates and other inositol phosphates which also bind to the purified InsP3 receptor, suggesting that ... The results suggest that there is an absolute increase in the level of the InsP3 receptor during HL-60 cell differentiation and ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ...
  http://www.biochemj.org/content/280/1/205
*  Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release...
Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ...
  http://www.biochemj.org/content/327/1/251
*  Inositol 1,4,5-trisphosphate receptors (InsP3R) | Pancreapedia
... correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ... Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 87(2): 593-658,2007. PMID: 17429043. ... Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies ... Calcium-dependent conformational changes in inositol trisphosphate receptors. J Biol Chem 285(32): 25085-25093,2010. PMID: ...
  https://www.pancreapedia.org/molecules/inositol-145-trisphosphate-receptors-insp3r
*  Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy |...
Przyklenk K, Maynard M, Whittaker P. First molecular evidence that inositol trisphosphate signaling contributes to infarct size ... anti-GAGAB receptors, anti-LGI1, anti-CASPR2, anti-glycine receptors, anti-ganglioside antibodies) was negative. ... T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology. 1998;51:1146-50.View ArticlePubMed ... Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128:1286-97.View ArticlePubMed ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0737-x
*  Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. -...
A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, ... The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized ... These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release ... Regulation of calcium spiking in mammalian oocytes through a combination of inositol trisphosphate-dependent entry and release. ...
  https://www.semanticscholar.org/paper/Block-of-Ca2%2B-wave-and-Ca2%2B-oscillation-by-antibody-Miyazaki-Yuzaki/83acfdbb74a191725a08009fbee9460190eb0644
*  Inositol 1,4,5-trisphosphate receptor type 1
Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 ... This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate ... Phospholipase C gamma signaling ( B cell receptor signaling ) 3 Phospholipase C gamma signaling ( CD4 T cell receptor signaling ... Cytosolic calcium ion concentration elevation (through IP3 receptor) ( GPCR GroupI metabotropic glutamate receptor signaling ...
  https://pharos.nih.gov/idg/targets/ITPR1
*  Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
HCA RNA Cell Line for Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1. ... Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. ...
  https://pharos.nih.gov/idg/targets/Q6GPH6
*  Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
Among these are the 7-transmembrane receptors (G protein-coupled receptors) coupling to G(s), G(i/o), Gā‚ā‚‚/ā‚ā‚ƒ, or G(q/11) G ... Inositol 1,4,5-triphosphate receptor 1 and myosin light chain kinase were recruited as key phosphorylation targets of ... In addition to the contribution from NMDA receptors, GluR-A-containing AMPA receptors were found to be critically required for ... Using pharmacological and conditional genetic tools in mice, we delineated receptor-mediated from non-receptor-mediated effects ...
  https://www.jove.com/author/Rohini_Kuner?language=Italian
*  bioimages
... and the expression of purinergic and inositol trisphosphate receptors, respectively. The results obtained revealed the ... In addition to the Ca2+ wave, the RT-PCR results indicated variability in the purinergic receptors and inositol 1,4,5- ... trisphosphate receptor subtypes within G1-phase cells. Based on these results, we propose that receptor expression and calcium ... Intracellular calcium dynamics and expression of P2Y and IP3 receptors in a cycling G1-phase cell ...
  https://www.jstage.jst.go.jp/browse/bioimages/24/0/_contents