Frontiers | Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin...
2018). Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation. Stem Cells 36, ... Hart, J. (2002). Inflammation. 2: its role in the healing of chronic wounds. J. Wound Care 11, 245-249. doi: 10.12968/jowc. ... Chan, B. D., Wong, W. Y., Lee, M. M. L., Cho, W. C. S., Yee, B. K., and Kwan, Y. W. (2019). Exosomes in inflammation and ... Inflammation. The EV are partially responsible for the immunomodulatory and immunosuppressant activities of the MSC. The ...
Frontiers | Venous stroke-a stroke subtype that should not be ignored
Inflammation. Inflammation may be triggered by various factors after cerebral ischemia, including vascular obstruction, ... One special question to start with: can HIF/NFkB be a target in inflammation? Endocr Metab Immune Disord Drug Targets. (2015) ... Hu S, Lee H, Zhao H, Ding Y, Duan J. Inflammation and severe cerebral venous thrombosis. Front Neurol. (2022) 13:873802. doi: ... Autophagy and inflammation in ischemic stroke. Neural Regen Res. (2020) 15:1388-96. doi: 10.4103/1673-5374.274331 ...
Frontiers | Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Inflammation. Aging and age-related diseases converge on inflammation. Inflammaging is a special term describing a chronic, ... sterile and low-grade inflammation that develops with advanced age. Systemic inflammation increases with age (Goldberg and ... 2017a). Inflammation and premature aging in advanced chronic kidney disease. Am. J. Physiol. Renal Physiol. 313 (4), F938-F950 ... Taniguchi, K., and Karin, M. (2018). NF-κB, inflammation, immunity and cancer: coming of age. Nat. Rev. Immunol. 18 (5), 309- ...
Frontiers | Moringa Genus: A Review of Phytochemistry and Pharmacology
Anti-inflammation. A study reported that an ethanolic extract of the M. concanensis flower and fruit inhibited inflammation by ... The major anti-inflammation mechanism reported for M. oleifera was the inhibition of the NF-κB pathway. Four fractions of M. ... in experimental immune inflammation. J. Ethnopharmacol. 130, 183-186. doi: 10.1016/j.jep.2010.04.024 ... 2014). Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry ...
Frontiers | Macrophage Autophagy and Bacterial Infections
Inflammation Dampening. Although inflammation is central to control bacterial infection, excessive inflammatory responses can ... Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A (2012 ... Inflammation Dampening. One example is Vibrio parahaemolyticus, which limits NLRC4 inflammasome-mediated IL-1beta production by ... The recombinant BCG DeltaureC::hly vaccine targets the AIM2 inflammasome to induce autophagy and inflammation. J Infect Dis ( ...
Frontiers | Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies?
Inflammation is also one of such ways of generating free radicals/ROS in the prostatic tissue. Prostatic inflammation can cause ... BPH and Inflammation. Inflammation is a natural defense mechanism against pathogens and it is associated with many pathogenic ... Dietary Polyphenols and Inflammation. Inflammation is an immunological defense mechanism by which tissues respond to an insult ... 2007). Does intraprostatic inflammation have a role in the pathogenesis and progression of benign prostatic hyperplasia? BJU ...
Frontiers | Ceramides in Adipose Tissue
Ceramide and Inflammation. Adipose tissue inflammation is a hallmark of obesity characterized by the increased recruitment and ... Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of ... The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. (2011) 17:179-88. doi: 10.1038/ ... Evidence that TLR4 Is not a receptor for saturated fatty acids but mediates lipid-induced inflammation by reprogramming ...
Frontiers | The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms
Genetic factors, obesity, inflammation, oxidative stress, hyperglycemia, hyperinsulinemia, cancer therapies, insulin and some ... Genetic factors, obesity, inflammation, oxidative stress, hyperglycemia, hyperinsulinemia, cancer therapies, insulin and some ... Inflammation and Oxidative Stress. Inflammation is a key element in the link between diabetes mellitus and cancer (93). T2DM is ... Chronic Inflammation, Chronic Obstructive Pulmonary Disease, and Lung Cancer. Curr Opin Pulm Med (2009) 15:303-7. doi: 10.1097/ ...
Frontiers | Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
... the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation ... the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation ... chronic inflammation and/or malignant transformation. Furthermore, translocation of immune cells from one anatomical ... chronic inflammation and/or malignant transformation. Furthermore, translocation of immune cells from one anatomical ...
Frontiers | Caffeine Protects Against Retinal Inflammation
Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate ... Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate ... We tested caffeine by using in vitro and in vivo paradigms of retinal inflammation. Human retinal pigment epithelial cells ( ... In conclusion, these findings suggest that caffeine is a good candidate to counteract inflammation in retinal diseases. ...
Frontiers | Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression
Reelin, Oxidative Stress, Inflammation, and Depression. A further link between ROS and depression has been suggested by recent ... There is also a key link with inflammation to consider in the context of these experiments. Many studies support the idea that ... Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., and Golden, S. A. (2018). Epigenetic modulation of inflammation and ... Czarny, P., Wigner, P., Galecki, P., and Sliwinski, T. (2018). The interplay between inflammation, oxidative stress, DNA damage ...
Frontiers | Impact of Federal, State, and Local Housing Policies on Disparities in Cardiovascular Disease in Black/African...
The inflammation caused by PM2.5 is thought to synergize with obesity-induced tissue inflammation, worsening insulin resistance ... and tissue inflammation. Lastly, we focus on the impact of inflammation on the immune system and the molecular mechanisms by ... Libby P. Inflammation in Atherosclerosis-No Longer a Theory. Clin Chem (2021) 67:131-42. doi: 10.1093/clinchem/hvaa275 ... Soehnlein O, Libby P. Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Nat Rev Drug Discov ...
Frontiers | Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis
The first type of inflammation dominates in acute and relapsing MS. The second type of inflammation is already present in early ... The other type of inflammation is a slow accumulation of T-cells and B-cells in the absence of major blood brain barrier damage ... The other type of inflammation is a slow accumulation of T-cells and B-cells in the absence of major blood brain barrier damage ... This type of inflammation is associated with the formation of subpial demyelinated lesions in the cerebral and cerebellar ...
Frontiers | Effects of high oleic acid peanuts on mice's liver and adipose tissue metabolic parameters and gut microbiota...
The effect of peanuts addition to diet on adipose tissue inflammation. The addition of peanuts to a normal diet did not elicit ... Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Med Cell ... The effect of diets on key players that participate in lipid metabolism and inflammation in adipose tissue. Mice consumed ... Zandani, G, Anavi-Cohen, S, Sela, N, Nyska, A, and Madar, Z. Broccoli consumption attenuates inflammation and modulates gut ...
Frontiers | Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis
Figure 3 CB controls spontaneous inflammation in cells from JIA patients. (A) TNF-α was measured in the plasma of blood from HD ... Spontaneous inflammation is a well-known hallmark of JIA. While elevated levels of IL-6 are easily measurable in the plasma of ... Figure 4 CB controls R848-induced inflammation in cells from JIA patients. (A) PBMCs from HD and JIA patients were incubated ... Figure 5 CB controls inflammation and disease onset in collagen induced arthritic mice. (A) The body weight of collagen induced ...
Frontiers | Interferon-α2b Treatment for COVID-19
Keywords: interferon, COVID-19, viral shedding, IL-6, inflammation, ARDS. Citation: Zhou Q, Chen V, Shannon CP, Wei X-S, Xiang ... Circulating cytokine levels (IL-2, IL-4, IL-10, IFN-γ, IL-6, TNFα) and biomarkers of inflammation (C-reactive protein, CRP and ... Reduction of markers of acute inflammation such as CRP and IL-6 correlated with this shortened viral shedding, suggesting IFN- ... Effects of IFN Treatment on Circulating Cytokine Levels and Biomarkers of Inflammation. ...
Frontiers in Immunology | Research Topics
Inflammation. *. Microbial Immunology. *. Molecular Innate Immunity. *. Mucosal Immunity. *. Multiple Sclerosis and ...
Frontiers | Effects of Combined Supplementation of Macleaya cordata Extract and Benzoic Acid on the Growth Performance, Immune...
Inflammation. (2014) 37:632-8. doi: 10.1007/s10753-013-9779-8. PubMed Abstract , CrossRef Full Text , Google Scholar ...
Frontiers | Dynamics of Colon Monocyte and Macrophage Activation During Colitis
Results We show that the macrophage:monocyte balance is disrupted in colon inflammation to favour recruitment of CD14+HLA-DRInt ... Finally, our data reveal that, independent of inflammation, murine colon macrophages act as major sources of Ccl7 and Ccl8 mRNA ... Finally, our data reveal that, independent of inflammation, murine colon macrophages act as a major source of Ccl7 a... ... macrophage balance is disrupted in colon inflammation to favour recruitment of CD14+HLA-DRInt cells in humans, and Ly6CHi ...
Frontiers | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic...
... levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. Due to the quantitative and qualitative ... levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. Due to the quantitative and qualitative ... CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal ... levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. In terms fibrosis, such as HYP content ...
Frontiers | Precision N-Glycoproteomic Profiling of Murine Peritoneal Macrophages After Different Stimulations
Hexose Uptake and Metabolism in Immune Homeostasis and Inflammation View all 8 Articles ...
Frontiers | Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological...
Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans (2017) 45(4): ... Baune BT, Rothermundt M, Ladwig KH, Meisinger C, Berger K. Systemic inflammation (interleukin 6) predicts all-cause mortality ... and obesity-associated inflammation (176-179). Thus, the M1/M2 paradigm for macrophages is likely to be an over-simplification ... non-specific mucosal inflammation, or airway epithelial cell trauma due to increased ventilation or exposure to cold air (21). ...
Frontiers | High Na+ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils
Infection and inflammation can augment local Na+ abundance. These increases in local Na+ levels boost proinflammatory and ... Infection and inflammation can augment local Na+ abundance. These increases in local Na+ levels boost proinflammatory and ... High salt diets (1, 2), renal impairment (3-6), inflammation, and infection (7-11) can induce Na+ accumulation in skin tissues ... Infection and inflammation can augment local Na+ abundance. These increases in local Na+ levels boost proinflammatory and ...
Frontiers | Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected...
... has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in ... has been proposed to play a role in the induction of acute inflammation. We hypothezised that the presence of active CTSB in ... The generation of ASC speck has been associated with high levels of IL-1β production and promotion of inflammation (52). It is ... 2Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and ...
Frontiers | Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological...
Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans (2017) 45(4): ... Baune BT, Rothermundt M, Ladwig KH, Meisinger C, Berger K. Systemic inflammation (interleukin 6) predicts all-cause mortality ... and obesity-associated inflammation (176-179). Thus, the M1/M2 paradigm for macrophages is likely to be an over-simplification ... non-specific mucosal inflammation, or airway epithelial cell trauma due to increased ventilation or exposure to cold air (21). ...
Frontiers | Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2...
Autoimmune responses and inflammation in type 2 diabetes. J Leuko Biol. (2020) 107:739-49. doi: 10.1002/JLB.3MR0220-243R ... Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front Physiol. (2020) 10:1607-26 ... T cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans. Arterioscler Thromb ... Setting the Stage for islet autoimmunity in type 2 diabetes: obesity-associated chronic systemic inflammation and endoplasmic ...
Frontiers | Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation
... were measured in the serum as markers of systemic inflammation using enzyme-linked immunosorbent assay.Results: Both KYN and ... were measured in the serum as markers of systemic inflammation using enzyme-linked immunosorbent assay. Results: Both KYN and ... metabolism in obese subjects relatively to non-obese controls and to determine their relationship with systemic inflammation. ... metabolism in obese subjects relatively to non-obese controls and to determine their relationship with systemic inflammation. ...
Frontiers | Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and...
Furthermore, long-term lipopolysaccharide (LPS) exposure mimicking immunosuppression in the resolution phase of inflammation ... Furthermore, long-term lipopolysaccharide (LPS) exposure mimicking immunosuppression in the resolution phase of inflammation ... thereby promoting inflammation. The interaction of GCs with macrophages in the immunosuppressive resolution phase upon ... thereby promoting inflammation. The interaction of GCs with macrophages in the immunosuppressive resolution phase upon ...
Frontiers | Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments
The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced ... The pathophysiology of sepsis includes inflammation, immune dysfunction and dysfunction of coagulation, while sepsis-induced ... Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats. Shock (2004) 21(4):352-7. doi: ... The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced ...
Frontiers | Structural plasticity in the dentate gyrus- revisiting a classic injury model
Fitch, M. T., and Silver, J. (2008). CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and ... 2005). Inhibition of astroglial nuclear factor kB reduces inflammation and improves functional recovery after spinal cord ... inflammation (Brambilla et al., 2005), and chronic pain (Milligan and Watkins, 2009). Furthermore, the glial scar can inhibit ...