Neuro-inflammation. *. Original research: Clinical feature and disease outcome in patients with myelin oligodendrocyte ...

Neuro-inflammation. *. Research paper: Superficial white matter damage in anti-NMDA receptor encephalitis (3 November, 2017) ...

High-grade inflammation as well as anti-inflammatory treatment alter traditional CV risk factors, such as lipids. In view of ... Systemic inflammation inherent to IJD. Although traditional risk factors for CV disease are generally more often present in ... In addition, suppressing inflammation may enhance HDLc efflux function even in the absence of quantitative changes in lipids. ... Furthermore, inflammation regardless of its aetiology weakens the plaques cap, making the plaque unstable and more prone to ...

Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses BMJ 2000; 321 :199 doi:10.1136/ ... Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. New Engl J Med 1997; 336: 973-979. ... potential triggers of systemic inflammation (such as persistent infection), and other markers of inflammation. ... C reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; ...

Conclusion Our study highlights the role of cytokine-activated FLS in orchestrating inflammation-associated synovial pathotypes ...

... mice lacking tenascin-C are protected from prolonged synovial inflammation and tissue destruction; while inflammation is ... Antibody treatment ameliorates inflammation in experimental arthritis. (A and B) Synovial biopsies from the Birmingham early ... Tenascin-C is dispensable for the induction of joint inflammation but required for its persistence(figure 3),8 indicating that ... This strategy could enable a move away from blocking TLR4-mediated inflammation at the receptor level, hitting only disease- ...

inflammation. *interventional cardiology. *intravascular ultrasound. *left main bifurcation disease. *percutaneous coronary ...

... oxidative stress and inflammation, endothelial function and thrombosis, have been studied. In this review, we summarise ...

Background Chronic inflammation is one of the key processes in the development of metabolic dysfunction under obesity which ... The Tribbles (Trib) family of proteins has been described as major regulators of inflammation and energy metabolism. ... obesity affect many organs and particularly the adipose tissue where macrophages are key effector cells modulating inflammation ...

To investigate which air pollution characteristics are associated with biomarkers for acute nasal airway inflammation in ...

Competing interests Individual sources of potential conflict are as follows: JRB: Consultant/Advisory Boards: Bristol-Myers Squibb, Celgene, Lily Merck, Genentech, Amgen, Janssen, Syndax. Grant/Research Funding: Bristol-Myers Squibb, Merck, MedImmune/AstraZeneca. PMF: Consultant/Advisory Board: Abbvie AstraZeneca, Boehringer, Bristol-Myers Squibb, Celgene, Eli Lilly, Novartis. Grant/Research Funding: AstraZeneca, BMS, Corvus, Kyowa, Novartis. DL: Consultant/Advisory Board: Bristol-Myers Squibb, Merck. Grant/Research Funding: Bristol-Myers Squibb, Merck, Aduro Biotech. Honoraria: Merck. EJL: Consultant/Advisory Board: Bristol-Myers Squibb, Novartis, EMD Serono, Array BioPharma, Macrogenics, Merck, Millennium. Grant/Research Funding: Bristol-Myers Squibb, Merck, Sysmex. Patent/Royalty/Intellectual Property: Method of prevent organ transplant rejection using agonist to the PD-1 checkpoint pathway. JN: Consulting/Advisory Board: AstraZeneca, Roche/Genentech, Bristol-Myers Squibb. Grant/Research ...

INFLAMMATION IN TERM INFANTS WITH HYPOXIC RESPIRATORY FAILURE. Woldesenbet et al measured pro-inflammatory cytokine levels in ...

Inflammation and cancer: triggers, mechanisms, and consequences. Immunity 2019;51:27-41.doi:10.1016/j.immuni.2019.06.025 pmid: ... Hepatocyte restricted GPX4 deletion induces ferroptosis and inflammation. To examine GPx4 function in liver, we crossed floxed ... Ferroptosis in infection, inflammation, and immunity. J Exp Med 2021;218:e20210518.doi:10.1084/jem.20210518 pmid:http://www. ... Gpx4 deletion causes ferroptosis in vitro as well as in vivo leading to acute liver failure and inflammation. ...

Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort ...

Sasha Bernatsky, Rosalind Ramsey-Goldman, Lawrence Joseph, Jean-Francois Boivin, Karen H Costenbader, Murray B Urowitz, Dafna D Gladman, Paul R Fortin, Ola Nived, Michelle A Petri, Soren Jacobsen, Susan Manzi, Ellen M Ginzler, David Isenberg, Anisur Rahman, Caroline Gordon, Guillermo Ruiz-Irastorza, Edward Yelin, Sang-Cheol Bae, Daniel J Wallace, Christine A Peschken, Mary Anne Dooley, Steven M Edworthy, Cynthia Aranow, Diane L Kamen, Juanita Romero-Diaz, Anca Askanase, Torsten Witte, Susan G Barr, Lindsey A Criswell, Gunnar K Sturfelt, Irene Blanco, Candace H Feldman, Lene Dreyer, Neha M Patel, Yvan St Pierre, Ann E Clarke ...

Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future ...

Despite the interest in the novel neuronal antibodies and their significance in specific forms of demyelinating disease or autoimmune encephalitis, and individual case reports on their presence in less typical syndromes, there have been no systematic studies. Within the limitation of the study, where not all samples from the national cohort were sent for antibody testing (higher rate of CIS compared with ADEM, see table 1) and that the follow-up period was for 1 year, we have identified glial antibodies in 14% of the patients. Interestingly, neuronal antibodies against NMDAR, VGKC-complex and GlyR were also detected, albeit at a lower frequency (8%). Nevertheless, since the antibody-positive group could not be distinguished from the negative group based on the demyelinating phenotype, and the frequency of any individual antibody was not high, the clinical relevance of these findings remains to be established.. Antibodies to MOG were seen in seven patients (12% of those tested). These antibodies ...

Rohini J Haar, Vincent Iacopino, Nikhil Ranadive, Madhavi Dandu, Sheri D Weiser ...

Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. Int J Endocrinol 2013;2013:678159. doi: ... Chronic inflammation underlies many disease states, such as obesity and metabolic syndrome.8 Obesity is an American public ... Immune regulation in obesity-associated Adipose inflammation. J Immunol 2013;191:527-32. doi:10.4049/jimmunol.1301035 ... Obesity is known to result in chronic, low-grade inflammation which supports the pathogenesis of a myriad of metabolic diseases ...

Competing interests FL received honoraria from Abbot and Talecris and research support from the Werner-Otto-Stiftung. IK received speaker honoraria and travel reimbursements from Bayer Healthcare, Biogen Idec, Merck Serono and Novartis, and research funding from Bayer Healthcare and Deutsche Forschungsgesellschaft. JM received honoraria from PETNet, Erlangen, Germany and research support from the Bayerisches Wissenschaftsministerium and BMBF. MG received honoraria from Biogen Idec and research funding from the Landesexzellenzinitiative Hamburg. TM received honoraria from Talecris and research support from the Werner-Otto-Stiftung and Landesexzellenzinitiative Hamburg. JD received royalties from the editorial board of Up-To-Date; from Athena Diagnostics for a patent for the use of Ma2 as autoantibody test. He has received a research grant from Euroimmun, and his contribution to the current work was supported in part by grants from the National Institutes of Health and National Cancer Institute ...

There can be diagnostic confusion at the onset of sCJD. One important immunotherapy-responsive disease that needs to be excluded is VGKC-complex antibody positive limbic encephalitis.3 ,4 Other immune-mediated diseases may be suspected depending on the clinical features. A high proportion of patients with eventual sCJD diagnosis (150/256; 59%) had sera referred for specific antibody assays, the requested tests presumably reflecting their clinical features at presentation. The number of positive results, however, was low, with NMDAR or VGKC-complex antibodies present in only four patients (,5%) and no other antibodies detected at that time. When systematically testing all 82 available sera for NMDAR, GlyR and VGKC-complex antibodies, only 4 (3 additional) were positive (5%) and mostly at relatively low levels; but, during the same period of time, three other patients were identified with high VGKC-complex antibodies (,400 pM). Although two of these died before treatment could be initiated, the ...

Sondra vanderVaart, Howard Berger, Carolyn Tam, Y Ingrid Goh, Violette M G J Gijsen, Saskia N de Wildt, Anna Taddio, Gideon Koren ...

The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol2020;20:363-74. doi:10.1038/s41577-020-0311-8 ... and unless there are signs of super-infection or other complications such as painful pleural inflammation, cough seems to be ... inflammation and continuing prothrombotic state), troponin (acute coronary syndrome or myocarditis) and D-dimer (thromboembolic ... inflammation and microthrombi, and down-regulation of ACE-2 receptors.515354 ...

Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis. Cancer Res2017;77:27-40. doi:10.1158/0008-5472 ... Association of Emulsifier and Highly Processed Food Intake with Circulating Markers of Intestinal Permeability and Inflammation ... promoting inflammation and colon carcinogenesis.111213454647 In addition to additives, newly formed contaminants with ...

The author of the Inflammation and Heart Disease Theory Cautions - Cholesterol and Saturated Fat are an Integral part of the ... The mere measurement of lipids and markers of inflammation (CRP, IL-6, et cetera) through serum testing, correlate poorly with ... Saturated fats and LDL-cholesterol are two of the major contributing factors responsible for Inflammation and Heart Disease, ... First author, authored the "Inflammation and Heart Disease" and "Angina" Theories. The authors have previously addressed issues ...

Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia aging study.Ann Neurol2002; 52:168-74. ... The metabolic syndrome, inflammation, and risk of cognitive decline.JAMA2004; 292:2237-42. ... inflammation, and adipocytokines on our findings is unknown. ... particularly in those with high levels of inflammation.23. ...

Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Aliment Pharmacol ... Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease. Inflamm Bowel Dis2006;12: ... Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Int J Colorectal Dis2007;22:429- ... A delay of up to one month was not considered problematic as it is unlikely that mucosal inflammation spontaneously disappears ...

inflammation. Data availability statement. Data are available upon reasonable request. Data are available upon reasonable ... inflammation. Introduction. The Posner-Schlossman syndrome (PSS) is clinically characterised by recurring unilateral uveitis ... When only antiviral therapy was performed, if IOP did not exceed 21 mm Hg and inflammation did not recur, the disease was ... However, the subset that causes inflammation in the anterior segment is distinct from the variants that cause posterior segment ...

Basal inflammation and innate immune response in chronic multisite musculoskeletal pain. Pain 2014;155:1605-12. doi:10.1016/j. ... Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. ... as well as by ocular surface inflammation, which is a well-described component of DED.34 However, when considered in the ...