"Antibodies to immunoglobulin heavy chain variable regions protect help" by J Puri, neriah Y. Ben et al.
Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen. ... Puri, J; Ben, neriah Y.; Givol, D; and Lonai, P, "Antibodies to immunoglobulin heavy chain variable regions protect helper ...https://mouseion.jax.org/ssbb1980/1413/
Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda
The constant (C) region is fully intact, comprising 105 residues, whereas the variable region (V) has only 30 residues. The V- ... such as the hinge regions of heavy (H) and light (L) chains and the hypervariable regions, are particularly susceptible to ... An internal molecular deletion occurring in a human lambda type immunoglobulin light (L)-chain (Sm lambda) has been defined by ... Carbohydrate is attached to an Asx residue at position 25, in the first hypervariable region, associated with the sequence ...https://eurekamag.com/research/041/068/041068912.php
Anti-Human Kappa Light Chain Goat Antibody | Human Kappa Light Chain Goat Antibody | Human Kappa Light Chain Antibody | Human...
Cloning Antibody Variable Regions * RNA * Overview * Poly A+ RNA, Human * Blood & Immune ... This product is an affinity-purified IgG antibody that recognizes the kappa light chains of human immunoglobulin G (IgG) ...http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Secondary_Antibodies/IgG_Kappa_Light_Chain?sitex=10020:22372:US&PEBCL1=brr6T3ZJr2ZxcK27YO2uTZVB07&PEBCL1_pses=ZG3D11BE890CE399DA771AAB4F7C369DC940A52BE7B2A00156C6DE1E4B7B028095B2E08E9CAE5D0F58FB36DC9D1639C305D7B6251025805666
Novel Analysis of Clonal Diversification in Blood B Cell and Bone Marrow Plasma Cell Clones in Immunoglobulin Light Chain...
Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ... Abraham RS, Geyer SM, Price-Troska TL, Allmer C, Kyle RA, Gertz MA, Fonseca R: Immunoglobulin light chain variable (V) region ... The kinetics of V region mutation and selection in germinal center B cells. J Exp Med 178:1293-1307, 1993PubMedCrossRefGoogle ... Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ...https://link.springer.com/article/10.1007%2Fs10875-006-9056-9
Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma
Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma. ... Analysis of the rearranged immunoglobulin variable region gene hypermutation has provided important information concerning the ... Additionally, abortive κ light chain variable region genes in λ-expressing myelomas carried a significant number of somatic ... Despite the already acknowledged evidence for a selectable distribution of mutations within the clonal immunoglobulin variable ...https://insights.ovid.com/imrv/199804000/00004210-199804000-00025
Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. - Semantic Scholar
The region comprises five V kappa sequences of subgroup I and one interspersed V kappa pseudogene of subgroup II. The six genes ... An 80,000 base-pair region from the gene locus encoding the variable regions of the human immunoglobulins of the kappa type (V ... An 80,000 base-pair region from the gene locus encoding the variable regions of the human immunoglobulins of the kappa type (V ... Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes. *Guido Kroemer, Arno ...https://www.semanticscholar.org/paper/Organization-and-evolution-of-a-gene-cluster-for-of-Pech-Jaenichen/a36d3dca34894c26f4e5ae08a1cf93d75a9995b4
北京大学医学部机构知识库(IR@PKUHSC): Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in...
Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with ... Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with ... Wang, Jing,et al."Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association ... Wang, Jing,Bu, Dingfang,&Zhu, Xuejun.(2007).Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells ...http://ir.bjmu.edu.cn/handle/400002259/50993
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions | PNAS
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. N Hozumi and S Tonegawa ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ...http://www.pnas.org/content/73/10/3628
Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa...
2017). Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in ... Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa ... Humans, Neoplasms, Adnexal and Skin Appendage, Eye Neoplasms, Genetic Predisposition to Disease, Immunoglobulin Variable Region ... DNA Mutational Analysis, Gene Silencing, Gene Rearrangement, Phenotype, Mutation, Genes, Immunoglobulin Heavy Chain, Lymphoma, ...https://www.repository.cam.ac.uk/handle/1810/269885
Rearrangement of immunoglobulin heavy chain variableregion genes - Haemolytic Anaemia
The central process in B-cell formation is the rearrangement of Ig variable-region genes. For rearrangement of V-region genes ... The CDR1 and CDR2 regions encode two out of the three parts of the variable region that determine the antigenic specificity of ... The variableregion component of the immunoglobulin heavy chain gene is divided into three types of gene segment. V segments, D ... The V gene segments are longer than J or D segments and encode much of the framework of the variable-region domain, together ...https://www.europeanmedical.info/haemolytic-anaemia/rearrangement-of-immunoglobulin-heavy-chain-variableregion-genes.html
Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. - Radcliffe Department of Medicine
... region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in ... A mouse cloned cDNA probe containing a variable (V) ... A mouse cloned cDNA probe containing a variable (V) region ... Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Mice, Nucleic Acid Hybridization, Structure-Activity Relationship ... Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. Rabbitts TH., Matthyssens G., Hamlyn PH ...https://www.rdm.ox.ac.uk/publications/601749
immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg A1072-5 | Gentaursearch
immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg datasheet and description hight quality ... immunoglobulin light chain variable region [ ]/[Mus musculus] 5mg. Short name: immunoglobulin light chain variable region [Homo ... immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg. Contact us. ... immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5 milligrams of pure chemical substance for ...http://gentaursearch.com/product/human/33337/immunoglobulin-light-chain-variable-region-fragment-homo-sapiens-mus-musculus-5mg.html
CD1D | Cancer Genetics Web
... no association was found between NKT-like cell frequency and immunoglobulin heavy chain variable region gene (IGHV) mutation or ... Identical immunoglobulin gene rearrangements were identified in both the hairy cell leukemia and Langerhans cell sarcoma ... Bisulfite sequencing and MSP revealed that GpG islands in the promoter regions of KDR and FLT4 were unmethylated in HUVECs, ... Both Ki7LI and MS were able to split luminal tumors into subgroups with significantly variable outcomes, independent of other ...http://www.cancerindex.org/geneweb/CD1D.htm
Obtention and engineering of non-human primate (NHP) antibodies for therapeutics.
Immunoglobulin Variable Region / genetics. Peptide Library. Primates / immunology*. Recombinant Proteins / genetics, immunology ... 0/Antibodies; 0/Immunoglobulin Variable Region; 0/Peptide Library; 0/Recombinant Proteins ... The framework regions (FR) - the regions most implicated in tolerance - of these NHP antibody fragments were shown to be very ...http://www.biomedsearch.com/nih/Obtention-Engineering-Non-Human-Primate/20105119.html
Immunoglobulin variable region heavy chain gene (IgVH) mutation.[9-13] The finding of significant numbers of mutations in this ... the immunoglobulin variable region heavy-chain (IgVH) mutational status, and the presence of 11q- or 17p- deletion established ... including the immunoglobulin variable region heavy-chain (IgVH) gene mutation, chromosomal abnormalities by fluorescent in situ ... identified four prognostic subgroups based on immunoglobulin variable region heavy-chain gene mutation (IgVH), clinical stage, ...https://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq
Southern blot analysis and quantitation of PCR amplifie | Open-i
Immunoglobulin Variable Region/genetics*. *Immunoglobulin kappa-Chains/genetics*. *Multigene Family*. *Recombination, Genetic* ... Mentions: The human Igκ locus contains 76 Vκ and 5 Jκ gene segments located in a distal and a proximal region, carrying 36 and ... Mentions: The human Igκ locus contains 76 Vκ and 5 Jκ gene segments located in a distal and a proximal region, carrying 36 and ... Accessibility of immunoglobulin (Ig) gene segments to V(D)J recombination is highly regulated and is normally only achieved in ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195934_JEM010340.f1b&req=4
Connection | Harvard Catalyst Profiles | Harvard Catalyst
Regulation of immunoglobulin variable-region gene assembly. Academic Article T helper cell membranes promote IL-4-independent ... Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Academic Article The molecular ... Control of immunoglobulin heavy chain constant region gene expression. Academic Article An expressed neo(r) cassette provides ... Mechanisms that control antigen receptor variable region gene assembly. Academic Article Mechanism of endogenous myc gene down- ...https://connects.catalyst.harvard.edu/Profiles/search/default.aspx?searchtype=whypeople&nodeuri=https://connects.catalyst.harvard.edu/Profiles/profile/1252168&searchfor=Transcription,%20Genetic&exactphrase=&perpage=15&offset=0&page=1&totalpages=161&searchrequest=&sortby=&sortdirection=&showcolumns=1
Toward quantitative fluorescence measurements with multicolor flow cytometry. - Semantic Scholar
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.. *Marta Crespo, ...https://www.semanticscholar.org/paper/Toward-quantitative-fluorescence-measurements-with-Wang-Gaigalas/4ea56dd469a7780e1654e0ee6c738af850bec02d
Lupus eritematoso diseminado | Portsmouth Regional Hospital
Immunoglobulin variable-region gene usage in systemic autoimmune diseases. Arthritis Rheum . 2001;44:2715-2727. ...https://portsmouthhospital.com/hl/?/11698/lupus/sp&com.dotmarketing.htmlpage.language=1
Lupus eritematoso diseminado | Medical City Dallas
Immunoglobulin variable-region gene usage in systemic autoimmune diseases. Arthritis Rheum . 2001;44:2715-2727. ...https://medicalcityhospital.com/hl/?/11698/lupus-eritematoso-sist%C3%A9mico/sp&com.dotmarketing.htmlpage.language=1
The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response | The Journal of Immunology
Human immunoglobulin variable region gene analysis by single cell RT-PCR. J. Immunol. Methods 244: 217-225. ... Ig variable region cloning. B cell Ig variable region libraries were built from tissue sections prepared on a cryostat, from ... Variable region sequences were analyzed using software available from the human variable region database on the ImMunoGeneTics ... The variable region cloning procedure (8) also captures the 5′ end of the Ig constant region, allowing the Ig isotype to be ...http://www.jimmunol.org/content/182/5/3310
Single polypeptide chain binding molecules - Genex Corporation
... show closely similar variable regions despite large differences in the hypervariable segments. The immunoglobulin variable ... The variable regions of an antibody are composed of a light chain and a heavy chain. Light and heavy chain variable regions ... 1) Prepare a list of conserved and variable residues for variable regions of antibodies (Fv region). Residues which vary from F ... As only the hypervariable loops change drastically from variable region to variable region (the remainder being constant in the ...http://www.freepatentsonline.com/4946778.html
Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins | JEM
1984) Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO (Eur Mol Biol Organ) J 3:1209-1219, ... 1986) Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 324:585-590, pmid ... 1988) Variable region (Vδ) gene segment most frequently utilized in adult thymocytes is 3′ of the constant (Cδ) region. Proc ... 1986) Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a ...http://jem.rupress.org/content/189/2/289
acute lymphoblastic leukemia l2 type 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Immunoglobulin Variable Region; 0 / Nuclear Proteins; 0 / RAG2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / V(D)J ... Body Location or Region. A188.8.131.52. Molecular Sequence. A184.108.40.206.1. Nucleotide Sequence. A220.127.116.11.2. Amino Acid Sequence. A2.1. ... Immunoglobulin Heavy Chains / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. *[MeSH-minor] Adult. Aged. ... In the Warmia and Mazury region inhabited by 1.4 mln people, 6-16 new cases od childhood acute leukaemia are reported every ...http://www.bmlsearch.com/?kwr=acute+lymphoblastic+leukemia+l2+type+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
ASMscience | Lyme Borreliosis
Variable serum immunoglobulin responses against different Borrelia burgdorferi sensu lato species in a population at risk for ... serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region ... Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme ... Role of immunoglobulin G in killing Borrelia burgdorferi by the classical complement pathway. Infect. Immun. 56:314-321.. ...http://www.asmscience.org/content/book/10.1128/9781555816490.chap11