*  Context: Novel and Previously Reported Mono(imino)pyridine-based Nickel(II) Complexes
Ozone/oxone-mediated oxidations of amino and O-benzylhydroxylamino sugars.. *P-C and C-C bond formation by Michael addition in ... Synthesis of a series of mono(imino)pyridines and corresponding nickel(II) complexes and synthesis of a C1-symmetric bis(imino) ... Synthesis of a series of mono(imino)pyridines and corresponding nickel(II) complexes and synthesis of a C1-symmetric bis(imino) ... Synthesis of a Series of Mono(imino)pyridines and Synthesis of and Computational Studies on Carbon1-Symmetric Bis(imino) ...
  http://bibliography.library.villanova.edu/Record/10903/HierarchyTree?hierarchy=folder-11&recordID=10903
*  Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar.
... been synthesized via selective coupling of an appropriate nucleobase at different positions of an orthogonally protected imino ... This synthetic strategy offers a straightforward protocol for the assembly of imino sugar containing nucleosides, establishing ... synthesized via selective coupling of an appropriate nucleobase at different positions of an orthogonally protected imino sugar ...
  http://www.biomedsearch.com/nih/Design-Divergent-Synthesis-Aza-Nucleosides/22551299.html
*  Iminosugar - Wikipedia
An iminosugar, also known as an iminosaccharide, is any analog of a sugar where a nitrogen atom has replaced the oxygen atom in ... Iminosugars are common components of plants and may be responsible for some of their medicinal properties. The first iminosugar ... Amino sugar Watson AA, Fleet GW, Asano N, Molyneux RJ, Nash RJ (2001). "Polyhydroxylated alkaloids-natural occurrence and ... The 1-deoxy analogs of iminosugars are C-glycosides, with the nitrogen as part of an ordinary amine linkage. Their piperidine, ...
  https://en.wikipedia.org/wiki/Iminosugar
*  Determination of protonation states of iminosugar-enzyme complexes using photoinduced electron transfer - Chemical Science ...
S. G. Withers, M. Namchuk and R. Mosi, in Imino sugars as Glycosidase Inhibitors, Nojirimycin and beyond, John Wiley & sons, ... Determination of the pKa values of iminosugars 6, 12 and 15 by fluorescence titration. Iminosugars 6, 12 and 15 were each ... Whether iminosugars are TS mimics or not, it is apparent that it is the norm to assume that iminosugars are, or become, ... 2 Many iminosugars are potent inhibitors of glycosidases, and the iminosugar structure has been used as a pharmacophore in ...
  http://pubs.rsc.org/en/content/articlehtml/2017/sc/c7sc01540b
*  IMINOSUGAR COMPOUNDS WITH ANTIFLAVIRUS ACTIVITY - Patent application
0162]Mehta A, Ouzounov S, Jordan R, Simsek E, Lu X, Moriarty R M, Jacob G, Dwek R A, and Block TM (2002b). Imino sugars that ... 0056]When used in combination with another radical when referring to the imino sugars, the term "alkyl" means a straight or ... Those skilled in the art that understand those imino sugars having asymmetric carbon atoms may exist in diastereomeric, racemic ... Novel alkylated imino sugars exhibiting glucosidase inhibition and their method of use. ...
  http://www.patentsencyclopedia.com/app/20090042268
*  Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated...
These data demonstrate that iminosugar inhibitors, currently used to treat type 1 Gaucher disease, are also of potential value ... Imino Sugars, Neuritis, Autoimmune, Experimental, Neurons, Neuroprotective Agents, PC12 Cells, Rats ... These data demonstrate that iminosugar inhibitors, currently used to treat type 1 Gaucher disease, are also of potential value ... Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated ...
  https://pharm.ox.ac.uk/publications/185285
*  Pamela Norton, PhD: Microbiology & Immunology - Drexel University College of Medicine
"Imino sugars as antiviral agents". Norton PA, Gu B, and TM Block.. In Iminosugars: From Synthesis to Therapeutic Applications. ... One imino sugar was tested in vivo against the related woodchuck hepatitis virus in conjunction with therapeutic vaccination to ... The imino sugars inhibit host glucosidases in the endoplasmic reticulum by interfering with correct N-glycan processing. ... The ability of certain imino sugars to augment epitope presentation by MHC class I in cultured cells suggests a possible role ...
  http://drexel.edu/medicine/faculty/profiles/pamela-norton/
*  Wiley: Amino Group Chemistry: From Synthesis to the Life Sciences - Alfredo Ricci
7.1.7 Iminosugars 262. 7.1.8 Sugar Amino Acids 264. 7.2 Synthesis of Aminated Sugars 266 ... 7 Aminated Sugars, Synthesis, and Biological Activity 257. Francesco Nicotra, Barbara La Ferla, and Cristina Airoldi ...
  http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527317414.html
*  Patent US6927294 - Nitrogen-containing heterocycles - Google Patents
Butters et al, "Molecular requirements of imino sugars for the selective control of N-linked glycosylation and ... Iminosugar compounds with antiflavirus activity. CN106349243A *. Aug 11, 2016. Jan 25, 2017. 雇末匝孧肚仾有陘公叻. 8, 8-difluoro- ... Iminosugar compounds with antiflavirus activity. US9326977. Apr 11, 2014. May 3, 2016. Phytoquest Limited. Anti-inflammatory ... Nicolaou et al., "Novel IBX-Mediated Process for the Synthesis of Amino Sugars and Libraries Thereof," Angew. Chem. Int. Ed. ...
  http://www.google.com/patents/US6927294?dq=6,563,928
*  US6465488B1 - Inhibition of glycolipid biosynthesis - Google Patents
It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof. ... One of these agents is the imino sugar designated 1,5-dideoxy-1,5-imino-D-glucitol (or deoxynojirimycin, hereinafter DNJ). ... Therapeutic applications of imino sugars in lysosomal storage disorders. US20110070196A1 (en) 2011-03-24. Hepatitis c virus ... Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity and Reducted Toxicity Urbina et al. 1996. Antiproliferative ...
  https://patents.google.com/patent/US6465488B1/en
*  Overview | Office of Technology Commercialization | Drexel University
IHVR03 - Novel imino sugar derivatives demonstrate potent antiviral activity and reducted toxicity. Block, Timothy M.. Rose, ...
  http://drexel.edu/commercialization/available-technologies/overview/
*  THETM c-Myc Tag Antibody, mAb, Mouse Antibody - GenScript
β-Glucosidase 2 (GBA2) Activity and Imino Sugar Pharmacology.J Biol Chem.2013Sep;288(36):26052-66. HJ Koo.,et al. Suites of ...
  https://www.genscript.com/antibody/A00704_40-_THE_sup_TM_sup_c_Myc_Tag_Antibody_mAb_Mouse.html
*  Migalastat - Wikipedia
It has a nitrogen atom in the ring instead of an oxygen, which makes it an iminosugar. The structure is formally derived from ... The molecule has four asymmetric carbon atoms with the same stereochemistry as the sugar D-galactose, but is missing the first ... Iminosugars: from synthesis to therapeutic applications. Wiley and Sons. p. 17. ISBN 0-470-03391-6. Miyake, Y; Ebata, M (1988 ... Asano, N (2007). "Naturally occurring iminosugars and related alkaloids: structure, activity and applications". In Compain, P; ...
  https://en.wikipedia.org/wiki/Migalastat
*  Trends in Glycoscience and Glycotechnology
... ceramide analogues and N-alkylated imino sugars. Both types of compound inhibit the first step in GSL biosynthesis, namely the ...
  https://www.jstage.jst.go.jp/browse/tigg/7/0/_contents/-char/en
*  SLC5A4 - Wikipedia
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human ...
  https://en.wikipedia.org/wiki/SLC5A4
*  Alpha-glucosidase - Wikipedia
The studies enhanced knowledge of the mechanism by which alpha-glucosidase binds to imino sugars. Diabetes: Acarbose, an alpha- ... "Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase ( ... It was shown that 1-deoxynojirimycin (DNJ) would bind the strongest of the sugars tested and blocked the active site of the ... Further studies of alglucosidase alfa revealed that iminosugars exhibit inhibition of the enzyme. It was found that one ...
  https://en.wikipedia.org/wiki/Alpha-glucosidase
*  Amino sugar - Wikipedia
Iminosugar N-Acetylglucosamine Galactosamine Glucosamine Sialic acid L-Daunosamine Lemieux, R. U.; Ratcliffe, R. M. (15 May ... In chemistry, an amino sugar (or more technically a 2-amino-2-deoxysugar) is a sugar molecule in which a hydroxyl group has ... More than 60 amino sugars are known, with one of the most abundant being N-Acetyl-d-glucosamine, which is the main component of ... Derivatives of amine containing sugars, such as N-acetylglucosamine and sialic acid, whose nitrogens are part of more complex ...
  https://en.wikipedia.org/wiki/Amino_sugar
*  Siddhartha Roy - Wikipedia
He is also reported to have performed the complete assignment of a nucleic acid imino proton spectra using Nuclear Overhauser ... Effect, regio-specific isotope labeling of sugars in nucleic acids and working along with Ad Bax and R. H. Griffey, developed ...
  https://en.wikipedia.org/wiki/Siddhartha_Roy
*  Nuclear magnetic resonance spectroscopy of nucleic acids - Wikipedia
... and sugar pucker conformations. The presence or absence of imino proton resonances, or of coupling between 15N atoms across a ... For nonexchangable protons, many of which are on the sugar moiety of the nucleic acid, COSY and TOCSY are used to identify ... It was quickly realized that spectra of the low-field imino protons were providing clues to the tertiary structure of tRNA in ... Nucleic acid NMR studies were performed as early as 1971, and focused on using the low-field imino proton resonances to probe ...
  https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy_of_nucleic_acids
*  Nucleic acid tertiary structure - Wikipedia
Because interactions with the minor groove are often mediated by the 2'-OH of the ribose sugar, this RNA motif looks very ... For example, the GGC triplex (GGC amino(N-2)-N-7, imino-carbonyl, carbonyl-amino(N-4); Watson-Crick) observed in the 50S ... OH groups of two adjacent sugars. Ribose zippers commonly occur in arrays that stabilize interactions between separate RNA ... element in which two RNA chains are held together by hydrogen bonding interactions involving the 2'OH of ribose sugars on ...
  https://en.wikipedia.org/wiki/Nucleic_acid_tertiary_structure
*  Azetidine-2-carboxylic acid - Wikipedia
Fowden, L. (1956). "Azetidine-2-carboxylic Acid: a New Cyclic Imino Acid Occurring in Plants". Biochemical Journal. 64 (2): 323 ... and sugar beets. It has been shown that when Azetidine-2-carboxylic acid is misincorporated into proteins in place of proline, ...
  https://en.wikipedia.org/wiki/Azetidine-2-carboxylic_acid
*  List of MeSH codes (D02) - Wikipedia
... imino furanoses MeSH D02.491.567.500 --- imino pyranoses MeSH D02.500.375.050 --- 4-acetamido-4'-isothiocyanatostilbene-2,2'- ... sugar acids MeSH D02.241.511.902.107 --- ascorbic acid MeSH D02.241.511.902.107.260 --- dehydroascorbic acid MeSH D02.241. ... polyisoprenyl phosphate sugars MeSH D02.455.849.690.700.700 --- polyisoprenyl phosphate monosaccharides MeSH D02.455.849.690. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
*  Francis Crick - Wikipedia
Furberg's results had also provided the correct orientation of the DNA sugars with respect to the bases. During their model ... rather than the imino and enol forms that Crick and Watson had assumed. They consulted Jerry Donohue who confirmed the most ... and these results were most consistent with the three sugar-phosphate backbones being on the outside of the molecule. ...
  https://en.wikipedia.org/wiki/Francis_Crick
*  Non-proteinogenic amino acids - Wikipedia
This imino acid differs from proline due to a hydroxyl group on carbon 4. Hypusine. This amino acid is obtained by adding to ... Most bacterial cells walls are formed by peptidoglycan, a polymer composed of amino sugars crosslinked with short oligopeptides ... albeit not an imino. The genetic code encodes 20 standard amino acids for incorporation into proteins during translation. ... whose amine group is a secondary amine and is consequently frequently referred to as an imino acid for traditional reasons, ...
  https://en.wikipedia.org/wiki/Non-proteinogenic_amino_acids
*  2-Pyridone - Wikipedia
The mutarotation of sugars and that 2-pyridone has a large effect on the reaction from activated esters with amines in nonpolar ... The formation and reactions of imino-compounds. Part I. Condensation of ethyl cyanoacetate with its sodium derivative". J. Chem ...
  https://en.wikipedia.org/wiki/2-Pyridone