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Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia. Journal of Applied Physiology, vol. 89, ... Hypoxia-Inducible Factor Expression and Angiogenesis - Analysis in the pituitary gland and patterns of death. In Vivo (Athens, ... Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection. Frontiers in Cellular Neuroscience, vol. 11, pp ... Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging. Neural Regeneration Research, ...

Wang X, Tang G, Sun H. Effect of hypoxia on the proliferation and expressions of hypoxia-inducible factor-1α vascular ... the role of hypoxia inducible factors-1alpha and-2alpha and vascular endothelial growth factor in lens epithelial cell survival ... A hypoxia-inducible factor-1α (HIF-1α) translation inhibitor and an HIF-2α translation inhibitor were independently employed to ... Qi B, Chen HL, Shang D, Dong Y, Zhang GX, Yu L. Effects of hypoxia-inducible factor-1α and matrix metalloproteinase-9 on ...

The key regulator of the hypoxia response is the hypoxia inducible factor 1 (HIF-1). HIF-1 has a complex role. HIF-1 can induce ... The key regulator of hypoxia induced apoptosis is hypoxia inducible factor 1 (HIF-1), which acts in combination with many other ... Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia. J Biol ... HYPOXIA INDUCIBLE FACTOR 1. HIF-1 is involved in embryonic development,15-17 tumour growth, metastasis,18,19 and apoptosis.12, ...

Hypoxia-inducible factor-1. In vitro antioxidant and anticancer activities of leaf extracts of Rhododendron arboreum and ...

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... had the consensus of a hypoxia-inducible factor 1 (HIF-1) site, and cross-competed for the binding of HIF-1 with functionally ... indicating an interaction between inducible factors binding the HIF-1 and CRE sites. ... by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism. To ... flanking region of the mouse gene encoding the hypoxically inducible enzyme lactate dehydrogenase A (LDH). Deletional and ...

... hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 Hypoxia-inducible factor-asparagine dioxygenase contains ... Hypoxia-inducible factor-asparagine dioxygenase (EC 1.14.11.30, HIF hydroxylase) is an enzyme with systematic name hypoxia- ... Dann CE, Bruick RK, Deisenhofer J (November 2002). "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl ... "Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin ...

Hypoxia-inducible factor 1 and cardiovascular disease. / Semenza, Gregg L. In: Annual review of physiology, Vol. 76, 02.2014, p ... Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all ... Hypoxia-inducible factor 1 and cardiovascular disease. Annual review of physiology. 2014 Feb;76:39-56. doi: 10.1146/annurev- ... Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all ...

Dexamethasone impairs hypoxia-inducible factor-1 function. A. E. Wagner, G. Huck, D. P. Stiehl, W. Jelkmann, T. Hellwig-Bürgel* ... Dexamethasone impairs hypoxia-inducible factor-1 function. / Wagner, A. E.; Huck, G.; Stiehl, D. P. et al. In: Biochemical and ... Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription-factor composed of α- and β-subunits. HIF-1 is not only ... N2 - Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription-factor composed of α- and β-subunits. HIF-1 is not ...

Timeline for Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1): *Family b.82.2.6: Hypoxia-inducible factor HIF ... Hypoxia-inducible factor HIF ihhibitor (FIH1) appears in SCOPe 2.06. *Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor ( ... Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species). *. Species Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB ... Lineage for Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1). *Root: SCOPe 2.07 *. Class b: All beta proteins [ ...

HIF-1α isoforms containing a three base pairs TAG insertion between exon 1 and exon 2 (designated HIF-1α TAG ) and HIF-1α 736 ... The HIF-1 protein is composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits. The ... HIF-1α TAG mRNA levels were also inversely correlated with both oestrogen and progesterone receptor status (P = 0.005 and P = ... The impact of HIF-1α alternative splice variant expression on breast cancer prognosis in terms of metastasis risk is not well ...

KandJMarketResearch add latest market research reports on Hypoxia Inducible Factor 1 Alpha Inhibitor Market, Global Outlook and ... Hypoxia Inducible Factor 1 Alpha Inhibitor Market, Global Outlook and Forecast 2022-2028. Report Code: KNJ1281488 , No. of ... Hypoxia Inducible Factor 1 Alpha Inhibitor Sales and Revenue in Global (2017-2022) 7.4.5 F. Hoffmann-La Roche Ltd. Key News 7.5 ... Hypoxia Inducible Factor 1 Alpha Inhibitor Sales and Revenue in Global (2017-2022) 7.3.5 Cerulean Pharma, Inc. Key News 7.4 F. ...

深入研究「Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell-type- ... T1 - Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell-type- ... Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell-type-specific ... Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell-type-specific ...

Hypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer. Yun Hwan Kim, In Ae Park, Woong Yang Park, Jae Weon ... Hypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer. / Kim, Yun Hwan; Park, In Ae; Park, Woong Yang et al ... Hypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer. In: International Journal of Gynecological Cancer. ... Hypoxia-inducible factor 1α polymorphisms and early-stage cervical cancer. International Journal of Gynecological Cancer. 2011 ...

... and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis.Conclusions Hypoxia-inducible ... Hypoxia-inducible factor-induced CXCL12 stimulates angiogenesis in vivo. Hypoxia is a major physiological cue for triggering ... Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood ... Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA ...

Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy. Hrabalova P ... This study characterized how the combination of HIF-1α deficiency and streptozotocin (STZ)-induced diabetes affects the cardiac ... 2023 Apr 18;22(1):88. doi: 10.1186/s12933-023-01824-5. Abstract Background: An altered sympathetic nervous system is implicated ... Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy. Hrabalova P ...

A reduction in oxygen delivery to the heart, hypoxia, is sensed and responded to by the hypoxia-inducible factor (HIF) and its ... Hypoxia is one of the main drivers of metabolic change in ischaemic disease and myocardial infarction, and we therefore suggest ... We then present an overview of research in the field of hypoxia-mimetic drugs recently developed in other treatment fields, ... In this review, we assess cardiac energy metabolism in health and disease, and how these can be regulated by HIF-1α activation ...

Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). ... Here we show, in articular chondrocytes, that IL-1β-induces primary cilia elongation with alterations to cilia trafficking of ... IL-1β). We have also shown the primary cilium elongates in response to IL-1β exposure. ... we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β ...

A reduction in oxygen delivery to the heart, hypoxia, is sensed and responded to by the hypoxia-inducible factor (HIF) and its ... Hypoxia is one of the main drivers of metabolic change in ischaemic disease and myocardial infarction, and we therefore suggest ... We then present an overview of research in the field of hypoxia-mimetic drugs recently developed in other treatment fields, ... In this review, we assess cardiac energy metabolism in health and disease, and how these can be regulated by HIF-1α activation ...

... entry for 1l8c.1. STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE ... Hypoxia-inducible factor 1 alpha: B. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ... hetero-1-1-mer. Ligands 3 x ZN: ZINC ION(Non-covalent). ZN.1: 8 residues within 4Å:*. Chain A: H.18, C.22, R.33, C.35, S.36, C. ... SMTL ID : 1l8c.1 STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE Coordinates. PDB Format ...

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth ... Resensitization of breast cancer cells to anoikis by Tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion * ... Regulation of reactive oxygen species, DNA damage and c-Myc function by peroxiredoxin 1 *Rachel A Egler ... Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the ...

Hypoxia-inducible factor 1 (HIF-1) mediates cellular adaptation to hypoxia by regulating biological processes important for ... Hypoxia-inducible factor 1 (HIF-1) mediates cellular adaptation to hypoxia by regulating biological processes important for ... In the absence of glucose, the onset and the degree of hypoxia-induced cell death in HIF-1-deficient PRPTC were comparable to ... the generation of adequate energy levels for the maintenance of PRPTC viability under hypoxia does not require HIF-1 and 2) ...

Clinical importance of serum and pleural fluid prominin-1 and hypoxia-inducible factor-1α concentration i ... Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA ... The expression of hypoxia-inducible factor-1α and its clinical significance in lung cancer: A systematic review and meta- ... Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 1999;59:5830-5. ...

Jeong W, Bazer FW, Song G, Kim J. Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and ... Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and epidermal growth factor. In: ... Hypoxia-inducible factor (HIF)-1 is a master regulator whereby cells adapt to changes in oxygen concentrations. In addition to ... Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and epidermal growth factor. / Jeong, ...

... hypoxia inducible factor 1alpha, hypoxia inducible factor 1beta, hypoxia inducible factor 2alpha, interleukin 8, messenger RNA ... Deletion or point mutation studies revealed that binding of the transcription factor hypoxia-inducible factor (HIF) 1a to a HIF ... Deletion or point mutation studies revealed that binding of the transcription factor hypoxia-inducible factor (HIF) 1a to a HIF ... Deletion or point mutation studies revealed that binding of the transcription factor hypoxia-inducible factor (HIF) 1a to a HIF ...

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth Share ... Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth ...

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis ... miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis ...

Hypoxia-inducible factor 1 alpha modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune ... Hypoxia-inducible factor 1 alpha modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune ...

Hypoxia-Inducible Factor 1 100% * Transferrin Receptors 96% * Hepatocytes 66% * Iron 65% ... Dive into the research topics of Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 ... transcription mediated by hypoxia inducible factor-1. Together they form a unique fingerprint. ... Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia ...