*  Pegylated Interferon Therapy for Acute Hepatitis C Infection in HIV-infected Patients - Full Text View - ClinicalTrials.gov
Background:HIV-infected individuals are at higher risk of developing a chronic course of hepatitis C after infection. Moreover, chronic hepatitis C is less well treatable in HIV-Coinfected than in hepatitis C monoinfected patients. There is basic research and clinical data on hepatitis C mono-infection supporting high sustained response rates of hepatitis C when treatment is started in the acute phase of infection.. Aim of the study: To determine whether pegylated interferon therapy is effective to treat acute hepatitis C infection in HIV-coinfected individuals.. Methods: Prospective, open-label, historical controlled trial. Eligible subjects are treated over 24 weeks with a pegylated interferon at standard dose. Weight-adjusted ribavirin comedication is recommended for HCV-genotypes 1 and 4. Treatment will be withheld for 12 weeks in order to allow spontaneous resolution in ...
  https://clinicaltrials.gov/show/NCT00132210
*  Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin: Case report and review of the literature |...
Hepatitis C is a common cause of chronic liver disease but is rarely associated with acute hepatitis. The majority of patients have no clinical symptoms and jaundice in this phase of acute viral hepatitis C. Clinical symptoms are not difference with other types of hepatitis [2]. It is necesseray to treat acute hepatitis C infection. HCV infection becomes chronic in about 85 % of individuals as demonstrated by the persistence of HCV. HCV is the major cause of cirrhosis and hepatocellular carcinoma [2]. Interferon-α is effective in improving biochemical outcomes and achieving sustained virologic clearance in patients with acute hepatitis C [3]. If acute infection is confirmed (with or without acute hepatitis), recent data suggest that early treatment of acute HCV infection with interferon-α may be highly effective in preventing chronic HCV ...
  https://ann-clinmicrob.biomedcentral.com/articles/10.1186/1476-0711-1-3
*  Hepatitis C - Epidemiology
Hepatitis C FAQ. Hepatitis C What is hepatitis C? Hepatitis means inflammation of the liver. When the inflammation is caused by infection with the hepatitis C virus (HCV), the disease is called hepatitis C. Hepatitis C can be either acute (short-term) or chronic (long-term). Approximately 75-85% of people who become infected with HCV develop chronic infection.. Who gets hepatitis C? The risk of hepatitis C is higher in anyone who has ever injected drugs, people who had a blood transfusion before 1992, healthcare workers with a blood exposure (e.g., by an accidental needle stick), children born to mothers with HCV infection, long-term dialysis patients, and persons with HIV infection.. How is hepatitis C spread? HCV lives in the blood. Hepatitis C is spread when blood of someone with ...
  http://www.vdh.virginia.gov/epidemiology/epidemiology-fact-sheets/hepatitis-c/
*  Hepatitis C virus infection in primary care: survey of registered nurses' knowledge and access to information - Frazer - 2010 -...
Aim. This paper is a report of a study conducted to compare knowledge of hepatitis C virus infection amongst three groups of registered nurses working in primary care, to identify their current sources of information and access to educational resources.. Background. Hepatitis C virus infection is a public health problem; no vaccine exists to prevent the disease. Previous studies identified limitations in nurses' knowledge of hepatitis C virus infection and the impact on care. Limited research has been conducted in primary care.. Methods. A cross-sectional postal census survey of 981 nurses working in one Irish health board region was conducted March-June 2006. Questionnaires measured knowledge of hepatitis C virus infection. Data were collected on demographics, current working practices, information resources and previous education.. Results. The response rate was 57·1% (n = 560). A minority (27·3% 145/531) of respondents agreed they were ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2648.2010.05489.x/full
*  Hepatitis C Treatments | Hepatitis C Mexico
In the early stages of infection, most hepatitis C patients do not receive treatment, either because the virus remains undiagnosed as it is mistaken for flu, or because treatment is not necessary.. However, if hepatitis C becomes chronic and starts to affect liver function, treatment is necessary. Conventional hepatitis C treatments are available with varying success, depending on the type of virus contracted. Alternative hepatitis C treatments are also available, again with varying degrees of proven success.. The Functional Medicine approach to Hepatitis C is an alternative Hepatitis C treatment program that supports the body's immunity and addresses the overall health and wellbeing of the patient, maximizing success rates and restoring the patient's health without the painful and distressing side effects commonly experienced in conventional treatment.. If treatment of ...
  http://hepatitiscmx.com/hepatitis-c-treatments/
*  Short-term interferon-alfa therapy for acute hepatitis C: A randomized controlled trial - Nomura - 2004 - Hepatology - Wiley...
Our randomized controlled trial in patients with acute hepatitis C demonstrates that short-term (4 weeks) IFN therapy is effective when the treatment is initiated 8 weeks after the onset of acute hepatitis. In this study, to demonstrate the efficacy of short-term IFN therapy for acute hepatitis C, we applied strict criteria for the diagnosis; patients with posttransfusion hepatitis were excluded. As substantiated by our study, acute hepatitis C is associated with a few subjective symptoms that are easily overlooked by many patients. Diagnosis requires finding elevated serum ALT levels, and conversion from HCV-RNA negative to HCV-RNA positive.. There are no standard methods for treatment of acute hepatitis C. Both IFN-alfa3-5, 13, 15-17 and IFN-beta12, 14 have been used. Previous studies have involved predominantly asymptomatic patients with posttransfusion hepatitis.13-15 Recent studies by ...
  http://onlinelibrary.wiley.com/doi/10.1002/hep.20196/full
*  Ledipasvir/Sofosbuvir for 6 Weeks in HIV-Infected Patients With Acute HCV Infection | CROI Conference
There is no currently approved treatment for acute HCV infection. Guidelines recommend 24 weeks of therapy with interferon (IFN) and ribavirin in HIV coinfected individuals who are diagnosed with acute HCV. Shorter duration therapy with all-oral agents may offer a better-tolerated more efficacious alternative. Here we evaluated the safety, tolerability and efficacy of ledipasvir (LDV)/sofosbuvir (SOF) fixed dose combination for 6 weeks in genotype 1 or 4 HIV-infected patients with acute HCV infection.. Patients with an acute HCV infection of ,24 weeks duration as per NEAT AHC guidelines were included. Patients were required to either be receiving HIV antiretroviral (ARV) therapy with HIV RNA ,200 copies/mL, or not be receiving any treatment for HIV with no plans to start therapy. Enrollment of patients with active illicit drug use was permitted. Patients with acute opportunistic infections or HBV co-infection were excluded. The primary endpoint was sustained viral response defined as HCV ...
  http://www.croiconference.org/sessions/ledipasvirsofosbuvir-6-weeks-hiv-infected-patients-acute-hcv-infection
*  Immune Response to Hepatitis C Virus - Full Text View - ClinicalTrials.gov
We will analyze the peripheral (blood) and intrahepatic (liver) immune response in hepatitis C infection in patients with clear hepatitis C infection and those who develop chronic infection. We hope to determine immune responses that are important for eliminating the infection. Currently, the treatments for hepatitis C are not effective for everyone. For those patients enrolled who begin hepatitis C treatment, we will evaluate the immune system of people who respond compared to those who do not respond. If the patient is HIV positive, the change in hepatitis C immune response once various HIV medicines (antiretrovirals) are started will also be examined. Any treatment for hepatitis C or HIV will be determined by the patient's primary physician and will not be affected by enrollment in the study.. Blood samples of ~70 cc will be obtained no more than once per week. Patients who begin ...
  https://clinicaltrials.gov/show/NCT00165919?order=195
*  Immune Response to Hepatitis C Virus - Full Text View - ClinicalTrials.gov
We will analyze the peripheral (blood) and intrahepatic (liver) immune response in hepatitis C infection in patients with clear hepatitis C infection and those who develop chronic infection. We hope to determine immune responses that are important for eliminating the infection. Currently, the treatments for hepatitis C are not effective for everyone. For those patients enrolled who begin hepatitis C treatment, we will evaluate the immune system of people who respond compared to those who do not respond. If the patient is HIV positive, the change in hepatitis C immune response once various HIV medicines (antiretrovirals) are started will also be examined. Any treatment for hepatitis C or HIV will be determined by the patient's primary physician and will not be affected by enrollment in the study.. Blood samples of ~70 cc will be obtained no more than once per week. Patients who begin ...
  https://clinicaltrials.gov/show/NCT00165919?order=239
*  Immune Response to Hepatitis C Virus - Full Text View - ClinicalTrials.gov
We will analyze the peripheral (blood) and intrahepatic (liver) immune response in hepatitis C infection in patients with clear hepatitis C infection and those who develop chronic infection. We hope to determine immune responses that are important for eliminating the infection. Currently, the treatments for hepatitis C are not effective for everyone. For those patients enrolled who begin hepatitis C treatment, we will evaluate the immune system of people who respond compared to those who do not respond. If the patient is HIV positive, the change in hepatitis C immune response once various HIV medicines (antiretrovirals) are started will also be examined. Any treatment for hepatitis C or HIV will be determined by the patient's primary physician and will not be affected by enrollment in the study.. Blood samples of ~70 cc will be obtained no more than once per week. Patients who begin ...
  https://clinicaltrials.gov/show/NCT00165919?order=566
*  What is Hepatitis C? (Brochure)
What is Hepatitis C?. Hepatitis C is a chronic liver disease caused by the Hepatitis C virus (HCV). An estimated 250,000 people in Canada are infected and between 3,200 and 5,000 are newly infected each year.. Why is Hepatitis C a health concern?. For many, chronic Hepatitis C can show no symptoms for years, but left untreated, may eventually lead to liver damage and liver cancer.. How do I get infected by Hepatitis C?. Hepatitis C is spread through infected blood to blood contact. Seventy (70) to eighty (80) per cent of Hepatitis C transmission is due to high risk behaviors such as injection drug use and sharing of contaminated needles and drug using materials.. ...
  http://caan.ca/2016/04/28/francais-what-is-hepatitis-c-brochure/
*  UK elimination of hepatitis C in jeopardy unless more patients found | World Hepatitis Alliance
Just one in three people with hepatitis C in the United Kingdom has been diagnosed according to the latest estimates released at this year's World Hepatitis Summit in São Paulo, Brazil (1-3 November). The estimate comes from a global synthesis of data on hepatitis C prevalence and diagnosis carried out by the Polaris Observatory, led by Dr Homie Razavi. The Polaris Observatory study shows that out of an estimated 162,000 people living with hepatitis C in the UK, only 62,200 (38%) are diagnosed. "Even these numbers overestimate how many people are available for treatment because the majority of the 'diagnosed' are not in touch with services for a variety of reasons", says Charles Gore, CEO of the national hepatitis C charity, The Hepatitis C Trust, and also President of the World Hepatitis Alliance. "Many were diagnosed years ago. They were never informed how deadly hepatitis ...
  http://www.worldhepatitisalliance.org/latest-news/infohep/3187129/uk-elimination-hepatitis-c-jeopardy-unless-more-patients-found
*  Hepatitis C | Nicklaus Children's Hospital
Chou R, Hartung D, Rahman B, Wasson N, Cottrell EB, Fu R. Comparative effectiveness of antiviral treatment for hepatitis C virus infection in adults: a systematic review. Ann Intern Med. 2013 Jan 15;158(2):114-23.. Ghany MG, Strader DB, Thomas DL, Seeff LB. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009;49:1335-1374.. Jou JH, Muir AJ. In the clinic. Hepatitis C. Ann Intern Med. 2008;148:ITC6-1-ITC6-16.. Moyer VA; U.S. Preventive Services Task Force. Screening for hepatitis C virus infection in adults: U.S. Preventive services task force recommendation statement. Ann Intern Med. 2013 Sep 3;159(5):349-57.. O'Leary JG, Davis GL. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 79.. Rosen HR. Clinical practice. ...
  https://www.nicklauschildrens.org/health-information-library/disease/hepatitis-c?lang=es-CO
*  Zepatier (elbasvir + grazoprevir) | CATIE - Canada's source for HIV and hepatitis C information
Hepatitis C virus is a disease that can injure the liver. A virus is a very tiny germ that makes copies of itself to survive by a process called replication. The hepatitis C virus has at least seven different strains, which are also known as genotypes.. Zepatier is a direct-acting antiviral (DAA) medication. DAAs are a group of medications that directly block the ability of the hepatitis C virus to make copies of itself.. Zepatier is a combination of two DAAs. One is grazoprevir, which is a protease inhibitor, and the other is elbasvir, which is an NS5A inhibitor. Grazoprevir interferes with the production of the pieces needed to build new virus particles, stopping the production of new hepatitis C virus. Elbasvir works by interfering with a protein needed to complete the hepatitis C virus life cycle in the liver cell.. Treatment with DAAs can usually cure a person from hepatitis C infection and can lessen ...
  http://www.catie.ca/en/fact-sheets/hepatitis/zepatier-elbasvir-grazoprevir
*  National Viral Hepatitis Roundtable Hails U.S. Preventive Services Task Force for New Hepatitis C Testing Recommendation | NVHR
Contact: Martha Saly707-242-3333mbsaly@nvhr.org National Viral Hepatitis Roundtable Hails U.S. Preventive Services Task Force for New Hepatitis C Testing RecommendationUSPSTF Recommendation to Test Individuals Born From 1945-1965 for Hepatitis C Will Save LivesJune 24, 2013, Washington, D.C. - The National Viral Hepatitis Roundtable (NVHR) today commended the U.S. Preventive Services Task Force (USPSTF) for releasing updated hepatitis C screening recommendations to test all people born from 1945 to 1965. Individuals born between these years have the highest rates of chronic viral hepatitis C and represent 75% of the more than 4 million cases of hepatitis C in the United States. "This may be the single most important development in the more than ten years that I have worked in hepatitis advocacy," said Martha Saly, Executive Director of NVHR. "With the ...
  http://nvhr.org/content/national-viral-hepatitis-roundtable-hails-us-preventive-services-task-force-new-hepatitis-c-?mini=calendar%2F2013-11
*  IDPH Releases Report on Hepatitis C Infection in Iowa (2/13/17)
The Iowa Department of Public Health (IDPH) has released its first report on hepatitis C infection in Iowa. Hepatitis C is the leading cause of liver cancer and liver transplants in the U.S.. A comparison of data from 2000 to 2015 shows the number of Iowans diagnosed with hepatitis C virus (HCV) infection increased nearly three-fold, from 754 cases in 2000 to 2,235 cases in 2015. The number of HCV diagnoses among those between the ages of 18 and 30 has more than quadrupled since 2009, with 303 diagnoses in 2015. According to the Centers for Disease Control and Prevention (CDC), most people with HCV infection don't have any symptoms and therefore are not tested or diagnosed. Because of this, the number of Americans and Iowans who are infected with hepatitis C is likely much higher than the report indicates.. According to Randy Mayer, Chief of the IDPH Bureau of HIV, STD, and Hepatitis, the increase in diagnoses is expected ...
  http://idph.iowa.gov/News/ArtMID/646/ArticleID/158153/IDPH-Releases-Report-on-Hepatitis-C-Infection-in-Iowa-21317
*  Hepatitis C and Diabetes - Liver Doctor
Hepatitis C was first identified and named in 1989. The virus infects liver cells and causes liver inflammation, along with several potential complications. Hepatitis C is most commonly transmitted among intravenous drug users through sharing needles, but also through non-sterile tattooing or body piercing. It is also possible to contract hepatitis C through contact with infected blood, or sexual contact. There is no vaccine for hepatitis C.. It has been known for some time that people with hepatitis C are more likely to develop type 2 diabetes than uninfected people. One explanation is that the hepatitis C virus promotes accumulation of fat inside the liver. A fatty liver is not able to absorb excess glucose from the bloodstream, therefore the blood sugar level can rise to an undesirable degree.. The majority of people with hepatitis C eventually develop insulin resistance (also known as ...
  https://www.liverdoctor.com/hepatitis-c-and-diabetes/
*  Why the CDC's new hepatitis C recommendations for boomers are a no brainer | Bureau County Republican
(BPT) - When Martha Saly, director of the National Viral Hepatitis Roundtable (NVHR), learned she had hepatitis C, a virus that attacks the liver, she was in disbelief. Saly never suspected she might be infected with the hepatitis C virus, and unfortunately, cases like Saly’s are not uncommon.In fact, 3.2 million Americans are living with hepatitis C, and most do not know they are infected. That’s why the Centers for Disease Control and Prevention (CDC) recently released hepatitis C screening recommendations calling for all adults born from 1945 through 1965, also known as baby boomers, to get tested for hepatitis C.“This test can mean the difference between life and death - it did for me,” says Saly. “You can live with hepatitis C for decades without feeling sick, but liver damage can occur silently during this time, which can lead to more serious problems such ...
  http://www.bcrnews.com/articles/ara/2012/12/12/8073710103/index.xml?page=2
*  FREE HEPATITIS C TESTING AT CLINIC IN BLUE RIDGE, JULY 10th
Born between 1945 and 1965? YOU need to be tested for Hepatitis C! The Fannin County Health Department is conducting a HEPATITIS C CLINIC on Monday, July 10th from 9 AM to Noon at their location at 95 Ouida Street in Blue Ridge. The clinic is offering FREE Rapid Hepatitis C Testing. Hepatitis C is 10 times more infectious that HIV and more than 75% of adults with Hepatitis C are Baby Boomers - people born between 1945 and 1965. Most people who are infected with Hepatitis C don't know it; therefore, getting tested is key! For more information about the upcoming HEPATITIS C CLINIC in Blue Ridge, contact the Fannin County Health Department at (706) 632-3023.
  http://www.nghd.org/pr/34-/872-free-hepatitis-c-testing-at-clinic-in-blue-ridge-july-10th.html
*  Nine countries now on track to eliminate hepatitis C | World Hepatitis Alliance
On 1- 3 November, Ministers of Health, public health experts and NGOs will come together at the World Hepatitis Summit to advance the elimination of viral hepatitis. Embargo: 0001H Sao Paulo local time, Wednesday 1 November [Sao Paulo, 1 November 2017] New data on hepatitis C released by the Polaris Observatory* and presented today at the World Hepatitis Summit (WHS) in Sao Paulo, Brazil show that nine countries - Australia, Brazil, Egypt, Georgia, Germany, Iceland, Japan, the Netherlands and Qatar - are on course to eliminate hepatitis C by 2030.. Worldwide, viral hepatitis kills more than one million people each year, and more than 300 million people are chronically infected with hepatitis B or C. Yet, with the development of highly-effective direct acting antivirals (DAAs) for hepatitis C and the increasing rates of hepatitis B treatment ...
  http://www.worldhepatitisalliance.org/node/3932
*  Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of...
The incidence of hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-infected men who have sex with men has increased in recent years and is associated with high-risk sexual behavior. Behavioral interventions that target high-risk behavior associated with HCV transmission and treatment with direct-acting antivirals may prevent further HCV infections. We predicted the effect of behavioral and treatment interventions on HCV incidence and prevalence among HIV-infected men who have sex with men up to 2030 using a HCV transmission model parameterized with data from the Swiss HIV Cohort Study. We assessed behavioral interventions associated with further increase, stabilization, and decrease in the size of the population with high-risk behavior. Treatment interventions included increase in treatment uptake and use of direct-acting antivirals. If we assumed that without behavioral interventions high-risk behavior spread further according to the trends observed over the last ...
  http://www.zora.uzh.ch/id/eprint/126829/
*  Hepatitis B - Thunderbird Endoscopy Center
What is the Difference between Hepatitis C and B? Hepatitis literally means "inflammation of the liver." Hepatitis is a viral disease which targets the liver includes several strains, but the most common types of viral hepatitis in the United States are hepatitis B and hepatitis C. Both of these diseases can range from mild cases lasting only a few weeks to a lifelong or chronic condition. Hepatitis C is an infection caused by the hepatitis C virus, which leads to liver inflammation. Most individuals who have hepatitis C are unaware that they have the disease until routine blood tests (possibly decades later) show that they have evidence of liver inflammation. Hepatitis C is widely accepted as the most common hepatitis virus causing chronic inflammation, and it is most often spread through ...
  https://tbirdendo.com/condition/hepatitis-b
*  Treatment of hepatitis C virus infection in the future | Clinical and Translational Medicine | Full Text
Hepatitis C virus (HCV) chronically infects an estimated 170 million people worldwide [1]. HCV infection is one of the major causes of end-stage liver disease and hepatocellular carcinoma (HCC) worldwide [2-4]. Approximately 30% of patients who develop acute hepatitis C recover spontaneously, signaled by improved symptoms, normalized liver-related chemistries, loss of HCV RNA from serum, and the development of HCV antibody [5-7]. In chronic hepatitis C, the progression of liver fibrosis is slow, but steady. It has been reported that the progression rate of liver fibrosis is 0.10-0.13 U/year in untreated patients [8]. Progression of chronic HCV infection is not linear in time, probably because many cofactors are involved in changing the rate of development of fibrosis, cirrhosis, and HCC [6]. Cirrhosis rates become significant after 20 years of HCV infection. About 20-30% of patients could develop a ...
  https://clintransmed.springeropen.com/articles/10.1186/2001-1326-2-9
*  Hepatitis C and fake dental clinics
HEPATITIS C is a contagious liver disease that results from infection with the hepatitis C virus. It can range in severity from a mild illness lasting a few weeks to a serious, lifelong illness. Every year, three to four million people are infected with hepatitis C virus.. About 150 million people are chronically infected and at risk of developing liver cirrhosis and/or liver cancer. More than 350,000 people die of hepatitis C-related liver diseases every year.. Hepatitis C is found worldwide. Countries with high rates of chronic infection are Egypt (15 per cent), Pakistan (4.8 per cent) and China (3.2 per cent).. The hepatitis C virus is usually spread when blood from an infected person enters the body of a susceptible person. This can occur through receipt of contaminated blood transfusions, blood products and organ transplants, injections given with contaminated syringes ...
  https://www.dawn.com/news/777899/hepatitis-c-and-fake-dental-clinics
*  HCV Research and News: New online course helps people manage hepatitis C
February 13, 2014 12:00 AM. A new self-learning course has been launched in British Columbia to help those at risk of, or affected by, hepatitis C.'Go For Care: Hepatitis C Knowledge Series' was developed by the BC Centre for Disease Control and released last week as an interactive module that provides basic information about hepatitis C. 'Our interviews with patients and health-care providers uncovered a need for a resource like this - a one-stop source of basic information that's easy to use,' said Dr. Gail Butt, clinical lead on hepatitis at BCCDC and an assistant professor at UBC. 'The Hepatitis Knowledge Series will help people in their understanding of hepatitis C and help them get the care they need.'. Hepatitis C is a virus that is spread when there is bloodto-blood contact with someone who has the disease, such as when drug users share needles and syringes or when someone is ...
  http://hepatitiscresearchandnewsupdates.blogspot.com/2014/02/new-online-course-helps-people-manage.html