*  Effect of Genetic Polymorphisms in CD14 and TLR4 on Cardiomyopathy | Open Access Journals

... whereas the other haplotypes did not show any significance statistically. Hence TG haplotype could be the risk haplotype for CM ... Of the all haplotypes obtained (Table 5), one haplotype carrying the recessive allele of CD14 and TLR4 polymorphism, TG was ... The TG haplotype was found to be predominant in CM than controls with a 2.02 fold significant increase, (OR 2.02, 95% CI 1.31- ... Table 5: Haplotype association with respect to various repair genes.. Secondary Protein Structure Predictions. The variant ...
https://omicsonline.org/open-access/effect-of-genetic-polymorphisms-in-cd14-and-tlr4-on-cardiomyopathy-imt-1000110.php?aid=68315

*  Variants in Host Viral Replication Cycle Genes Are Associate... : JAIDS Journal of Acquired Immune Deficiency Syndromes

17 Haplotypes were inferred for each of the 51 candidate genes using the Haplotype Mapping Project (HapMap) Yoruba from Ibadan ... Malhotra R, Hu L, Song W, et al.. Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of ... Conrad DF, Jakobsson M, Coop G, et al.. A worldwide survey of haplotype variation and linkage disequilibrium in the human ... Here we report the association of these candidate and haplotype-tagging SNPs (tagSNPs) with HIV-1 outcomes in the same ...
journals.lww.com/jaids/Fulltext/2014/06010/Variants_in_Host_Viral_Replication_Cycle_Genes_Are.3.aspx

*  F7 Gene - GeneCards | FA7 Protein | FA7 Antibody

Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women. (PMID: 17059418) Reiner ...
genecards.org/cgi-bin/carddisp.pl?gene=F7&snp=476

*  SLE glomerulonephritis - The Clinical Advisor

HLA haplotypes DR2 and DR3 are associated with SLE.. *. There are genetic linkages to development of lupus nephritis because ...
clinicaladvisor.com/pediatrics/sle-glomerulonephritis/article/622133/

*  Library System/Howard University

Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, ift27 and ...
howard.edu/apps/keyword/huauthors.cfm?format=&yeartype=OneYear&department=Medicine&bysubject=Display Publications&letteroflastname=&oneyear=2012&yearrange1=0&yearrange2=0&bylastletter=&Page=12

*  Christopher J Earley, M.B.B.Ch., Ph.D.

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. Hum Mol ...
hopkinsmedicine.org/profiles/results/directory/profile/0006845/christopher-earley?CLEARPAGECACHE=false&appRedirRef=http://google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CC4QFjAB&url=http%3A%2F%2Fhopkinsmedicine.org%2Fdoctors%2Fresults%2Fdirectory%2Fprofile%2F0006845%2Fchristopher-earley&ei=TRseUp7nF6izsATioIGIAg&usg=AFQjCNEUI0v3s7AlCK2G1kUVDhmbCZoHvg&bvm=bv.51156542,d.cWc

*  Dienekes' Anthropology Blog: Amerindian-like admixture in northern Europe is real

Why Y-STR haplotype clusters are not clades. Racial Type of the Ancient Hellenes. Anthropological Evidence and the Fallmerayer ... We know that haplotypes are no close indicator at all of aDNA. They are quite capable of introgressing into different ...
dienekes.blogspot.com/2013/06/amerindian-like-admixture-in-northern.html?showComment=1370466224478

*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

The SNPViz software enables users to analyze region-specific haplotypes from single nucleotide polymorphism (SNP) datasets for ... Cellular Biology, Issue 45, Gene expression, regulatory variant, haplotype, association study, primer extension, MALDI-TOF mass ... Major soybean maturity gene haplotypes revealed by SNPViz analysis of 72 sequenced soybean genomes. ... to evaluate the consistency of the haplotypes with characterized variant alleles, and to identify evidence of artificial ...
https://jove.com/visualize/abstract/24727730/major-soybean-maturity-gene-haplotypes-revealed-snpviz-analysis-72

*  Begoña Martínez-Jarreta

haplotypes*ethnic groups*ecuador*el salvador*gene frequency*spain*occupational medicine*microsatellite repeats*polymerase chain ... 42.-Haplotype distribution of nine Y-chromosome STR-loci in two northern Spanish populations (Asturias and Aragon). Martinez- ... Haplotype distribution of nine Y-chromosome STR-loci in two northern Spanish populations (Asturias and Aragon). Begoña Martínez ... Y-chromosome STR haplotypes in three different population groups from Ecuador (South America). Fabricio González-Andrade. ...
https://labome.org/expert/spain/university/martnez-jarreta/bego--a-mart--nez-jarreta-361648.html

*  lectins

Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. Iara de Messias-Reason. Department ... The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels. L Munthe-Fog. Tissue Typing Laboratory, ... Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients. Tong V Hoang. Institute of ... No FCN2 promoter haplotypes were significantly distributed between mild and severe cases... ...
https://labome.org/topics/chemicals/and/proteins/lectins-14603.html

*  SLC45A2 and human skin color - Gene Expression

We previously reported significant associations of two coding region polymorphisms with hair, skin, and eye color in Caucasians. Here we characterize the promoter region of MATP [SLC45A2] identifying two new transcription start sites and a novel duplication…A total of 700 individuals from five different population groups (529 Caucasians, 38 Asians, 46 African Americans, 47 Australian Aborigines, and 40 Spanish Basques) were genotyped for known promoter polymorphisms…Allele frequencies of all three polymorphisms were significantly different between population groups. In Caucasians, the -1721G, +dup, and -1169A alleles were significantly associated with olive skin color. The three promoter polymorphisms were found to be in linkage disequilibrium with each other but not with the two previously reported coding region polymorphisms. Functional analyses in a melanoma cell line showed that the promoter haplotype -1721G, +dup, -1169A significantly decreased MATP transcription. This report provides ...
scienceblogs.com/gnxp/2007/03/21/slc45a2-and-human-skin-color/

*  Dienekes' Anthropology Blog: Thomas Jefferson's Y chromosome

1% of chromosomes worldwide, and most common in East Africa and the Middle East. Phylogenetic network analysis of its Y-STR (short tandem repeat) haplotype shows that it is most closely related to an Egyptian K2 haplotype, but the presence of scattered and diverse European haplotypes within the network is nonetheless consistent with Jefferson's patrilineage belonging to an ancient and rare indigenous European type. This is supported by the observation that two of 85 unrelated British men sharing the surname Jefferson also share the President's Y-STR haplotype within haplogroup K2. Our findings represent a cautionary tale in showing the difficulty of assigning individual ancestry based on a Y-chromosome haplotype, particularly for rare lineages where population data are scarce ...
dienekes.blogspot.com/2007/02/thomas-jeffersons-y-chromosome.html

*  Important papers on recent human evolution - Gene Expression

This post is more of a personal note…here are three papers that are really cool must reads:. Williamson SH, Hubisz MJ, Clark AG, Payseur BA, Bustamante CD, et al. (2007) Localizing Recent Adaptive Evolution in the Human Genome. PLoS Genet 3(6): e90 doi:10.1371/journal.pgen.0030090. Voight BF, Kudaravalli S, Wen X, Pritchard JK (2006) A Map of Recent Positive Selection in the Human Genome. PLoS Biol 4(3): e72 doi:10.1371/journal.pbio.0040072. Tang K, Thornton KR, Stoneking M (2007) A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome. PLoS Biol 5(7): e171 doi:10.1371/journal.pbio.0050171. E.T. Wang, G. Kodama, P. Baldi, R.K. Moyzis, Global landscape of recent inferred Darwinian selection for Homo sapiens, Proc. Natl. Acad. Sci. USA 103, 135-140 (2006). doi:10.1073/pnas.0509691102. All 4 papers are Open Access! The statistical & computational techniques can be hard to follow sometimes, but these HapMap datasets are the tip of the iceberg, so get comfy and ...
scienceblogs.com/gnxp/2007/09/29/important-papers-on-recent-hum/

*  Preventing Inbreeding | Science Signaling

It is not uncommon for plants to fertilize themselves. However, several species of Brassica reject their own pollen and are self-incompatible. Self-incompatibility is controlled by the highly polymorphic S locus, which contains two genes that encode the S receptor kinase (SRK) and S locus glycoprotein (SLG). Takasaki et al. transfected self-incompatible plants (bearing the S60 or S52/60 haplotypes) with SRK or SLG (bearing the S28 haplotype) separately and determined that the expression of SRK28 alone conferred incompatibility to S28 pollen. Although expression of SLG28 alone was incapable of promoting self-incompatibility, coexpression of SLG28 with SRK28 resulted in greater self-incompatibility than that observed with SRK28 alone. Therefore, expression of SRK is necessary and sufficient to control self-incompatibility, whereas SLG can augment the response. By having a mechanism that prevents inbreeding, plants increase their robustness through hybrid vigor.. Takasaki, T., Hatakeyama, K., ...
stke.sciencemag.org/content/2000/21/tw1

*  European man, Y chromosomes & tea leaves - Gene Expression

This inference was made in large part based upon the contemporary patterns of genetic variation, by assigning modern haplogroups to putative ancient populations. To the left is a map of the frequency of haplogroup R1b, which is the most common Y chromosomal lineage in western Europe. The frequency is highest among the Basques, who were presumed to be the most pristine reservoir of the genetic substratum of Paleolithic Europe. The conception here was that the Basques were clearly indigenous to Iberia, they were already there before the arrival of outsiders such as the Celts, Phoenicians, and finally Romans (this has influenced modern Basque nationalism to some extent). Their non-Indo-European language was assumed to be a relic of many dialects which once existed before Indo-European swept over them. Using R1b, and other haplogroups at high frequency among the "indigenous peoples" of Europe, historical geneticists pegged the ancestral quanta of hypothetical prehistoric groups using these putative ...
blogs.discovermagazine.com/gnxp/2010/09/a-tale-of-y-chromosomes-and-tea-leaves/

*  DNA - Genealem's Genetic Genealogy: 2009

In genetic genealogy the Y-chromosome is used to test the all male line (top line of a pedigree chart with the tester as number one on that chart) as this chromosome is consistent over time. For this reason a living male can be tested to determine the DNA signature of his ancestors in his all male line. The same is true of sections of the mitochondrial (mtDNA) which tests a person's all female line (bottom line of the pedigree chart if the tester is number one on that chart). Men can test both their Ydna and their mtDNA as every mother passes her mtDNA to all her children. However, only the daughters can pass the mtDNA to her children. Women can only their their mtDNA, as naturally, they do not carry their father's Y-chromosome. As Ydna mutates (changes that do no harm the species) more often it is possible to determine matches between testers within genealogical time. The mtDNA is slower to mutate, thus common the common ancestor of testers who match is not always within genealogical time. ...
genealem-geneticgenealogy.blogspot.com.au/2009/

*  Home - Human Longevity, Inc.

Welcome to the era of health intelligence. Human Longevity, Inc. (HLI) is revolutionizing human health by generating more data and deeper understanding into what can keep you living healthier longer. HLI's scientists have created the world's largest database of sequenced genomes and phenotypic (physical traits) data, to uncover unprecedented insights capable of transforming healthcare from reactive to proactive. ...
humanlongevity.com

*  Testing mechanisms of parasite-mediated selection on MHC genetic diversity - Jillian Detwiler

The long-term objective of this proposal is to better understand how host immune systems have and are currently evolving due to parasitism. Genetic variation at...
grantome.com/grant/NIH/F32-GM101963-01A1

*  U.S. plans to drop gray wolves from endangered list - latimes

Federal authorities intend to remove endangered species protections for all gray wolves in the Lower 48 states, carving out an a exception for a small pocket of about 75 Mexican wolves in the wild
articles.latimes.com/2013/apr/25/local/la-me-wolves-20130426

*  Genes and Race: Human History? | RNA-Mediated

In the context of genes and race, Wade sticks with mutations and natural selection as the cause of differences that somehow evolved. No one says, Boo!
rna-mediated.com/genes-and-race-human-history/

*  The Founders Arms, Young's Pubs on the River, London Bankside Pubs, SE1

Join us at the Founders Arms, where we serve brunch, lunch and dinner and everything in between with an amazing atmosphere on Bankside.
foundersarms.co.uk

*  Unlimited Nursing CMEs and Nursing CEU with RN CEUS for $25.00

Online Nursing Continuing EducationProvider and we provide Unlimited Nursing and Healthcare Contact Hours with a Free CE Course. We provide RN CEU, NursingCEU, RN Contact Hours, Larry Snyder
lsnyder.com/NursingRecruiters.php