R1b-L21 & Z290 Haplogroup and Subclades Y DNA
We share data on haplotypes, relationships and new SNP discoveries. All L21+/Z290+ people, including those that are of any ... Wow! Our 111 STR haplotype data is growing out of sight. .... -- On Friday, January 24, 2014 10:20 AM, Mike W ,mwwdna@..., ... I will attempt to somehow note on the ExtHts (111 STR) tab of the R1b-L21_Haplotypes spreadsheet NGS tested youthful SNPs. This ... This also plays into the idea of having a modal haplotype for every youthful terminal SNP, however, we generally don't have ...https://groups.yahoo.com/neo/groups/R1b-L21-Project/conversations/messages/22816
An investigation of 10 Y-STR loci and the detection of specific haplotype frequencies in Turkish population
The aHt haplotype has found a higher discriminatory potential than minHt haplotype with a better Pd combined value (0.9999936 ... aHt haplotype can be proposed as an alternative to minHt in paternity testing and forensic medicine applications involving ... When our minHt haplotypes frequencies compared with the other seven populations, we have found statistically significant ... Gene diversity per locus varied from 0.5788 (DYS388) to 0.8903 (DYS385a/b). The numbers of haplotypes in minHt recommended by ...http://www.scirp.org/journal/PaperInformation.aspx?PaperID=6248
Abstract P259: Functional Characterization of an ALOX15 Promoter Variant Associated with Coronary Artery Calcification:...
We demonstrated a 65% higher activity of the A-carrying promoter haplotype as compared to the G-carrying promoter haplotype. ... This haplotype was uniquely tagged by a promoter variant (rs2255888). We carried out an in vitro characterization of this ... However, the A allele-carrying promoter haplotype had an 83% increased in vitro binding of vimentin compared to the G allele- ... We evaluated the activity of ALOX15 variant A-carrying and wild type G-carrying promoter haplotypes using a luciferase assay. ...http://circres.ahajournals.org/content/109/Suppl_1/AP259
Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context : Human...
Of the haplotypes that include the four functional IL1B promoter SNPs (−3737, −1464, −511, −31), the four haplotypes that ... This finding underlines the importance of understanding the haplotype structure of populations used for genetic studies and may ... We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide ... We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide ...http://oxfordindex.oup.com/view/10.1093/hmg/ddi469
HLA A1-B8 haplotype - Wikipedia
In Europe A1-B8 is found, generally as part of the HLA A1-B8-DR3-DQ2 haplotype. This haplotype is 4.7 million nucleotides in ... Underlying this move was the HLA A1-B8-DR3-DQ2 haplotype, a haplotype that is in acute linkage disequilibrium in the European ... A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are ... Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, ...https://en.wikipedia.org/wiki/HLA_A1-B8_haplotype
IJMS | Free Full-Text | Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic...
In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p , 0.001). In ... Keywords: metabolic syndrome; LPL and CETP polymorphisms; ESR1 haplotype metabolic syndrome; LPL and CETP polymorphisms; ESR1 ... Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from ... "Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from ...http://www.mdpi.com/1422-0067/16/9/21539
Killer Ig-Like Receptor Haplotype Analysis by Gene Content: Evidence for Genomic Diversity with a Minimum of Six Basic...
... "classical haplotype A" frequency, the sum of frequencies for haplotype 1 (haplotype A-1D) and haplotype 2 (haplotype A-2DS4) ... haplotype A-1D had the highest haplotype frequency of 38.8%, while haplotype A-2DS4 had a haplotype frequency of 11.8%. ... Haplotype 1 in Fig. 7⇑ is synonymous with the canonical haplotype A, with the remainder comprising the classical B haplotype. ... 5⇑A, haplotype 1), and the other containing KIR2DS4, designated as haplotype A-2DS4 (Fig. 5⇑A, haplotype 2). In the family ...http://www.jimmunol.org/content/169/9/5118.long
Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium...
Common haplotypes (frequency ,3%) are shown in the top panel, and together they compose 92% of all haplotypes in this region; ... OR = 1.17 for E23K). Haplotype E carries the K allele of E23K, but it is the only haplotype that carries the minor allele at ... Haplotype structure.. To evaluate the haplotype structure of the SUR1/Kir6.2 gene region, we genotyped 129 publicly available ... Haplotype structure across the SUR1/Kir6.2 gene region.. To characterize haplotype structure across the SUR1/Kir6.2 gene region ...http://diabetes.diabetesjournals.org/content/53/5/1360.full
Y Chromosome Haplotype Reference Database - Wikipedia
By October 2017 more than 197,000 9-locus haplotypes, among them 145,816 17-locus haplotypes, 39,414 23-locus haplotypes, ... The analysis of ~12,000 European Haplotypes by AMOVA demonstrates that three largely homogeneous pools of European Haplotypes ... the generation of reliable frequency estimates for Y-STR Haplotypes and Y-SNP Haplotypes to be used in the quantitative ... Haplotypes within a haplogroup could be highly similar or even "identical by descent" (IBD). In thus, the haplogroup could be ...https://en.wikipedia.org/wiki/Y_Chromosome_Haplotype_Reference_Database
Developing a Haplotype Map of the Human Genome to Find Genes Related to Health and Disease: Meeting Summary - National Human...
Report on National Human Genome Research Institute's meeting on Developing a Haplotype Map of the Human Genome for Finding ... A haplotype map. A haplotype map would show the haplotype blocks and the SNPs that define them. A haplotype map thus would ... Haplotype Block Structure as the Rationale for a Haplotype Map. Block pattern of haplotypes. Some recent studies found that ... how similar haplotypes must be to be considered the 'same' haplotype when figuring out which haplotypes are common, and how ...https://www.genome.gov/10001665/
Haplotype structure.. To evaluate the haplotype structure of the IDE gene at high density, we first downloaded data for 35 SNPs ... and haplotypes on both type 2 diabetes and glycemic traits. We sought to characterize the haplotype structure of IDE in detail ... The frequency of the CC haplotype formed by the above two SNPs was similar in our samples (range 14-17%). When the CC haplotype ... Possible ambiguity in haplotype assignments due to incomplete data were accounted for by estimating haplotype frequencies in ...http://diabetes.diabetesjournals.org/content/55/1/128
Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent...
... than patients carrying TT/AA and TG/GA haplotypes. The common SLCO1B3 GG/AA haplotype is associated with impaired testosterone ... Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent ... and the relationship between SLCO1B3 haplotypes and survival was examined in patients. Cells transfected with wild-type (334T/ ... patients with SLCO1B3 334GG/699AA haplotype showed longer median survival (8.5 versus 6.4 years; P = 0.020) and improved ...https://www.sigmaaldrich.com/catalog/papers/18519758
Abstract 3118: The MBL2 "LYQA Secretor" Haplotype is an Independent Predictor of Postoperative Myocardial Infarction (MI) in...
... on the backbone of the extended haplotype CGTCGGCGGGT was significantly higher than Caucasians not expressing the haplotype (42 ... Within the MBL2 gene are seven "secretor" haplotypes that code for altered serum MBL levels and complement activation. As ... Conclusions: The MBL2 LYQA secretor haplotype is a novel independent predictor of postoperative MI in Caucasians undergoing ... Results: The incidence of postoperative MI in Caucasians (n = 843) expressing the MBL2 LYQA secretor haplotype (CGTCGG) ...http://circ.ahajournals.org/content/114/Suppl_18/II_658.4
DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to...
DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to ... DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to ... DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to ... DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to ...http://atvb.ahajournals.org/content/37/7/e82
HAPLOTYPE STUDY OF THE CYP4A11 GENE AND CORONARY ARTERY DISEASE IN A HAN AND A UYGUR POPULATION OF CHINA | Heart
... and the overall distribution of haplotypes constructed with these SNPs was significant (p=0.023). The G-G-T haplotype in CAD ... The G-G-T haplotype could be a useful genetic marker of CAD in a Han population of China. There is no association between the 4 ... HAPLOTYPE STUDY OF THE CYP4A11 GENE AND CORONARY ARTERY DISEASE IN A HAN AND A UYGUR POPULATION OF CHINA ... HAPLOTYPE STUDY OF THE CYP4A11 GENE AND CORONARY ARTERY DISEASE IN A HAN AND A UYGUR POPULATION OF CHINA ...http://heart.bmj.com/content/98/Suppl_2/E40.2
A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
The CwB haplotype peaks in Sardinia along with the rest of the haplotype and can be found in high resolution studies of the S. ... There are other haplotypes that have similar origins (e.g. A2-Cw7-B58-DR16-DQ5.2) and combined these haplotypes represent ... Long haplotypes, like A30::DQ2, are generally the result of descent by common ancestry. As haplotypes increase in size, ... Excepting A*3002:Cw*0501:B*1801 haplotype, A*3002, the A30 allele found in the A30-Cw5-B18 haplotype, is rare in Europe. ...https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
"PRNP Haplotype Associated with Classical BSE Incidence in European Ho" by Brenda M. Murdoch, Michael L. Clawson et al.
A haplotype within the region of high LD was found to be associated with BSE unaffected animals (p-value = 0.000114). ... Methodology/Principal Findings: In this study, haplotype tagging single nucleotide polymorphisms (htSNPs) within PRNP were used ... Conclusion/Significance: A PRNP haplotype association with classical BSE incidence has been identified. This result suggests ... to test for association between PRNP haplotypes and BSE disease. A combination of Illumina goldengate assay, sequencing and PCR ...https://digitalcommons.unl.edu/hruskareports/286/
Comparative SNP and Haplotype Analysis Reveals a Higher Genetic Diversity and Rapider LD Decay in Tropical than Temperate...
The big window size haplotypes (3-SNP slide-window covering 2160 kb on average) revealed much higher genetic diversity than the ... The polymorphic information content values revealed by the haplotypes (0.436-0.566) were generally much higher than individual ... markers of high quality and compared for genetic diversity and LD decay using the SNPs and their haplotypes developed from ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024861
Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The...
Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The ... We analyzed the association of five polymorphisms (−1357G>A, −403T>C, Arg92His, Ile198Thr, Ala379Val) and related haplotypes at ... it is still unclear whether these polymorphisms or haplotypes are associated with the risk and outcome of cardiovascular ...https://insights.ovid.com/thrombosis-haemostasis/jthrh/2009/01/000/genetic-variants-haplotypes-lipoprotein-associated/7/00149457
C, haplotype pattern across the HER-2 gene and the estimated frequency of each haplotype. The haplotypes are designated from I ... of the total predicted haplotype variation. We were able to distinguish these three common haplotypes with only two haplotype- ... The haplotypes and individual SNPs were not associated with breast cancer risk. In patients with at least one copy of haplotype ... We found that in patients lacking haplotype I [(C)-(G)-(A)-A-C-(C)], the most common haplotype in the HER-2 gene, HER-2 protein ...http://clincancerres.aacrjournals.org/content/11/13/4775
List of haplotype estimation and genotype imputation software - Wikipedia
This is a list of notable software for haplotype estimation and genotype imputation. Alphabetical order: AlphaImpute Beagle ...https://en.wikipedia.org/wiki/List_of_haplotype_estimation_and_genotype_imputation_software
Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With...
Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With ... Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With ... Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With ... Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With ...https://dash.harvard.edu/handle/1/4745730?show=full
Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
Again, there was no significant main effect of UCP2 haplotype group and no significant interaction between UCP2 haplotype group ... We did not find any significant effects of UCP2 haplotype group on grey or white matter structure or resting-state functional ... One-way ANOVAs were performed to determine UCP2 haplotype group effects on imaging measures and post-hoc tests were performed ... Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5542610/
"Mapping Haplotype-haplotype Interactions with Adaptive LASSO " by Ming Li, Roberto Romero et al.
Results In this article, we propose a new strategy in modeling haplotype-haplotype interactions under the penalized logistic ... Recently, haplotype-based analysis has gained its popularity among genetic association studies. When multiple sequence or ... The method is applied to test haplotype interactions involved in mother and offspring genome in a small for gestational age ( ... Simulation studies show that it has low false positive rate and reasonable power in detecting haplotype interactions. ...https://digitalcommons.wayne.edu/biomedcentral/91/
An identical novel mutation in BRCA1 and a common haplotype in familial ovarian cancer in non-Ashkenazi Jews. | Base...
An identical novel mutation in BRCA1 and a common haplotype in familial ovarian cancer in non-Ashkenazi Jews. R f. 168134 ... Mots-cl s Pascal : Tumeur maligne, Ovaire, Mutation, G ne suppresseur tumeur, Haplotype, Juif, Ethnie, D pistage, Isra l, Asie ... Mots-cl s Pascal anglais : Malignant tumor, Ovary, Mutation, Tumor suppressor gene, Haplotype, Jew, Ethnic group, Medical ... Allelotyping of mutation carriers using intragenic BRCA 1 markers revealed that the haplotype was identical in these seemingly ...http://www.bdsp.ehesp.fr/Base/168134/