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*  PND Association | Guanosine Triphosphate Cyclohydrolase I Deficiency
Guanosine Triphosphate Cyclohydrolase I Deficiency (GTPCH) deficiency is a rare metabolic disorder which produces a lack of the ... What is Guanosine Triphosphate Cyclohydrolase I Deficiency (GCH I, GTP Cyclohydrolase, GTPCH)?. Home , Diseases ... PDF/Printable Guide to Guanosine Triphosphate Cyclohydrolase I Deficiency(GCH I, GTP Cyclohydrolase, GTPCH) ... Guanosine Triphosphate Cyclohydrolase I Deficiency. Key Words: "GTP Cyclohydrolase". Access Listing: 600225. http://www.ncbi. ...
  http://www.pndassoc.org/diseases/gtpch.html
*  Human Metabolome Database: Showing metabocard for Xanthylic acid (HMDB0001554)
Adenosine triphosphate + Xanthylic acid + Ammonia → Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate. details ... Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water → Adenosine monophosphate + Pyrophosphate + Guanosine ... Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate ( ... 6. Inosine triphosphate pyrophosphatase. General function:. Involved in hydrolase activity. Specific function:. ...
  http://www.hmdb.ca/metabolites/HMDB0001554
*  Tetrahydrobiopterin deficiency - Wikipedia
... deficiency Autosomal recessive guanosine triphosphate cyclohydrolase I (GTPCH) deficiency Pterin-4alpha-carbinolamine ...
  https://en.wikipedia.org/wiki/Tetrahydrobiopterin_deficiency
*  Guanosine triphosphate - Factbites
Guanosine triphosphate -- Facts, Info, and Encyclopedia article Guanosine triphosphate (GTP) is also known as guanosine-5'- ... Guanosine triphosphate - Wikipedia, the free encyclopedia. Guanosine triphosphate (GTP) is also known as guanosine-5'- ... guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate). ... Guanosine phosphate (GMP) - a constituent of nucleic acids Guanosine diphosphate (GDP) and guanosine triphosphate (GTP) - used ...
  http://www.factbites.com/topics/Guanosine-triphosphate
*  GUANOSINE TRIPHOSPHATE | C10H16N5O14P3 - PubChem
GUANOSINE TRIPHOSPHATE , C10H16N5O14P3 , CID 6830 - structure, chemical names, physical and chemical properties, classification ...
  https://pubchem.ncbi.nlm.nih.gov/compound/6830
*  Guanosine triphosphate | definition of guanosine triphosphate by Medical dictionary
What is guanosine triphosphate? Meaning of guanosine triphosphate medical term. What does guanosine triphosphate mean? ... Looking for online definition of guanosine triphosphate in the Medical Dictionary? guanosine triphosphate explanation free. ... Related to guanosine triphosphate: adenosine triphosphate, GTP guanosine. [gwah´no-sēn] a nucleoside, guanine riboside, one of ... guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.. guanosine triphosphate (GTP) a ...
  http://medical-dictionary.thefreedictionary.com/guanosine+triphosphate
*  Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease).
... код для вставки. код для вставки на ... Autosomal Dominant Guanosine Triphosphate Cyclohydrolase I Deficiency (Segawa Disease) Masaya Segawa, MD, PhD,1 Yoshiko Nomura ... Ann Neurol 2003;54 (suppl 6):S32-S45 Autosomal dominant guanosine triphosphate cyclohydrolase I (GCH-I) deficiency (Segawa ... Ueno S, Hirano M. Missense mutants inactivate guanosine triphosphate cyclohydrolase I in hereditary progressive dystonia. Brain ...
  https://www.docme.ru/doc/1904133/autosomal-dominant-guanosine-triphosphate-cyclohydrolase-...
*  Guanosine triphosphate - Wikipedia
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It can act as a substrate for both the synthesis of RNA ... Cyclic guanosine triphosphate (cGTP) helps cyclic adenosine monophosphate (cAMP) activate cyclic nucleotide-gated ion channels ... and the triphosphate moiety attached to the 5' carbons of the ribose. It also has the role of a source of energy or an ... in second-messenger mechanisms where it is converted to guanosine diphosphate (GDP) through the action of GTPases. GTP is ...
  https://en.wikipedia.org/wiki/Guanosine_triphosphate
*  Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells |...
Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells. Timothy ... Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells ... Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells ... Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells ...
  http://hyper.ahajournals.org/content/early/2008/12/22/HYPERTENSIONAHA.108.115709
*  Guanosine-triphosphate guanylyltransferase - Wikipedia
... and guanosine triphosphate-guanose triphosphate guanylyltransferase. Warner AH, Beers PC, Huang FL (1974). "Biosynthesis of the ... In enzymology, a guanosine-triphosphate guanylyltransferase (EC 2.7.7.45) is an enzyme that catalyzes the chemical reaction 2 ...
  https://en.wikipedia.org/wiki/Guanosine-triphosphate_guanylyltransferase
*  Inhibition of bacteriophage-Q β ribonucleic acid polymerase by guanosine triphosphate analogues | Biochemical Journal
Inhibition of bacteriophage-Q β ribonucleic acid polymerase by guanosine triphosphate analogues. R R Brooks ... Inhibition of bacteriophage-Q β ribonucleic acid polymerase by guanosine triphosphate analogues ... Inhibition of bacteriophage-Q β ribonucleic acid polymerase by guanosine triphosphate analogues ... Inhibition of bacteriophage-Q β ribonucleic acid polymerase by guanosine triphosphate analogues ...
  http://www.biochemj.org/content/183/1/65
*  Guanosine Triphosphate Phosphohydrolases - Semantic Scholar
Proteins that hydrolyze guanine triphosphate to yield guanine diphosphate. This is a class of proteins that belongs to a family ... Guanosine Triphosphate Phosphohydrolases. Known as: Guanosinetriphosphatase, Triphosphate Phosphohydrolases, Guanosine, GTPases ... Proteins that hydrolyze guanine triphosphate to yield guanine diphosphate. This is a class of proteins that belongs to a family ...
  https://www.semanticscholar.org/topic/Guanosine-Triphosphate-Phosphohydrolases/3660
*  Solution structure of the ternary complex between aminoacyl-tRNA, elongation factor Tu, and guanosine triphosphate
... Bilgin, N ... TRIPHOSPHATE Identifiers. URN: urn:nbn:se:uu:diva-79266OAI: oai:DiVA.org:uu-79266DiVA: diva2:107179 ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:107179
*  Single turnover kinetic studies of guanosine triphosphate hydr...
Single turnover kinetic studies of guanosine triphosphate hydrolysis and peptide formation in the elongation factor Tu- ... Single turnover kinetic studies of guanosine triphosphate hydrolysis and peptide formation in the elongation factor Tu- ...
  https://www.mysciencework.com/publication/show/single-turnover-kinetic-studies-guanosine-triphosphate-hydrolysis-peptide-formation-elongation-factor-tu-dependent-bind-74d1a04b
*  Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial...
Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial ... Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial ... Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial ... APC = anesthetic preconditioning; CON = control; eNOS = endothelial nitric oxide synthase; GTPCH-1 = guanosine triphosphate ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2411186
*  7-Methyl-Guanosine-5'-Triphosphate - DrugBank
7-Methyl-Guanosine-5'-Triphosphate. Accession Number. DB02716 (EXPT02167) Type. Small Molecule. Groups. Experimental. ... Purine ribonucleoside triphosphates. Alternative Parents. Purine ribonucleoside monophosphates / Pentose phosphates / ... Purine ribonucleoside triphosphate / Purine ribonucleoside monophosphate / Pentose phosphate / Pentose-5-phosphate / Glycosyl ... These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.. Kingdom. Organic compounds. Super ...
  https://www.drugbank.ca/drugs/DB02716
*  GUANOSINE 5'-TRIPHOSPHATE, [8-3H], (GTP,[3H]) | PerkinElmer
GUANOSINE 5'-TRIPHOSPHATE (GTP) are available for your research. Application of [3H]GTP can be found in: mitochondrial ... Guanosine-5'-triphosphate (GTP) is a purine nucleotide. It can act as a substrate for the synthesis of RNA during the ...
  http://www.perkinelmer.com/product/guanosine-5-triphosphate-8-3h-net1201001mc
*  guanosine 3'-diphosphate 5'-triphosphate (CHEBI:16690)
... is a guanosine 5'-phosphate (CHEBI:37121) guanosine 3'-diphosphate 5'- ... guanosine 3'-diphosphate 5'-triphosphate (CHEBI:16690) is conjugate acid of guanosine 3'-diphosphate 5'-triphosphate(6−) (CHEBI ... guanosine 3'-diphosphate 5'-triphosphate(6−) (CHEBI:60028) is conjugate base of guanosine 3'-diphosphate 5'-triphosphate (CHEBI ... guanosine 3'-diphosphate 5'-triphosphate (CHEBI:16690) is conjugate acid of guanosine 3'-diphosphate 5'-triphosphate hexaanion ...
  https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:14382
*  Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its...
Aberrant degradation of guanosine 5′-triphosphate cyclohydrolase 1 (GTPCH1) with consequent deficiency of tetrahydrobiopterin ... Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its ... Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its ... Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its ...
  http://diabetes.diabetesjournals.org/content/62/12/4247?with-ds=yes
*  gppA - Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase - Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) - gppA...
Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the ... Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation. ,p>Manual ... guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC. View the complete GO annotation on ... Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation. ,p>Manual validated information which has been ...
  http://www.uniprot.org/uniprot/A9MXF2
*  Guanosine-5'-triphosphate,3'-diphosphate diphosphatase - Wikipedia
... guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase, and ... guanosine 5'-diphosphate,3'-diphosphate + phosphate Thus, the two substrates of this enzyme are guanosine 5'-triphosphate,3'- ... In enzymology, a guanosine-5'-triphosphate,3'-diphosphate diphosphatase (EC 3.6.1.40) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase. Other names in common ...
  https://en.wikipedia.org/wiki/Guanosine-5'-triphosphate,3'-diphosphate_diphosphatase
*  A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts
Casein kinase II - Chloroplast envelope - Guanosine triphosphate-ADP phosphotransferase - Guanosine triphosphate-protein kinase ... A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes ... Soll, Jürgen; Fischer, Irene und Keegstra, Kenneth (1988): A guanosine 5′-triphosphate-dependent protein kinase is localized in ...
  https://epub.ub.uni-muenchen.de/3492/index.html
*  Kinetic studies of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate-aminoacyl-tRNA complexes. - Semantic Scholar
Kinetic studies of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate-aminoacyl-tRNA complexes.. @article{ ... Louie1985KineticSO, title={Kinetic studies of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate-aminoacyl-tRNA ...
  https://www.semanticscholar.org/paper/Kinetic-studies-of-Escherichia-coli-elongation-Louie-Jurnak/29cd087f3023e327d0e69bd8a3ccacef239f16d9
*  GTP (Guanosine-5'-triphosphate) | Abcam中国
... triphosphate) (CAS 86-01-1),水溶的purine nucleoside。使用Abcam高品质的GTP (Guanosine-5'-triphosphate)帮助您更 ...
  http://www.abcam.cn/gtp-guanosine-5-triphosphate-ab120628.html

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*  "GTP hydrolysis by complexes of the signal recognition particle and the" by Timothy Connolly and Reid Gilmore
Translocation of proteins across the endoplasmic reticulum membrane is a GTP-dependent process. The signal recognition particle (SRP) and the SRP receptor both contain subunits with GTP binding domains. One GTP-dependent reaction during protein translocation is the SRP receptor-mediated dissociation of SRP from the signal sequence of a nascent polypeptide. Here, we have assayed the SRP and the SRP receptor for GTP binding and hydrolysis activities. GTP hydrolysis by SRP was not detected, so the maximal GTP hydrolysis rate for SRP was estimated to be | 0.002 mol GTP hydrolyzed x mol of SRP-1 x min-1. The intrinsic GTP hydrolysis activity of the SRP receptor ranged between 0.02 and 0.04 mol GTP hydrolyzed x mol of SRP receptor-1 x min-1. A 40-fold enhancement of GTP hydrolysis activity relative to that observed for the SRP receptor alone was obtained when complexes were formed between SRP and the SRP receptor. GTP hydrolysis activity was inhibited by GDP, but not by ATP. Extended incubation of the SRP or
  http://escholarship.umassmed.edu/oapubs/955/
*  Guanine nucleotide-binding protein subunit beta-5 | definition of guanine nucleotide-binding protein subunit beta-5 by Medical...
Looking for online definition of guanine nucleotide-binding protein subunit beta-5 in the Medical Dictionary? guanine nucleotide-binding protein subunit beta-5 explanation free. What is guanine nucleotide-binding protein subunit beta-5? Meaning of guanine nucleotide-binding protein subunit beta-5 medical term. What does guanine nucleotide-binding protein subunit beta-5 mean?
  http://medical-dictionary.thefreedictionary.com/guanine+nucleotide-binding+protein+subunit+beta-5
*  Ras-related GTP-binding protein B
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008 ...
  https://pharos.nih.gov/idg/targets/Q5VZM2
*  RRAGA - Ras-related GTP-binding protein A - Homo sapiens (Human) - RRAGA gene & protein
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
  http://www.uniprot.org/uniprot/Q7L523
*  SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a...
The Rac proteins, Rac1 and Rac2, are essential components of the NADPH oxidase system of phagocytes and regulate the actin assembly associated with membrane ruffling. These functions are controlled by the GTP-bound form of Rac. The biochemical interaction between Rac and its only known GDP-dissociation stimulator (termed smgGDS) was characterized. SmgGDS was able to stimulate the incorporation of guanosine 5′-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2. Isoprenoid modification of these proteins was not absolutely required for the interaction with smgGDS. Interestingly, the activity of smgGDS toward Rac1 could not be observed in a [3H]GDP/GTP exchange assay under conditions where it stimulated incorporation of GTP[gamma S] into Rac1. We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of ...
  http://www.biochemj.org/content/303/3/761
*  Rragc - Ras-related GTP-binding protein C - Mus musculus (Mouse) - Rragc gene & protein
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity).
  http://www.uniprot.org/uniprot/Q99K70
*  Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes | Heart and Circulatory...
ATP-sensitive K+ (K+[ATP]) current is thought to be regulated by GTP-binding proteins (G proteins), but the pathways that couple receptor, G protein, and channel have not been defined. We studied regulation of tolbutamide-sensitive K+[ATP] current in neonatal rat ventricular myocytes. Application of 0.1 mM ATP to the intracellular side of membrane patches reduced K+ [ATP] channel activity, and addition of the nonhydrolyzable GTP analogue guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) at 0.1 mM restored activity. Application of 0.1 mM intracellular GTP plus 10 microM extracellular adenosine or 100 nM N6-cyclohexyladenosine had the same effect as GTP gamma S; hence K+[ATP] channels may be coupled to adenosine receptors via G proteins. To determine which G protein, we applied G alpha subunits, preactivated with GTP gamma S to the cytoplasmic side of membrane patches, and found that alpha i1, alpha i2, and alpha i3 mimicked the effect of GTP gamma S, but not alpha o or Gs, ...
  http://ajpheart.physiology.org/content/259/3/H820.long
*  etd AT Indian Institute of Science: Structure-Function Correlative Studies On The Biochemical Properties (Polymerisation, GTP...
FtsZ, the principal cell-division protein, polymerizes in GTP-dependent manner in vitro (Bramhill and Thompson, 1994; Mukherjee and Lutkenhaus, 1994; Rivas et al., 2000). FtsZ polymerization at the mid-cell site of bacterium leads to formation of a guiding scaffold, the Z-ring, for bacterial cytokinesis (Bi and Lutkenhaus, 1991; Sun and Margolin, 1998). GTP-induced polymerization process of FtsZ can be monitored in vitro Using 90º light scattering (Mukherjee and Lutkenhaus, 1999) and polymers formed can be visualized using transmission electron microscopy (Lu and Erickson, 1998) or quntitated in terms of the amount of FtsZ polymer pelleted during ultracentrifugation (Mukherjee and Lutkenhaus, 1998). The research work presented in this thesis focused on structure-function correlative analysis of Mycobacterium tuberculosis FtsZ(MtFtsZ0 and FtsZ proteins of Mycobacterium leprae (M1FtsZ), Mycobacterium smegmatis(MsFtsZ), and Streptomyces coelicolor (ScFtsZ) (as it is from Actinomycetes family to ...
  http://etd.ncsi.iisc.ernet.in/handle/2005/661
*  Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go |...
A guanine-nucleotide-binding protein (G-protein) was purified from cholate extracts of bovine brain membranes by sequential DEAE-Sephacel, Ultrogel AcA-34, heptylamine-Sepharose and Sephadex G-150 chromatography. Guanosine 5′-[gamma-[35S]thio]triphosphate (GTP[35S])-binding activity copurified with a 25,000 Da peptide and a 35,000-36,000 Da protein doublet. Neither pertussis toxin nor cholera toxin catalysed the ADP-ribosylation of a protein associated with the GTP[35S]-binding activity. Photoaffinity labelling of the purified protein with 8-azido[gamma-32P]GTP indicated that the GTP-binding site resides on the 25,000 Da protein. The 35,000-36,000 Da protein doublet was electrophoretically indistinguishable from the beta-subunits of other GTP-binding proteins, and the 36,000 Da protein was recognized by antiserum to oligomeric Gt. The purified protein specifically bound 17.2 nmol of GTP[35S]/mg of protein. The Kd of the binding site for radioligand was approx. 15 nM. The ...
  http://www.biochemj.org/content/246/2/431
*  Plus it
Agonist binding to guanine nucleotide-binding protein (G protein)-coupled receptors in membranes of myeloid differentiated human leukemia (HL-60) cells is inhibited by guanine nucleotides, most potently by the GTP analog guanosine 5'-(gamma-thio)triphosphate (GTP gamma S). In order to study whether GTP gamma S formed locally from adenosine 5'-(gamma-thio)triphosphate (ATP gamma S) and GDP by nucleoside diphosphokinase has any advantage over exogenously added GTP gamma S in binding to and activating G proteins, regulation of complement component 5a (C5a) binding to its receptors, as well as formation of GTP gamma S, was studied in membranes of HL-60 cells. GTP gamma S added to HL-60 membranes potently inhibited binding of 125I-C5a (IC50 about 3 nM), an effect not influenced by addition of either GDP or ATP gamma S. When HL-60 membranes were incubated with the combination of ATP gamma S and GDP, a marked potentiation (up to 300-fold) of the inhibition caused ...
  http://molpharm.aspetjournals.org/content/42/5/731
*  Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors | Science Signaling
The guanosine triphosphate (GTP)-loaded form of the guanosine triphosphatase (GTPase) Ras initiates multiple signaling pathways by binding to various effectors, such as the kinase Raf and phosphatidylinositol 3-kinase (PI3K). Ras activity is increased by guanine nucleotide exchange factors that stimulate guanosine diphosphate release and GTP loading and is inhibited by GTPase-activating proteins that stimulate GTP hydrolysis. KRAS is the most frequently mutated RAS gene in cancer. Here, we report that monoubiquitination of lysine-147 in the guanine nucleotide-binding motif of wild-type K-Ras could lead to enhanced GTP loading. Furthermore, ubiquitination increased the binding of the oncogenic Gly12Val mutant of K-Ras to the downstream effectors PI3K and Raf. Thus, monoubiquitination could enhance GTP loading on K-Ras and increase its affinity for specific downstream effectors, providing a previously unidentified mechanism for Ras ...
  http://stke.sciencemag.org/content/4/163/ra13
*  Geisha
C12-3, c12.3, Guanine nucleotide-binding protein beta subunit2-like 1, MHC B complex protein 12.3, RACK1, guanine nucleotide binding 12.3, guanine nucleotide-binding protein beta subunit 2-like 1, guanine nucleotide-binding protein subunit beta-2-like 1, guanine nucleotide-binding protein subunit beta-like protein 12.3, receptor for activated C kinase, receptor of activated protein kinase C 1, Guanine nucleotide-binding protein subunit beta 2-like 1, Guanine nucleotide-binding protein subunit beta-like protein 12.3, Receptor of activated protein kinase C 1 (RACK1), RACK1, Receptor for activated C ...
  http://geisha.arizona.edu/geisha/search.jsp?search=stage&stage=24
*  The mechanism of action of GTP on Ca2+ efflux from rat liver microsomal vesicles | Biochemical Journal
1. Guanosine 5′-[gamma-thio]triphosphate (GTP[S]), if added before GTP, blocks both Ca2+ efflux promoted by GTP and the effect of GTP on enhancement of inositol 1,4,5-triphosphate (IP3)-promoted Ca2+ release from preloaded microsomal vesicles. If, however, GTP[S] is added after GTP, it does not reverse the Ca2+ efflux promoted by GTP, nor does it inhibit IP3-promoted Ca2+ release. 2. The effect of GTP in enhancing IP3-promoted Ca2+ release is maintained after washing the microsomal vesicles free of added GTP. After this treatment, enhancement of IP3-promoted Ca2+ efflux can be observed in the absence of poly(ethylene glycol). 3. Electron microscopy shows that during GTP treatment of microsomal vesicles there is rapid production of very large vesicular structures, apparently produced by fusion of smaller vesicles. 4. Light-scattering changes are detectable during the fusion process. 5. Both Ca2+ efflux promoted by GTP and the enhancement of IP3-promoted Ca2+ ...
  http://www.biochemj.org/content/244/1/87
*  Immediate GTP hydrolysis upon FtsZ polymerization - Scheffers - 2002 - Molecular Microbiology - Wiley Online Library
To understand the polymerization dynamics of FtsZ, a bacterial cell division protein similar to tubulin, insight is required into the nature of the nucleotide bound to the polymerized protein. In a previous study, we showed that the FtsZ polymers contain mostly GDP. A recent study challenged this result, suggesting that the polymerized FtsZ is in a GTP-bound state. Here, we show that, when radiolabelled [γ-32P]-GTP is used to polymerize FtsZ, GTP is hydrolysed instantaneously. The FtsZ polymer contains both GDP and the radiolabelled inorganic phosphate. ...
  http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2002.02828.x/abstract
*  The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium | Science
It has been debated whether the potassium channel of the atrium is activated by the alpha subunit or by the beta gamma subunits of guanine nucleotide binding (G) proteins, which dissociate on activation with guanosine triphosphate (GTP). Therefore, the channel-activating effectiveness of these subunits on isolated guinea pig atrial cells was tested. The activated alpha K subunit from human erythrocytes activated the channel in subpicomolar concentrations. The beta gamma dimer from bovine brain activated the channel in nanomolar concentrations. These results support the view that, physiologically, the alpha subunit activates the channel. ...
  http://science.sciencemag.org/content/240/4860/1782
*  Gnaq - Guanine nucleotide-binding protein G(q) subunit alpha - Rattus norvegicus (Rat) - Gnaq gene & protein
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  http://www.uniprot.org/uniprot/P82471
*  GNAZ - Guanine nucleotide-binding protein G(z) subunit alpha - Homo sapiens (Human) - GNAZ gene & protein
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  http://www.uniprot.org/uniprot/P19086
*  Rap2a - Ras-related protein Rap-2a precursor - Mus musculus (Mouse) - Rap2a gene & protein
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
  http://www.uniprot.org/uniprot/Q80ZJ1
*  Gnb1 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 - Mus musculus (Mouse) - Gnb1 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/H3BKR2
*  GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - Homo sapiens (Human) - GNB3 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/E9PCP0
*  Biology-Online • View topic - What is the source of new nucleotides for replication?
Actually, nucleotides are used in DNA replication/repair/etc. in a triphosphate form(eg. ATP, CTP, GTP, TTP). These are also used in other cellular processes in addition to DNA uses. Just off the top of my (shaved) head, ATP and GTP are both used to store energy for other processes ...
  http://www.biology-online.org/biology-forum/post-4734.html
*  Biology-Online • View topic - pls check
2. Ans. is other than B & E. IN the presence of GTP & all the process has -deltaG & the original AA to Prot reaction has been combined with the GTP hydrolysis as its individual deltaG is positive. MOre than that for deltaG to be positive u can't have -deltaH along with +deltaS. I'm seeing for more info ...
  http://www.biology-online.org/biology-forum/about5926.html?hilit=adenosylhomocysteine%20deaminase
*  泰7月公债逾5兆铢 占GDP44% - 资讯 - 东盟百科信息网
泰国公共债务管理办事处负责人朱拉乐女士日前表示,今年7月分公债总额为5兆2111亿9401万铢,在国内生产总值(GDP)占比约44.11%,与今年6月相比,公债规模减少127亿1700万铢。
  http://asean.zwbk.org/newsdetail/32095.html
*  Manoza-1-fosfat guanililtransferaza - Википедија, слободна енциклопедија
Manoza-1-fosfat guanililtransferaza (EC 2.7.7.13, GTP-manoza-1-fosfat guanililtransferaza, PIM-GMP (fosfomanoza izomeraza-guanozin 5'-difosfo-D-manoza pirofosforilaza), GDP-manoza pirofosforilaza, guanozin 5'-difosfo-D-manoza pirofosforilaza, guanozin difosfomanoza pirofosforilaza, guanozin trifosfat-manoza 1-fosfat guanililtransferaza, manoza 1-fosfat guanililtransferaza (guanozin trifosfat)) je enzim sa sistematskim imenom GTP:alfa-D-manoza-1-fosfat guanililtransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...
  https://sr.wikipedia.org/wiki/Manoza-1-fosfat_guanililtransferaza