A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a...
3) receptor antagonist (1) has been modified so as to modulate the basicity, sterics, and dipole moment of the 2-pyridyl moiety ... Guanosine 5-O-(3-Thiotriphosphate) Grants and funding * R01 GM 52722/GM/NIGMS NIH HHS/United States ... A recently reported dual LPA(1)/LPA(3) receptor antagonist (1) has been modified so as to modulate the basicity, sterics, and ... This study has resulted in the development of the first nonhydrolyzable and presumably phosphatase-resistant LPA(3)-selective ...
Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its...
Treatment of such N-ethylmaleimide-treated membranes, termed C- liver membranes, with guanosine 5-[gamma-thio]triphosphate ( ...
Plus it
Nevertheless, the (+)-isomer was markedly more efficacious than its (-)-counterpart in stimulating the binding of guanosine 5′- ... thiotriphosphate) ([35S]-GTPγS) at h5-HT1A receptors, a measure of coupling to G-proteins; 90 vs. 57% maximal stimulation ... 5-HT. serotonin. DRN. dorsal raphe nucleus. SNPC. substantia nigra pars compacta. VTA. ventral tegmental area. CHO. Chinese ... 5-HT1Areceptors and their inhibition of the firing of VTA as compared to DRN neurones is mediated by hD3/hD2 and 5-HT1A ...
Plus it
... guanosine 5′-O-(3-thio)triphosphate; DRG, dorsal root ganglion; CFP, δ-cerulean fluorescent protein; PBS, phosphate-buffered ... ABBREVIATIONS: VDCC, voltage-dependent Ca2+ channel; DAMGO, [d-Ala2,Phe4,Gly5-ol]-enkephalin; DPDPE, [d-Pen2,Pen5]-enkephalin; ... Neurons deficient in δ receptors exhibited reduced inhibition of VDCCs by morphine and [d-Ala2,Phe4,Gly5-ol]-enkephalin (DAMGO ... neither the density of VDCCs nor their inhibition by either the GABAB receptor agonist baclofen or intracellular guanosine 5′-O ...
JWH-030 - Wikipedia
... thio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 ( ... "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5-O-(3-[35S] ... 284 (3): 241-7. doi:10.1016/0014-2999(95)00318-f. PMID 8666005. Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME (May ... In the United States, CB1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-030 are Schedule I Controlled ...
Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-...
... thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist. Leigh A. Stoddart, Andrew J. Brown and Graeme ... To allow effective ligand equilibration, GPR40-Gαq was used in guanosine 5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding ... Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[ ... Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[ ...
Plus it
1994) Photoaffinity guanosine 5′-triphosphate analogs as a tool for the study of GTP-binding proteins. Methods Enzymol 237:100- ... guanosine 5′-O-(3-thiotriphosphate) (GTPγS), GppNHp, GDP, or [32P]P3(4-azidoanilido)-P1-5′-GTP (AAGTP)] for 30 min on ice. ... guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments. J Biol Chem 267 ... A biphasic pattern of response of PLCβ1 to dimeric tubulin with guanosine 5′-(β,γ-imido)triphosphate (GppNHp) bound (tubulin- ...
DI-fusion Activation of guanosine 5'-[gamma-(35)S]thio-triphosphate...
... thio-triphosphate binding through M(1) muscarinic receptors in transfected Chinese hamster ovary cell membranes; 1. ... Activation of guanosine 5-[gamma-(35)S]thio-triphosphate binding through M(1) muscarinic receptors in transfected Chinese ... pivotal phase 3 study par Leal, Ticiana , KOTECHA, RUPESH , Ramlau, Rodryg , Milanowski, Janusz , Cobo, Manuel , Roubec, ...
The Journal of Physiology
... gamma-thio]triphosphate (GTP gamma S) and guanosine 5-[beta,gamma-imido]triphosphate (GMP-PNP), induced sustained and dose- ... 2. Intracellular application of guanosine 5-O-(3-thiotriphosphate) (GTP gamma S, 500 microM) evoked a noisy inward current at ... 2. Sodium fluoride or non-hydrolysable analogues of GTP, guanosine 5-[ ... Guanosine 5-[beta-thio]diphosphate (GDP beta S), a non-hydrolysable analogue of GDP that competitively inhibits the binding of ...
MS spectra
DSpace
... guanosine 5-3-O- (thio)triphosphate binding to membranes. Consistent with the PAF receptor phosphorylation, both thrombin and ... AP-PCR produced 4-10 DNA bands in the 0.5-5 kb regions and distinguished 9, 13 or 17 genotypes, depending on the specific ... Transformed tobacco leaves expressed Cry2Aa2 protoxin at levels between 2% and 3% of total soluble protein, 20- to 30-fold ...
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding...
... and guanosine 5-[beta gamma-imido]triphosphate (p[NH]ppG) stimulated rapid LH exocytosis, which was maximal between 5 and 10 ... A similar inhibition was observed with adenosine 5-[gamma-thio]triphosphate, probably by its conversion into GTP[S]. These ... At resting cytosolic [Ca2+]free (pCa 7), 5-[gamma-thio]triphosphate (GTP[S]) ... gamma-thio]triphosphate (GTP[S]) and guanosine 5-[beta gamma-imido]triphosphate (p[NH]ppG) stimulated rapid LH exocytosis, ...
Bio2Vec
ID: http://www.ncbi.nlm.nih.gov/gene/8997 Type: http://bio2vec.net/ontology/gene Label: KALRN Synonyms: KALRN, ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin RhoGEF kinase, kalirin, huntingtin-associated protein interacting protein (duo), serine/threonine-protein kinase with Dbl- and pleckstrin homology domain Alternative IDs: 8997 API: GO SPARQL: GO ...
Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce...
2-thio]triphosphate (Sp-diastereomer) = GTP = guanosine 5-O-[2-thio]diphosphate (GDP[beta S] = ADP greater than adenosine 5-[ ... 2-thio]triphosphate (Rp-diastereomer) (Rp)-UTP[beta S]) = UTP greater than CTP. Uracil nucleotides were similarly effective ... 2-thio]triphosphate] (Rp-diastereomer). Pyrimidine nucleotides stimulated fMet-Leu-Phe-induced O2- formation in the ... greater than ITP greater than guanosine 5-O-[3-thio]triphosphate (GTP[gamma S]) greater than ATP = adenosine 5-O-[ ...
Ribonucleotides - Guanosine Triphosphate | CU Experts | CU Boulder
Ribonucleotides - Guanosine Triphosphate PubMed MeSh Term *Overview. Overview. subject area of * 5 EXON REQUIREMENT FOR SELF- ... Ribonucleotides - Guanosine 5-O-(3-Thiotriphosphate) PubMed MeSh Term * Ribonucleotides - Guanylyl Imidodiphosphate PubMed ... GUANOSINE BINDING REQUIRED FOR CYCLIZATION OF THE SELF-SPLICING INTERVENING SEQUENCE RIBONUCLEIC-ACID FROM TETRAHYMENA- ... THE CONSERVED U.G PAIR IN THE 5 SPLICE SITE DUPLEX OF A GROUP-I INTRON IS REQUIRED IN THE 1ST BUT NOT THE 2ND STEP OF SELF- ...
Carboxyl methylation of ras-related proteins during signal transduction in neutrophils<...
In human neutrophils, as in other cell types, Ras-related guanosine triphosphate-binding proteins are directed toward their ... N2 - In human neutrophils, as in other cell types, Ras-related guanosine triphosphate-binding proteins are directed toward ... AB - In human neutrophils, as in other cell types, Ras-related guanosine triphosphate-binding proteins are directed toward ... abstract = "In human neutrophils, as in other cell types, Ras-related guanosine triphosphate-binding proteins are directed ...
Ras GTPase activating protein 1
Guanosine 5-[beta-thio]diphosphate (GDP[S]) does not alter the action of either Ins(2,4,5)P3 or Ins(1,3,4,5)P4. Finally, the ... gamma-thio]triphosphate (GTP[S]) enhances the effect of Ins(1,3,4,5)P4 on Ins(2,4, 5)P3-stimulated Ca2+ mobilization, but has ... The activation status of the guanosine triphosphate (GTP)-binding protein Ras is dictated by the relative intensities of two ... Cell 96(5): 655-65. Chou, T. B., Noll, E. and Perrimon, N. (1993). Autosomal P[ovoD1] dominant female-sterile insertions in ...
Search Results | AVMA
... guanosine 5-(γ-thio) triphosphate ([35S]GTPγS).. Results-Saturable high affinity [3H]DPCPX binding (A1) sites were detected in ... Sample Population-Brain tissue specimens obtained during necropsy from 5 adult male research ... 3H]DPCPX and the A2a-selective ligand [3H]ZM241385. Functional responses to adenosine receptor agonists and antagonists were ... cerebral cortex and striatum, whereas high-affinity [3H]ZM241385 binding (A2a) sites were detected only in striatum. Caffeine ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
Consistent data were obtained from GPR82-mediated binding analysis of guanosine-5-O-(3-thiotriphosphate) to cell membranes. ... 3. The tyrosine kinase inhibitor nintedanib enhances the efficacy of 90Y-labeled B5209B radioimmunotherapy targeting ROBO1 ... After 3 days, AlPcS2a was injected subcutaneously around the tumor and the area was illuminated at 650 nm for 30 min. The ... Pentraxin 3 (PTX3), a member of the pentraxin family that is classified as a carbohydrate-binding protein based on its ...
Association and interactions of GTP-binding proteins with rat medullary H<sup>+</sup>...
Guanosine 5′-triphosphate (GTP)-binding proteins (G proteins) are expressed in a heterogeneous manner in the mammalian kidney. ... N2 - Guanosine 5′-triphosphate (GTP)-binding proteins (G proteins) are expressed in a heterogeneous manner in the mammalian ... AB - Guanosine 5′-triphosphate (GTP)-binding proteins (G proteins) are expressed in a heterogeneous manner in the mammalian ... abstract = "Guanosine 5′-triphosphate (GTP)-binding proteins (G proteins) are expressed in a heterogeneous manner in the ...
Effects of neonatal cocaine treatment and gender on opioid agonist-stimulated [(35)S]GTP gamma S binding in the striatum and...
Meyer JS, Shani I, Rice D. Effects of neonatal cocaine treatment and gender on opioid agonist-stimulated [(35)S]GTP gamma S binding in the striatum and nucleus accumbens. Brain Res Bull. 2000 Sep 15; 53(2):147-52 ...
Purification of an AlF<sub>4</sub><sup>-</sup> and G-protein βγ-subunit-regulated phospholipase C...
... thio)triphosphate also activated the reconstituted phospholipase C in a manner that was inhibited by guanosine 5-2-O-(thio)- ... thio)triphosphate also activated the reconstituted phospholipase C in a manner that was inhibited by guanosine 5-2-O-(thio)- ... thio)triphosphate also activated the reconstituted phospholipase C in a manner that was inhibited by guanosine 5-2-O-(thio)- ... thio)triphosphate also activated the reconstituted phospholipase C in a manner that was inhibited by guanosine 5-2-O-(thio)- ...
Heterologous mu-opioid receptor adaptation by repeated stimulation of kappa-opioid receptor: up-regulation of G-protein...
3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide hydrochloride [(-)U-50,488H] on antinociception and G- ... Using the guanosine-5′-o-(3-[35S]thio) triphosphate ([35S]GTP gamma S) binding assay, we found that (-)U-50,488H was able to ... 3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide hydrochloride [(-)U-50,488H] on antinociception and G- ...
Paul Prather's research topics | Profiles RNS
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2018 - Neuropsychopharmacology Research Group - UPV/EHU
... thio)triphosphate ([(35)S]GTPγS) binding or [(35)S]GTPγS/immunoprecipitation assay Purinergic Signalling, 2018; 14, 177 - 190 ... receptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5-O-(3-[(35)S] ... Serotonin 5-HT(3) receptor antagonism potentiates the antidepressant activity of citalopram Neuropharmacology, 2018; 133, 491 ... Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway Neuropsychopharmacology, ...
DeCS 2017 - December 21, 2017 version
gamma Thio GTP use Guanosine 5-O-(3-Thiotriphosphate) gamma Thromboglobulin use Platelet Factor 4 ... Ganglioside Beta-1-3-Galactosyltransferase, UDP-Galactose-GM2 use Ganglioside Galactosyltransferase Ganglioside Degradation ... Gamma Glutamylphosphate Reductase use Glutamate-5-Semialdehyde Dehydrogenase gamma Glutamyltransferase use gamma- ... G Protein Coupled Inwardly Rectifying Potassium Channel 3 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
DeCS 2017 - July 04, 2017 version
gamma Thio GTP use Guanosine 5-O-(3-Thiotriphosphate) gamma Thromboglobulin use Platelet Factor 4 ... Gangliosidosis, Generalized GM1, Type 3 use Gangliosidosis, GM1 Gangliosidosis, Generalized GM1, Type I use Gangliosidosis, GM1 ... Ganglioside Beta-1-3-Galactosyltransferase, UDP-Galactose-GM2 use Ganglioside Galactosyltransferase Ganglioside Degradation ... Gamma Glutamylphosphate Reductase use Glutamate-5-Semialdehyde Dehydrogenase gamma Glutamyltransferase use gamma- ...
DeCS 2018 - July 31, 2018 version
gamma Thio GTP use Guanosine 5-O-(3-Thiotriphosphate) gamma Thromboglobulin use Platelet Factor 4 ... Gangliosidosis, Generalized GM1, Type 3 use Gangliosidosis, GM1 Gangliosidosis, Generalized GM1, Type I use Gangliosidosis, GM1 ... Ganglioside Beta-1-3-Galactosyltransferase, UDP-Galactose-GM2 use Ganglioside Galactosyltransferase Ganglioside Degradation ... Gamma Glutamylphosphate Reductase use Glutamate-5-Semialdehyde Dehydrogenase gamma Glutamyltransferase use gamma- ...
DeCS 2017 - December 21, 2017 version
gamma Thio GTP use Guanosine 5-O-(3-Thiotriphosphate) gamma Thromboglobulin use Platelet Factor 4 ... Gangliosidosis, Generalized GM1, Type 3 use Gangliosidosis, GM1 Gangliosidosis, Generalized GM1, Type I use Gangliosidosis, GM1 ... Ganglioside Beta-1-3-Galactosyltransferase, UDP-Galactose-GM2 use Ganglioside Galactosyltransferase Ganglioside Degradation ... Gamma Glutamylphosphate Reductase use Glutamate-5-Semialdehyde Dehydrogenase gamma Glutamyltransferase use gamma- ...