Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell...
Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell ... Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell ... Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell ... Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia ...http://www.haematologica.org/content/early/2016/01/25/haematol.2015.139501
The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia...
In vivo, the combination reduced the risk of graft-versus-host disease without hampering graft-versus-leukemia effect, as shown ... graft-versus-leukemia without graft-versus-host disease. We also wanted to evaluate whether the immunosuppressive effect of the ... Remarkably, the antitumor effect was due to both a direct cytotoxic effect of the drugs on the tumor cells and to a GVL effect ... The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia ...http://www.haematologica.org/content/97/9/1329
Characterization and improvement of graft versus leukemia effects - Austin Barrett
2013) Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem ... Characterization and improvement of graft versus leukemia effects Barrett, Austin John National Heart, Lung, and Blood ... Characterization and improvement of graft versus leukemia effects. Barrett, Austin J. / U.S. National Heart Lung and Blood Inst ... Characterization and improvement of graft versus leukemia effects. Barrett, Austin John / U.S. National Heart Lung and Blood ...http://grantome.com/grant/NIH/ZIA-HL006107-03
Group items tagged disease - Eco20/20 | Diigo Groups
... ft-versus-leukemia-effect.html Acute graft versus host disease donor T cells leukemia effect gvhd ... GRAFT VERSUS LEUKEMIA EFFECT ~ HEALTH:THEGREATESTGIFTOFGOD - 0 views. healththegreatestgiftofgod.blogspot.com/... ... Acute graft versus host disease is a condition in which the graft versus host reaction occurs in the first 3 months of the ... Acute graft versus host disease is a condition in which the graft versus host reaction occurs in the first 3 months of the ...https://groups.diigo.com/group/eco2020/content/tag/disease?dm=middle
Clinical grade ex vivo expanded human natural killer (NK) cells - English
graft-versus-leukemia effect. Blood 2002;100:1935Á47. 19 Wang J, Jensen M, Lin Y, Sui X, Chen E, Lindgren CG et al. 5 Karre K, ... Antitumor effects of effects of donor T-cell cytokines on outcome with continuous bortezomib (PS-341) on primary effusion ... 280 pg/mL) in cultures of expanded NK cells when 50 and 500 U/mL IL-2 were added for 24 h (data not shown). The effect of IL-2 ... The effect on NK-cell presence of viral contaminants and infectious EBV. We proliferation of varying the percentage of CO2 from ...https://www.slideshare.net/lifextechnologies/clinical-grade-ex-vivo-expanded-human-natural-killer-nk-cells
Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant...
... graft-versus-leukemia' takes control. Further, rituximab could augment the 'graft-versus-leukemia' effect by activating donor ... Leukemia. Leukemia, Lymphoid. Leukemia, Lymphocytic, Chronic, B-Cell. Leukemia, Prolymphocytic. Leukemia, Large Granular ... Donor cells will attack the patient's leukemia. This is called the 'graft-versus-leukemia' effect. Rituximab will be given 3 ... Leukemia, B-cell, Chronic Large Granular Lymphocyte Leukemia Aggressive NK Cell Leukemia ...https://clinicaltrials.gov/ct2/show/NCT00104858?cond=%22Leukemia%22&rank=15
Pilot Study of Hematopoietic Stem Cell Transplantation From Two Matched Sibling Donors in Treating Patients With Poor Prognosis...
... new measures to enhance graft versus leukemia effect and reduce relapse rates are needed. ... lower compared to matched sibling and matched unrelated donor transplantations due to better graft versus leukemia effect. ... Leukemia. Acute Disease. Neoplasms by Histologic Type. Neoplasms. Disease Attributes. Pathologic Processes. ... from 2 matched siblings may improve GVL effect and reduce relapse rate in patients with high risk acute leukemias and other ...https://clinicaltrials.gov/show/NCT01385072
Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignances - Full Text View - ClinicalTrials.gov
The attack against the malignant cells is called a graft-versus-leukemia effect. Therefore, donor T cells are given to the ... Leukemia. Transplant - Mortality. Immunosuppression. Radiation. Cure. Peripheral Blood Stem Cells. Graft-Versus Leukemia/ ... leukemia effect. The aim is to create the transplant conditions that permit rapid donor immune recovery without causing graft- ... Patients between 10 and 55 years of age with chronic myelogenous leukemia, acute lymphoblastic leukemia, acute myelogenous ...https://clinicaltrials.gov/show/NCT00353860
Frontiers | Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications | Immunology
... and of CAR-engineered T cells to treat relapsed leukemia. ... and of CAR-engineered T cells to treat relapsed leukemia. ... donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft ... donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft ... Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood (1995) 86(5):2041-50. ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00500/full
Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid...
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 2002;100:1935-1947. ... 3 Because the graft-versus-leukemia (GvL) effect is conventionally achieved through T-cell-mediated alloreactions directed ... family members is an option for patients with high-risk acute leukemia who urgently need a graft and do not have matched ... we observed donor-versus-recipient NK cell alloreactivity reduced the risk of leukemia relapse, did not cause graft-versus-host ...http://www.bloodjournal.org/content/110/1/433?ijkey=86534e1ce5cc763cd030137b29d939a3c4fb5d65&keytype2=tf_ipsecsha&sso-checked=true
CiNii 論文 - Methylprednisolone induces preferential and rapid differentiation of CD34^+ cord...
Natural killer cell receptors : new biology and insights into the graft-versus-leukemia effect FARAG S. S. ... Effect of IL-21 on NK cells derived from different umbilical cord blood populations PEREZ Sonia A. , MAHAIRA Louisa G. , ... KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor ... The corticosteroid-induced inhibitory effect on NK cell function reflects down-regulation and/or dysfunction of triggering ...https://ci.nii.ac.jp/naid/10021240721
Generation of Tumor Antigen-Specific T Cell Lines from Pediatric Patients with Acute Lymphoblastic Leukemia-Implications for...
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995;86:2041-50. ... Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell ... there is strong evidence for a T cell-mediated graft-versus-leukemia effect (6). However, DLI rarely induces responses in ... Immunotherapy is an effective tool for the treatment of leukemia. First shown in patients with chronic myelogenous leukemia ( ...http://clincancerres.aacrjournals.org/content/19/18/5079
Graft-versus-tumor effect - Wikipedia
Kolb HJ (2008). "Graft-versus-leukemia effects of transplantation and donor lymphocytes". Blood. 112 (12): 4371-83. doi:10.1182 ... Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains ... Rezvani AR, Storb RF (2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic ... This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer. It is closely ...https://en.wikipedia.org/wiki/Graft-versus-tumor_effect
GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro | The...
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 100:1935. ... The graft was sutured with 8-12 single stitches with a 5-0 filament. Vaseline gauze was put on the graft, followed by a soft ... but they are in the graft-infiltrating cell population and may therefore contribute to graft damage (49). Under standard ... Rejection of the graft was assessed from day 7 on by morphological changes. The time of rejection was defined as complete ...http://www.jimmunol.org/content/171/2/938
NK Cells and Cancer | The Journal of Immunology
Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 100: 1935-1947. ... graft-vs-host) in the absence of graft-vs-host disease. The absence of NK mediated graft-vs-host disease in KIR-incompatible ... Mouse models of leukemia have demonstrated efficacy of anti-KIR-blocking Abs without adverse effects on normal cells, ... Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood 97: 3132-3137. ...http://www.jimmunol.org/content/178/7/4011.long
CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen...
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995 Sep 1;86(5):2041-2050. [ ... evidence for a graft-versus-myeloma effect. Leukemia. 1997 Feb;11(2):281-283. [PubMed] ... Induction of graft-versus-host disease as immunotherapy for relapsed chronic myeloid leukemia. N Engl J Med. 1994 Jan 13;330(2 ... Graft-versus-myeloma effect in two cases. Lancet. 1996 Mar 23;347(9004):800-801. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC508480/?lang=en-ca
Craig A. Byersdorfer, MD, PhD | Department of Immunology | University of Pittsburgh
Augmentation of graft-versus-leukemia effects. Hematologic malignancy is a common indication for blood and marrow ... as well as retrovirally-induced models of human leukemias, to ask probing questions regarding T cell-driven, anti-leukemia ... Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease. J. Pharm. Exp ... Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood. 2013. 122(18):3230-3237. ...http://immunology.medicine.pitt.edu/graduate/person/craig-byersdorfer-md-phd-0
Table of Contents | Blood Journal
Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units Michael ... miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with ... Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal Michael Heuser, ... Cutaneous tumor lysis syndrome in a patient with HTLV-1 adult T-cell lymphoma/leukemia Jean-David Bouaziz, Nadège Cordel, ...http://www.bloodjournal.org/content/114/19?sso-checked=true
Childhood Hematopoietic Cell Transplantation (PDQ®): Treatment - Health Professional Information [NCI] - North Kansas City...
... an additional graft-versus-tumor (GVT) or graft-versus-leukemia (GVL) treatment effect can occur. Although autologous ... Graft-versus-leukemia (GVL) effect. Early studies in HCT focused on delivery of intense myeloablative preparative regimens ... The GVL effect is challenging to use therapeutically because of a strong association between GVL and clinical graft-versus-host ... Effect of reduced toxicity/reduced intensity/nonmyeloablative regimens. On the basis of clear evidence of dose effect and the ...https://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000700000
When stem cell transplant is done - Canadian Cancer Society
The new stem cells' ability to destroy cancer cells is called graft-versus-tumour or graft-versus-leukemia effect. ... This is called graft rejection.. * The donor's stem cells may see the recipient's cells as foreign and attack them. This is ... Cancer affects all Canadians. Nearly 1 in 2 Canadians is expected to be diagnosed with cancer in their lifetime. ... Some cancers (such as leukemia, lymphoma and multiple myeloma) respond very well to chemotherapy, but they may not be cured ...http://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/stem-cell-transplant/when-stem-cell-transplant-is-done/?region=mb
Frontiers | Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host...
... while preserving the beneficial graft-versus-leukemia (GVL) of the allogeneic response. Previous studies using a mouse model of ... while preserving the beneficial graft-versus-leukemia (GVL) of the allogeneic response. Previous studies using a mouse model of ... Graft-versus host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting ... Graft-versus host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00756/full
Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17...
Purpose: The graft versus leukemia effect by natural killer (NK) cells prevents relapse following hematopoietic stem cell ... cells exerting a graft versus leukemia (GVL) effect capable of eradicating remaining AML cells. We have shown that ... evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients. Blood 2011;118:1402-12. ... HLA class I antigen cell surface expression is preserved on acute myeloid leukemia blasts at diagnosis and at relapse. Leukemia ...http://clincancerres.aacrjournals.org/content/19/14/3844
Cytokines in Graft-Versus-Host Disease and the Graft-Versus-Leukemia Reaction | SpringerLink
Graft-versus-host disease (GVHD) is the major complication after allogeneic hemopoietic stem cell transplantation. GVHD is ... Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease.Blood. 1999;94:825-31.PubMed ... Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graft-versus-host disease can be ... Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus ...https://link.springer.com/article/10.1007%2FBF02982546
Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10...
... inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. ... and diminish the morbidity and mortality of graft-versus-host disease (24), others have highlighted the proinflammatory effects ... In contrast to their well-known effects upon cancer cells, little is still known about the immunological effects of HDIs. ... Such an effect was also displayed by other members of the hydroxamic acid family like LBH589, TSA, and SAHA, but not by the ...http://www.jimmunol.org/content/186/7/3986.long
Drug-Free Organ Transplants From Unrelated Donors - Slashdot
1) The concern about graft-versus-leukemia effects is a valid one and it will need to be studied. However, that is not an issue ... For leukemias, the GVL effect is strongest in CML, then AML, and weakest in ALL (kids don't get CLL, so I don't know much about ... Normally, such transplants would trigger graft-versus-host disease (GvHD) - an often deadly complication that occurs when ... in which the graft is enriched in hematopoietic stem cells and tolerogenic graft facilitating cells. There have been past ...https://science.slashdot.org/story/12/03/08/2159252/drug-free-organ-transplants-from-unrelated-donors?sdsrc=prev