Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3...
... to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Inhibition of GCS activity ... Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) ... Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.. *Yong-Yu ... Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form ...https://www.semanticscholar.org/paper/Histidine-193-of-rat-glucosylceramide-synthase-res-Wu-Marks/10dfd8adfdbf3493bc72de4c127393e8da39fcd9
AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE - Patent application
0152] Quantitation of tissue glucosylceramide levels Glucosylceramide levels were quantified by mass spectrometry as described ... 0165] Quantitation of tissue glucosylceramide levels by mass spectrometry. Glucosylceramide was quantified by mass spectrometry ... Improved Management of Lysosomal Glucosylceramide Levels in a Mouse Model A. Fabry Disease.  To determine if the combined ... Glucosylceramide levels in liver, lung, vasculature and spleen were evaluated at the end of the study by HP-TLC. Data are ...http://www.patentsencyclopedia.com/app/20130137743
The increase in glucosylceramide mass does not appear to reflect a change in glucosylceramide synthase mass or localization, as ... Glucosylceramide is increased in diabetic retinas. A: Glucosylceramides were also assessed after 4 weeks from control and ... Glucosylceramide synthase is unaltered in the diabetic retina. Glucosylceramide synthase localization was assessed between ... suggesting that the increase in glucosylceramide may reflect changes in glucosylceramide synthase and not mass action. We also ...http://diabetes.diabetesjournals.org/content/55/12/3573
Frontiers | Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells | Immunology
... were hampered by early embryonal lethality of mice deficient for the key GSL-synthesizing enzyme glucosylceramide (GlcCer) ... were hampered by early embryonal lethality of mice deficient for the key GSL-synthesizing enzyme glucosylceramide (GlcCer) ... Keywords: CD1, glycosphingolipid, glucosylceramide, glucosylceramide synthase, natural killer T cell, thymus. Citation: Popovic ... Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction. Proc Natl Acad Sci U S A (2014 ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00848/full
Glucosylceramide beta-1,4-galactosyltransferase - Wikipedia
... glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose ... Glucosylceramide beta-1,4-galactosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Trinchera, M.; Fiorilli, A.; Ghidoni, R. (1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→ ... Glucosylceramide beta-1,4-galactosyltransferase (EC 18.104.22.1684, lactosylceramide synthase, uridine diphosphate-galactose: ...https://en.wikipedia.org/wiki/Glucosylceramide_beta-1,4-galactosyltransferase
Liu YY, Han TY, Giuliano AE, Cabot MC Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers ... Glucosylceramide Synthase Assay.. The assay for GCS was performed as described previously (21) . Briefly, cells were lysed in ... Up-Regulation of Glucosylceramide Synthase mRNA, Protein, and Activity in Response to Doxorubicin in HL-60/ADR Cells, but Not ... In HL-60/ADR cells (but not in HL-60 cells), the levels of mRNA, protein, and activity in glucosylceramide synthase (GCS), ...http://cancerres.aacrjournals.org/content/64/17/6271
F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable cyst production by...
F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable cyst production by ... Hehl, A B (2013). F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable ...http://www.zora.uzh.ch/id/eprint/90574/
or pharmaceutically acceptable salts thereof, where R1 is: lower alkylene-OH, lower alkylene-N(R0)(R6), lower alkylene-CO2R0, C5-6cycloalkyl, C6-10cycloalkenyl, aryl, heterocyclic group, -(lower alkylen, substituted OR0)-aryl or lower alkylene-heterocyclic group, where the lower alkylene in R1 can be substituted with 1-2 groups G1; cycloalkyl, cycloalkenyl and heterocyclic group in R1 can be substituted with 1-2 groups G2; aryl can be substituted with 1-2 groups G3; R0: identical or different from each other, each denotes H or a lower alkyl; R6: R0, or -S(O)2-lower alkyl, R2 is: lower alkyl, lower alkylene-OR0, lower alkylene-aryl, lower alkylene-O-lower alkylene-aryl, -CO2R0, -C(O)N(R0)2, -C(O)N(R0)-aryl, -C(O)N(R0)-lower alkylene-aryl, aryl or heterocyclic group, where the aryl in R2 can be substituted with 1-3 groups G4; R3 is: H or lower alkyl, or R2 and R3 can be combined to form C5-alkylene; R4 is: -N(R7)(R8), -N(R10)-OR7, -N(R0)-N(R0)(R7), -N(R0)-S(O)2-aryl or -N(R0)-S(O)2-R7, R7 is: ...http://russianpatents.com/patent/264/2645675.html
Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the...
Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the ... Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the ... Moreover, the synthesis of glucosylceramide, the precursor of most glycosphingolipids, was also analyzed. In the purified ERGIC ... results suggest that in the secretory pathway of Vero cells O-glycan initiation and sphingomyelin as well as glucosylceramide ...https://dspace.library.uu.nl/handle/1874/293948
Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease | Annals of the Rheumatic Diseases
Glucosylceramide. Glucosylceramide concentration in plasma was determined as described elsewhere, using HPLC analysis of ... Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C ... We also measured C reactive protein, plasma glucosylceramide, and indices of dyslipidaemia. ... 23 whereas glucosylceramide, a neutral glycosphingolipid, augments the inactivation of factor Va by activated protein C.7 ...http://ard.bmj.com/content/63/11/1445
JCI - Welcome
Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. Philipp C. Rittershaus ... ...https://jci.org/tags/29
Sphingolipids in essential hypertension and endothelial dysfunction
Chapter 6: The association between blood pressure and glucosylceramides in spontaneously hypertensive rats. ...http://dare.uva.nl/search?metis.record.id=393001
Effect of seed development stage on sphingolipid and phospholipid contents in soybean seeds.
Glucosylceramide (GlcCer) and ceramide (Cer) are the predominant sphingolipids (SL) in soybeans. They have been recognized as ... 0/Ceramides; 0/Glucosylceramides; 0/Phospholipids; 0/Sphingolipids From MEDLINE®/PubMed®, a database of the U.S. National ... Glucosylceramides / analysis. Phospholipids / analysis*. Seeds / chemistry*, growth & development*. Soybeans / growth & ... Glucosylceramide (GlcCer) and ceramide (Cer) are the predominant sphingolipids (SL) in soybeans. They have been recognized as ...http://www.biomedsearch.com/nih/Effect-seed-development-stage-sphingolipid/17002456.html
Lipidomic analysis of the liver identifies changes of major and minor lipid species in adiponectin deficient mice.
Glucosylceramides / metabolism. Lipid Metabolism*. Lipogenesis. Liver / metabolism*. Male. Mice. Mice, Knockout. ... Glucosylceramide postulated to contribute to liver damage was decreased. This study demonstrates that adiponectin deficiency is ... 0/Adiponectin; 0/Bile Acids and Salts; 0/Cholesterol Esters; 0/Cytochromes; 0/Dietary Fats; 0/Fatty Acids; 0/Glucosylceramides ...http://www.biomedsearch.com/nih/Lipidomic-analysis-liver-identifies-changes/22465357.html
IJMS | Free Full-Text | The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase...
... glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 significantly enhanced FasL-induced ... Keywords: CD95; apoptosis; necrosis; sphingomyelin synthase; glucosylceramide synthase; ALPS CD95; apoptosis; necrosis; ... glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 significantly enhanced FasL-induced ...http://www.mdpi.com/1422-0067/13/7/8834
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
Cer, ceramide; GlcCer, glucosylceramide; LacCer, lactosylceramide; Gal, galactose; Glc, glucose; GalNAc, N-acetylgalactosamine ...https://www.hindawi.com/journals/jir/2017/5604891/
Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice | Arteriosclerosis,...
On the one hand, SMS1,1,21 glucosylceramide synthase,22 and ganglioside synthases23 are located in the same Golgi compartment. ... E and F, Quantitative display of NBD-glucosylceramide and NBD-SM in medium from WT and Sms1 KO macrophages. Values are mean ± ... Glucosylceramide and GM3 again showed a dramatic increase (3.8-fold and 5.5-fold, respectively) compared with controls (Table). ... D, Glucosylceramide synthase activity measurement. Macrophages were incubated with 3 µg/mL N-(7-nitrobenz-2-oxa-1,3-diazol-4yl ...http://atvb.ahajournals.org/content/32/7/1577
The molecular bases of δ/αβ T cell-mediated antigen recognition | JEM
α-glucosylceramide. BSA. buried surface area. CDR. complementarity-determining region. MAIT cell. mucosal-associated invariant ... such as α-glucosylceramide, was distinct from type I NKT cells. Thus, δ/αβTCRs contribute new patterns of Ag specificity to the ... α-glucosylceramide (α-GlcCer), sulfatide, 3′-deoxy-α-GalCer, 4′-deoxy-α-GalCer, and OCH, known NKT cell ligands (Wun et al., ...http://jem.rupress.org/content/211/13/2599.long
KEGG ENZYME: 22.214.171.124
glucosylceramide sphingomyelin deacylase;. sphingomyelin glucosylceramide deacylase;. SM glucosylceramide GCer deacylase;. SM- ... The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N- ... Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction ...http://www.genome.jp/dbget-bin/www_bget?ec:126.96.36.199
CLN3 Gene - GeneCards | CLN3 Protein | CLN3 Antibody
Complete information for CLN3 gene (Protein Coding), CLN3, Battenin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiumhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CLN3&origene_3utr_trans=2
JCI Insight - Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial...
Cytosolic lipids as well as 1,3-DAG, dihydroceramides, and glucosylceramides in any compartment were not related to insulin ... CER, ceramides; DHCER, dihydroceramides; SPM, sphingomyelins; GluCER, glucosylceramides; LacCER, lactosylceramides. ¥. P. , ...https://insight.jci.org/articles/view/96805/figure/2
Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
glycosyl linkage of glucosylceramide . Deficiency of this enzyme due to mutations in its gene (GBA) causes the most common ...http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002141&imageURI=info:doi/10.1371/journal.pgen.1002141.t003
Glucosylceramide synthase and sphingomyelin synthase 1 were assayed upon recombinant expression in COS-1 cells using NBD-Cer as ... We found that inhibition of glucosyl ceramide synthase by tamoxifen allows for synergy with NVP-231 to increase NBD-Cer levels ... which inhibits glucosyl ceramide synthase (Cabot et al., 1996; Lavie et al., 1997). In one set of experiments, cells were ... glucosylceramide; SM, sphingomyelin; M-CSF, macrophage colony stimulating factor; PLA2G4A, cytosolic phospholipase A2 α; NBD, N ...http://molpharm.aspetjournals.org/content/74/4/925
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