Glucosylceramide beta-1,4-galactosyltransferase - Wikipedia
... glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose ... Glucosylceramide+beta-1,4-galactosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal ... Trinchera M, Fiorilli A, Ghidoni R (March 1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide ... Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose: ...
Gaucher Disease Medication: Enzyme replacement therapy, Glucosylceramide Synthase Inhibitors
Glucosylceramide Synthase Inhibitors. Class Summary. These agents inhibit the enzyme glucosylceramide synthase, the initial ... Eliglustat is a specific inhibitor of glucosylceramide synthase, thereby reducing production of glucosylceramide. It is ... The glucosylceramide synthase inhibitors, miglustat and eliglustat, were approved for adults with type 1 Gaucher disease in ... Reduces GSL production by inhibiting glucosylceramide synthase. Reduces spleen and liver volume and increases hemoglobin and ...
Lessons from glucosylceramide and Gaucher's disease - MDC Repository
Plasma ceramides and glucosylceramides predict cognitive decline among cognitively normal Parkinson's disease patients - MDS...
Plasma ceramides and glucosylceramides predict cognitive decline among cognitively normal Parkinsons disease patients. M.M. ... Plasma ceramides and glucosylceramides were determined by LC/ESI/MS/MS. Linear mixed models were used to assess the association ... For example, each log unit increase in the ceramide to glucosylceramide C18:0 ratio was associated with greater decline in all ... Conclusions: Our results suggest that a higher plasma ceramide to glucosylceramide C18:0 ratio is predictive of greater rates ...
Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. - Oxford Neuroscience
We treated both multidrug-resistant cell lines with the glucosylceramide synthase inhibitors PDMP (d-threo-1-phenyl-2- ... However, the N-alkylated iminosugars C9DGJ and C4DGJ, which are more selective glucosylceramide synthase inhibitors than PDMP, ... Our results suggest that (a) inhibition of glucosylceramide synthase does not reverse multidrug resistance and (b) the ... Inhibiting glycolipid biosynthesis by blocking glucosylceramide synthase has been proposed to reverse drug resistance in MDR ...
Gaucher disease: MedlinePlus Genetics
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation - The Kennedy Institute of...
Structural determination of glucosylceramides isolated from marine sponge by fast atom bombardment collision-induced...
Ahn, Y. M., Lee, W. W., Jung, J. H., Lee, S. G., & Honga, J. (2009). Structural determination of glucosylceramides isolated ... Ahn YM, Lee WW, Jung JH, Lee SG, Honga J. Structural determination of glucosylceramides isolated from marine sponge by fast ... Five glucosylceramides (GlcCers) were isolated by reversed phase high-performance liquid chromatography from the MeOH extracts ... Ahn, YM, Lee, WW, Jung, JH, Lee, SG & Honga, J 2009, Structural determination of glucosylceramides isolated from marine sponge ...
gaucher disease; Cerebroside Lipidosis Syndrome; Glucocerebrosidase Deficiency Disease; Glucosylceramide Beta-Glucosidase...
Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive...
Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinsons Disease and Associated with Cognitive ... Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinsons Disease and Associated with Cognitive ... Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinsons Disease and Associated with Cognitive ... Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinsons Disease and Associated with Cognitive ...
JoF | Free Full-Text | Medical Application of Substances Derived from Non-Pathogenic Fungi Aspergillus oryzae and A. luchuensis...
Oral intake of glucosylceramide improves relatively higher level of transepidermal water loss in mice and healthy human ... Structural determination of glucosylceramides in the distillation remnants of shochu, the Japanese traditional liquor, and its ... Quantitation and structural determination of glucosylceramides contained in sake lees. J. Oleo Sci. 2014, 63, 15-23. [Google ... Since the glycosylceramide contained in koji contains the same species of glucosylceramide contained in konjac [23], the ...
2019 Parkinson's Disease Conference GRC
Frontiers | Targeting Sphingolipids for Cancer Therapy
Targeting Glucosylceramide Synthase Synergizes With C 6 -Ceramide Nanoliposomes to Induce Apoptosis in Natural Killer Cell ... The complex glycosphingolipids are hydrolyzed to glucosylceramide and galactosylceramide. These lipids are then hydrolyzed by ... to form ceramide-1-phosphate or it can be glycosylated by glucosylceramide synthase to form glycosphingolipids (cerebrosides, ...
Ghent University Academic Bibliography
Harlequin Ichthyosis: Background, Etiology, Epidemiology
Ghent University Academic Bibliography
Evidence Mounting for Eliglustat in Gaucher's Disease
The disease occurs when the lipid glucosylceramide accumulates in the bone marrow, lungs, spleen, liver, and sometimes the ... In contrast, substrate reduction therapy works by inhibiting glucosylceramide synthase, slowing the production of ... glucosylceramide. The FDA has approved another agent for substrate reduction, miglustat (Zavesca, Actelion), but only for ... that can be given intravenously to supplement the patients glucocerebrosidase and break down accumulated glucosylceramide. ...
Azra Miljanovic | University of Gothenburg
Nutrients | Free Full-Text | Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
... glucosylceramide, and resistance to cancer treatment [229,230,231]. Levels of glucosylceramide are regulated by the activity of ... Lucci, A.; Cho, W.I.; Han, T.Y.; Giuliano, A.E.; Morton, D.L.; Cabot, M.C. Glucosylceramide: A marker for multiple-drug ... Liu, Y.Y.; Han, T.Y.; Giuliano, A.E.; Cabot, M.C. Expression of glucosylceramide synthase, converting ceramide to ... glucosylceramide synthase) in breast cancer cells. J. Surg. Oncol. 2011, 104, 466-471. [Google Scholar] [CrossRef] ...
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents | Nature...
Glucosylceramide and glucosylsphingosine quantitation by liquid chromatography-tandem mass spectrometry to enable in vivo ... glucosylceramide (GlcCer), galactosylceramide (GalCer), sulfatides, and sphingomyelins (SMs). There may also be a decrease of ... Levels of glucosylceramide (GlcCer), galactosylceramide (GalCer), glucosylsphingosine (GlcSph), and galactosylsphingosine ( ...
Q1 2021 Results | PPT
Proteome Profiler Mouse Cytokine Array Kit, Panel A (ARY006): R&D Systems
HEK-Blue human MD2-CD14 SEAP reporting cell lines: engineered HEK293
D-<i>threo</i>-PDMP | Lipids and Biochemicals | Matreya, LLC -...
PDMP This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large ... This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of ... "Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and ... 3. N. Radin, et al., "Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell ...
Characterizing Region-specific Lipid Profiles in Parkinson's Disease and Gaucher Disease | Parkinson's Disease
Zavesca, Opfolda (miglustat) dosing, indications, interactions, adverse effects, and more
Miglustat is a competitive and reversible inhibitor of glucosylceramide synthase, the initial enzyme in a series of reactions ... glucosylceramide) that builds up due to this condition. This can help improve symptoms of Gauchers disease, such as tiredness ... resulting in synthesis of most glygosphingolipids; decreases rate of glycosphingolipid glucosylceramide formation ... the enzyme that mediates glycosphingolipid glucosylceramide degradation ...
Gaucher Disease | Profiles RNS
Publications Citing Globals Software - Laboratory for Fluorescence Dynamics
There was also a 1.7-fold increase in BBM glucosylceramide content (528 +/- 63 vs. 312 +/- 41 ng/mg BBM protein in control, P ... These cultures upregulate glucosylceramide synthase and make normal-appearing lipid lamellar bilayers. The epidermal ... 0.02). To determine whether the alteration in glucosylceramide content per se played a functional role in the decrease in Na-Pi ... cotransport, control rats were treated with the glucosylceramide synthase inhibitor, D-threo-1-phenyl-2-decanoyl-amino-3- ...