Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3...
... to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Inhibition of GCS activity ... Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) ... Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.. *Yong-Yu ... Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form ...https://www.semanticscholar.org/paper/Histidine-193-of-rat-glucosylceramide-synthase-res-Wu-Marks/10dfd8adfdbf3493bc72de4c127393e8da39fcd9
AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE - Patent application
0152] Quantitation of tissue glucosylceramide levels Glucosylceramide levels were quantified by mass spectrometry as described ... 0165] Quantitation of tissue glucosylceramide levels by mass spectrometry. Glucosylceramide was quantified by mass spectrometry ... Improved Management of Lysosomal Glucosylceramide Levels in a Mouse Model A. Fabry Disease.  To determine if the combined ... Glucosylceramide levels in liver, lung, vasculature and spleen were evaluated at the end of the study by HP-TLC. Data are ...http://www.patentsencyclopedia.com/app/20130137743
The increase in glucosylceramide mass does not appear to reflect a change in glucosylceramide synthase mass or localization, as ... Glucosylceramide is increased in diabetic retinas. A: Glucosylceramides were also assessed after 4 weeks from control and ... Glucosylceramide synthase is unaltered in the diabetic retina. Glucosylceramide synthase localization was assessed between ... suggesting that the increase in glucosylceramide may reflect changes in glucosylceramide synthase and not mass action. We also ...http://diabetes.diabetesjournals.org/content/55/12/3573
Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity | PNAS
1977) Blood glucosylceramide levels in Gaucher's disease and its distribution amongst lipoprotein fractions. Clin Chim Acta 75: ... 2012) Beta-glucosylceramide administration (i.p.) activates natural killer T cells in vivo and prevents tumor metastasis in ... 2008) Plasma glucosylceramide and ceramide in type 1 Gaucher disease patients: Correlations with disease severity and response ... One such ceramide is β-glucosylceramide (β-GlcCer), which is the first intermediate in the synthesis of a large family of GSLs ...https://www.pnas.org/content/114/16/E3285
Frontiers | Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells | Immunology
... were hampered by early embryonal lethality of mice deficient for the key GSL-synthesizing enzyme glucosylceramide (GlcCer) ... were hampered by early embryonal lethality of mice deficient for the key GSL-synthesizing enzyme glucosylceramide (GlcCer) ... Keywords: CD1, glycosphingolipid, glucosylceramide, glucosylceramide synthase, natural killer T cell, thymus. Citation: Popovic ... Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction. Proc Natl Acad Sci U S A (2014 ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00848/full
Glucosylceramide beta-1,4-galactosyltransferase - Wikipedia
... glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose ... Glucosylceramide beta-1,4-galactosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Trinchera, M.; Fiorilli, A.; Ghidoni, R. (1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→ ... Glucosylceramide beta-1,4-galactosyltransferase (EC 126.96.36.1994, lactosylceramide synthase, uridine diphosphate-galactose: ...https://en.wikipedia.org/wiki/Glucosylceramide_beta-1,4-galactosyltransferase
Liu YY, Han TY, Giuliano AE, Cabot MC Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers ... Glucosylceramide Synthase Assay.. The assay for GCS was performed as described previously (21) . Briefly, cells were lysed in ... Up-Regulation of Glucosylceramide Synthase mRNA, Protein, and Activity in Response to Doxorubicin in HL-60/ADR Cells, but Not ... In HL-60/ADR cells (but not in HL-60 cells), the levels of mRNA, protein, and activity in glucosylceramide synthase (GCS), ...http://cancerres.aacrjournals.org/content/64/17/6271
The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ...http://jpet.aspetjournals.org/content/326/3/849
F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable cyst production by...
F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable cyst production by ... Hehl, A B (2013). F1000Prime Recommendation of: Glucosylceramide transferase activity is critical for encystation and viable ...http://www.zora.uzh.ch/id/eprint/90574/
or pharmaceutically acceptable salts thereof, where R1 is: lower alkylene-OH, lower alkylene-N(R0)(R6), lower alkylene-CO2R0, C5-6cycloalkyl, C6-10cycloalkenyl, aryl, heterocyclic group, -(lower alkylen, substituted OR0)-aryl or lower alkylene-heterocyclic group, where the lower alkylene in R1 can be substituted with 1-2 groups G1; cycloalkyl, cycloalkenyl and heterocyclic group in R1 can be substituted with 1-2 groups G2; aryl can be substituted with 1-2 groups G3; R0: identical or different from each other, each denotes H or a lower alkyl; R6: R0, or -S(O)2-lower alkyl, R2 is: lower alkyl, lower alkylene-OR0, lower alkylene-aryl, lower alkylene-O-lower alkylene-aryl, -CO2R0, -C(O)N(R0)2, -C(O)N(R0)-aryl, -C(O)N(R0)-lower alkylene-aryl, aryl or heterocyclic group, where the aryl in R2 can be substituted with 1-3 groups G4; R3 is: H or lower alkyl, or R2 and R3 can be combined to form C5-alkylene; R4 is: -N(R7)(R8), -N(R10)-OR7, -N(R0)-N(R0)(R7), -N(R0)-S(O)2-aryl or -N(R0)-S(O)2-R7, R7 is: ...http://russianpatents.com/patent/264/2645675.html
Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the...
Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the ... Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the ... Moreover, the synthesis of glucosylceramide, the precursor of most glycosphingolipids, was also analyzed. In the purified ERGIC ... results suggest that in the secretory pathway of Vero cells O-glycan initiation and sphingomyelin as well as glucosylceramide ...https://dspace.library.uu.nl/handle/1874/293948
Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease | Annals of the Rheumatic Diseases
Glucosylceramide. Glucosylceramide concentration in plasma was determined as described elsewhere, using HPLC analysis of ... Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C ... We also measured C reactive protein, plasma glucosylceramide, and indices of dyslipidaemia. ... 23 whereas glucosylceramide, a neutral glycosphingolipid, augments the inactivation of factor Va by activated protein C.7 ...http://ard.bmj.com/content/63/11/1445
Fatty Acid Synthase (FAS) Inhibitor -Pipeline Insight, 2018
Glucosylceramide Synthase Inhibitor -Pipeline Insight, 2018 * Drug Pipelines. *. FROM €906EUR$1,000USD£806GBP ...https://www.researchandmarkets.com/reports/4382523/fatty-acid-synthase-fas-inhibitor-pipeline
JCI - Welcome
Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. Philipp C. Rittershaus ... ...https://jci.org/tags/29
Genzyme Osteopenia/Osteoporosis Study
Glucosylceramides. Cerebrosides which contain as their polar head group a glucose moiety bound in glycosidic linkage to the ... Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2. ... A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. ...https://www.bioportfolio.com/resources/trial/159022/Genzyme-Osteopenia-Osteoporosis-Study.html
Sphingolipids in essential hypertension and endothelial dysfunction
Chapter 6: The association between blood pressure and glucosylceramides in spontaneously hypertensive rats. ...http://dare.uva.nl/search?metis.record.id=393001
Gaucher Disease Symptoms, Types, Treatment & Prognosis
These drugs are known as glucosylceramide synthase inhibitors and are taken by mouth. Two drugs in this class are miglustat ( ...https://www.medicinenet.com/gaucher_disease/article.htm
Effect of seed development stage on sphingolipid and phospholipid contents in soybean seeds.
Glucosylceramide (GlcCer) and ceramide (Cer) are the predominant sphingolipids (SL) in soybeans. They have been recognized as ... 0/Ceramides; 0/Glucosylceramides; 0/Phospholipids; 0/Sphingolipids From MEDLINE®/PubMed®, a database of the U.S. National ... Glucosylceramides / analysis. Phospholipids / analysis*. Seeds / chemistry*, growth & development*. Soybeans / growth & ... Glucosylceramide (GlcCer) and ceramide (Cer) are the predominant sphingolipids (SL) in soybeans. They have been recognized as ...http://www.biomedsearch.com/nih/Effect-seed-development-stage-sphingolipid/17002456.html
Lipidomic analysis of the liver identifies changes of major and minor lipid species in adiponectin deficient mice.
Glucosylceramides / metabolism. Lipid Metabolism*. Lipogenesis. Liver / metabolism*. Male. Mice. Mice, Knockout. ... Glucosylceramide postulated to contribute to liver damage was decreased. This study demonstrates that adiponectin deficiency is ... 0/Adiponectin; 0/Bile Acids and Salts; 0/Cholesterol Esters; 0/Cytochromes; 0/Dietary Fats; 0/Fatty Acids; 0/Glucosylceramides ...http://www.biomedsearch.com/nih/Lipidomic-analysis-liver-identifies-changes/22465357.html
IJMS | Free Full-Text | The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase...
... glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 significantly enhanced FasL-induced ... Keywords: CD95; apoptosis; necrosis; sphingomyelin synthase; glucosylceramide synthase; ALPS CD95; apoptosis; necrosis; ... glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 significantly enhanced FasL-induced ...http://www.mdpi.com/1422-0067/13/7/8834
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
Cer, ceramide; GlcCer, glucosylceramide; LacCer, lactosylceramide; Gal, galactose; Glc, glucose; GalNAc, N-acetylgalactosamine ...https://www.hindawi.com/journals/jir/2017/5604891/
Sphingolipids related to apoptosis from the point of view of membrane structure and topology. - Semantic Scholar
Recently discovered functions of glucosylceramides in plants and fungi. *Dirk C. Warnecke, Ernst Heinz ...https://www.semanticscholar.org/paper/Sphingolipids-related-to-apoptosis-from-the-point-Blitterswijk-Luit/b784d58129f2fa636e4cb297b19f952ccc82b369
Eliglustat (Professional Patient Advice) - Drugs.com
Glucosylceramide Synthase Inhibitor. Pharmacology. Eliglustat inhibits the enzyme needed to produce glycosphingolipids and ... Glucosylceramide accumulates in type 1 Gaucher disease, causing complications specific to this disease. ... decreases the rate of glycosphingolipid glucosylceramide formation. ...https://www.drugs.com/ppa/eliglustat.html