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SHIP2 inhibition represses hepatic gluconeogenesis.. To test whether hepatic gluconeogenesis is affected by SHIP2 inhibition, ... We showed that gluconeogenesis is markedly reduced in dnSHIP2-expressing KKAy animals due to a reduction of PEPCK and G6Pase ... In the liver, in addition to gluconeogenesis, several other pathways are involved in glucose metabolism and are dominantly ... Despite the reduction of hepatic gluconeogenesis, we could not detect a significant decrease in the fasting blood glucose ...
Table of Contents | Diabetes
Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia. E Cersosimo, P E Molina and N N Abumrad ...
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mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc Natl Acad Sci U S A 2010;107:3281-3282pmid: ... As a result, Foxo transcription factors are unsuppressed and thus promote hepatic gluconeogenesis (Fig. 8). The data from the ... As a result, macromolecule biosynthesis proceeds, in addition to suppression of hepatic gluconeogenesis. Our data suggest that ... but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A 2010;107:3441-3446pmid:20133650. ...
Index by author | Diabetes
Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo Ralph W Stevenson, Kurt E Steiner ... Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo Ralph W Stevenson, Kurt E Steiner ... Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo Ralph W Stevenson, Kurt E Steiner ... Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo Ralph W Stevenson, Kurt E Steiner ...
Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in...
Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. J ... EGFR activation inhibits renal gluconeogenesis and stimulates glycolysis in proximal tubule (37,38) and has been reported to ...
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T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis Atsushi ...
Association of SSTR2 Polymorphisms and Glucose Homeostasis Phenotypes | Diabetes
Both growth hormone and glucagon exhibit potent antagonistic effects on insulin action by increasing hepatic gluconeogenesis ...
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing...
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy ...
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MacDonald MJ, McKenzie DI, Walker TM, Kaysen JH: Lack of gluconeogenesis in pancreatic islets: expression of gluconeogenic ...
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GCK regulates glycogen synthesis and gluconeogenesis, and its activity is competitively inhibited by glucokinase regulatory ...
Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of...
... although it is known that inhibition of the hepatic gluconeogenesis has an important role (2). Metformin is mainly eliminated ... from the hepatocyte will lead to higher metformin levels in the hepatocyte and a stronger inhibition of the gluconeogenesis, ...