"A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011- ... Human glucokinase is coded for by the GCK gene on chromosome 7. This single autosomal gene has 10 exons. Genes for glucokinase ... Glucokinase likely serves as a glucose signal here as well. Glucokinase has also been found in cells of the anterior pituitary ... Most of the glucokinase in a mammal is found in the liver, and glucokinase provides approximately 95% of the hexokinase ...
Cpd A The Glucokinase Activator, Cpd A, also referenced under CAS 603108-44-7, modulates Glucokinase. This small molecule/ ... inhibitor is primarily used for Activators/Inducers applications.; CAS Number: 603108-44-7; Synonyms: Glucokinase Activator, ... The Glucokinase Activator, Cpd A, also referenced under CAS 603108-44-7, modulates Glucokinase. This small molecule/inhibitor ... Glucokinase Activator, Cpd A, Hexokinase D Activator, Hexokinase IV Activator, 2-Amino-5-(4-methyl-4H-(1,2,4)-triazole-3-yl- ...
Glucokinase of Escherichia coli: induction in response to the stress of overexpressing foreign proteins. Arora, K.K., Pedersen ... Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different ... Structure of yeast glucokinase, a strongly diverged specific aldo-hexose-phosphorylating isoenzyme. Albig, W., Entian, K.D. ... Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary. Liang, Y., ...
CRYSTAL STRUCTURE OF A NOVEL ADP-DEPENDENT GLUCOKINASE FROM THERMOCOCCUS LITORALIS ... Structural Basis for the ADP-Specificity of a Novel Glucokinase from a Hyperthermophilic Archaeon. Ito, S., Fushinobu, S., ... CRYSTAL STRUCTURE OF A NOVEL ADP-DEPENDENT GLUCOKINASE FROM THERMOCOCCUS LITORALIS. *PDB DOI: https://doi.org/10.2210/pdb1GC5/ ... hyperthermophilic archaea such as Thermococcus litoralis and Pyrococcus furiosus utilize unusual ADP-dependent glucokinases and ...
Biotin is known to influence hepatic glucokinase (GK) expression both at a transcriptional and at a translational level. The ... Effect of biotin on glucokinase activity, mRNA expression and insulin release in cultured beta-cells Acta Diabetol. 1996 Jul;33 ... Biotin is known to influence hepatic glucokinase (GK) expression both at a transcriptional and at a translational level. The ...
Type 2 Maturity Onset Diabetes of the Young (MODY2) is a monogenic autosomal disease characterized by a primary defect in insulin secretion and hyperglycemia. It results from GCK gene mutations that impair enzyme activity. Between 2006 and 2010, we investigated GCK mutations in 66 diabetic children from southern Italy with suspected MODY2. Denaturing High Performance Liquid Chromatography (DHPLC) and sequence analysis revealed 19 GCK mutations in 28 children, six of which were novel: p.Glu40Asp, p.Val154Leu, p.Arg447Glyfs, p.Lys458_Cys461del, p.Glu395_Arg397del and c.580-2A|T. We evaluated the effect of these 19 mutations using bioinformatic tools such as Polymorphism Phenotyping (Polyphen), Sorting Intolerant From Tolerant (SIFT) and in silico modelling. We also conducted a functional study to evaluate the pathogenic significance of seven mutations that are among the most severe mutations found in our population, and have never been ...
To identify the amino acids involved in the specific regulatory properties of glucokinase, and particularly its low affinity ... Study of the regulatory properties of glucokinase by site-directed mutagenesis: conversion of glucokinase to an enzyme with ... M A Moukil, M Veiga-da-Cunha, E Van Schaftingen; Study of the regulatory properties of glucokinase by site-directed mutagenesis ... The location of N166, Y214, and K296 in the three-dimensional structure of glucokinase suggests that these mutations act by ...
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In contrast to those of vertebrates, glucokinases from bacteria are functionally distinct from hexokinase ... Escherichia coli glucokinase (EC 2.7.1.2) is an intracellular enzyme responsible for the phosphorylation of glucose to glucose- ... Escherichia coli glucokinase (EC 2.7.1.2) is an intracellular enzyme responsible for the phosphorylation of glucose to glucose- ... Escherichia coli glucokinase (EC 2.7.1.2) is an intracellular enzyme responsible for the phosphorylation of glucose to glucose- ...
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens) * cytosolic GCK1:GKRP complex <=> glucokinase (GCK1 ... The cytosolic glucokinase (GCK1):glucokinase regulatory protein (GKRP) complex dissociates.However, while GCK1:GKRP complex ... Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export ... cytosolic GCK1:GKRP complex ,=, glucokinase (GCK1) + glucokinase regulatory protein (GKRP) Stable Identifier ...
... By Edward Jenner 2021-05-08. #Glucokinase, #Glucose, #Glucose Tolerance, #Insulin ... Glucokinase (GK) is the rate-limiting enzyme of hepatic glucose metabolism and acts as a sensor for glucose-stimulated insulin ... Glucokinase catalyses the conversion of glucose to glucose-6 phosphate. It catalyses a key regulatory step in the liver to ... GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). It also stimulates insulin release from mouse islets of ...
Ref # 01133 Therapeutic Inhibitors of Hexokinase and Glucokinase The University of South Carolina is offering licensing ...
Naturally occurring mutations in the gene for the β-cell enzyme glucokinase (GCK) result in both hyper- and hypo-glycaemia. ... and careful study of the mutational mechanisms for a number of these has provided important insights into glucokinase ... Glucokinase (GCK) and other susceptibility genes for β-cell dysfunction: the candidate approach ... Naturally occurring mutations in the gene for the β-cell enzyme glucokinase (GCK) result in both hyper- and hypo-glycaemia. ...
Glucokinase said: Hey!! i was just wondering if they called you or if you got just a letter ...
Inhibition of Trypanosoma cruzi Glucokinase with 2,6-Dideoxy-2,6-Diamino-D-Glucose. Publication Type:. Poster ... Home » Inhibition of Trypanosoma cruzi Glucokinase with 2,6-Dideoxy-2,6-Diamino-D-Glucose. ...
et al., Sulfhydryl groups of liver hexokinase and glucokinase and their participation in catalysis of the glucokinase reaction ... Sulfhydryl groups of liver hexokinase and glucokinase and their participation in catalysis of the glucokinase reaction. ... Sulfhydryl groups of liver hexokinase and glucokinase and their participation in catalysis of the glucokinase reaction // ... Sulfhydryl groups of liver hexokinase and glucokinase and their participation in catalysis of the glucokinase reaction. Voprosy ...
DISCOVERY OF 2-PYRIDYL UREAS AS GLUCOKINASE ACTIVATORS - 4RCH , canSARS ...
Glucokinase is among four members from the hexokinase category of enzymes.. Glucokinase is among four members from the ... cell glucokinase having a larger effect on blood sugar homeostasis than liver organ glucokinase, and provided solid support for ... Since 2003, many glucokinase activators (GKAs) have already been created, and their capability to lower the blood sugar has ... Insights From Mutations in Human beings The crucial part of glucokinase in regulating the blood sugar levels can be illustrated ...
The PITG_06016 gene codes for one of the 7 glucokinases present in this phytopathogen. This glucokinase, known as PiGlcK-1, is ... A comparative analysis of the primary structure of P. infestans glucokinase-1 with different glucokinases available in the ... infestans glucokinase to be biochemically characterized; based on its sequence, it would belong to the glucokinase A group of ... glucokinase of Homo sapiens (HsGlcK)(accession number AAB_97681.1) and ADP-specific glucokinase of Pyrococcus furiosus (PfGlcK ...
Liver glucokinase(A456V) induces potent hypoglycemia without dyslipidemia through a paradoxical induction of the catalytic ... We studied mRNA encoding proteins involved in metabolism such as glycolysis [Glucokinase (GK), Liver-pyruvate kinase (L-PK), ... glucokinase; GLP-1, glucagon-like peptide-1; GTT, glucose tolerance test; HC, high carbohydrate; HF, high fat; HK2, hexokinase ...
Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY). Share Share Share ... Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY). ...
Ketogenic diet as elective treatment in patients with drug-unresponsive hyperinsulinemic hypoglycemia caused by glucokinase ...
Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase. Diabetologia. 1995 ... Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase. ... Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase. ...
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. ... From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. ... From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation ...
... to the plasma membrane and regulates downstream targets involved in glycogen synthesis including GSK-3β and glucokinase [99]. ...
... partial glucokinase activator targeting both pancreatic and hepatic glucokinase. As the second glucokinase activator ... partial glucokinase activator targeting both pancreatic and hepatic glucokinase. As the second glucokinase activator studied ... Glucokinase activators for type 2 diabetes: challenges and future developments. Drugs. 2020;80(5):467-75. CrossRefPubMed ... Glucokinase, glucose homeostasis, and diabetes mellitus. Curr Diab Rep. 2005;5(3):171-6. CrossRefPubMed ...
... liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR) (Journal ...
Human ADP-dependent glucokinase (hADP-GK) is the most recently discovered glycolytic enzyme that has been shown experimentally ... The functional role of hADP-GK within the cell and the significance of utilizing an ADP-dependent glucokinase have yet to be ... The unsolved mystery of human ADP-dependent glucokinase : a thesis presented in partial fulfilment of the requirement for the ... The unsolved mystery of human ADP-dependent glucokinase : a thesis presented in partial fulfilment of the requirement for the ...
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of ... beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of ...
The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown ... The majority of the mutations that have been identified are missense mutations that result in the synthesis of a glucokinase ... Using a model for the three-dimensional structure of human glucokinase based on the crystal structure of the related enzyme ... Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: ...