Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor
Compounds 1-5 showed -12.53 to -10.11 kcal/mol potential binding affinity with glucocorticoid receptor (GR) and good ... Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone ... Betamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn&# ... M. D. Heitzer, I. M. Wolf, E. R. Sanchez, S. F. Witchel, and D. B. DeFranco, "Glucocorticoid receptor physiology," Reviews in ...
Neurotoxicity of Tumor Immunotherapy: The Emergence of Clinical Attention
... and glucocorticoids are needed for management as soon as possible [26, 128, 129]. High-dose glucocorticoids may be required if ... An elaborative approach to the glucocorticoid taper and appropriate patient counseling is necessary to assure a successful ... Peripheral neuropathy induced by immunotherapy can also be treated with glucocorticoids. For severe peripheral neuropathy ...
Inflammatory Myofibroblastic Tumors in Paranasal Sinus and Nasopharynx: A Clinical Retrospective Study of 13 Cases
Glucocorticoids are especially recommended as a basic part of the integrated therapy. However, the standard treatment needs ... For unresectable nasal IMT, combined therapy with glucocorticoids, chemotherapy, and radiotherapy is sometimes a better choice ... Glucocorticoids are especially recommended as a basic part of the integrated therapy. The standard treatment for nasal IMT ... Glucocorticoids are especially recommended as a basic part of the integrated therapy. However, the standard treatment needs ...
Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The...
K. Barczyk, J. Ehrchen, K. Tenbrock et al., "Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation ... γ augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism," Journal of the American Society of ... Glucocorticoids suppress tissue inflammation by inducing the anti-inflammatory phenotype of tissue macrophages [101, 102]. ... "Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene," Journal of ...
Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2...
K. A. Lamia, S. J. Papp, R. T. Yu et al., "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor," Nature, ...
Evaluation of Magnetic Resonance Imaging for Microsurgical Efficacy and Relapse of Rolandic Meningioma
Accordingly, appropriate mannitol and glucocorticoid therapy were given to the patients with severe edema. ...
Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation
M2 macrophages are generated in response to various stimuli, including IL-4, IL-13, IL-10, and glucocorticoids. Tumor- ... and glucocorticoid hormones. In general, M2 macrophages have an immune suppressive phenotype and release cytokines including IL ...
Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A
K. De Bosscher, W. Vanden Berghe, and G. Haegeman, "The interplay between the glucocorticoid receptor and nuclear factor-κB or ... C. Brostjan, J. Anrather, V. Csizmadia et al., "Glucocorticoid-mediated repression of NFκB activity in endothelial cells does ... A wide variety of drugs from different groups of functionality was tested in our cellular model, namely, (a) a glucocorticoid ( ... M. Eggert, M. Schulz, and G. Neeck, "Molecular mechanisms of glucocorticoid action in rheumatic autoimmune diseases," The ...
IgG4 as a Biomarker in Graves' Orbitopathy
However, based on studies on IgG4-RD, IgG4-ROD, GO in general, and some case reports, treatment with glucocorticoids is the ... Both B cell depletion treatment with rituximab and glucocorticoid treatment improved the symptoms and decreased CD4+ CTL levels ... Plasmablasts declined after B cell depletion treatment with rituximab and glucocorticoid treatment, which resulted in clinical ... Tfh cells decreased following glucocorticoid treatment, while the disease relapse resulted in their upturn [42, 45]. Tfh cells ...
A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse
Indeed, a primary treatment for DMD patient is glucocorticoids (GC) whose main effect is the inhibition of numerous ... Immunosuppressive therapy, such as treatment with glucocorticoids, improves muscle strength and prolongs ambulation in DMD ...
Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current...
... this association is thought to result from the effects of stress induced elevated glucocorticoids (GC). Elevated GC are ...
Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced...
V. G. Moisiadis and S. G. Matthews, "Glucocorticoids and fetal programming part 2: mechanisms," Nature Reviews Endocrinology, ... D. V. Kratschmar, D. Calabrese, J. Walsh et al., "Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and ... J. R. Seckl and M. C. Holmes, "Mechanisms of disease: glucocorticoids, their placental metabolism and fetal programming of ... even though glucocorticoids are recommended to women at risk of preterm birth to accelerate fetal lung maturation [2], a ...
12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled...
Levels of the primary human anti-inflammatory glucocorticoid, cortisol, are often insufficient to evaluate the function of the ... a precursor of the sex hormones testosterone and estrogen and a glucocorticoid antagonist, in order to calculate the molar ...
Sinonasal Manifestations in Cystic Fibrosis
Systemic glucocorticoids are commonly used in CF patients to reduce pulmonary symptoms, and might have a beneficial effect on ... The positive effect of oral glucocorticoids on chronic sinusitis in the general population [22, 23] suggests a role for these ... to be further studied to establish the role of both systemic antibiotics and anit-inflammatory agents such as glucocorticoids. ...
The Pathology of T Cells in Systemic Lupus Erythematosus
... effective immunosuppressive therapies with glucocorticoids and rituximab have been shown to restore the number of functional ...
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
... and glucocorticoid receptors [48-50] favouring the binding to their DNA targets [62, 63]. The interactions with hormone ...
Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection
... β 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids," Nature Medicine, vol. 5 ...
Potential Involvement of IL-17F in Asthma
A. Vazquez-Tello, A. Semlali, J. Chakir et al., "Induction of glucocorticoid receptor-β expression in epithelial cells of ... Other studies have reported that IL-17F induced expression of glucocorticoid receptor- (GR-) β mRNA in bronchial epithelial ...
Association of High Vitamin D Status with Low Circulating Thyroid-Stimulating Hormone Independent of Thyroid Hormone Levels in...
... glucocorticoids and iodine, were excluded. ...
Acute Acalculous Cholecystitis Induced by Acute Hepatitis B Virus Infection
... plasmapheresis and glucocorticoid," Internal Medicine, vol. 45, no. 3, pp. 145-149, 2006. ...
Oxygenation of the Intraportally Transplanted Pancreatic Islet
"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen," ...
Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity
"Risk of ocular hypertension or open-angle glaucoma in elderly patients on oral glucocorticoids," Lancet, vol. 350, no. 9083, pp ...
MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma
... such as the glucocorticoid receptor, vitamin D receptor (VDR), and peroxisome proliferator-activated receptor gamma [155], thus ...
Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT
I. J. Elenkov, D. A. Papanicolaou, R. L. Wilder, and G. P. Chrousos, "Modulatory effects of glucocorticoids and catecholamines ...
Clinical Symptoms and Quality of Life Improvement Value of Ornidazole Mixture in Auxiliary Filling Treatment of Patients with...
... the dexamethasone contained in this mixture belongs to a long-acting glucocorticoid, which can further catalyze the ...
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
... such as glucocorticoid, cyclosporine, anti-TNF-beta antibody, and whole intestinal nutrition). The efficacy of each step can be ...
Adjudication of the Alleged Role of Vitamin D in the Antimicrobial Pathway
O. Wrange, P. Eriksson, and T. Perlmann, "The purified activated glucocorticoid receptor is a homodimer," The Journal of ... Y. Honma, T. Kasukabe, J. Okabe, and M. Hozumi, "Glucocorticoid binding and mechanism of resistance in some clones of mouse ... like glucocorticoids [41], 1. ,25(OH)2D could induce terminal differentiation of myeloid leukemic blasts [42, 43]. Although the ... "The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain," Nature, vol ...
C-Reactive Protein Levels and Clinical Prognosis in LAA-Type Stroke Patients: A Prospective Cohort Study
... glucocorticoid use, or severe liver or kidney disease, and recent trauma or major surgery; (4) patients lost to follow-up. All ...
Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection
P. C. Johnston, M. C. Lansang, S. Chatterjee, and L. Kennedy, "Intra-articular glucocorticoid injections and their effect on ... H. Derendorf, H. Mollmann, A. Gruner, D. Haack, and G. Gyselby, "Pharmacokinetics and pharmacodynamics of glucocorticoid ...
The Many Faces of Stress: Implications for Neuropsychiatric Disorders | Hindawi
... original research articles as well as review articles that highlight the multifaceted impact of stress and glucocorticoids on ...