*  Glucose Control of Glucagon Secretion: There Is More to It Than KATP Channels | Diabetes
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic α-cell. Cell ... Islet β-cell secretion determines glucagon release from neighbouring α-cells. Nat Cell Biol 2003;5:330-335pmid:12640462. ... Ca2+ oscillations in pancreatic islet cells secreting glucagon and somatostatin. Biochem Biophys Res Commun 1995;208:644-649 ... A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells. Pflugers Arch 1999;437:324- ...
  http://diabetes.diabetesjournals.org/content/62/5/1391
*  Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular...
... of the tested cells. The number of glucose-responsive cells increased after pretreatment of the cells with glucagon-like ... Similar increases in [Ca2+]i were also observed in voltage-clamped cells, although there was neither activation of a background ... i only in cells exposed to elevated glucose concentrations (, or = 5.6 mmol/l). The action of GLP-I(7-36)amide and forskolin ... peptide I (GLP-I)(7-36)amide and at 10(-11) mol/l; 84% of the cells responded to glucose with a rise in [Ca2+]i. GLP-I(7-36) ...
  https://www.rdm.ox.ac.uk/publications/9064
*  Human Physiology/The endocrine system - Wikibooks, open books for an open world
... secrete two hormones. The beta cells secrete insulin; the alpha cells secrete glucagon. The level of sugar in the blood depends ... also consist of other secretory cells called alpha cells. It is these alpha cells that secrete glucagon. Glucagon is a hormone ... Alpha cells secrete glucagon. When the concentration of blood glucose drops such as during exercise, alpha cells secrete ... The glucagon secreting alpha cells in the pancreas, like the beta cells, respond to changes in the concentration of glucose in ...
  https://en.wikibooks.org/wiki/Human_Physiology/The_endocrine_system
*  endocrine system | anatomy | Britannica.com
... in reptiles and birds there is a predominance of glucagon-secreting cells and relatively few insulin-secreting cells. ... the cells that correspond to the adrenal cortex in mammals are called interrenal cells, and the cells that correspond to the ... The pancreas in nonmammals is an endocrine gland that secretes insulin, glucagon, and somatostatin. Pancreatic polypeptide has ... Each molt is aided by a small amount of juvenile hormone (JH) secreted by endocrine cells of the corpora allata. Without JH ...
  https://www.britannica.com/science/endocrine-system
*  ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but...
... paradoxically reduces alpha cell Ca(2+) entry and glucagon exocytosis. Finally, we consider whether the glucagon secretory ... of that in beta cells. Like beta cells, alpha cells respond to hyperglycaemia with K(ATP) channel closure, membrane ... K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under ... Yet, hyperglycaemia reciprocally regulates glucagon (inhibition) and insulin secretion (stimulation). Here we discuss how this ...
  https://www.rdm.ox.ac.uk/publications/469379
*  The Division of Biology & Biomedical Sciences
The islet contains glucagon secreting Alpha-cells, insulin-secreting Beta-cells, and somatostatin-secreting Delta-cells, among ... but somatostatin alone does not inhibit glucagon secretion from isolated Alpha-cells. This suggests that other cell-cell ... Interactions with other islet cell types are thought to be involved in glucose-inhibition of glucagon secretion, since this ... Somatostatin and Insulin Mediate Glucose-Inhibited Glucagon Secretion in the Pancreatic α-Cell by Lowering cAMP. Am. J. Physiol ...
  http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=6550
*  Hyperlipid: Diabetes in Sweden update
As well as both types of cell monitoring glucose it seems as if the glucagon secreting cells look at the local amount of ... It also contains alpha cells which secrete glucagon when glucose levels are too low. The cells are right next door to each ... When glucagon is secreted in large quantities, regardless of the blood sugar level, the liver is stimulated to secrete ... The body probably uses cross talk between cells to control everything. The pancreas has beta cells which secrete insulin when ...
  http://high-fat-nutrition.blogspot.com/2008/06/diabetes-in-sweden-update.html
*  β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release | Diabetes
Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon secretion is inhibited by ... Transcript for the glucagon-like peptide 1 (GLP-1) receptor was not detected in α-cells nor did GLP-1 stimulate α-cell glucagon ... Glucagon, a hormone secreted from α-cells in the pancreatic islets, is critical for blood glucose homeostasis. It is the major ... Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330-335, 2003. ...
  http://diabetes.diabetesjournals.org/content/54/6/1808
*  SLC30A5 Gene - GeneCards | ZNT5 Protein | ZNT5 Antibody
... undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. ... mRNA expression in embryonic tissues and stem cells from LifeMap Discovery. *span" data-trigger="SectionLoaded"> Heart ( ... Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ... May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC30A5
*  Mahvash Disease: Pancreatic Neuroendocrine Tumor Syndrome Caused by Inactivating Glucagon Receptor Mutation | OMICS...
Mahvash disease is a novel pancreatic neuroendocrine tumor syndrome caused by inactivating glucagon receptor mutations. Its ... The pancreatic α cells secrete glucagon which stimulates liver glucose output. The hepatocytes, through a yet-to-be identified ... Most of the islet cells were positive for glucagon but negative for insulin. Glucagon-positive cells were readily detected in ... pancreatic α cell fate regulation by glucagon signaling, and safety of glucagon signaling inhibition for diabetes treatment. ...
  https://www.omicsonline.org/open-access/mahvash-disease-pancreatic-neuroendocrine-tumor-syndrome-glucagon-receptor-mutation-1747-0862.1000084.php?aid=19904
*  Expression of the Vesicular Inhibitory Amino Acid Transporter in Pancreatic Islet Cells | Diabetes
... where glucagon-secreting α-cells and other non-β-cells are located (Fig. 5). Immunostaining with a third antibody, VGAT/1 (21 ... where glucagon-producing α-cells and other non-β-cells are localized. VIAAT was also present in the β-cells but in a lower ... C and F: Staining for glucagon and GAD65. The diabetic islets contain α-cells, as indicated by glucagon staining (C), but are ... and PP-cells (31,32). Accordingly, the β-cell-depleted islets studied here stained positive for glucagon but not for GAD65 (Fig ...
  http://diabetes.diabetesjournals.org/content/51/6/1763
*  Biology A2 (Unit 5) - Revision Cards in A Level and IB Biology
Alpha cells secrete glucagon, Beta cells stop producing insulin.. *Glucagon binds to receptors on the liver. ... Red blood cells come from stem cells, they contains no nucleus and lots of haemoglobin. The stem cell produces a new cell in ... Both adrenaline and glucagon can activate glycogenesis inside a cell, even through they bind to receptors outside the cell. ... The plant cell grows and divides into a mass of unspecialised cells. If the conditions are right the cells develop into ...
  https://getrevising.co.uk/revision-cards/biology_a2_unit_5
*  Hyperglucagonemia Clinical Presentation: History, Physical, Causes
In healthy individuals, insulin has a suppressive effect on alpha-cell function and on glucagon secretion. ... Hyperglucagonemia is a state of excess glucagon secretion. ... A glucagon-secreting alpha-cell carcinoma of the pancreas. N ... Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology (second of two parts). N Engl J Med. 1981 Jun 25. 304 ... Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology (first two parts). N Engl J Med. 1981 Jun 18. 304(25 ...
  https://emedicine.medscape.com/article/121575-clinical
*  Patent US7465441 - Use of gp130 activators in diabetic neuropathy - Google Patents
... without involvement of the glucagon-secreting alpha-cells. The antibodies present at diagnosis usually become undetectable ... Such patients lose both insulin-secreting and glucagon-secreting islets. Therefore, they may be mildly hyperglycemic and ... cells expressing and secreting IL-6R/IL-6 chimera in sufficient amounts have been generated by transfection into the cells ... IL-6 is secreted by a number of different tissues including the liver, spleen, and bone marrow and by a variety of cell types ...
  http://www.google.co.uk/patents/US7465441
*  Homeostasis - Flashcards in A Level and IB Biology
Islet of Langerhans (pancrease) has alpha cells which secrete glucagon. bind to cells on liver 1)enzyme that breaks down ... Islet of Langerhans (pancrease) has beta cells which secrete insulin. binds to liver/muscle cells 1)increase permeability so ... secreted from adrenal glands. binds to receptors on liver cells to activate glycogenolysis and inhibit glycogensis so increase ... What effect does blood glucose concentration have on body cells? too high=water moves out of cells so they shrivel up. too low= ...
  https://getrevising.co.uk/revision-tests/homeostasis_30
*  Human GLP1 peptide (ab50245) | Abcam
Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from ... In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 ... Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. ... Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell ...
  http://www.abcam.com/human-glp1-peptide-ab50245.html
*  Browse by Ulster Authors and Editors - Ulster Institutional Repository
Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, ... Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells. Journal of Molecular ... Gormley, Noella, Flatt, Peter and McKillop, Aine (2014) Targeting GPR120 by novel lipid agonists in a glucagon secreting cell ... and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets. ...
  http://uir.ulster.ac.uk/view/author_or_editor/228.html
*  The β-Cell/EC Axis: How Do Islet Cells Talk to Each Other? | Diabetes
... including glucagon-secreting α-cells, somatostatin-secreting δ-cells, pancreatic polypeptide-secreting γ-cells, and ghrelin- ... Endothelial cells as cytotoxic effector cells: cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via ... As the major secreted β-cell product, insulin acts in an autocrine and paracrine manner to promote β-cell survival. ... The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 2011;8:281-293pmid: ...
  http://diabetes.diabetesjournals.org/content/63/1/3.full
*  Homeostasis - Revision Cards in A Level and IB Biology
Controlled by the hormones insulin & glucagon (negative feedback). *Beta cells secrete insulin & alpha cells secrete glucagon. ... Glucagon raises BGC when it's too low.... *Binds to specific receptors in liver cells, activates enzymes which convert glycogen ... Can also activate glycogenolysis inside a cell.... *Adrenaline& glucagon bind to receptors- activate adenylate cyclase enzyme. ... Too high- water potential reduced so H2O molecules diffuse by osmosis out of cells into blood (cells shrivel up & die) Too low ...
  https://getrevising.co.uk/revision-cards/homeostasis_63
*  α-cell role in β-cell generation and regeneration.
We present recent evidence obtained from lineage-tracing studies showing that α-cells can serve as progenitors of β-cells and ... This review considers the role of α-cells in β-cell generation and regeneration. ... Cell Differentiation / physiology. Glucagon / metabolism. Glucagon-Like Peptide 1 / metabolism. Glucagon-Secreting Cells / ... such as stromal cell-derived factor-1, that cause the de-differentiation of adjacent α-cells into pro-α-cells. Pro-α-cells ...
  http://www.biomedsearch.com/nih/cell-role-in-generation-regeneration/22847495.html
*  Pancreas | definition of pancreas by Medical dictionary
Alpha cells secrete glucagon, which raises blood glucose; beta cells secrete insulin, which lowers blood glucose; delta cells ... and delta cells. The alpha cells secrete the hormone glucagon, which elevates blood sugar. The beta cells secrete insulin, ... beta and delta cells. The alpha cells secrete the hormone glucagon, which elevates blood sugar. The beta cells secrete insulin ... Groups of cells known as ISLETS OF LANGERHANS secrete two hormones into the blood system; large 'alpha' cells secrete GLUCAGON ...
  http://medical-dictionary.thefreedictionary.com/Pancreas
*  Deletion of the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Results in Impaired Insulin Secretion
... specifically insulin secreting beta cells, but recent data suggest that it is also expressed in glucagon secreting alpha cells ... Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes. 2005; ... zinc release from beta cells inhibits glucagon secretion from alpha cells [3, 22, 23]. ... J Cell Sci. 2006;119:4199-4206. [PubMed]. 11. Chimienti F, Favier A, Seve M. ZnT-8, a pancreatic beta-cell-specific zinc ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2929527/
*  Patrik Rorsman - Wikipedia
Patch-clamp studies on pancreatic glucagon- and insulin-secreting cells (PhD thesis). Uppsala University. The value of the ... supervision of Nobel laureate Bert Sakmann in 1986 for patch clamp studies of pancreatic cells and their secretion of glucagon ... Rorsman, P.; Renstrom, E. (2003). "Insulin granule dynamics in pancreatic beta cells". Diabetologia. 46 (8): 1029. doi:10.1007/ ... MacDonald, P. E.; Joseph, J. W.; Rorsman, P. (2005). "Glucose-sensing mechanisms in pancreatic -cells". Philosophical ...
  https://en.wikipedia.org/wiki/Patrik_Rorsman
*  Patent US6122536 - Implantable sensor and system for measurement and control of blood ... - Google Patents
The pancreas also secretes glucagon, a hormone which has cellular functions that are diametrically opposed to those of insulin ... and amino acids into the cells, forcing the cells to use other compounds for energy and cell growth. Diabetics exhibit a ... Normally, blood glucose concentration is regulated by two hormones, insulin and glucagon, secreted by the pancreas. Insulin is ... The algorithm may also control insulin pump 16 to release a glucagon bolus, (1 mg of glucagon, when blood glucose levels trend ...
  http://www.google.com.au/patents/US6122536