Globin - Wikipedia
The globin fold is found in its namesake globin families as well as in phycocyanins. The globin fold was thus the first protein ... Globin E: a globin responsible for storing and delivering oxygen to the retina in birds Globin-coupled sensors: chimeric, with ... Eight globins are known to occur in vertebrates: androglobin (Adgb), cytoglobin (Cygb), globin E (GbE, from bird eye), globin X ... IPR011406 Globin, nematode InterPro: IPR012085 Globin, lamprey/hagfish type InterPro: IPR013314 Globin, annelid-type InterPro: ...
Methemoglobinemia, beta-globin type: MedlinePlus Genetics
... beta-globin type is a condition that affects the function of red blood cells. Explore symptoms, inheritance, genetics of this ... HBB gene mutations that cause methemoglobinemia, beta-globin type change the structure of beta-globin and promote the heme iron ... This gene provides instructions for making a protein called beta-globin. Beta-globin is one of four components (subunits) that ... In adults, hemoglobin normally contains two subunits of beta-globin and two subunits of another protein called alpha-globin. ...
Zeta-Globin ELISA and Hemoglobin H Screen to Detect Alpha0-Thalassemia
How do results from zeta-globin ELISA and shortened hemoglobin H inclusion body screen compare with gap PCR in carrier ... A positive ζ-globin ELISA result is diagnostic of SEA α-thalassemia, and routine use of the ζ-globin ELISA in combination with ... Calculated Sensitivities and Specificities of the HbH Inclusion Body, ζ-Globin ELISA, and HbH Inclusion Body and ζ-Globin ELISA ... Calculated Sensitivities and Specificities of the HbH Inclusion Body, ζ-Globin ELISA, and HbH Inclusion Body and ζ-Globin ELISA ...
Nitric oxide reactivity with globins as investigated through computer simulation. | BSC-CNS
Palabras clave: Biomechanics, Computer Simulation, Energy Metabolism, Globins, Heme, Kinetics, Metabolic Detoxication, Drug, ... Nitric oxide reactivity with globins as investigated through computer simulation.. Journal 2008 ...
QIAseq FastSelect −rRNA HMR and −Globin Handbook - QIAGEN
NIH Guide: DEVELOPMENTAL PROCESSES IN DIFFERENTIAL EXPRESSION OF GLOBIN GENES
In the last decade, the DNA of the human alpha- and beta-globin gene clusters have been fully mapped and sequenced. Similar ... Research into the globin LCR is anticipated to expand our understanding of large-scale chromosomal regulatory mechanisms ... There is a fundamental need to clarify fully the elements involved in the regulation of the expression of globin genes through ... Recent studies have shown that the locus control region (LCR) is a dominant regulator of many aspects of globin gene expression ...
Fecal Globin, By Immunochemistry (InSure) (11290) | Rady Children's Hospital
Haplotypes of the beta-globin gene as prognostic factors in sickle-cell disease
1999). Haplotypes of the beta-globin gene as prognostic factors in sickle-cell disease. EMHJ - Eastern Mediterranean Health ... Haplotypes of the beta-globin gene as prognostic factors in sickle-cell disease. ... Our results suggest that beta-globin gene haplotypes influence the clinical presentation of sickle-cell disease, and that there ...
High pressure reveals structural determinants for globin hexacoordination: neuroglobin and myoglobin cases | Computational...
Moreover, our data suggest that the equilibrium between 5c and 6c states in globins is largely controlled by the structure and ... High pressure reveals structural determinants for globin hexacoordination: neuroglobin and myoglobin cases. Posted June 8th, ... High pressure reveals structural determinants for globin hexacoordination: neuroglobin and myoglobin cases. ... Globins/chemistry; Humans; Mice; Models, Tertiary; Thermodynamics. ...
Collection of Human Biospecimens for Basic and Clinical Research into Globin Variants | NIH: National Institute of Allergy and...
Regulation of the human α globin gene cluster in transgenic mice - Open Research Online
High level a globin gene expression can also be achieved in mice containing the α globin regulatory element, HS-40 and the α ... Regulation of the human α globin gene cluster in transgenic mice.. PhD thesis The Open University. ... Our understanding of ɑ and ß globin gene regulation has been advanced by the development of transgenic mouse technology. Major ... The aim of this project was to identify potentially important regions in the a globin gene cluster. Mice, transgenic for a ...
The molecular pathology of the alpha globin genes - PubMed
A Severe Case of Hemoglobin H Disease due to Compound Heterozygosity for Deletion of the Major α-Globin Regulatory Element (MCS...
Wu MY, He Y, Yan JM, Li DZ: A novel selective deletion of the major α-globin regulatory element (MCS-R2) causing α-thalassemia ... Coelho A, Picanço I, Seuanes F, Seixas MT, Faustino P: Novel large deletions in the human α-globin gene cluster: clarifying the ... Ren S, Luo XN, Atweh GF: The major regulatory element upstream of the alpha-globin gene has classical and inducible enhancer ... A Severe Case of Hemoglobin H Disease due to Compound Heterozygosity for Deletion of the Major α-Globin Regulatory Element (MCS ...
NIH VideoCast - Hematopoietic Stem Cells as Vehicles for Therapeutic Gene Delivery in Disorders of Globin Synthesis
Hematopoietic Stem Cells as Vehicles for Therapeutic Gene Delivery in Disorders of Globin Synthesis ... Hematopoietic stem cells as vehicles for the therapeutic gene delivery in disorders of globin synthesis / John F. Tisdale. ... Hematopoietic Stem Cells as Vehicles for Therapeutic Gene Delivery in Disorders of Globin Synthesis. ... Hematopoietic Stem Cells as Vehicles for Therapeutic Gene Delivery in Disorders of Globin Synthesis ...
Molecular genealogy of some Nematode taxa as based on cytochrome c and globin amino acid sequences.
Interestingly, the second globin repeat evolved at a faster rate in both species examined. This is possibly related to the ... There are two globin genes in Nippostrongylus, expressed in anatomically distinct compartments (body and cuticle), and the ... We have begun to reconstruct the ancient history of the nematode phylum based on cytochrome c and globin amino acid sequences. ... Molecular genealogy of some Nematode taxa as based on cytochrome c and globin amino acid sequences. Mol. Phyl. Evol. 3(2):92- ...
Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies. | NCBS
Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies.. ... Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies.. ... Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies.. ... Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies. ...
RePub, Erasmus University Repository: Identification and characterization of mechanistically distinct inducers of gamma...
We measured gamma-globin transcription in K562 cells transfected with either gamma promoter elements fused with the locus ... Identification and characterization of mechanistically distinct inducers of gamma-globin transcription. Publication. ... or a beta-yeast artificial chromosome in which the luciferase reporter gene was recombined into the gamma-globin coding ... we developed a high-throughput screening approach based on induction of gamma-globin gene expression in erythroid cells. ...
RePub, Erasmus University Repository: Synthetic Human β-Globin 5'HS2 Constructs Function as Partially Active Locus Control...
Synthetic Human β-Globin 5HS2 Constructs Function as Partially Active Locus Control Regions.. Publication. Publication. EMBO ... Transgenes linked to the beta-globin locus control region (LCR) are transcribed in a copy-dependent manner that is independent ... Ellis, J, Talbot, D, Dillon, N.O, & Grosveld, F.G. (1993). Synthetic Human β-Globin 5HS2 Constructs Function as Partially ... Globins), 9007-49-2 (dna), Animals, Base Sequence, Cell Line, DNA-Binding Proteins/genetics, DNA/genetics/isolation & ...
Dryad | Data -- Stepwise colonization of the Andes by Ruddy Ducks and the evolution of novel β-globin variants
Data from: Stepwise colonization of the Andes by Ruddy Ducks and the evolution of novel β-globin variants. Muñoz-Fuentes, ... While no nonsynonymous substitutions were found in either α globin gene, three amino acid substitutions were observed in the βA ... This stepwise colonization pattern accompanied by polarized βA globin amino acid replacements suggest that ruddy ducks first ... globin. Based on phylogenetic reconstruction and power analysis, the first βA substitution, found in all Andean individuals, ...
Developmental regulation of the human beta-globin locus and the role of the O and P regions in beta-like globin gene expression
... to fetal γ-globin occurs at six weeks of gestation and the second switch from γ-globin to adult β- and δ-globin occurs shortly ... in the abolishment of ϵ-globin gene expression during embryonic erythropoiesis and a substantial decrease in β-globin globin ... then the deletion of these regions from the human β-globin locus would result in the persistence of γ-globin in the adult ... The human β-globin locus is a highly complex genetic system that has become a classical model for studying the regulation of ...
Beta-Globin Gene Sequencing, Blood - Mayo Clinic Laboratories Extended Catalog
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Our data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor ... Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is ... Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.. ...
Coregulated human globin genes are frequently in spatial proximity when active | Journal of Cell Biology | Rockefeller...
We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin ... the β-globin signals sitting away from any speckles. Bar, 5 μm. (C and D) Proportion of α-globin (C) and β-globin (D) FISH ... the β-globin signals sitting away from any speckles. Bar, 5 μm. (C and D) Proportion of α-globin (C) and β-globin (D) FISH ... for human β-globin; BAC 14567 (Incyte) for mouse α-globin; and BAC 357K20 (Research Genetics) for mouse β-globin. Additional ...
globiin (ingl. Globin) | Geneetika
Analysis of the human alpha-globin gene cluster in transgenic mice. - Oxford Stem Cell Institute
... upstream of the alpha-globin gene cluster, has been identified as the major tissue-specific regulator of the alpha-globin genes ... These results suggest that the region upstream of the human alpha-globin genes is not equivalent to that upstream of the beta ... Position-independent, high-level expression of the human zeta- and alpha-globin genes was consistently observed in embryonic ... Analysis of the human alpha-globin gene cluster in transgenic mice. Sharpe JA., Wells DJ., Whitelaw E., Vyas P., Higgs DR., ...
Beta Thalassemia: Practice Essentials, Etiology, Epidemiology
... thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin ... Beta-globin gene mutations. Mutations in globin genes cause thalassemias. Beta thalassemia affects one or both of the beta- ... 2] (Alpha thalassemia affects the alpha-globin gene[s].) These mutations, by causing impaired synthesis of the beta-globin ... globin genes. More than 200 beta-globin gene mutations have been identified in these patients; this underlies the wide ...
Which Human Chromosome Carries Alpha Globin Gene? - ConceptEra
SWR E R
LBDRLP - Roche LA low positive globin control. Variable Name: LBDRLP. SAS Label: Roche LA low positive globin control. English ... LBDRHP - Roche LA high positive globin control. Variable Name: LBDRHP. SAS Label: Roche LA high positive globin control. ... If beta-globin is not present, both LBDRHP and LBDRLP are negative in the sample and no HPV type is detected, the sample is ... Roche LA high positive globin control. Target: Females only 14 YEARS - 17 YEARS. Code or Value. Value Description. Count. ...
Beta Globin Mimetic Peptides and Their Use | Technology Transfer
NIH Researchers discovered that not only the alpha globin but also the beta globin subunits of hemoglobin are expressed in the ... Feedback vasodilation by endothelium-derived nitric oxide (NO) is under the regulation of globins. ... or commercialize Beta Globin Mimetic Peptides and Their Use. For collaboration opportunities, please contact Peter Tung, PhD at ... hemoglobin binding to eNOS has led inventors to develop novel mimetic peptides that disrupt the binding of beta globin to eNOS ...