The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
Glial cell line-derived neurotrophic factor induces cell migration in human oral squamous cell carcinoma. Oral oncology. 2013; ... The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able ... Determinants of Ligand Binding Specificity in the Glial Cell Line-derived Neurotrophic Factor Family Receptor alpha s?. Journal ... The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. Int J Med Sci. 19 ...
Glial cell line-derived neurotrophic factor - Wikipedia
Glial cell line-derived neurotrophic factor has been shown to interact with GFRA1 and GDNF family receptor alpha 1. The ... Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small ... Glial+Cell+Line-Derived+Neurotrophic+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles ... January 2005). "Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine ...
Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial...
Exposure to nicotine predominantly induced mRNA expression of glial cell line-derived neurotrophic factor (GDNF) among the ... Exposure to nicotine predominantly induced mRNA expression of glial cell line-derived neurotrophic factor (GDNF) among the ... Exposure to nicotine predominantly induced mRNA expression of glial cell line-derived neurotrophic factor (GDNF) among the ... Exposure to nicotine predominantly induced mRNA expression of glial cell line-derived neurotrophic factor (GDNF) among the ...
The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons...
Renal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Treatment, Interleukin-2 and Interferon
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. It accounts for approximately 3 ... and the glial cell-line-derived neurotrophic factor receptor (RET). A study by Verma et al concluded that the use of tyrosine ... a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in ... IL-2 is a T-cell growth factor and activator of T cells and natural killer (NK) cells. IL-2 affects tumor growth by activating ...
NYU Oral Cancer Center Awarded $2.5 Million NIH Grant to Study Cancer Pain
Artemin is one of four members of the glial cell line-derived-neurotrophic factor (GDNF) family of proteins. Neurotrophins are ... Artemin contributes to pain by inducing expression of receptors on sensory neurons. ... Cancer-derived mediators sensitize pain signaling neurons. Cancers also induce growth of neurons in the tumor. Subsequently ...
Frontiers | β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and...
β-Adrenergic receptor stimulation with norepinephrine (1 μmol/L) attenuated alternans by 60 [52-65]% [interquartile range] and ... β-adrenergic receptor stimulation with norepinephrine (1 µmol/L) attenuated alternans by 60 [52-65] % [interquartile range] and ... We hypothesize that the border zone is most vulnerable to alternans, that β-adrenergic receptor stimulation can suppresses this ... Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of ...
Mouse GFR alpha-like (NP 995316) VersaClone cDNA RDC1171: R&D Systems
Gfra4 | Knockout Mouse | Research Models | Taconic Biosciences
Gene Description: glial cell line derived neurotrophic factor family receptor alpha 4. Synonyms: G630015H18Rik, GFR alpha-4. ... For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as ... Price per Line $/€. Price per Line for Comprehensive Phenotype Data $/€. For Profit (Commercial). $24,000. €21,000. $10,000. € ... Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and ...
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The glial cell-line derived neurotrophic factor (GDNF) and neurturin (NTN) belong to a structurally related family of ... neurotrophic factors. NTN exerts its effect through a multi-component receptor system consisting of the ... ... Study of GDNF-Family Receptor Alpha 2 And Inhibitory Activity of GDNF-Family Receptor Alpha 2b (GFRα2b) Isoform Yoong, Li Foong ...
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Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1- ... Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the ... Glial cell line-derived neurotrophic factor (GDNF) receptor α-1 (GFR α-1) is highly selective for GDNF versus artemin. ... a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci USA 95:1295-1300. ...
JCI - Citations to Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in...
It has recently been shown that glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which binds to ... Thus, enteric neuron survival is sensitive to RET dosage, and cell death is potentially involved in the etiology of HSCR. ... HSCR and developed colonic aganglionosis due to impaired migration and successive death of enteric neural crest-derived cells. ... where reduction of Ret expression was induced after the period of enteric neural crest cell migration, indicating that ...
Browsing by discipline "Biokemia ja kehitysbiologia"
... the receptor of Glial-cell-line-derived neurotrophic factor (Gdnf), in embryonic kidneys. Isolated Plxnb2 / ureteric buds fail ... We found that IU1 activates AMPK in Huh7 cells, but has no apparent effect in HEK293 cells. By assessing the mitochondria ... Our results suggests that IU1 activates AMPK in certain cell lines with the possible underlying mechanism being the inhibition ... Huh7 and HEK293 cells were treated with IU1 for variable time periods. Western blotting was applied to investigate the protein ...
Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1α, VEGF and p38 MAPK signaling pathway...
... and secrete glial cell line-derived neurotrophic factor through VEGFR-2 receptor (20). GDNF can prevent neuronal apoptosis and ... Cell culture and experimental protocols. Human neuroglioma cells H4 cell was purchased from Shanghai Cell Bank and cultured in ... Cell Signaling Technology, Inc., Danvers, MA, USA), HIF-1α (Cell Signaling Technology, Inc.), VEGF (Cell Signaling Technology, ... The effects of Vitexin on cell growth of sevoflurane-induced human neuroglioma cells. Then, we needed to explore the effects of ...
GFR alpha1, IN (GDNFRa, Glial -derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb- Neurotrophic Factor Receptor...
Glial derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, ... Order GFR alpha1 IN GDNFRa Glial Cell-derived Neurotrophic Factor Receptor a1 RETL1 Ret ligand 1 TGFb-related Neurotrophic ... Factor Receptor 1 TrnR1 Glycosylphosphadidylinositol linked Protein Antibody 01012519501 at Gentaur GFR alpha1, IN (GDNFRa, ... Glial cell line-derived neurotrophic factor receptor alpha; glial cell line derived neurotrophic factor family receptor alpha 1 ...
Glial cell-derived neurotrophic factor receptor alpha-3 (GFR alpha-3), Rabbit Polyclonal Antibody
Rabbit anti-Glial cell-derived neurotrophic factor receptor alpha-3 (GFR alpha-3) Polyclonal Antibody (Unconjugated), suitable ... Scientific Background FUNCTION: Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin- ... Product Name Glial cell-derived neurotrophic factor receptor alpha-3 (GFR alpha-3), Rabbit Polyclonal Antibody ... Glial cell-derived neurotrophic factor receptor alpha-3 (GFR alpha-3), Rabbit Polyclonal Antibody ...
Enhanced Nigrostriatal Neuron-specific, Long-term Expression by Using Neural-specific Promoters in Combination with Targeted...
... glial cell line-derived neurotrophic factor (GDNF) or brain-derived neurotrophic factor (BDNF) proteins. HSV-1 vector particles ... which contain specific receptors for GDNF or BDNF. A second approach to achieve neuronal type-specific expression is to use a ... cell type-specific promoter, and we have used the tyrosine hydroxylase (TH) promoter to restrict expression to ...
The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving | Neuropsychopharmacology
Next, we assessed the effect of reversible inactivation of CeA or BLA by GABAA+GABAB receptor agonists (muscimol+baclofen, 0.03 ... In this regard, we previously found that GDNF (glial cell line-derived neurotrophic factor) activity in ventral tegmental area ... Boudreau AC, Reimers JM, Milovanovic M, Wolf ME (2007). Cell surface AMPA receptors in the rat nucleus accumbens increase ... Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biol Psychiatry 66 ...
Caprelsa (vandetanib) dosing, indications, interactions, adverse effects, and more
... germline mutations of the RET gene RET encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor ... Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT ... Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT ... Vandetanib has activity against RET as well as vascular endothelial growth factor (VEGF) ...
Karsten Ruscher - Research output
- Lund University
Dopamine receptor activation increases glial cell line-derived neurotrophic factor in experimental stroke.. Kuric, E., Wieloch ... Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke.. ... Durrant, C. S., Ruscher, K., Sheppard, O., Coleman, M. P. & Özen, I., 2020, In: Cell Death and Disease. 11, 2, 98.. Research ... Impact of estrogen receptor beta activation on functional recovery after experimental stroke.. Madinier, A., Wieloch, T., ...
Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway | Aging
LIFUS can increase the expression of orexin-A (OX-A) and OXR1, significantly inhibit the activation of nuclear factor-κB (NF-κB ... protein and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome after TBI, and reduce the release of pro- ... inflammatory factors after TBI; however, SB334867 can reverse this effect. Conclusions: This study suggests that LIFUS may play ... After establishing the TBI model, the hypothalamus region was covered with LIFUS radiation, and an orexin receptor 1 (OXR1) ...
Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain - McMaster...
... glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor mRNA expression were observed. The robust ... conserved dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor, were detected in the ... Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain Journal ... up-regulate the G-protein-coupled melatonin MT1 receptor in rat C6 glioma cells. To determine whether this effect occurs in ...
Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons - Fingerprint - University of Texas...
Glial Cell Line-Derived Neurotrophic Factor 78% * LY 379268 74% * Corpus Striatum 57% ... Dive into the research topics of Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons. ... Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons. ...
Clinic of Otorhinolaryngology<...
Glial Cell Line-Derived Neurotrophic Factor 66% * Glial Cell Line-Derived Neurotrophic Factor Receptors 60% ... Mast cell regulated innate immunity in otitis media; pro-inflammatory and immunosuppressive effects of mast cells in otitis ... Comparison of Two Cisplatin Regimens for Chemoradiation in Patients With Squamous-cell Carcinoma of the Head and Neck. Zwaan, I ...
Targeting nigral tyrosine hydroxylase to improve locomotion in aging - Fingerprint - HSC
Positive Phase-III-Studie Bavencio plus Inlyta - News - EMD Group
Positive top-line results from phase III Javelin Renal 101 study ... and the glial cell-line derived neurotrophic factor receptor ( ... stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), ... and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRα and PDGFRβ), vascular endothelial growth ... 6-8 BAVENCIO has also been shown to induce NK cell-mediated direct tumor cell lysis via antibody-dependent cell-mediated ...
Planteome: Term Details for "glial cell-derived neurotrophic factor receptor signaling pathway" (GO:0035860)
... glial cell derived neurotrophic factor receptor signaling pathway, glial cell line-derived neurotrophic factor receptor ... glial cell-derived neurotrophic factor receptor signaling pathway glial cell-derived neurotrophic factor receptor signaling ... 0016167 glial cell-derived neurotrophic factor receptor activity * GO:2000701 glial cell-derived neurotrophic factor receptor ... glial cell-derived neurotrophic factor receptor signaling pathway is_a transmembrane receptor protein tyrosine kinase signaling ...
Renal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Treatment, Adjuvant Treatment Strategies
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. It accounts for approximately 3 ... and the glial cell-line-derived neurotrophic factor receptor (RET). A study by Verma et al concluded that the use of tyrosine ... a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in ... IL-2 is a T-cell growth factor and activator of T cells and natural killer (NK) cells. IL-2 affects tumor growth by activating ...
Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate<...
We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor ... We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor ... We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor ... We report that glial cell-line-derived neurotrophic factor (GDNF) signaling through the RET tyrosine kinase/GFRA1 receptor ...
market report - Resource KT
June 6, 2021 Factor market Comments Off on Glial Cell Line Derived Neurotrophic Factors Market To Show Healthy Annual Growth ... June 7, 2021 Factor market Comments Off on Global NT 3 Growth Factor Receptor Market 2021-2026 Financial Outlook, Company ... Glial Cell Line Derived Neurotrophic Factors Market To Show Healthy Annual Growth Rate Over 2021-2026 Period ... The latest glial cell line-derived neurotrophic factor market study offers a comprehensive analysis of information gathered ...