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*  Oxidative stress in ocular disease: Does lutein play a protective role?
αA Crystallin May Protect against Geographic Atrophy--Meta-Analysis of Cataract vs. Cataract Surgery for Geographic Atrophy ... Background: Cataract and geographic atrophy (GA, also called advanced "dry" age-related macular degeneration) are the two major ...
  http://connection.ebscohost.com/c/articles/18415266/oxidative-stress-ocular-disease-does-lutein-play-protective-role
*  Searching for Objects in Everyday Scenes: Measuring Performance in People With Dry Age-Related Macular Degeneration | IOVS |...
The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and ... Sadda SR, Chakravarthy U, Birch DG, Staurenghi G, Henry EC, Brittain C. Clinical endpoints for the study of geographic atrophy ... Long-term follow-up of fixation patterns in eyes with central scotomas from geographic atrophy that is associated with age- ... To conclude, some people with dry AMD, particularly those with geographic atrophy, have measurable difficulties on a computer- ...
  http://iovs.arvojournals.org/article.aspx?articleid=2616205
*  Lampalizumab for Geographic Atrophy Enters Phase 3 Trials - The American Society of Retina Specialists
Lampalizumab for Geographic Atrophy Enters Phase 3 Trials. Roche (Basel, Switzerland) announced that it has initiated 2 Phase 3 ... for the treatment of geographic atrophy (GA). The identical trials, Chroma and Spectri, will evaluate the safety and efficacy ...
  http://www.asrs.org/education/clinical-updates/353/
*  EURETINA Official | Official EURETINA Website | European Society of Retina Specialists
... geographic atrophy (GA). After correcting for age and gender, the presence of RPD was significantly associated (OR=3.96, 95% CI ...
  http://www.euretina.org/london2014/programme/free-papers-details.asp?id=3400&day=0
*  Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy | IOVS | ARVO Journals
In this 90-day dose-escalation study, subjects with the advanced form of dry AMD (geographic atrophy) received ACU-4429 (2, 5, ... Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy ... Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy ... Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy. Invest. Ophthalmol. Vis. Sci. 2012;53 ...
  http://iovs.arvojournals.org/article.aspx?articleid=2352663
*  Designing a Clinical Study to Evaluate Potential Therapeutics for Geographic Atrophy Secondary to Non-Exudative Age-Related...
Study design was determined using demographic and outcome data from the Geographic Atrophy Natural History Study and the Age- ... Designing a Clinical Study to Evaluate Potential Therapeutics for Geographic Atrophy Secondary to Non-Exudative Age-Related ... Designing a Clinical Study to Evaluate Potential Therapeutics for Geographic Atrophy Secondary to Non-Exudative Age-Related ... compared with placebo on the rate of change in area of geographic atrophy (GA) as measured by change in area of GA for patients ...
  http://iovs.arvojournals.org/article.aspx?articleid=2332644
*  Autologous Translocation of the Choroid and RPE in Patients With Geographic Atrophy | IOVS | ARVO Journals
Methods: : All patients had visual loss due to geographic atrophy related to age-related macular degeneration. An autologous ... Autologous Translocation of the Choroid and RPE in Patients With Geographic Atrophy ... Autologous Translocation of the Choroid and RPE in Patients With Geographic Atrophy ... in patients with geographic atrophy. Design: : Prospective non-randomized study in 18 patients with AMD with a follow-up of , 6 ...
  http://iovs.arvojournals.org/article.aspx?articleid=2392528
*  Apellis Pharma raises $33 mln | Startups@KSTC
... reduce the growth of retinal lesions through the intravitreal injection of APL-2 in patients suffering from geographic atrophy ...
  http://startups.kstc.com/apellis-pharma-raises-33-mln/
*  Dry Age-related Macular Degeneration (AMD) | Prevent Blindness
Advanced stage of dry AMD: The advanced stage of dry AMD is also known as geographic atrophy affecting the fovea or center of ... Dry AMD - Geographic Atrophy (Credit: National Eye Institute, National Institutes of Health) ... A fundus photograph provides a picture of the retina and may document the amount of drusen or geographic atrophy to compare at ... which may help with the identification of geographic atrophy.. Optical coherence tomography (OCT): The OCT examination provides ...
  https://nebraska.preventblindness.org/dry-amd
*  StudyPages - Metformin vs. no treatment in the progression of geographic atrophy (GA), a type of age-related macular eye...
"Can Metformin, used to treat Diabetes, slow the progression of geographic atrophy in patients with age-related macular eye ... no treatment in the progression of geographic atrophy (GA), a type of age-related macular eye degeneration (AMD) ... Exclusion Criteria: Subjects with insufficient baseline size of geographic atrophy, less than 1.25 mm2 (0.5 Macular ... defined by the characteristic presence of drusen and/or pigmentary changes as well as geographic atrophy Subject must have ...
  https://studypages.com/s/metformin-vs-no-treatment-in-the-progression-of-geographic-atrophy-ga-a-type-of-age-related-macular-eye-degeneration-amd-468402/?ref=gallery
*  Geographic atrophy phenotype identification by cluster analysis | British Journal of Ophthalmology
The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and ... The natural history of geographic atrophy, the advanced atrophic form of age-related macular degeneration. Mol Vis 1999;5:25. ... Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J ... Reappraisal of geographic atrophy patterns seen on fundus autofluorescence using a latent class analysis approach. Invest ...
  http://bjo.bmj.com/content/102/3/388
*  OSA | Semi-automatic geographic atrophy segmentation for SD-OCT images
Automated geographic atrophy segmentation for SD-OCT images using region-based C-V model via local similarity factor Sijie Niu ... Semi-automatic geographic atrophy segmentation for SD-OCT images Qiang Chen, Luis de Sisternes, Theodore Leng, Luoluo Zheng, ... Geographic atrophy (GA) is a condition that is associated with retinal thinning and loss of the retinal pigment epithelium (RPE ... P. Maguire and A. K. Vine, "Geographic atrophy of the retinal pigment epithelium," Am. J. Ophthalmol. 102(5), 621-625 (1986). [ ...
  https://www.osapublishing.org/boe/abstract.cfm?URI=boe-4-12-2729
*  Targeting Complement Factor D Reduces Progression of AMD-Related Geographic Atrophy - American Academy of Ophthalmology
... and noted a potential therapeutic effect on geographic atrophy. ... Factor D Reduces Progression of AMD-Related Geographic Atrophy ... have implicated dysregulation of the alternative complement pathway in the pathogenesis of geographic atrophy (GA). Yaspan et ...
  https://www.aao.org/eyenet/article/targeting-complement-factor-d
*  Author Response: Geographic Atrophy and Cardiovascular Disease | IOVS | ARVO Journals
Geographic Atrophy and Cardiovascular Disease. Change of β-Zone Parapapillary Atrophy During Axial Elongation: Boramae Myopia ... Geographic atrophy and cardiovascular disease. Invest Ophthalmol Vis Sci . 2014; 55: 6262. [CrossRef] [PubMed] ... We are very grateful for Dr Smith's 1 important comments on our article 2 on a specific subtype of geographic atrophy (GA), the ... Author Response: Geographic Atrophy and Cardiovascular Disease You will receive an email whenever this article is corrected, ...
  https://iovs.arvojournals.org/article.aspx?articleid=2166388
*  Pseudo-Cysts: A Previously Undescribed Sign of Geographic Atrophy | IOVS | ARVO Journals
Pseudo-Cysts: A Previously Undescribed Sign of Geographic Atrophy M.-H. Nghiem-Buffet; S. Y. Cohen; L. Dubois; S. Ayrault; F. ... Purpose: : To describe the presence of pseudo-cysts in retinal layers in eyes with geographic atrophy (GA) of age-related ... Pseudo-Cysts: A Previously Undescribed Sign of Geographic Atrophy You will receive an email whenever this article is corrected ... Methods: : Retrospective analysis of consecutive patients with geographic atrophy assessed by spectral-domain OCT (Cirrus SD- ...
  https://iovs.arvojournals.org/article.aspx?articleid=2373541
*  Geographic atrophy - Wikipedia
Geographic Atrophy (GA), also known as atrophic age-related macular degeneration (AMD) or advanced dry AMD, is an advanced form ... Geographic atrophy (GA) is a chronic disease, which leads to visual function loss. This often results in difficulties ... September 2009). "Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26". Archives ... The incidence of advanced AMD, both geographic atrophy and neovascular AMD, increases exponentially with age and while there ...
  https://en.wikipedia.org/wiki/Geographic_atrophy
*  Geographic Atrophy and Activity of Neovascularization in Retinal Angiomatous Proliferation | IOVS | ARVO Journals
Geographic Atrophy and Activity of Neovascularization in Retinal Angiomatous Proliferation Jiwon Baek; Jae Hyung Lee; Jun Yong ... Geographic atrophy (GA) is a common feature of RAP, irrespective of treatment.15-18 In one study, approximately 40% developed ... 2, middle). Geographic atrophy involved the foveal center in 10 eyes (23%) in the GA group, and the mean logMAR VA at year 3 in ... Geographic Atrophy and Activity of Neovascularization in Retinal Angiomatous Proliferation You will receive an email whenever ...
  https://iovs.arvojournals.org/article.aspx?articleid=2511251
*  Choroidal neovascularisation complicating geographic atrophy in age-related macular degeneration | British Journal of...
Results 21 treatment-naive eyes of 21 consecutive patients (4 men, 17 women, mean age 86.9±1.6 years) were included. In 95.2% of eyes a type 2 CNV was present, extrafoveal in 42.8% of cases. After a mean of 5.0±0.87 (range 1-20) intravitreal ranibizumab injections, best-corrected visual acuity (BCVA) significantly worsened at the 24-month follow-up visit (0.73±0.05 vs 0.88±0.08 logMAR, respectively; p=0.01). A significant reduction of intraretinal cystic lesions, subretinal fluid and pigment epithelium detachment (p,0.001) and a significant increase of GA area (p=0.003) were present at last visit.. ...
  http://bjo.bmj.com/content/early/2012/10/16/bjophthalmol-2012-302191
*  Visual acuity changes in foveal sparing geographic atrophy due to AMD | IOVS | ARVO Journals
To investigate the impact of atrophy progression in patients exhibiting a "foveal-sparing" pattern geographic atrophy (GA) on ... Visual acuity changes in foveal sparing geographic atrophy due to AMD Lindner Moritz; Rolf Fimmers; Matthias Mauschitz; Arno P ... Visual acuity changes in foveal sparing geographic atrophy due to AMD You will receive an email whenever this article is ... Visual acuity changes in foveal sparing geographic atrophy due to AMD. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2830. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2332639
*  Optical coherence tomography angiography of the foveal vasculature in geographic atrophy | IOVS | ARVO Journals
Optical coherence tomography angiography of the foveal vasculature in geographic atrophy Hammurabi Bartuma; Urban Amrén; Manuel ... Optical coherence tomography angiography of the foveal vasculature in geographic atrophy You will receive an email whenever ... Purpose : To examine the foveal vasculature in patients with age-related macular degeneration-associated geographic atrophy (GA ... Optical coherence tomography angiography of the foveal vasculature in geographic atrophy. Invest. Ophthalmol. Vis. Sci. 2016;57 ...
  https://iovs.arvojournals.org/article.aspx?articleid=2559092
*  Designing Clinical Trials for Age-Related Geographic Atrophy of the Macula | IOVS | ARVO Journals
Designing Clinical Trials for Age-Related Geographic Atrophy of the Macula C.A. Applegate; B.S. Hawkins; N.M. Bressler; E. ... Designing Clinical Trials for Age-Related Geographic Atrophy of the Macula You will receive an email whenever this article is ... Purpose: : To describe factors important for designing clinical trials for geographic atrophy (GA) from AMD. ... Designing Clinical Trials for Age-Related Geographic Atrophy of the Macula . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2123. ...
  http://iovs.arvojournals.org/article.aspx?articleid=2391980
*  Photoreceptor Damage Surrounding Geographic Atrophy in Dry Age-related Macular Degeneration | IOVS | ARVO Journals
Photoreceptor Damage Surrounding Geographic Atrophy in Dry Age-related Macular Degeneration Ayako Takahashi; Sotaro Ooto; Kenji ... Photoreceptor Damage Surrounding Geographic Atrophy in Dry Age-related Macular Degeneration You will receive an email whenever ... To quantify the area with photoreceptor damage surrounding geographic atrophy (GA), and to evaluate the relationship between ... Photoreceptor Damage Surrounding Geographic Atrophy in Dry Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2015 ...
  http://iovs.arvojournals.org/article.aspx?articleid=2332651
*  Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration | IOVS | ARVO Journals
Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration F. Alten; S. Schmitz-Valckenberg; J. ... Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration You will receive an email whenever this ... Purpose: : To characterize reticular drusen (RD) in patients with geographic atrophy (GA) secondary to age-related macular ... Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51( ...
  https://iovs.arvojournals.org/article.aspx?articleid=2369209
*  Progression of Age-Related Geographic Atrophy: Role of the Fellow Eye | IOVS | ARVO Journals
Designing clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural ... Sunness JS Gonzalez-Baron J Applegate CA . Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age- ... The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and ... Maguire P Vine AK . Geographic atrophy of the retinal pigment epithelium. Am J Ophthalmol. 1986;102:621-625. [CrossRef] [PubMed ...
  https://iovs.arvojournals.org/article.aspx?articleid=2187896