Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12...
... and pathways of the three phenotypes by conducting a multivariate genome-wide assoc … ... A genome-wide association study of cognitive function in Chinese adult twins. Xu C, Zhang D, Wu Y, Tian X, Pang Z, Li S, Tan Q. ... A genetic correlation and bivariate genome-wide association study of grip strength and depression. Zhang T, Ji L, Luo J, Wang W ... The genome-wide efficient mixed-model analysis identified 164 SNPs reaching suggestive significance (P , 1 × 10-5). Among them ...
Whole Genome Sequencing | CDC
Whole genome sequencing will improve the efficiency of surveillance and help solve foodborne outbreaks sooner. ... How does whole genome sequencing work?. Scientists conduct whole genome sequencing by following these four main steps:. *DNA ... Whole genome sequencing is a laboratory procedure that determines the order of bases in the genome of an organism in one ... What is whole genome sequencing (WGS)?. All organisms (bacteria, vegetable, mammal) have a unique genetic code, or genome, that ...
Genome Integrity & Environmental Stress
Expanding Genome Integrity Assays in Population Studies (closed) - Supported the development and pilot testing of assays, such ... Damage to DNA from exposures to these agents can result in permanent changes in the genome affecting key cellular functions and ... as DNA repair capacity or mutation detection, to facilitate the wider use of genome integrity investigation in epidemiological ...
Genome Microevolution of Chikungunya Viruses
II, LF, GG, and SB assembled the genome sequence. IS, II, LF, MCV, SD, FAR, and SB analyzed sequence data. MPF, ACB, and PD ... Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak Isabelle Schuffenecker; Isabelle Iteman; Alain ... Methods and Findings: We report the nearly complete genome sequence of six selected viral isolates (isolated from five sera and ... Cite this: Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak - Medscape - Jul 01, 2006. ...
Plant & Animal Genome Conference 2023 (PAG 30)
Plant Genome
Whole-Genome Sequencing (WGS) Project | NHLBI, NIH
Learn about the Whole-Genome Sequencing project, which collects genomic data from individuals with well-defined phenotypes and ... Whole-Genome Sequencing (WGS) Project The WGS project is making strides to establish a genomic resource that reflects the ... The WGS project has sequenced over 90,000 genomes from over 30 studies, and the project aims to sequence more than 120,000 ... The goal of the WGS project is to collect whole-genome sequencing data from individuals with well-defined phenotypes and ...
What are genome-wide association studies?: MedlinePlus Genetics
Genome-wide association studies help scientists identify which genes are involved in human disease. Learn more about this ... The National Human Genome Research Institute provides a detailed explanation of genome-wide association studies.. In addition, ... Because genome-wide association studies examine SNPs across the genome, they represent a promising way to study complex, common ... Through genome-wide association studies, individual SNPs are identified that account for only a small percentage of disease ...
Orangutan Genome Sequenced | National Institutes of Health (NIH)
Researchers have decoded the orangutan genome, revealing intriguing clues about the evolution of primates, including humans. ... The orangutan genome sequence comes from the DNA of a single Sumatran female. In addition to this detailed sequence, 5 Sumatran ... "In terms of evolution, the orangutan genome is quite special among great apes in that it has been extraordinarily stable over ... The study was funded in part by NIHs National Human Genome Research Institute (NHGRI) and other NIH components. The results ...
Mouse CRISPR/Cas9 Genome Editing Facility - NIDDK
NIH Guide: RAT GENOME DATABASE
Genome Informatics Program National Human Genome Research Institute 38 Library Drive, Room 614, MSC 6050 Bethesda, MD 20892- ... RAT GENOME DATABASE Release Date: March 5, 1999 RFA: HL-99-013 P.T. National Heart, Lung and Blood Institute National Institute ... Recognizing the usefulness of the rat as a model system, the NIH funded the Rat Genome Project and the Rat EST Project to ... This RFA calls for applications to establish and develop a comprehensive Rat Genome Database to meet the needs of the broad ...
Fine-Mapping Genome-Wide Associated Loci to Identify Proximate Causal Mechanisms
Greater than 90% of genome-wide significant variants associated with traits fall within non-coding regions of the genome. A ... Due to the correlated nature of nearby SNVs (i.e., linkage disequilibrium), GWAS implicate regions of the genome (loci) and do ... Home , Funding , Grant Writing & Approval Process , Concept Clearances , Fine-Mapping Genome-Wide Associated Loci to Identify ... Genome-wide association studies (GWAS) identify statistical relationships between common single nucleotide variants (SNVs) ...
RFA-HG-10-016: Mendelian Disorders Genome Centers (U54)
Mendelian Disorders Genome Centers (U54) RFA-HG-10-016. NHGRI ... More generally, the Genome Centers are expected to take a ... Both whole genome sequencing, and exome-based sequencing using selective capture of genome-wide protein coding regions, have ... Genome Sequencing and Identification of Genetic Variants 85% or so of the known Mendelian variants reside in the protein-coding ... National Human Genome Research Institute. 5635 Fishers Lane Suite 4076, MSC 9305. Bethesda, MD 20892 Telephone: (301) 496-7531 ...
Scientists unveil search-and-replace genome editing
Researchers have designed a more precise and versatile genome editing system, named prime editing, that harnesses the power of ... one that targets a specific DNA site in the cells genome and another that includes the desired edits to the cells genome. The ... "Each type of genome editing technology has its strengths and weaknesses and will have a role in basic research and human ... Of the three billion DNA bases in the human genome, devastating diseases can occur when only one letter of a cells DNA is ...
Somatic Cell Genome Editing Consortium
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain. Editor Project: ... Delivery Technologies for In Vivo Genome Editing. Delivery Project (2): Bioengineered red blood cells as extracellular vesicle- ... close x Human microtissues for in situ detection and functional measurement of adverse consequences caused by genome editing ... Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools. Biological Systems Project: Innovative ...
Home - Genome - NCBI
This resource organizes information on genomes including sequences, maps, chromosomes, assemblies, and annotations. ... Genome. This resource organizes information on genomes including sequences, maps, chromosomes, assemblies, and annotations. ...
HIV Testing Overview: Overview, HIV Virion and Genome, HIV Testing Recommendations
The genome contains 3 major genes that encode structural proteins: gag, pol, and env. [8, 9] The gag gene encodes for p24, p17 ... HIV Virion and Genome. Human immunodeficiency virus (HIV)-1 is a member of the Retroviridae family. It is an enveloped virus ... a basic understanding of the structure of the HIV virion and its genome is necessary. ...
NIDCD scientists honored for contributions to The Cancer Genome Atlas | NIDCD
... for their contributions to The Cancer Genome Atlas (TCGA). ... NIDCD scientists honored for contributions to The Cancer Genome ... TCGA is a joint effort of the National Institutes of Healths National Cancer Institute (NCI) and National Human Genome ... for their contributions to The Cancer Genome Atlas (TCGA). ...
genome sequencing
Assessing the Value for Money of Using Genome Sequencing in Child Health. If you have a child with a neurodevelopmental ... genome sequencing - Genomics and Precision Health Blog ...
Mouse mm10 chr12:52,713,333-62,634,435 UCSC Genome Browser v455
What's a Genome? | NIH News in Health
Learn more about the genome and how it works to better understand more about your own health and make informed health decisions ... "Genome" is a fancy word for all your DNA. From potatoes to puppies, all living things have their own genomes. ... The more you know about the genome and how it works, the more youll understand your own health and make informed health ...
Browsing EB112 by Subject "Genome"
Translational Capabilities: Genome-scale metabolic models | National Institute on Aging
Support the development of genome-scale metabolic models to capture the heterogeneity of metabolic transitions from healthy to ... Support the development of genome-scale metabolic models to capture the heterogeneity of metabolic transitions from healthy to ... development of open-source, genome-scale, metabolic models for use in target validation and disease sub-classification. ...
RFA-HG-06-001: Genome Sequencing Centers (U54)
Comparative genome sequencing can also help inform our understanding of how genomes evolved, including understanding of genome ... Parasite and vector genomes. The genomes of fewer than 20 important eukaryotic pathogens of human, and only six vectors of ... 6.I.2 Genome sequence production. The applicant should include a concise description of past experience in large-scale genome ... National Human Genome Research Institute (NHGRI), (http://www.genome.gov) Title: Genome Sequencing Centers (U54). Announcement ...