*  Genistein-induced apoptosis in prostate cancer cells.
... Nutr Cancer. 1998;32(3):123-31.. Genistein-induced upregulation of ... We have evaluated the mechanism by which genistein may inhibit PCa cell growth. Here we report that genistein inhibits PCa cell ... The isoflavone genistein is believed to be the anticancer agent found in soy, and significant levels of genistein have been ... RE: Genistein-induced apoptosis in prostate cancer cells. Prostate cancer is the most popular non-skin cancer and second only ...
  http://medcapsules.com/forum/showthread.php?tid=3063&pid=5422
*  Plus it
... genistein = 382 ± 33 nM). On the other hand, the inactive analog of genistein, genistin, failed to alter to NE transport in ... Genistein causes a time- and concentration-dependent reduction of NE transport in SK-N-SH cells. Serum-starved cells were ... The effects of genistein, wortmannin, and LY-294002 on NE transport could be mediated by a nonspecific disruption of ion ... 11A). Similarly, genistein, wortmannin, and LY-294002 also produce a significant decrease in [3H]nisoxetine binding (Table 1), ...
  http://jpet.aspetjournals.org/content/299/2/666
*  Plus it
... both pure genistein and a commercially available form of genistein called Genistein Combined Polysacharride (GCP), against two ... Genistein treatment. Genistein (Sigma) was dissolved in DMSO to make a 200 mg/mL stock solution that was added directly to the ... Genistein was dissolved in 100% methanol to create a stock solution (1 mg/mL) of genistein base. The stock solution was further ... Genistein is also active against human lymphoid neoplasia (18, 19). Genistein induces apoptosis via mitochondrial damage in T ...
  http://clincancerres.aacrjournals.org/content/15/4/1269
*  Despite concerns, soy probably safe for thyroid | Lifescript.com
... the soy-based dietary supplement genistein may not harm postmenopausal women's thyroid... ... Genistein is a type of soy isoflavone, a plant chemical that is structurally similar to estrogen and may have certain estrogen- ... However, he told Reuters Health by email, those studies used genistein doses that were 10 to 250 times higher than the doses ... According to Squadrito, it is not surprising that studies would find thyroid effects of very high doses of genistein. However, ...
  http://www.lifescript.com/health/centers/multiple_sclerosis/alternative_treatments/vitamin_d_articles/despite_concerns_soy_probably_safe_for_thyroid.aspx
*  Genistin - Wikipedia
It is hydrolyzed by removing the covalently bound glucose to form genistein and that genistein is the form of the compound that ... The effect of genistein was greater than that of genistin. It is also revealed that genistin has a strong bone loss preventive ... Genistin, like genistein, is a phytoestrogen as it was shown to stimulate estrogen-dependent breast cancer cell growth in vivo ... The presence of genistein or genistin in the tissue culture caused a significant increase in alkaline phosphatase activity, ...
  https://en.wikipedia.org/wiki/Genistin
*  GENISTEIN || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
  http://www.ewg.org/skindeep/ingredient/702561/GENISTEIN/
*  What is Genistein? (with pictures)
Along with other related compounds, genistein is thought to... ... Genistein is a polyphenol that's found in soybeans and other ... Genistein is a polyphenol that is found in soybeans and other plants, such as red clover and kudzu. It is a type of flavonoid ... Genistein has been shown to slow the growth of a variety of cancer cells in laboratory studies. It has several different ... Treatment with genistein has been found to increase bone density in women who took it as a dietary supplement. ...
  https://www.wisegeek.com/what-is-genistein.htm
*  Concerns over Genistein, Part II-Beyond the heart | Science News
Genistein had no fattening effect in females. Here again, Di Lorenzo notes, the doses of genistein were high, but comparable to ... Part I: "Concerns over Genistein, Part I-The heart of the issue" is available at Concerns over Genistein, Part I-The heart of ... Part I: "Concerns over Genistein, Part I-The heart of the issue" is available at Concerns over Genistein, Part I-The heart of ... eating genistein diminished the normal estrogen-triggered functions of a tissue-presumably because genistein, a weak estrogen, ...
  https://www.sciencenews.org/node/4941
*  Genistein - What It Is, Uses, How It Works | Lifescript.com
Uses for genistein, how it works, and more. ... 55 Genistein was taken at a dose of 54 mg per day. The results ... Genistein may help reduce risk of various forms of cancer . In one study, newborn female rats treated with genistein had less ... Red clover is also a good source of genistein. Like other phytoestrogens, genistein can work in two ways: either by increasing ... This happens because genistein binds to special sites on cells called estrogen receptors. Genistein stimulates these receptors ...
  http://www.lifescript.com/health/centers/diabetes/alternative_treatments/genistein.aspx
*  Genistein | EGFR inhibitor | Read Reviews & Product Use Citations
Find all the information about Genistein for cell signaling research. ... Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. ... Tags: buy Genistein , Genistein supplier , purchase Genistein , Genistein cost , Genistein manufacturer , order Genistein , ... 1] Genistein blocks the mitogenic effect mediated by EGF, insulin and thrombin on NIH-3T3 cells.[2] Genistein also acts as an ...
  https://www.selleckchem.com/products/Genistein.html
*  Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis | SpringerLink
Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein. Nutr Cancer. ... Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day ... Genistein induces deleterious effects during its acute exposure in Swiss mice. Biomed Res Int. 2014;2014:619617.PubMed ... Genistein inhibits pro-inflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. Int J ...
  https://link.springer.com/article/10.1007/s00011-018-1146-7
*  Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride
Genistein has anti-inflammatory and antinecrotic effects on experimental liver damage caused by CCl. 4. . Genistein reduces ... Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride. Nalan Kuzu,1 Kerem Metin,2 Adile Ferda ... for 3 days (group 2). The third group was injected with subcutaneous 1 mg/kg genistein for 4 days starting one day before CCl. ... The fifth group was injected with subcutaneous 1 mg/kg genistein for 8 days starting one day before CCl. 4. injection. Plasma ...
  https://www.hindawi.com/journals/mi/2007/036381/abs/
*  A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor
Genistein is a natural product found in soy beans; its consumption has been associated with a low incidence of metastatic ... A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor. Genistein is a natural product found in soy beans; its ... This study seeks to determine the pharmacokinetics of genistein in. humans by administering a single dose of genistein and ... Patients will be treated with two formulations of genistein (a 43% genistein. preparation or a 90% preparation). This is a ...
  http://www.knowcancer.com/cancer-trials/NCT00001696/
*  Prostate Cancer Prevention Trial With Quercetin and Genistein - Full Text View - ClinicalTrials.gov
Active Comparator: Genistein supplement Dietary Supplement: Genistein supplement 100 mg/d genistein (+ vitamin C + folic acid ... Quercetin- and genistein blood concentrations [ Time Frame: Every three months (over a period of 18 months) ]. *IPSS ( ... The isoflavone genistein and the flavonoid quercetin have been identified as likely preventive candidates. The aim of the ... Prostate Cancer Prevention Trial With Quercetin and Genistein (QUERGEN). The recruitment status of this study is unknown. The ...
  https://clinicaltrials.gov/ct2/show/NCT01538316?recr=Open&intr=dietary+supplements&rank=8
*  Soy Genistein Isoflavone Powder - 4 oz (113 Grams)
PureFormulas offers free standard shipping for Soy Genistein Isoflavone Powder 4 oz (113 Grams), which contains soy extracts ... Genistein and daidzein are the two most active isoflavones in soybean. Genistein may reduce the effects of estrogen in the body ... Soy Genistein Isoflavone Powder - 4 oz (113 Grams). 0.0 (0) Write a Review ... Soy Genistein Isoflavone Powder 4 oz (113 Grams) from Planetary Herbals may support women's health. Our endocrine system is a ...
  https://www.pureformulas.com/soy-isoflavone-powder-4-oz-by-planetary-herbals.html?N=4294855304
*  A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor - Full Text View - ClinicalTrials.gov
Patients will be treated with two formulations of genistein (a 43% genistein preparation or a 90% preparation). This is a phase ... Patients will be treated with two formulations of genistein (a 43% genistein preparation or a 90% preparation). This is a phase ... This study seeks to determine the pharmacokinetics of genistein in humans by administering a single dose of genistein and ... This study seeks to determine the pharmacokinetics of genistein in humans by administering a single dose of genistein and ...
  https://www.clinicaltrials.gov/ct2/show/NCT00001696
*  Genistein and Cancer: Current Status, Challenges, and Future Directions
The ability of genistein to induce G2/M cell cycle arrest was tested in SGC-7901 and BGC-823 cells. Here, genistein (20-80 μM) ... Genistein Metabolites and Cancer. Although genistein is reported to be metabolized mainly through oxidation, sulfation, ... All of these data reveal that the major structural features of genistein pave the way for synthesis of new genistein ... Cloning the enzyme IFS from a genistein-rich soybean cultivar resulted in transgenic rice lines with 30-fold more genistein ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4496735/
*  Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) - Full Text View - ClinicalTrials.gov
Drug: Genistein (Unconjugated Isoflavones 100) Every participant will be administered a perfusion of 50 MicroM of Genistein ( ... Drug: Genistein (Unconjugated Isoflavones 100) Every participant will be administered a perfusion of 50 MicroM of Genistein ( ... Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis). The safety and scientific validity of ... Genistein is a naturally occurring substance that is found in food products such as soy and tofu, but is also an ...
  https://clinicaltrials.gov/ct2/show/NCT00590538?term=phenylbutyrate&rank=11
*  Genistein - Wikipedia
B43-genistein, an anti-CD19 antibody linked to genistein e.g. for leukemia. (S)-Equol Liquiritigenin Menerba Walter, E. D. ( ... Genistein was found to also possess toxic properties toward brain cells. Among many pathways stimulated by genistein, autophagy ... Genistein among other flavonoids is suspected to increase risk of infant leukemia when consumed during pregnancy. Genistein ... Genistin is the 7-O-beta-D-glucoside of genistein.[citation needed] Wighteone can be described as 6-isopentenyl genistein ...
  https://en.wikipedia.org/wiki/Genistein
*  Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women - Full Text View - ClinicalTrials.gov
Efficacy of genistein on DNA and apoptosis [ Time Frame: 112 days ]. Compare the effects of genistein vs placebo on DNA damage ... Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women. The safety and scientific validity of ... Genistein. Anticarcinogenic Agents. Protective Agents. Physiological Effects of Drugs. Antineoplastic Agents. Protein Kinase ... Compare the effects of genistein vs placebo on DNA damage and apoptosis by conducting COMET, TUNEL, Caspase-3, and AP site ...
  https://clinicaltrials.gov/ct2/show/study/NCT00099008?view=results
*  Genistein Can Mitigate the Effect of Radiation on Rat Lung Tissue
The genistein diet was formulated from the control diet, supplemented with 750 mg/kg of genistein, which has been used by other ... We investigated whether genistein could protect the lung from radiation-induced injury. We hypothesized that genistein would ... radiation and genistein diet (n = 16), no radiation and control diet (n = 8), and no radiation and genistein diet (n = 8). The ... Genistein Can Mitigate the Effect of Radiation on Rat Lung Tissue. Victoria L. Calveley,a Salomeh Jelveh,a Aimee Langan,a,e ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3139496/?lang=en-ca
*  CiNii 論文 - Genistein, a Soybean Isoflavone, Inhibits Inward Rectifier K^+ Channels in Rat...
Genistein, a Soybean Isoflavone, Inhibits Inward Rectifier K^+ Channels in Rat Osteoclasts * * Okamoto Fujio OKAMOTO Fujio ... Inhibitory effects of genistein on ATP-sensitive K^+ channels in rabbit portal vein smooth muscle OGATA R. ... Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes CHIANG ... Inhibition of vascular smooth muscle cell K^+ currents by tyrosine kinase inhibitors genistein and ST 638 SMIRNOV SV. ...
  http://ci.nii.ac.jp/naid/10008294516
*  Genistein, but not estradiol, inhibits MMP-9 secretion by mammary cancer cells | Cancer Research
We are currently investigating other cellular pathways through which genistein may regulate MMP-9 secretion. If genistein ... Genistein, but not estradiol, inhibits MMP-9 secretion by mammary cancer cells. Mona Hdeib, Jimmy D. Browning Jr. and Ruth S. ... We hypothesize that genistein, the primary isoflavone in soy, reduced mammary cancer metastasis by inhibiting secretion of MMP- ... Genistein was a potent inhibitor of MMP-9 secretion in these cells however, suggesting an estrogen-receptor independent ...
  http://cancerres.aacrjournals.org/content/64/7_Supplement/898.1
*  Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
Figure 7: ATM activation in HCT 116 wt cells treated with genistein (100 μM), camptothecin CPT (1 μM), and genistein ... Synthesis of Genistein Glycoconjugates. Genistein, like other flavonoid polyphenolic compounds, is a notoriously difficult ... In cells treated with genistein and genistein derivatives the induction of autophagy, visible as vesicular LC3 pattern, was ... 2.1.3. Regioselective Alkylation of Genistein. Hydroxyalkyl derivatives of genistein were prepared according to procedures ...
  https://www.hindawi.com/journals/jchem/2013/191563/
*  Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
... A. Byczek,1 J. ... G.-X. Hu, B.-H. Zhao, Y.-H. Chu et al., "Effects of genistein and equol on human and rat testicular 3Β-hydroxysteroid ... S. Banerjee, Y. Li, Z. Wang, and F. H. Sarkar, "Multi-targeted therapy of cancer by genistein," Cancer Letters, vol. 269, no. 2 ... K.-L. Chang, M.-L. Kung, N.-H. Chow, and S.-J. Su, "Genistein arrests hepatoma cells at G2/M phase: involvement of ATM ...
  https://www.hindawi.com/journals/jchem/2013/191563/ref/