*  Genistein-induced apoptosis in prostate cancer cells.
... Nutr Cancer. 1998;32(3):123-31.. Genistein-induced upregulation of ... We have evaluated the mechanism by which genistein may inhibit PCa cell growth. Here we report that genistein inhibits PCa cell ... The isoflavone genistein is believed to be the anticancer agent found in soy, and significant levels of genistein have been ... RE: Genistein-induced apoptosis in prostate cancer cells. Prostate cancer is the most popular non-skin cancer and second only ...
  http://medcapsules.com/forum/showthread.php?tid=3063&pid=5422
*  Plus it
... both pure genistein and a commercially available form of genistein called Genistein Combined Polysacharride (GCP), against two ... Genistein treatment. Genistein (Sigma) was dissolved in DMSO to make a 200 mg/mL stock solution that was added directly to the ... Genistein was dissolved in 100% methanol to create a stock solution (1 mg/mL) of genistein base. The stock solution was further ... Genistein is also active against human lymphoid neoplasia (18, 19). Genistein induces apoptosis via mitochondrial damage in T ...
  http://clincancerres.aacrjournals.org/content/15/4/1269
*  Despite concerns, soy probably safe for thyroid | Lifescript.com
... the soy-based dietary supplement genistein may not harm postmenopausal women's thyroid... ... Genistein is a type of soy isoflavone, a plant chemical that is structurally similar to estrogen and may have certain estrogen- ... However, he told Reuters Health by email, those studies used genistein doses that were 10 to 250 times higher than the doses ... According to Squadrito, it is not surprising that studies would find thyroid effects of very high doses of genistein. However, ...
  http://www.lifescript.com/health/centers/multiple_sclerosis/alternative_treatments/vitamin_d_articles/despite_concerns_soy_probably_safe_for_thyroid.aspx
*  GENISTEIN || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
  http://www.ewg.org/skindeep/ingredient/702561/GENISTEIN/
*  Concerns over Genistein, Part II-Beyond the heart | Science News
Genistein had no fattening effect in females. Here again, Di Lorenzo notes, the doses of genistein were high, but comparable to ... Part I: "Concerns over Genistein, Part I-The heart of the issue" is available at Concerns over Genistein, Part I-The heart of ... Part I: "Concerns over Genistein, Part I-The heart of the issue" is available at Concerns over Genistein, Part I-The heart of ... eating genistein diminished the normal estrogen-triggered functions of a tissue-presumably because genistein, a weak estrogen, ...
  https://www.sciencenews.org/node/4941
*  Genistein - What It Is, Uses, How It Works | Lifescript.com
Uses for genistein, how it works, and more. ... 55 Genistein was taken at a dose of 54 mg per day. The results ... Genistein may help reduce risk of various forms of cancer . In one study, newborn female rats treated with genistein had less ... Red clover is also a good source of genistein. Like other phytoestrogens, genistein can work in two ways: either by increasing ... This happens because genistein binds to special sites on cells called estrogen receptors. Genistein stimulates these receptors ...
  http://www.lifescript.com/health/centers/diabetes/alternative_treatments/genistein.aspx
*  Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride
Genistein has anti-inflammatory and antinecrotic effects on experimental liver damage caused by CCl. 4. . Genistein reduces ... Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride. Nalan Kuzu,1 Kerem Metin,2 Adile Ferda ... for 3 days (group 2). The third group was injected with subcutaneous 1 mg/kg genistein for 4 days starting one day before CCl. ... The fifth group was injected with subcutaneous 1 mg/kg genistein for 8 days starting one day before CCl. 4. injection. Plasma ...
  https://www.hindawi.com/journals/mi/2007/036381/abs/
*  A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor
Genistein is a natural product found in soy beans; its consumption has been associated with a low incidence of metastatic ... A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor. Genistein is a natural product found in soy beans; its ... This study seeks to determine the pharmacokinetics of genistein in. humans by administering a single dose of genistein and ... Patients will be treated with two formulations of genistein (a 43% genistein. preparation or a 90% preparation). This is a ...
  http://www.knowcancer.com/cancer-trials/NCT00001696/
*  Prostate Cancer Prevention Trial With Quercetin and Genistein - Full Text View - ClinicalTrials.gov
Active Comparator: Genistein supplement Dietary Supplement: Genistein supplement 100 mg/d genistein (+ vitamin C + folic acid ... Quercetin- and genistein blood concentrations [ Time Frame: Every three months (over a period of 18 months) ]. *IPSS ( ... The isoflavone genistein and the flavonoid quercetin have been identified as likely preventive candidates. The aim of the ... Prostate Cancer Prevention Trial With Quercetin and Genistein (QUERGEN). The recruitment status of this study is unknown. The ...
  https://clinicaltrials.gov/ct2/show/NCT01538316?recr=Open&intr=dietary+supplements&rank=8
*  Genistein and Cancer: Current Status, Challenges, and Future Directions
The ability of genistein to induce G2/M cell cycle arrest was tested in SGC-7901 and BGC-823 cells. Here, genistein (20-80 μM) ... Genistein Metabolites and Cancer. Although genistein is reported to be metabolized mainly through oxidation, sulfation, ... All of these data reveal that the major structural features of genistein pave the way for synthesis of new genistein ... Cloning the enzyme IFS from a genistein-rich soybean cultivar resulted in transgenic rice lines with 30-fold more genistein ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4496735/
*  Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) - Full Text View - ClinicalTrials.gov
Drug: Genistein (Unconjugated Isoflavones 100) Every participant will be administered a perfusion of 50 MicroM of Genistein ( ... Drug: Genistein (Unconjugated Isoflavones 100) Every participant will be administered a perfusion of 50 MicroM of Genistein ( ... Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis). The safety and scientific validity of ... Genistein is a naturally occurring substance that is found in food products such as soy and tofu, but is also an ...
  https://clinicaltrials.gov/ct2/show/NCT00590538?term=phenylbutyrate&rank=11
*  Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women - Full Text View - ClinicalTrials.gov
Efficacy of genistein on DNA and apoptosis [ Time Frame: 112 days ]. Compare the effects of genistein vs placebo on DNA damage ... Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women. The safety and scientific validity of ... Genistein. Anticarcinogenic Agents. Protective Agents. Physiological Effects of Drugs. Antineoplastic Agents. Protein Kinase ... Compare the effects of genistein vs placebo on DNA damage and apoptosis by conducting COMET, TUNEL, Caspase-3, and AP site ...
  https://clinicaltrials.gov/ct2/show/study/NCT00099008?view=results
*  Genistein Can Mitigate the Effect of Radiation on Rat Lung Tissue
The genistein diet was formulated from the control diet, supplemented with 750 mg/kg of genistein, which has been used by other ... We investigated whether genistein could protect the lung from radiation-induced injury. We hypothesized that genistein would ... radiation and genistein diet (n = 16), no radiation and control diet (n = 8), and no radiation and genistein diet (n = 8). The ... Genistein Can Mitigate the Effect of Radiation on Rat Lung Tissue. Victoria L. Calveley,a Salomeh Jelveh,a Aimee Langan,a,e ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3139496/?lang=en-ca
*  CiNii 論文 - Genistein, a Soybean Isoflavone, Inhibits Inward Rectifier K^+ Channels in Rat...
Genistein, a Soybean Isoflavone, Inhibits Inward Rectifier K^+ Channels in Rat Osteoclasts * * Okamoto Fujio OKAMOTO Fujio ... Inhibitory effects of genistein on ATP-sensitive K^+ channels in rabbit portal vein smooth muscle OGATA R. ... Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes CHIANG ... Inhibition of vascular smooth muscle cell K^+ currents by tyrosine kinase inhibitors genistein and ST 638 SMIRNOV SV. ...
  http://ci.nii.ac.jp/naid/10008294516
*  Genistein, but not estradiol, inhibits MMP-9 secretion by mammary cancer cells | Cancer Research
We are currently investigating other cellular pathways through which genistein may regulate MMP-9 secretion. If genistein ... Genistein, but not estradiol, inhibits MMP-9 secretion by mammary cancer cells. Mona Hdeib, Jimmy D. Browning Jr. and Ruth S. ... We hypothesize that genistein, the primary isoflavone in soy, reduced mammary cancer metastasis by inhibiting secretion of MMP- ... Genistein was a potent inhibitor of MMP-9 secretion in these cells however, suggesting an estrogen-receptor independent ...
  http://cancerres.aacrjournals.org/content/64/7_Supplement/898.1
*  Genistein - Wikipedia
B43-genistein, an anti-CD19 antibody linked to genistein e.g. for leukemia. (S)-Equol Liquiritigenin Menerba Walter, E. D. ( ... Genistein was found to also possess toxic properties toward brain cells. Among many pathways stimulated by genistein, autophagy ... Genistein among other flavonoids is suspected to increase risk of infant leukemia when consumed during pregnancy. Genistein ... Genistin is the 7-O-beta-D-glucoside of genistein.[citation needed] Wighteone can be described as 6-isopentenyl genistein ...
  https://en.wikipedia.org/wiki/Genistein
*  Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
Figure 7: ATM activation in HCT 116 wt cells treated with genistein (100 μM), camptothecin CPT (1 μM), and genistein ... Synthesis of Genistein Glycoconjugates. Genistein, like other flavonoid polyphenolic compounds, is a notoriously difficult ... In cells treated with genistein and genistein derivatives the induction of autophagy, visible as vesicular LC3 pattern, was ... 2.1.3. Regioselective Alkylation of Genistein. Hydroxyalkyl derivatives of genistein were prepared according to procedures ...
  https://www.hindawi.com/journals/jchem/2013/191563/
*  Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
... A. Byczek,1 J. ... G.-X. Hu, B.-H. Zhao, Y.-H. Chu et al., "Effects of genistein and equol on human and rat testicular 3Β-hydroxysteroid ... S. Banerjee, Y. Li, Z. Wang, and F. H. Sarkar, "Multi-targeted therapy of cancer by genistein," Cancer Letters, vol. 269, no. 2 ... K.-L. Chang, M.-L. Kung, N.-H. Chow, and S.-J. Su, "Genistein arrests hepatoma cells at G2/M phase: involvement of ATM ...
  https://www.hindawi.com/journals/jchem/2013/191563/ref/
*  FOSTEUM (Cholecalciferol,Genistein,Zinc bisglycinate) dosage, indication, interactions, side effects | EMPR - ONA
Genistein,Zinc bisglycinate) drug information & product resources from MPR including dosage information, educational materials ... Genistein (as aglycone) 27mg, citrated zinc (as bisglycinate) 20mg, cholecalciferol (Vit.D3) 200IU; caps; lactose-, gluten-free ...
  https://www.oncologynurseadvisor.com/fosteum/drug/2234/
*  IDEALS @ Illinois: The effects of adult exposure to genistein on female reproductive outcomes
Human exposure to genistein varies based on diet, but is present in many populations of adults and children. Genistein can bind ... There was no significant change in follicle numbers after 60 days of exposure to genistein. However, mice exposed to genistein ... I found that exposure to genistein did not significantly affect progesterone and estradiol levels at any time point. Genistein ... Genistein Ovary Follicle Folliculogenesis Steroidogenesis Fertility Pregnancy Preconception exposure Endocrine disruption. ...
  https://www.ideals.illinois.edu/handle/2142/97673
*  Abstract #3399: Genistein inhibits growth of cervical cancer cells by modulating EGFR signaling pathway | Cancer Research
We also examined the effects of genistein on the downstream signals of EGFR including Akt, ERK, p38 and JNK. Genistein ... In this study, we examined the anticancer effect of genistein on EGFR signaling in cervical cancer cells. Genistein inhibited ... Abstract #3399: Genistein inhibits growth of cervical cancer cells by modulating EGFR signaling pathway. Su-Hyeon Kim and Yong- ... Genistein, a soy derived isoflavone, has been shown to have anticancer effects in various human cancer cells. However, the ...
  http://cancerres.aacrjournals.org/content/69/9_Supplement/3399
*  Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females - Cooke - 2005 -...
Meng Zhang, Katsumi Ikeda, Jin-Wen Xu, Yukio Yamori, Xiu-Mei Gao, Bo-Li Zhang, Genistein suppresses adipogenesis of 3T3-L1 ... Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females. Authors. *. Paul S. ... Z. C. Dang, Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: mechanisms of action, Obesity Reviews, 2009 ...
  http://onlinelibrary.wiley.com/doi/10.1002/bdra.20142/abstract
*  Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle : Figure 9
a) control; (b) genistein (100 μM); (c) Gen-5′ (20 μM); (d) Ram-2′ (3 μM), (e) Ram-3′ (40 μM), (f) Ram-5′ (20 μM).. ...
  https://www.hindawi.com/journals/jchem/2013/191563/fig9/
*  Genistein Inhibits Cardiac L-Type Ca2+ Channel Activity by a Tyrosine Kinase-Independent Mechanism | Molecular Pharmacology
Effect of Intracellular Genistein on the L-Type Ca2+Current.. If the genistein-induced reduction of the Ca2+ current is really ... Effect of Extracellular Genistein on the L-Type Ca2+Current.. Bath application of 50 μM genistein inhibited the amplitude of ... 2). In cells dialyzed with 50 μM genistein, exposure to 50 μM extracellular genistein resulted in inhibition of the Ca2+ ... during exposure to 50 μM of genistein alone (b), and 50 μM genistein plus 100 μM PVN (c). C and D, examples of L-type Ca2+ ...
  http://molpharm.aspetjournals.org/content/62/3/554
*  Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage | Cancer Prevention Research
Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage. Liliana Souza, Erica Silva, Elissa Calloway, Omer ... Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage. Liliana Souza, Erica Silva, Elissa Calloway, Omer ... Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage. Liliana Souza, Erica Silva, Elissa Calloway, Omer ... Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage Message Subject (Your Name) has forwarded a page ...
  http://cancerpreventionresearch.aacrjournals.org/content/early/2014/03/08/1940-6207.CAPR-13-0295