*  Variation in BRCA1 cancer risks by mutation position
In contrast to previous reports, the ovarian:breast cancer ratio associated with mutations in a central region of the gene ( ... Variation in BRCA1 cancer risks by mutation position. Thompson, Deborah; Easton, Douglas; Borg, Åke LU ; Loman, Niklas LU ; ... In contrast to previous reports, the ovarian:breast cancer ratio associated with mutations in a central region of the gene ( ... In contrast to previous reports, the ovarian:breast cancer ratio associated with mutations in a central region of the gene ( ...
  https://lup.lub.lu.se/search/publication/1123906
*  BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer
... or between the position of the mutation in the BRCA1 gene and the presence of ovarian cancer in a family. Conclusions:. Among ... Conformation-sensitive gel electrophoresis and DNA sequencing were used to identify BRCA1 mutations. Results:. BRCA1 mutations ... BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer. Couch FJ, DeShano ML, Blackwood MA, et al. ... Only 7 percent of women from families with a history of breast cancer but not ovarian cancer had BRCA1 mutations. The rates ...
  https://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/97274029/PMID/9145677
*  Cell Changes in Fallopian Tubes of BRCA Mutation Carriers May Lead to Strategies for Preventing Ovarian Cancer - ONA
Recognition of early changes in the Fallopian tube cells of BRCA gene mutation carriers may be key to new strategies for ... Ovarian cancer risk is known to be increased by BRCA1 and BRCA2 gene mutations, but recent developments have led researchers to ... "These new findings take us a step closer to understanding how ovarian cancers develop in BRCA1/2 gene mutation carriers, ... of the women carrying the BRCA1 or BRCA2 gene mutation. These subcellular changes were similar to those seen in cells from ...
  http://www.oncologynurseadvisor.com/ovarian-cancer/cell-changes-in-fallopian-tubes-may-lead-to-ovarian-cancer-prevention/article/502601/
*  Phase II Study of AZD2281 in Patients With Known BRCA Mutation Status or Recurrent High Grade Ovarian Cancer or Patients With...
Patients with non-serous ovarian cancer who do not have a harmful mutation in the 'breast cancer genes' BRCA1 or BRCA2 ... Patients with non-serous ovarian cancer who do not have a harmful mutation in the 'breast cancer genes' BRCA1 or BRCA2 ... Patients with non-serous ovarian cancer who do not have a harmful mutation in the 'breast cancer genes' BRCA1 or BRCA2 ... Patients with serous ovarian cancer who do not have a harmful mutation in the 'breast cancer genes' BRCA1 or BRCA2 ...
  https://clinicaltrials.gov/ct2/show/results/NCT00679783?sect=X30156&view=results
*  Womens Care Consultants - Breast Cancer (BRCA) Gene Test
... in genes that help control normal cell growth. Finding changes in these genes, called BRCA1 and BRCA2, can help determine your ... Breast Cancer (BRCA) Gene Test admin 2015-11-16T20:37:37+00:00 Breast Cancer (BRCA) Gene Test. A breast cancer (BRCA) gene test ... A woman's risk of breast and ovarian cancer is higher if she has BRCA1 or BRCA2 gene changes. Breast cancer is extremely rare ... Certain people have a higher chance of inheriting BRCA1 or BRCA2 gene changes. ...
  http://stlwomenscareconsultants.com/services/gynecology/breast-cancer-brca-gene-test/
*  New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer | EurekAlert! Science News
... and it only targets a part of the BRCA1 and BRCA2 genes. A group of Canadian scientists has developed a new sequencing approach ... Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of developing breast and ovarian cancers. ... to provide a more effective method of BRCA1/2 mutational analysis. ... Philadelphia, PA, August 6, 2012 - Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of ...
  https://www.eurekalert.org/pub_releases/2012-08/ehs-nmp080312.php
*  flush suicide resistant TV enclosures Things To Know Before You Buy
... that many family members with BRCA1 or BRCA2 linkage are easily recognized by finding out LOH across the site info faulty gene ... When regarded mutation carriers are faraway from the group, no indication of further more linkage to BRCA1 or BRCA2 is noticed ... A populace examine of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations manage ... Screening for your G5193A BRCA1 and 999del5 BRCA2 mutations confirmed the 999del5 mutation from the 11 BRCA2 suggestive pairs ...
  http://ligature-resistant-tv-enc18527.jiliblog.com/8700918/flush-suicide-resistant-tv-enclosures-things-to-know-before-you-buy
*  Genetic analysis of BRCA1 and BRCA2 in Nigerian breast cancer patients | Cancer Research
Germline mutations in the BRCA1 and BRCA2 tumor suppressor genes are highly penetrant for breast/ovarian cancer, and genetic ... Genetic analysis of BRCA1 and BRCA2 in Nigerian breast cancer patients. James Fackenthal, Bifeng Zhang, Devin Burrill, Dezheng ... Genetic analysis of BRCA1 and BRCA2 in Nigerian breast cancer patients. James Fackenthal, Bifeng Zhang, Devin Burrill, Dezheng ... Genetic analysis of BRCA1 and BRCA2 in Nigerian breast cancer patients. James Fackenthal, Bifeng Zhang, Devin Burrill, Dezheng ...
  http://cancerres.aacrjournals.org/content/67/9_Supplement/4536
*  "BRCA1 185delAG mutant protein, BRAt, amplifies caspase-mediated apopto" by Joshua D. O'Donnell
The most commonly mutated genes in familial ovarian cancer are BRCA1 and BRCA2. It has been reported that cells carrying the ... IOSE cell lines carrying the BRCA1 185delAG mutation showed higher maspin levels than wild-type BRCA1 IOSE cell lines. BRCA1 ... Here, we report on the transfection of cDNA coding for the putative truncated protein product of the BRCA1 185delAG mutant gene ... Additionally, both heterozygous carriers of the BRCA1 185delAG mutation and cells transfected with BRAt protein show an ...
  http://scholarcommons.usf.edu/etd/433/
*  Risk of Pancreatic Cancer in Breast Cancer Families from the Breast Cancer Family Registry | Cancer Epidemiology, Biomarkers &...
The same genes, in particular BRCA1 and BRCA2, are also found to be mutated in a high percentage of families with hereditary ... Pancreatic cancer risk for BRCA1 and BRCA2 mutation carriers: results using imputed genotypes. Estimated SIRs for BRCA1 and ... PALB2, a new BC suppressor gene (11, 27, 28), has recently been reported as a pancreatic cancer susceptibility gene (9); ... CIs for pancreatic cancer between BRCA1 and BRCA2 mutation carriers and BRCA1 and BRCA2 families. ...
  http://cebp.aacrjournals.org/content/22/5/803?rss=1
*  The choice. BRCA1 testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and...
BRCA1 testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes ... This gene has been implicated in familial breast and ovarian cancer. Of 279 men and women whose family members had been tested ... BRCA1 testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes. ... or ovarian cancer who understand the benefits of genetic screening seem more likely to undergo testing for the BRCA1 gene. ...
  http://www.readabstracts.com/Health/The-choice-BRCA1-testing-in-families-with-hereditary-breast-ovarian-cancer-a-prospective-study-of-pa.html
*  New Drug Reduces Tumor Size in Women with Advanced Hereditary Ovarian or Breast Cancer - Healthcanal.com : Healthcanal.com
... non-chemotherapy treatment to show benefit to patients with cancers that result from BRCA1 or BRCA2 gene mutations," said ... Approximately 10 percent of these cases have an inherited mutation in the BRCA 1 or 2 genes, the type of cases treated in this ... can reduce the size of tumors in women with advanced hereditary ovarian cancer with BRCA gene mutations. ...
  https://www.healthcanal.com/cancers/10052-new-drug-reduces-tumor-size-in-women-with-advanced-hereditary-ovarian-or-breast-cancer.html
*  Which Patients With Early-Stage Triple-Negative Breast Cancer Should Receive a Platinum? - Hematology & Oncology
The gene expression pattern for most triple-negative breast cancers (TNBCs)-the subtype referred to as basal-like, which ... A larger study, by Byrski and colleagues in Poland, enrolled only patients with a BRCA1 mutation and demonstrated a 61% pCR ... Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat. 2014; ...
  http://www.hematologyandoncology.net/archives/july-2017/which-patients-with-early-stage-triple-negative-breast-cancer-should-receive-a-platinum/
*  Brca1 - BRCA1 - Rattus norvegicus (Rat) - Brca1 gene & protein
Gene namesi. Name:Brca1Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> , ... tr,Q9JKL6,Q9JKL6_RAT BRCA1 (Fragment) OS=Rattus norvegicus GN=Brca1 PE=2 SV=1 ... BRCA1Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/manual ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ...
  http://www.uniprot.org/uniprot/Q9JKL6
*  Patent on BRCA1 gene should never have been granted, researchers say | The BMJ
Patent on BRCA1 gene should never have been granted, researchers say BMJ 2010; 340 :c1629 ... Patent on BRCA1 gene should never have been granted, researchers say. BMJ 2010; 340 doi: https://doi.org/10.1136/bmj.c1629 ( ... Patent on BRCA1 gene.... *Patent on BRCA1 gene should never have been granted, researchers say ...
  http://www.bmj.com/content/340/bmj.c1629/related
*  BRCA1 gene found to inhibit two sex hormones, not just one
The BRCA1 gene and a second gene, BRCA2, were discovered to be breast cancer susceptibility genes in 1994 and 1995, ... Could help explain why women who have mutations in their BRCA1 gene are susceptible to hormone-dependent cancers including ... and then genetically manipulated them to either over or under-express the BRCA1 gene in order to assess the gene s effect on ... Rosen and his research team undertook the study to understand why loss of the BRCA1 gene results in cancers in tissues that are ...
  http://www.innovations-report.com/html/reports/life-sciences/report-54465.html
*  I Inherited The BRCA1 Gene And Had A Double Mastectomy And My Ovaries Removed
"But the BRCA1 gene has been linked to prostate cancer and our family history echoes that very significantly," she says. "That ... I Inherited The BRCA1 Gene And Had A Double Mastectomy And My Ovaries Removed. ... Just like the Hollywood actor, Niki discovered she had inherited the faulty BRCA1 gene, which significantly increases the ... "It was while I was waiting to find out if I had the gene that my mum died at 58, just two years older than Angelina Jolie's. ...
  http://www.huffingtonpost.co.uk/2015/03/25/i-inherited-the-brca1-gene-and-had-a-double-mastectomy-and-my-ovaries-removed_n_7315344.html
*  Researchers Hope Function of BRCA1 Gene Holds Key to New Treatments | Cancer Network | The Oncology Journal
New knowledge about the normal function of the BRCA1 gene, various mutations of which have been shown to cause breast and ... of inquiry is BRCA1 mRNA. Dr. Holt's group observed that although the BRCA1. gene is rarely mutated in sporadic breast or ... Gene therapy that delivers nonmutated BRCA1 to the tumor employing a. retroviral vector may be able to suppress tumor growth. ... that mutant BRCA1 genes do not inhibit growth or suppress tumors provides. additional evidence. This is the first direct ...
  http://www.cancernetwork.com/articles/researchers-hope-function-brca1-gene-holds-key-new-treatments
*  RCSB PDB - Gene View - BRCA1 - BRCA1, DNA repair associated
Gene View The Gene Browser allows to navigate the human genome and investigate the relationship between PDB entries and genes. ... BRCA1 Gene Structure. Chromosome: chr17 Genbank ID: NM_007294 Orientation: - Length coding sequence : 5589 nucleotides. Region ... Number of PDB entities (unique chains) for this gene: 28 View list of all current human gene IDs ... Gene. This track represents the gene-structure on the genome. White boxes represent UTRs (untranslated regions). Orange: ...
  http://www.rcsb.org/pdb/gene/BRCA1?chromosome=chr17&range=41228505&v=hg19
*  Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999) | Breast Health...
... develop breast cancer more frequently than women with BRCA1 mutations alone. Women with mutated BRCA1 genes currently account ... Women with malfunctioning BRCA1 or BRCA2 genes also have a 20% to 60% chance of developing ovarian cancer.(1) ... Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999). ... Both men and women may inherit BRCA1 and BRCA2 gene mutations. Families that typically pass on BRCA defects have the following ...
  http://www.imaginis.com/breast-health-news/link-between-brca1-gene-and-atm-protein-may-explain-increased-breast-cancer-risk-dateline-november-1
*  Diagnostic Strategy for Analytical Scanning of BRCA1 Gene by Fluorescence-assisted Mismatch Analysis Using Large,...
The same strategy was applied to scan 16140 nucleotides of the BRCA1 gene (19.1% of the total gene length) comprising the 22 ... of the total gene sequence. Whereas linkage analysis indicates an 81% contribution of the BRCA1 gene to the pathogenesis of ... BRCA1 is a tumor suppressor gene spanning a region of 81 kb of genomic DNA (4) and is characterized by 22 coding exons (open ... Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am. J. Hum. Genet., 62: ...
  http://clincancerres.aacrjournals.org/content/7/6/1638
*  c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells | BMC Cancer | Full Text
The distal BRCA1 promoter region is associated with c-Myc and contributes to BRCA1 gene activation. ... BRCA1 mRNA expression and BRCA1 protein expression were determined by quantitative RT-PCR and western blot, respectively and ... Depletion of c-Myc was found to be correlated with reduced expression levels of BRCA1 mRNA and BRCA1 protein. Depletion of c- ... Myc decreased BRCA1 promoter activity, while ectopically expressed c-Myc increased BRCA1 promoter activity. In the distal BRCA1 ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-246
*  COsegregation of VARiants in the BRCA1/2 Genes - Full Text View - ClinicalTrials.gov
The BRCA1 and BRCA2 genes are the two major high-risk breast and/or ovarian cancer susceptibility genes. Monoallelic germline ... COsegregation of VARiants in the BRCA1/2 Genes (COVAR). The safety and scientific validity of this study is the responsibility ... Study of Family COsegregation of VARiants in the BRCA1/2 Genes to Validate Their Use in Genetic. ... In september 2011, the French UMD-BRCA1/2 database comprised 706 different variants in 1,300 BRCA1 families and 1,089 different ...
  https://clinicaltrials.gov/ct2/show/NCT01689584?recr=Open&intr=%22Genetic+Counseling%22&rank=11
*  Lirias: A somatic mutation in the 5 ' UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation...
We have analysed the effect of a somatic point mutation (117 G , C) in position -3 with respect to the AUG of the BRCA1 gene, ... We constructed chimeric genes encoding the luciferase reporter sequence downstream of the wild type or the mutated BRCA1 5'UTR ... Initiation of translation from a downstream in-frame AUG codon in BRCA1 gene was recently identified in normal cells and ... A somatic mutation in the 5 ' UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. ...
  https://lirias.kuleuven.be/handle/123456789/253034
*  Myriad v Ambry - Myriad looks to enforce its BRCA1/BRCA2 gene patents - Lexology
Just when you thought it was safe to begin testing your own genes, you need to think again... On 13 June 2013 the Supreme Court ... The particular DNA sequences at issue were the DNA sequences of naturally occurring mutants of the human BRCA1/BRCA2 genes. No ... Myriad v Ambry - Myriad looks to enforce its BRCA1/BRCA2 gene patents AJ Park ... Perhaps the surprising aspect of these events is Ambry's decision to offer genetic diagnostic testing for BRCA1/BRCA2 at all. ...
  https://www.lexology.com/library/detail.aspx?g=e445931f-fc0b-4942-8913-a525ada0c99a