*  An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment.
Gene Expression Regulation, Neoplastic*. Glioma / metabolism*, pathology. Humans. Mice. Neoplasm Proteins / biosynthesis*. ... 2008A toolbox of novel murine house-keeping genes identified by meta-analysis of large scale gene expression profiles.Biochim ... The HPRT gene has been reported as a constitutively expressed house-keeping gene [43]. Total RNA was isolated using the peq ... Year: 2007Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in ...
  http://www.biomedsearch.com/nih/allograft-glioma-model-reveals-dependence/22590566.html
*  JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.
Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Inhibitory Concentration 50. Liver ... JNK1, JNK2 and JNK3 mRNA expression levels were quantified by real-time PCR. Expression and phosphorylation of JNK1, JNK2, and ... Previous Document: Relationship between the expression of IP-10 and IP-10 mRNA in peripheral blood and HBV DNA level in.... ... Flow cytometry was used to analyze the cell cycle distribution and to measure the expression levels of P-glycoprotein (P-gp) ...
  http://www.biomedsearch.com/nih/JNK1-JNK2-JNK3-are-involved/20525557.html
*  RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells.
We previously reported that gene amplification and overexpression of HER2 and uPAR occur in 70% of HER2-amplified ... Gene Expression Regulation, Neoplastic. Genetic Vectors. Humans. Plasmids. RNA Interference / physiology*. Receptor, erbB-2 / ... Down-Regulation. Extracellular Matrix / pathology. Extracellular Signal-Regulated MAP Kinases / metabolism*. Female. ... We previously reported that gene amplification and overexpression of HER2 and uPAR occur in 70% of HER2-amplified tumor cells ...
  http://www.biomedsearch.com/nih/RNAi-mediated-downregulation-uPAR-synergizes/20063318.html
*  Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells.
Cell Transformation, Neoplastic / metabolism. Gene Expression Regulation, Neoplastic. Humans. Insulin Receptor Substrate ... The interaction between IRS-1 and oxidative stress in the regulation of autophagy and cell growth. The reported signaling ... The amount of total IRS-1 was greater in cells infected with retrovirus encoding for the IRS-1 gene than it was in the control ... Lum JJ,Bauer DE,Kong M,Harris MH,Li C,Lindsten T,Thompson CB,Growth factor regulation of autophagy and cell survival in the ...
  http://www.biomedsearch.com/nih/Insulin-receptor-substrate-1-prevents/22788551.html
*  Approaching Ewing sarcoma.
Gene Expression Regulation, Neoplastic. Humans. RNA-Binding Protein EWS / genetics, metabolism. Research / trends. Sarcoma, ... this rare malignancy opens insights in pathological gene and protein regulation. Despite decades of basic and translational ...
  http://www.biomedsearch.com/nih/Approaching-Ewing-sarcoma/20624127.html
*  Metallothionein 1 h tumour suppressor activity in prostate cancer is mediated by euchromatin methyltransferase 1.
Down-Regulation. Female. Gene Expression Regulation, Neoplastic. Histone-Lysine N-Methyltransferase / genetics, metabolism*. ... Low expression of MT1h was associated with poor clinical outcomes in both prostate and liver cancer. We found that the promoter ... Forced expression of MT1h induced cell growth arrest, suppressed colony formation, retarded migration, and reduced invasion. ... SCID mice with tumour xenografts with inducible MT1h expression had lower tumour volumes as well as fewer metastases and deaths ...
  http://www.biomedsearch.com/nih/Metallothionein-1h-Tumor-Suppressor-Activity/23355073.html
*  Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin...
... gene in the medullary thyroid carcinoma (MTC) cell line TT is modulated by a neuroendocrine-specific enhancer fragment ( ... Gene Expression Regulation, Neoplastic*. Hela Cells. Humans. Molecular Sequence Data. Oligodeoxyribonucleotides / chemistry. ... 11494129 - Change in gene expression subsequent to induction of pnn/drs/mema: increase in p21(cip1.... 11409709 - Efficacy of ... 18631289 - Microgenomic analysis reveals cell type-specific gene expression patterns between ray a.... 8804409 - Pwp2, a member ...
  http://www.biomedsearch.com/nih/Modified-binding-proteins-from-calcitonin/8265349.html
*  REGULATION OF FIBROBLAST PROLIFERATION AND GENE EXPRESSION: IMPLICATIONS FOR OCULAR SURFACE FIBROSIS, SYSTEMIC INFLAMMATORY AND...
SYSTEMIC INFLAMMATORY AND NEOPLASTIC DISEASE. ScholarBank@NUS Repository. ... REGULATION OF FIBROBLAST PROLIFERATION AND GENE EXPRESSION: IMPLICATIONS FOR OCULAR SURFACE FIBROSIS, SYSTEMIC INFLAMMATORY AND ... LAN WANWEN (2015-08-14). REGULATION OF FIBROBLAST PROLIFERATION AND GENE EXPRESSION: IMPLICATIONS FOR OCULAR SURFACE FIBROSIS, ... I validated expression levels of 24 lincRNAs found to be dysregulated in pterygium and showed that some of these have impacts ...
  http://scholarbank.nus.edu.sg/handle/10635/125237
*  Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.
Gene Expression Regulation, Neoplastic / drug effects. Humans. Injections, Intraperitoneal. Ki-67 Antigen / metabolism. ... Gene expression analysis revealed the induction of interferon- and cell death-related genes that were associated with ... BI-69A11-resistant Nras((Q61K)) ::Ink4a(-/-) tumors exhibited increased CD45 expression, reflective of immune cell infiltration ... Biweekly administration of BI-69A11 starting at 10 weeks or as late as 24 weeks after the induction of mutant Nras expression ...
  http://www.biomedsearch.com/nih/Inhibition-melanoma-development-in-Nras/23035722.html
*  Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate...
Gene Expression Regulation, Neoplastic / drug effects. Glutamate Carboxypeptidase II / genetics*, immunology, metabolism. ... Conversely, antiandrogens up-regulate PSMA expression. These expression changes, including increased PSMA expression in ... 16439467 - Differential expression proteomics of human colon cancer.. 1212647 - The control of large bowel cancers. present ... Collectively, these results establish that relative changes in PSMA expression levels can be quantitatively measured using a ...
  http://www.biomedsearch.com/nih/Noninvasive-measurement-androgen-receptor-signaling/21606347.html
*  The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen...
Gene Expression Regulation, Neoplastic / drug effects. Genes, Immediate-Early / drug effects. Genes, fos / drug effects. Genes ... Furthermore, expression of the immediate early genes c-fos and c-jun was up-regulated by TPA only in LNCaP and DU-145 cells, ... The regulation of the c-myc mRNA by TPA correlated inversely with activation of cell death being down-regulated in LNCaP cells ... Genes, myc / drug effects. Humans. Male. Prostatic Neoplasms / enzymology*, genetics, pathology*. Protein Kinase C / ...
  http://www.biomedsearch.com/nih/protein-kinase-C-activator-phorbol/9514905.html
*  Cytotoxicity of natural extract from Tegillarca granosa on ovarian cancer cells is mediated by multiple molecules.
Gene Expression Regulation, Neoplastic / drug effects. Humans. Ovarian Neoplasms / drug therapy. Proto-Oncogene Proteins c-bcl- ... Apoptosis associated gene bcl-2 and caspase-3, tumor metastasis associated gene ?-catenin, but not E-cadherin, and CD24, but ... RT-PCR or flow cytometric analysis was used to investigate the expression of bcl-2, caspase-3, p53, beta-catenin, E-cadherin, ... 7512028 - B cells regulate expression of cd40 ligand on activated t cells by lowering the mrna le.... 10573108 - Overexpression ...
  http://www.biomedsearch.com/nih/Cytotoxicity-natural-extract-from-Tegillarca/19796578.html
*  Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF...
The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell ... Gene Expression Regulation, Neoplastic / drug effects*. Homeodomain Proteins / metabolism*. Humans. Leukemia / metabolism*. ... In agreement with this conclusion de-regulated VSP gene expression is associated with CML [8]. We infer that the elevation of ... We conclude that the re-establishment of VSP gene regulation by PRH is responsible in large part for the effects of these ...
  http://www.biomedsearch.com/nih/Dasatinib-inhibits-leukaemic-cell-survival/22874537.html
*  The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
Gene Expression Regulation, Neoplastic / drug effects. Humans. Interleukin-6 / metabolism. Morpholines / pharmacology. Multiple ... BMSCs and OCs upregulate Pim-2 expression in MM cells largely via the IL-6/STAT3 and NF-κB pathway, respectively. Pim-2 short ... but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in MM cells. ...
  http://www.biomedsearch.com/nih/kinase-Pim-2-novel-anti/21475253.html
*  Primary Faculty | Department of Biomedical Informatics
... gene expression regulation, neoplastic; imaging informatics; informatics; laboratories, hospital; medical informatics; next ... Regulation and function of long noncoding RNAs (lncRNAs) -Transcription and transcriptomics -Breast cancer biology ...
  https://www.dbmi.pitt.edu/people/faculty
*  Steady-state ubiquitination of TRAIL-R1 on lysine resid | Open-i
Gene Expression Regulation, Neoplastic*. *Neoplasm Proteins/genetics/metabolism*. *Neoplasms/genetics/metabolism*. *Receptors, ... Upon exogenous (over)expression, a number of these ligases can affect the trafficking of membrane molecules. However, only for ... Upon exogenous (over)expression, a number of these ligases can affect the trafficking of membrane molecules. However, only for ... Gene silencing identified MARCH-8 as the endogenous ligase that ubiquitinates TRAIL-R1 and attenuates its cell surface ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585101_zbc0121341270004&req=4
*  FAS mRNA colocalizes with Wig-1 protein in SGs. RNA FIS | Open-i
Wig-1, also known as ZMAT3, is a p53 target gene that encodes an RNA-binding zinc-finger protein involved in the regulation of ... Mentions: The CCR4-NOT complex is known to regulate gene expression in response to stress.26 To explore whether CNOT6 interacts ... Wig-1, also known as ZMAT3, is a p53 target gene that encodes an RNA-binding zinc-finger protein involved in the regulation of ... Mentions: The CCR4-NOT complex is known to regulate gene expression in response to stress.26 To explore whether CNOT6 interacts ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4150987_onc2013594f6&req=4
*  Schema of our method. We first calculate correlations b | Open-i
We first calculate correlations between phenotypes and expression values as meta-expression values, while preparing a sequence ... Gene Expression Profiling/methods*. *Gene Expression Regulation, Neoplastic*. Minor. *Algorithms. *Bayes Theorem ... We first calculate correlations between phenotypes and expression values as meta-expression values, while preparing a sequence ... We first calculate correlations between phenotypes and expression values as meta-expression values, while preparing a sequence ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2572072_1471-2105-9-404-1&req=4
*  Smyd3 methylates H4K5 in vitro and in vivo. (A) Methyla | Open-i
Gene Expression Regulation, Neoplastic*. *Histone-Lysine N-Methyltransferase/genetics/metabolism*. *Histones/genetics/ ... Bottom Line: Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation.Here we show that Smyd3 ... Bottom Line: Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation.Here we show that Smyd3 ... Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3368817_epi-7-340-g2&req=4
*  Inactivation of Akt is an essential downstream signal i | Open-i
Gene Expression Regulation, Neoplastic. *HEK293 Cells. *Hep G2 Cells. *Humans. *Mice, Inbred BALB C ... in BEL-7404 cells after over-expression of miR-26a or knockdown of ITGA5. (C) The anoikis activity of BEL-7404 cells treated ... in BEL-7404 cells after over-expression of miR-26a or knockdown of ITGA5. (C) The anoikis activity of BEL-7404 cells treated ... in BEL-7404 cells after over-expression of miR-26a or knockdown of ITGA5. (B) Western blot analysis was performed to determine ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4385851_oncotarget-06-2277-g006&req=4
*  Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias. - CAPRARO Valérie
en] Antineoplastic Agents/therapeutic use ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia, Myeloid, Acute/drug ... and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. ... hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT ... B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher ...
  http://orbi.ulg.ac.be/handle/2268/110202
*  Effects of ω3PUFAs on HMGCoAR transcription, phosphory | Open-i
Gene Expression Regulation, Neoplastic. *HT29 Cells. *Humans. *P-Glycoprotein/genetics/metabolism. *Phosphorylation ... These results suggest that DHA and EPA did not decrease HMGCoAR expression by down-regulating gene transcription. SREBP-1 was ... These results suggest that DHA and EPA did not decrease HMGCoAR expression by down-regulating gene transcription. SREBP-1 was ... Results: MDR cells, which overexpressed Pgp and MRP1, had a dysregulated cholesterol metabolism, due to the lower expression of ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4225767_1476-4598-12-137-3&req=4
*  Over-expression of WAVE3 activates NFκB signaling.(A) | Open-i
Over-expression of WAVE3 activates NFκB signaling.(A) Western blot analysis of WAVE3-GFP protein levels in GFP and GFP-W3- ... Gene Expression Regulation, Neoplastic. *Humans. *MCF-7 Cells. *Neoplasm Invasiveness/genetics. *Neoplasm Metastasis ... We have shown that the WAVE3-mediated activation of cancer cell invasion is due, in part, to its regulation of expression and ... We have shown that the WAVE3-mediated activation of cancer cell invasion is due, in part, to its regulation of expression and ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4199728_pone.0110627.g002&req=4
*  Mulibrey nanism
Gene Expression Profiling. en. dc.subject.mesh. *Gene Expression Regulation, Neoplastic. en. ... Mulibrey (MUscle-LIver-BRain-EYe) nanism is a rare autosomal recessive disorder caused by mutations in TRIM37 gene and ...
  http://documents.irevues.inist.fr/handle/2042/68164?show=full